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Entacapone promotes hippocampal neurogenesis in mice

Neural Regeneration Research 2021年第6期16卷 1005-1010页

作者： Dae Young Yoo Hyo Young Jung Woosuk Kim Kyu Ri Hahn Hyun Jung Kwon sung Min Nam Jin Young Chung yeo sung yoon Dae Won Kim In Koo Hwang Department of Anatomy and Cell Biology College of Veterinary Medicineand Research Institute for Veterinary ScienceSeoul National UniversitySeoulSouth Korea Department of Anatomy College of MedicineSoonchunhyang UniversityCheonanSouth Korea Department of Biomedical Sciences and Research Institute for Bioscience and BiotechnologyHallym UniversityChuncheonSouth Korea Department of Biochemistry and Molecular Biology Research Institute of Oral SciencesCollege of DentistryGangneung-Wonju National UniversityGangneungSouth Korea Department of Anatomy College of Veterinary MedicineKonkuk UniversitySeoulSouth Korea Department of Veterinary Internal Medicine and Geriatrics College of Veterinary MedicineKangwon National UniversityChuncheonSouth Korea

Entacapone,a catechol-O-methyltransferase inhibitor,can strengthen the therapeutic effects of levodopa on the treatment of Parkinson’s ***,few studies are reported on whether entacapone can affect hippocampal neurogenesis in *** investigate the effects of entacapone,a modulator of dopamine,on proliferating cells and immature neurons in the mouse hippocampal dentate gyrus,60 mice(7 weeks old)were randomly divided into a vehicle-treated group and the groups treated with 10,50,or 200 mg/kg *** results showed that 50 and 200 mg/kg entacapone increased the exploration time for novel object *** staining results revealed that after entacapone treatment,the numbers of Ki67-positive proliferating cells,doublecortin-positive immature neurons,and phosphorylated cAMP response element-binding protein(pCREB)-positive cells were significantly *** blot analysis results revealed that treatment with tyrosine kinase receptor B(TrkB)receptor antagonist significantly decreased the exploration time for novel object recognition and inhibited the expression of phosphorylated TrkB and brain-derived neurotrophic factor(BDNF).Entacapone treatment antagonized the effects of TrkB receptor *** results suggest that entacapone treatment promoted hippocampal neurogenesis and improved memory function through activating the BDNF-TrkB-pCREB *** study was approved by the Institutional Animal Care and Use Committee of Seoul National University(approval ***-130730-1)on February 24,2014.

关键词： brain-derived neurotrophic factor entacapone hippocampus neurogenesis neurotrophic factor phosphorylated cAMP response element-binding protein tyrosine kinase receptor B receptor

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Hypothyroidism affects astrocyte and microglial morphology in type 2 diabetes

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Neural Regeneration Research 2013年第26期8卷 2458-2467页

作者： sung Min Nam Yo Na Kim Dae Young Yoo Sun Shin Yi Jung Hoon Choi In Koo Hwang Je Kyung Seong yeo sung yoon Department of Anatomy and Cell Biology College of Veterinary Medicine Research Institute for Veterinary Science Seoul National University Department of Biomedical Laboratory Science College of Biomedical Sciences Soonchunhyang University Department of Anatomy College of Veterinary Medicine Kangwon National University

In the present study, we investigated the effects of hypothyroidism on the morphology of astrocytes and microglia in the hippocampus of Zucker diabetic fatty rats and Zucker lean control rats. To induce hypothyroidism, Zucker lean control and Zucker diabetic fatty rats at 7 weeks of age orally received the vehicle or methimazole, an anti-thyroid drug, treatment for 5 weeks and were sacrificed at 12 weeks of age in all groups for blood chemistry and immunohistochemical staining. In the me- thimazole-treated Zucker lean control and Zucker diabetic fatty rats, the serum circulating triiodo- thyronine （T3） and thyroxine （＇I＂4） levels were significantly decreased compared to levels observed in the vehicle-treated Zucker lean control or Zucker diabetic fatty rats. This reduction was more prominent in the methimazole-treated Zucker diabetic fatty group. Glial fibrillary acidic protein im- munoreactive astrocytes and ionized calcium-binding adapter molecule 1 （Iba-1）-immunoreactive microglia in the Zucker lean control and Zucker diabetic fatty group were diffusely detected in the hippocampal CA1 region and dentate gyrus. There were no significant differences in the glial fibril- lary acidic protein and Iba-1 immunoreactivity in the CA1 region and dentate gyrus between Zucker lean control and Zucker diabetic fatty groups. However, in the methimazole-treated Zucker lean control and Zucker diabetic fatty groups, the processes of glial fibrillary acidic protein immunoreac- tive astrocytes and Iba-1 immunoreactive microglia, were significantly decreased in both the CA1 region and dentate gyrus compared to that in the vehicle-treated Zucker lean control and Zucker diabetic fatty groups. These results suggest that diabetes has no effect on the morphology of as- trocytes and microglia and that hypothyroidism during the onset of diabetes prominently reduces the processes of astrocytes and microglia.

关键词： neural regeneration astrocytes microglia diabetes hypothyroidism complications thyroid hormone obesity methimazole Zucker diabetic fatty rat grants-supported paper neuroregeneration

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Neurons in the hippocampal CA1 region,but not the dentate gyrus,are susceptible to oxidative stress in rats with streptozotocin-induced type 1 diabetes

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Neural Regeneration Research 2015年第3期10卷 451-456页

作者： Sang Gun Lee Dae Young Yoo Hyo Young Jung sung Min Nam Jong Whi Kim Jung Hoon Choi Sun Shin Yi Moo-Ho Won yeo sung yoon In Koo Hwang Seung Myung Moon Departments of Neurosurgery Dongtan Sacred Heart HospitalCollege of MedicineHallym University Department of Anatomy and Cell Biology College of Veterinary Medicineand Research Institute for Veterinary ScienceSeoul National University Department of Anatomy College of Veterinary MedicineKangwon National University Department of Biomedical Laboratory Science College of Medical SciencesSoonchunhyang University Department of Neurobiology School of MedicineKangwon National University

In this study, we investigated the effects of streptozotocin-induced type 1 diabetes on antioxi- dant-like protein-1 immunoreactivity, protein carbonyl levels, and malondialdehyde formation, a marker for lipid peroxidation, in the hippocampus. For this study, streptozotocin （75 mg/kg） was intraperitoneally injected into adult rats to induce type 1 diabetes. The three experimental pa- rameters were determined at 2, 3, 4 weeks after streptozotocin treatment. Fasting blood glucose levels significantly increased by 20.7-21.9 mM after streptozotocin treatment. The number of antioxidant-like protein-1 immunoreactive neurons significantly decreased in the hippocampal CA1 region, but not the dentate gyrus, 3 weeks after streptozotocin treatment compared to the control group. Malondialdehyde and protein carbonyl levels, which are modified by oxidative stress, significantly increased with a peak at 3 weeks after malondialdehyde treatment, and then decreased 4 weeks after malondialdehyde treatment. These results suggest that neurons in the hippocampal CA1 region, but not the dentate gyrus, are susceptible to oxidative stress 3 weeks after malondialdehyde treatment.

关键词： nerve regeneration hippocampus dentate gyrus lipid peroxidation type 1 diabetes malondialdehyde neurons neural regeneration

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Glucose metabolism and neurogenesis in the gerbil hippocampus after transient forebrain ischemia

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Neural Regeneration Research 2016年第8期11卷 1254-1259页

作者： Dae Young Yoo Kwon Young Lee Joon Ha Park Hyo Young Jung Jong Whi Kim yeo sung yoon Moo-Ho Won Jung Hoon Choi In Koo Hwang Department of Anatomy and Cell Biology College of Veterinary Medicineand Research Institute for Veterinary ScienceSeoul National University Department of Anatomy College of Veterinary Medicine and Institute of Veterinary ScienceKangwon National University Department of Neurobiology School of MedicineKangwon National University

Recent evidence exists that glucose transporter 3（GLUT3） plays an important role in the energy metabolism in the *** previous studies have been conducted using focal or hypoxic ischemia models and have focused on changes in GLUT3 expression based on protein and m RNA levels rather than tissue *** the present study,we observed change in GLUT3 immunoreactivity in the adult gerbil hippocampus at various time points after 5 minutes of transient forebrain *** the sham-operated group,GLUT3 immunoreactivity in the hippocampal CA1 region was weak,in the pyramidal cells of the CA1 region increased in a time-dependent fashion 24 hours after ischemia,and in the hippocampal CA1 region decreased significantly between 2 and 5 days after ischemia,with high level of GLUT3 immunoreactivity observed in the CA1 region 10 days after *** a double immunofluorescence study using GLUT3 and glial-fibrillary acidic protein（GFAP）,we observed strong GLUT3 immunoreactivity in the ***3 immunoreactivity increased after ischemia and peaked 7 days in the dentate gyrus after ischemia/*** a double immunofluorescence study using GLUT3 and doublecortin（DCX）,we observed low level of GLUT3 immunoreactivity in the differentiated neuroblasts of the subgranular zone of the dentate gyrus after ***3 immunoreactivity in the sham-operated group was mainly detected in the subgranular zone of the dentate *** results suggest that the increase in GLUT3 immunoreactivity may be a compensatory mechanism to modulate glucose level in the hippocampal CA1 region and to promote adult neurogenesis in the dentate gyrus.

关键词： nerve regeneration transient forebrain ischemia glucose transporter 3 pyramidal cells astrocytes neuroblasts neural regeneration

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Time- and cell-type specific changes in iron, ferritin, and transferrin in the gerbil hippocampal CA1 region after transient forebrain ischemia

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Neural Regeneration Research 2016年第6期11卷 924-930页

作者： Dae Young Yoo Ki-yeon Yoo Joon Ha Park Hyun Jung Kwon Hyo Young Jung Jong Whi Kim Goang-Min Choi Seung Myung Moon Dae Won Kim yeo sung yoon Moo-Ho Won In Koo Hwang Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Department of Oral Anatomy Research Institute of Oral Sciences College of Dentistry Gangneung-Wonju National University Department of Neurobiology School of Medicine Kangwon National University Department of Biochemistry and Molecular Biology Research Institute of Oral Sciences College of Dentistry Gangneung-Wonju National University Department of Thoracic and Cardiovascular Surgery Chuncheon Sacred Heart Hospital College of Medicine Hallym University Department of Neurosurgery Dongtan Sacred Heart Hospital College of Medicine Hallym University

In the present study, we used immunohistochemistry and western blot analysis to examine changes in the levels and cellular localization of iron, heavy chain ferritin（ferritin-H）, and transferrin in the gerbil hippocampal CA1 region from 30 minutes to 7 days following transient forebrain ischemia. Relative to sham controls, iron reactivity increased significantly in the stratum pyramidale and stratum oriens at 12 hours following ischemic insult, transiently decreased at 1–2 days and then increased once again within the CA1 region at 4–7 days after ischemia. One day after ischemia, ferritin-H immunoreactivity increased significantly in the stratum pyramidale and decreased at 2 days. At 4–7 days after ischemia, ferritin-H immunoreactivity in the glial components in the CA1 region was significantly increased. Transferrin immunoreactivity was increased significantly in the stratum pyramidale at 12 hours, peaked at 1 day, and then decreased significantly at 2 days after ischemia. Seven days after ischemia, Transferrin immunoreactivity in the glial cells of the stratum oriens and radiatum was significantly increased. Western blot analyses supported these results, demonstrating that compared to sham controls, ferritin H and transferrin protein levels in hippocampal homogenates significantly increased at 1 day after ischemia, peaked at 4 days and then decreased. These results suggest that iron overload-induced oxidative stress is most prominent at 12 hours after ischemia in the stratum pyramidale, suggesting that this time window may be the optimal period for therapeutic intervention to protect neurons from ischemia-induced death.

关键词： ferritin transferrin hippocampal stratum minutes glial Ferritin hippocampus rabbit reactivity

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Performance evaluations on inner vs. outer decomposition first parallel join algorithms for two nested loop joins

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Journal of Central South University 2014年第10期21卷 3873-3882页

作者： Seo-Young NOH Heejun yoon Il-yeon yeo yoon-su JEONG Hyungwoo PARK National Institute of Supercomputing and Networking Korea Institute of Science and Technology Information Department of Information Communication Engineering Mokwon University

Two popular traditional join algorithms and their parallel versions are introduced. When designing join algorithms in serial computing environment, decomposing inner relation is considered as the right direction to save disk I/Os. However, two different decomposition algorithms are compared, such as inner vs. outer decomposition first algorithms for tuple-based and block-based nested loop joins, showing that the proposed approach is 20% better than general approach. Also lemmas are proved, when we have to use the outer decomposition first parallel join algorithms.

关键词： parallel join performance inner decomposition outer decomposition

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Advances in Wireless,Batteryless,Implantable Electronics for Real‑Time,Continuous Physiological Monitoring

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Nano-Micro Letters 2024年第3期16卷 254-302页

作者： Hyeonseok Kim Bruno Rigo Gabriella Wong yoon Jae Lee Woon‑Hong yeo IEN Center for Wearable Intelligent Systems and Healthcare Georgia Institute of TechnologyAtlantaGA 30332USA George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Tech and Emory University School of MedicineAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Institute for MaterialsInstitute for Robotics and Intelligent MachinesGeorgia Institute of TechnologyAtlantaGA 30332USA

This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health *** considerations,such as biological constraints,energy sourcing,and wireless communication,are discussed in achieving the desired performance of the devices and enhanced interface with human *** addition,we review the recent achievements in materials used for developing implantable systems,emphasizing their importance in achieving multi-functionalities,biocompatibility,and *** wireless,batteryless devices offer minimally invasive device insertion to the body,enabling portable health monitoring and advanced disease ***,we summarize the most recent practical applications of advanced implantable devices for human health care,highlighting their potential for immediate commercialization and clinical uses.

关键词： Implantable electronics Biomedical systems Batteryless devices Wireless electronics Physiological signal monitoring

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3D Face Reconstruction from a Single Image Using a Combined PCA-LPP Method

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Computers, Materials & Continua 2023年第3期74卷 6213-6227页

作者： Jee-Sic Hur Hyeong-Geun Lee Shinjin Kang yeo Chan yoon Soo Kyun Kim Department of Computer Engineering Jeju National UniversityJeju63243Korea School of Games Hongik UniversitySejong30016Korea Department of Artificial Intelligence Jeju National UniversityJeju63243Korea

In this paper, we proposed a combined PCA-LPP algorithm toimprove 3D face reconstruction performance. Principal component analysis(PCA) is commonly used to compress images and extract features. Onedisadvantage of PCA is local feature loss. To address this, various studies haveproposed combining a PCA-LPP-based algorithm with a locality preservingprojection (LPP). However, the existing PCA-LPP method is unsuitable for3D face reconstruction because it focuses on data classification and *** the existing PCA-LPP, the adjacency graph, which primarily shows the connectionrelationships between data, is composed of the e-or k-nearest neighbortechniques. By contrast, in this study, complex and detailed parts, such aswrinkles around the eyes and mouth, can be reconstructed by composing thetopology of the 3D face model as an adjacency graph and extracting localfeatures from the connection relationship between the 3D model *** verified the effectiveness of the proposed method. When theproposed method was applied to the 3D face reconstruction evaluation set,a performance improvement of 10% to 20% was observed compared with theexisting PCA-based method.

关键词： Principal component analysis locality preserving project 3DMM face reconstruction face modeling

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Heating energy performance and part load ratio characteristics of boiler staging in an office building

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Frontiers in Energy 2019年第2期13卷 339-353页

作者： Da Young LEE Byeong Mo SEO yeo Beom yoon sung Hyup HONG Jong Min CHOI Kwang Ho LEE Graduate School Hanbat National UniversityDaejeon 305-719South Korea College of Design North Carolina State University RaleighNC 27695-7701USA Department of Mechanical Engineering Hanbat National UniversityDaejeon 305-719South Korea Department of Architectural Engineering Hanbat National UniversityDaejeon 305-719South Korea

Commercial buildings account for significant portions of the total building energy in South Korea and thus a variety of research on the boiler operation related to heating energy in office buildings has been carried out thus far. However, most of the researches have been conducted on the boiler itself, i.e., the part load ratio characteristics and the corresponding gas energy consumption patterns are not analyzed in the existing studies. In this study, the part load ratio and the operating characteristics of gas boiler have been analyzed within an office building equipped with the conventional variable air volume system. In addition, the gas consumption among different boiler staging schemes has been comparatively analyzed. As a result, significant portions of total operating hours, heating load and energy consumption has been found to be in a part load ratio range of 0 through 40% and thus energy consumption is significantly affected by boiler efficiency at low part load conditions. This suggests that boiler operation at the part load is an important factor in commercial buildings. In addition, utilizing sequential boiler staging scheme can save a gas usage of about 7%. For annual heating energy saving, applying the sequential control boiler with a 3:7 proportion staging is considered to be the optimal control algorithm for maximum efficiency of boilers.

关键词： EnergyPlus boiler part load ratio gas con-sumption office building boiler staging

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Heating energy savings potential from retrofitting old apartments with an advanced double-skin façade system in cold climate

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Frontiers in Energy 2020年第2期14卷 224-240页

作者： yeo Beom yoon Byeongmo SEO Brian Baewon KOH Soolyeon CHO College of Design North Carolina State UniversityRaleighNC27695-7701USA Sun&Light Corp.Ltd41Seocho-daero 42-gilSeocho-guSeoulRepublic of Korea

Apartments account for over 60%of total residential buildings and consume a significant portion of primary energy in South *** energy efficiency measures have been implemented for both new apartment constructions and existing apartment *** apartment structures have poor thermal performances,resulting in a high energy *** South Korean government initiated retrofitting projects to improve the energy efficiency in old *** owners typically replace old windows with high-performance windows;however,there is still a demand for better and more innovative retrofit methods for a highly improved energy *** paper proposes an advanced double-skin façade(DSF)system to replace existing balcony windows in old *** the cold climate conditions of Seoul,South Korea,it mainly discusses heating energy *** case models were developed:Base-Case with existing apartment,Case-1 with typical retrofitting,and Case-2 with the proposed DSF *** EnergyPlus simulation program was used to develop simulation models for a floor radiant heating system.A typical gas boiler was selected for low-temperature radiant system *** air flow network method was used to model the proposed DSF *** heating months,i.e.,November to March,and one representative day,i.e.,January 24,were selected for detailed *** main heat loss areas consist of windows,walls,and *** results reveal that the apartment with the DSF retrofit saves 38.8%on the annual heating energy compared to the Base-Case and 35.2%compared to Case-1.

关键词： double-skin façade retrofitting high-rise apartment heating energy building simulation

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