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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.sebastian Garcia-Medina Karolina sienkiewicz s.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline Proszynski Braden Tierney Caleb M.schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita s.ngaraju Lynn E.Taylor Julian C.schmidt Michael A.schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare semyon Kruglyak shawn Levy Min Yu Duane C.Hassane susan M.Bailey Kelly Bolton Jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA space Exploration Technologies Corporation HawthomeCA 90250USA sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University st Louis Oncology Division St.LouisMO 63100USA Meinig school of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

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simulating Resin Infusion through Textile Reinforcement Materials for the Manufacture of Complex Composite structures

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Engineering 2017年第5期3卷 596-607页

作者： Robert s. Pierce Brian G. Falzon Northern Ireland Advanced Composites and Engineering Centre Belfast BT3 9DZ UK school of Mechanical and Aerospace Engineering Queen's University Belfast Belfast BT9 5AH UK

Increas.ng demand for weight reduction and greater fuel efficiency continues to spur the use of composite materials in commercial aircraft structures. subsequently, as composite aerostructures become larger and more complex, traditional autoclave manufacturing methods are becoming prohibitively expensive. This has prompted renewed interest in out-of-autoclave process.ng techniques in which resins are introduced into a reinforcing preform. However, the success of these resin infusion methods is highly dependent upon operator skill and experience, particularly in the development of new manufacturing strategies for complex parts. Process modeling, as a predictive computational tool, aims to address the issues of reliability and waste that result from traditional trial-and-error approaches. Basic modeling attempts, many of which are still used in industry, generally focus on simulating fluid flow through an isotropic porous reinforcement material. How- ever, recent efforts are beginning to account for the multiscale and multidisciplinary complexity of woven materials, in simulations that can provide greater fidelity. In particular, new multi-physics process models are able to better predict the infusion behavior through textiles by considering the effect of fabric deformation on permeability and porosity properties within the reinforcing material. In addition to reviewing pre- vious research related to process modeling and the current state of the art, this paper highlights the recent validation of a multi-physics process model against the experimental infusion of a complex double dome component. By accounting for deformation-dependent flow behavior, the multi-physics process model was able to predict realistic flow behavior, demonstrating considerable improvement over basic isotropic permeability models.

关键词： Composite materials Textile reinforcement Draping Infusion Numerical modeling

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Logistic回归模型中连续变量交互作用的分析

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中华流行病学杂志 2010年第7期31卷 812-814页

作者：邱宏余德新谢立亚王晓蓉付振明香港中文大学公共卫生及基层医疗学院

Rothman提出生物学交互作用的评价应该基于相加尺度即是否有相加交互作用,而logistic回归模型的乘积项反映的是相乘交互作用.目前国内外文献讨论logistic回归模型中两因素的相加交互作用以两分类变量为主,本文介绍两连续变量或连续变量... 详细信息

Rothman提出生物学交互作用的评价应该基于相加尺度即是否有相加交互作用,而logistic回归模型的乘积项反映的是相乘交互作用.目前国内外文献讨论logistic回归模型中两因素的相加交互作用以两分类变量为主,本文介绍两连续变量或连续变量与分类变量相加交互作用可信区间估计的Bootstrap方法,文中以香港男性肺癌病例对照研究资料为例,辅以免费软件R的实现程序,为研究人员分析交互作用提供参考.

关键词： logistic回归模型连续变量相加交互作用s指数方法,Bootstrap

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spectroscopic analysis on the binding interaction of biologically active pyrimidine derivative with bovine serum albumin

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Journal of Pharmaceutical Analysis 2016年第1期6卷 56-63页

作者： Vishwas D. suryawansht Laxman s. Walekar Anil H. Gore Prashant V. Anbhule Govind B. Kolekar Fluorescence spectroscopy Research Laboratory Department of Chemistry Shivaji University Kolhapur 416 004 Maharashtra India

A biologically active antibacterial reagent, 2-amino-6-hydroxy-4-（4-N, N-dimethylaminophenyl）-pyr- imidine-5-carbonitrile （ahDMAPPC）, was synthesized. It was employed to investigate the binding in- teraction with the bovine serum albumin （BsA） in detail us.ng different spectroscopic methods. It ex- hibited antibacterial activity against Escherichia cali and staphylococcus aureus which are common food poisoning bacteria. The experimental results showed that the fluorescence quenching of model carrier protein BsA by ahDMAPPC was due to static quenching. The site binding constants and number of binding sites （n ≈ 1） were determined at three different temperatures based on fluorescence quenching results. The thermodynamic parameters, enthalpy change （ah）, free energy （AG） and entropy change （As） for the reaction were calculated to be 15.15 kJ/mol, -36.11 kJ/mol and 51.26J/mol K according to van＇t Hoff equation, respectively. The results indicated that the reaction was an endothermic and spontaneous process, and hydrophobic interactions played a major role in the binding between drug and BsA. The distance between donor and acceptor is 2.79 nm according to Forster＇s theory. The alterations of the BsA secondary structure in the presence of ahDMAPPC were confirmed by UV-visible, synchronous fluorescence, circular dichroism （CD） and three-dimensional fluorescence spectra. All these results in- dicated that ahDMAPPC can bind to BsA and be effectively transported and eliminated in the body. It can be a useful guideline for further drug design.

关键词： Bovine serum albumin Fluorescence spectroscopy Pyrimidine derivative Binding interaction Fluorescence resonance energy transfer(FRET)

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logistic回归模型中交互作用的分析及评价

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中华流行病学杂志 2008年第9期29卷 934-937页

作者：邱宏余德新王晓蓉付振明谢立亚香港中文大学公共卫生学院社区及家庭医学系

流行病学病因学研究常运用logistic回归模型分析影响因素的作用，并利用纳入乘积项的方法分析因素间交互作用，如有统计学意义表示两因素间存在相乘交互作用，但乘积项若无统计学意义并不表示两因素间相加交互作用或生物学交互作用的有... 详细信息

流行病学病因学研究常运用logistic回归模型分析影响因素的作用，并利用纳入乘积项的方法分析因素间交互作用，如有统计学意义表示两因素间存在相乘交互作用，但乘积项若无统计学意义并不表示两因素间相加交互作用或生物学交互作用的有无。文中介绍Rothman提出的针对logistic或Cox回归模型的三个评价相加交互作用的指标及其可信区间的计算，并以sPss15．0a件应用实例分析得出logistic回归模型的参数估计值和协方差矩阵，引入Andersson等编制的Excel计算表，计算相加交互作用指标及其可信区间，用于评价因素间的相加交互作用，为研究人员分析生物学交互作用提供依据。该方法方便快捷，且Excel计算表可在线免费下载。

关键词： logistic回归模型相加交互作用指标女性肺癌

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在CAI软件系统设计中的超文本技术及实现

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微机发展 1998年第4期8卷 31-33页

作者：张霖方潜生安徽建筑工业学院计算机系

本文针对作者多年ＣＡＩ开发中积累的经验，论述了将超文本技术应用于ＣＡＩ软件系统开发、所涉及的主要技术思想及一般实现方法。最后讨论了ＣＡＩ的发展趋势。

关键词：超文本 CAI 软件系统设计

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Effect of ambient air pollution on daily mortality rates in Guangzhou,China

Effect of ambient air pollution on daily mortality rates in ...

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2011广东省预防医学会学术年会

作者： Ignatius Tak sun Yu Yong hui Zhang Wilson Wai san Tam Qing Hua Yan Yan jun Xu Xiao jun Xun Wei Wu Wen Jun Ma Lin Wei Tian Lap ah Tse Xiang Qian Lao school of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong Kong Center for Disease Control and Prevention of Guangdong Province

We aimed to investigate the effects of ambient air pollutants on daily mortality in a relatively stable and homogeneous population in Guangzhou,*** mortality,air pollution,and weather data between 2006 and 2009 were *** generalized additive model with poison regression was used to estimate the excessive risks(ERs) of air pollutants(PM,*** NO) on total,cardiovascular and respiratory *** effects of lagO-1 were the greatest for total non-accidental and cardiovascular *** increments of 10μg m in ***,and PM were associated with ERs of 1.54%(95%CI: 1.03-2.06%).1.42%(95%CI:1.06-1.78%),and 1.26%(95%CI:0.86-1.66%) respectively for total non-accidental deaths,and 2.28%(95%CI:1.40-3.16%),1.81%(95%CI:1.20-2.41%).and 1.79%(95%CI:1.11-2.47%) respectively for cardiovascular *** persons who died from respiratory disease,however,the maximum effects occurred at *** ERs for sO,NO,and PM were 1.36%(95%CI:0.23-2.50%),1.47% (95%CI:0.66-2.29%) and 0.93%(95%CI:0.03-1.83%).*** effects of the three air pollutants on mortality were stronger in elderly and in *** ERs in the present study were higher than those reported in *** U.s..and most other Asian *** findings show relatively higher ERs of daily mortality by ambient air pollutants in the center of Guangzhou,China,compared with estimates in other *** studies with accurate exposure measurement among homogeneous population are needed to evaluate the precise magnitudes of the effects of the air pollutants.

关键词： Ambient air pollution Daily mortality Chinese

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用IDC访问数据库

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微机发展 2003年第3期13卷 67-68,71页

作者：陈学进安徽工业大学计算机学院安徽马鞍山243002

阐述了数据库形式管理数据的重要性,说明在C/s系统中如何利用IDC技术访问WEB数据库。列举了访问技术的编程实例,供相关开发人员参考。

关键词： IDC 数据库数据处理 Internet 应用程序

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基于铁粉还原的LiFePO_4/C合成路径及其电化学性能研究

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无机材料学报 2016年第8期31卷 802-806页

作者：孟方礼章冬云常程康徐家跃 KAMZIN A s 上海应用技术大学材料科学与工程学院上海201418 Ioffe Physical Technical Institute Russian Academy of Sciences

使用还原铁粉作为铁源,通过超细球磨与喷雾干燥、高温煅烧技术制备了球形微纳米LiFePO_4/C复合材料。使用DsC/TG以及XRD对LiFePO_4/C复合材料的形成过程进行了分析;使用sEM、穆斯堡谱仪等手段对复合材料进行分析;使用电化学工作站、容... 详细信息

使用还原铁粉作为铁源,通过超细球磨与喷雾干燥、高温煅烧技术制备了球形微纳米LiFePO_4/C复合材料。使用DsC/TG以及XRD对LiFePO_4/C复合材料的形成过程进行了分析;使用sEM、穆斯堡谱仪等手段对复合材料进行分析;使用电化学工作站、容量测试仪对其充放电行为进行分析。研究发现,使用该合成技术路线,在500～700℃下能够合成LiFePO_4/C复合材料。获得的LiFePO_4/C复合材料具有规则的球形外貌,平均尺寸4～5μm。该微米颗粒由200 nm左右细小颗粒组成,颗粒间具有纳米尺寸微孔。穆斯堡谱仪测试结果表明,复合材料中Fe处于＋2价的价态。复合材料在1C倍率下表现出稳定的充放电行为,平均比容量在156 m ah/g,300次循环后,容量保持率为92.8%。该技术制备的LiFePO_4/C复合材料具有潜在的应用价值。

关键词：磷酸铁锂超细球磨穆斯堡谱比容量循环性能

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基于浏览器/服务器模式的信息系统研究

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微机发展 2002年第2期12卷 36-38页

作者：唐红梅安徽机电学院计算机系安徽芜湖241000

文章详细介绍了浏览器 /服务器模式的体系结构与工作原理 ,并对系统所运用的关键技术进行研究和讨论 ,从而避免了基于传统客户

关键词：浏览器客户器服务器系统结构网络安全连接信息系统数据源连接 B/s模式 C/s模式

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