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Air pollution and heart failure: Relationship with the ejection fraction

World Journal of Cardiology 2013年第3期5卷 49-53页

作者： Alberto Dominguez-Rodriguez Javier Abreu-Afonso Sergio Rodríguez Ruben A Juarez-Prera Eduardo Arroyo-Ucar yenny gonzalez Pedro Abreu-gonzalez Pablo Avanzas Department of Cardiology Hospital Universitario de Canarias Universidad Europea de Canarias Facultad de Ciencias de la Salud Instituto Universitario de Tecnologías Biomédicas Department of Applied Physics Universidad de Valencia Center for Atmospheric Research Izaa AEMET-CSIC Department of Physiology Universidad de la Laguna Department of Cardiology Hospital Universitario Central de Asturias

AIM: To study whether the concentrations of particulate matter in ambient air are associated with hospitaladmission due to heart failure in patients with heart failure with preserved ejection fraction and reduced ejection fraction. METHODS: We studied 353 consecutive patients admitted into a tertiary care hospital with a diagnosis of heart failure. Patients with ejection fraction of ≥ 45% were classified as having heart failure with preserved ejection fraction and those with an ejection fraction of < 45% were classified as having heart failure with reduced ejection fraction. We determined the average concentrations of different sizes of particulate matter (< 10, < 2.5, and < 1 μm) and the concentrations of gaseous pollutants (carbon monoxide, sulphur dioxide, nitrogen dioxide and ozone) from 1 d up to 7 d prior to admission. RESULTS: The heart failure with preserved ejection fraction population was exposed to higher nitrogen dioxide concentrations compared to the heart failure with reduced ejection fraction population (12.95 ± 8.22 μg/m 3 vs 4.50 ± 2.34 μg/m 3 , P < 0.0001). Multivariate analysis showed that nitrogen dioxide was a significant predictor of heart failure with preserved ejection fraction (odds ratio ranging from (1.403, 95%CI: 1.003-2.007, P = 0.04) to (1.669, 95%CI: 1.043-2.671, P = 0.03). CONCLUSION: This study demonstrates that shortterm nitrogen dioxide exposure is independently associated with admission in the heart failure with preserved ejection fraction population.

关键词： Air pollution Heart failure Preserved ejection fraction Reduced ejection fraction Nitrogen dioxide

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