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High Prevalence of Genetic Alterations in Infantile-Onset Cardiomyopathy

Congenital Heart Disease 2021年第4期16卷 397-410页

作者： Junsung Park Go Hun Seo yena lee Yunha Choi Minji Kang Hyo-Sang Do Young-Hwue Kim Jeong Jin Yu Ellen Ai-Rhan Kim Euiseok Jung Byong Sop lee Jae Suk Baek Beom Hee lee Department of Pediatrics Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea billion Inc.SeoulKorea Genome Research Center for Birth Defects and Genetic Diseases Asan Institute for Life SciencesAsan Medical CenterSeoulKorea Division of Cardiology Department of PediatricsAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Division of Neonatology Department of PediatricsAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Medical Genetics Center Asan Medical Center Children’s HospitalUniversity of Ulsan College of MedicineSeoulKorea

Background and Method:The genetic cause of infantile-onset cardiomyopathy is rarely ***,we conducted whole exome sequencing(WES)and mitochondrial DNA(mtDNA)sequencing in eight patients with infantile-onset cardiomyopathy to identify genetic ***:Among these patients,two(25%)had dilated cardiomyopathy(DCMP),two(25%)had left ventricular non-compaction(LVNC),and four(50%)had hypertrophic cardiomyopathy(HCMP).Except four patients identified prenatally,the remaining patients presented at a median age of 85.5 *** identified genetic variants in a total of seven(87.5%)patients and mtDNA sequencing in the other ***1 and MYH7 variants were identified in the two patients with DCMP;MYH11 and MYLK2 variants in the two patients with LVNC;HRAS,BRAF,and MYH7 variants in three patients with HCMP;and MT-ND1 variant in one patient with HCMP having high blood lactic acid *** the eight variants,four were classified as pathogenic or likely-pathogenic according to the American College of Medical Genetics(ACMG)guidelines,and the remaining were identified as variants of unknown significance(VUSs).Three pathogenic mutations were de novo,whereas four(likely-pathogenic or VUSs)were inherited from a respective parent,excluding one variant where parental testing was unavailable,questioning whether these inherited variants are *** patients died before 3 months of ***:Genomic studies,such as WES with additional mtDNA sequencing,can identify a genetic variant in high proportions of patients with infantile-onset *** clinical implication of the parentally inherited variant needs to be assessed in a larger patient and family cohort with a longitudinal follow-up.

关键词： Cardiomyopathy whole exome sequencing infantile-onset

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Relationship between catchment characteristics and nitrogen forms in Cao-E River Basin, Eastern China

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Journal of Environmental Sciences 2009年第4期21卷 429-433页

作者： JIN Shuquan LU Jun CHEN Dingjiang SHEN yena SHI Yiming Department of Natural Resources College of Environmental Science and Natural Resources Zhefiang University Hangzhou 310029 China. China Ministry of Education Key Laboratory of Environmental Remediation and Ecological Health Zhefiang University Hangzhou 310029 China Zhejiang Provincial Key Laboratory of Subtropic Soil and Plant Nutrition Hangzhou 310029 China Ecology and Environment Institute Ningbo Academy of Agricultural Science Ningbo 315040 China

The distribution of different nitrogen forms and their spatial and temporal variations in different pollution types of tributaries or reaches were investigated. Based on the catchments characteristics the tributaries or reaches can be classified into 4 types, including headwater in mountainous areas （type Ⅰ）, agricultural non-point source （NPS） pollution in rural areas （type Ⅱ）, municipal and industrial pollution in urban areas （type Ⅲ）, and combined pollution in main stream （type IV）. Water samples were collected monthly from July 2003 to June 2006 in the Cao-E River Basin in Zhejiang, eastern China. The concentrations of NO3^--N, NH4^＋ -N, and total nitrogen （TN） were measured. The mean concentrations of NO3^- -N were decreased in the sequence type IV 〉 type Ⅱ〉 type Ⅲ 〉 type Ⅰ, whereas, NH4^＋-N, total organic nitrogen （TON）, and TN were in the sequence： type Ⅲ〉 type Ⅳ 〉 type Ⅱ〉 type Ⅰ. In headwater and rural reaches, CNO^-2-N was much higher than Crea^＋ 4-N. In urban reaches, TON and NH4^＋ -N were the main forms, accounting for 54.7% and 32.1% of TN, respectively. In the whole river system, Crea^＋ 4--N decreased with increasing distance from cities, and CNo^-3 -N increased with the increasing area of farmland in the catchments. With increased river flow, CNO^-3 N increased and Crea4^＋-N decreased in all types of reaches, while the variations of CTON and CTN were different. For TN, the concentration may be decreased with the increase of river flow, but the export load always increased.

关键词： catchment characteristics nitrogen forms spatial and temporal variation Cao-E River Basin

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Glasesterterpenoids A-C:three sesterterpenoids with 7-cyclohexyl-decahydronaphthalene carbon skeleton isolated from the root of Lindera glauca

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Chinese Journal of Natural Medicines 2024年第9期22卷 864-868页

作者： HE Shiting ZOU Qinghui ZHANG Qi LUO Yingming YAN Die HE Jingxin LIU yena CUI Hui School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060China

Three novel sesterterpenoids glasesterterpenoids A-C(1-3),featuring an unprecedented 7-cyclohexyldecahydronaphthalene carbon skeleton,were isolated from the root of Lindera glauca(***).Their structures were elucidated by quantum chemical calculations and spectroscopic *** biogenetic pathway for 1-3 is *** the bioassay,glasesterterpenoid C exhibited DNA topoisomerase 1(Top1)inhibitory activity compared with the positive control,*** findings represent the first examples of sesterterpenoids with a 7-cyclohexyldecahydronaphthalene carbon skeleton from the root of ***.

关键词： Sesterterpenoids Lindera glauca

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商务英语周末课堂电话英语 1版

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丛书名：新东方大愚商务英语丛书

2010年

作者：（韩）yena Shin

《商务英语周末课堂——电话英语》专门针对想提高电话交流水平的读者编写。由于无法借肋表情、手势来促进交流，通过电话进行日常交流、商务往来，咨询问题以及应对危机等时，对打电话和接电话的人的英语水平要求要更高。鉴于此，本书... 详细信息

ISBN: (数字)9787560536446

ISBN: (纸本)9787560536446

《商务英语周末课堂——电话英语》专门针对想提高电话交流水平的读者编写。由于无法借肋表情、手势来促进交流，通过电话进行日常交流、商务往来，咨询问题以及应对危机等时，对打电话和接电话的人的英语水平要求要更高。鉴于此，本书按篇章归类，整理出“基础篇”、“商务篇”和“生活篇”三部分内容，同时每部分又细分成多个小的主题场景，帮助读者分解电话用语情境，使其全面、系统地掌握工作和生活中的各种情景表达，达到自如地用电话沟通、交流、处理工作和解决问题的能力。随书附赠的MP3光盘对书中的“Key Expressions”、“强化串记”、“迷你测验”及“综合训练”四部分内容进行了朗读。

关键词：口语英语商务

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商务英语周末课堂电子邮件英语 1版

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丛书名：新东方大愚商务英语丛书

2010年

作者：（韩）yena Shin

《商务英语周末课堂——电子邮件英语》专门针对想提高英语电子邮件写作水平的读者编写。与相对可以自由发挥的私人信件不同，商务电子邮件必须写得规范得体，而且电子邮件常常要作为商务往来的凭证予以保留。在电子邮件交流中，由于措... 详细信息

ISBN: (数字)9787560536460

ISBN: (纸本)9787560536460

《商务英语周末课堂——电子邮件英语》专门针对想提高英语电子邮件写作水平的读者编写。与相对可以自由发挥的私人信件不同，商务电子邮件必须写得规范得体，而且电子邮件常常要作为商务往来的凭证予以保留。在电子邮件交流中，由于措辞不当或者疏忽了文化差异而让收信人感到不愉快的情况时有发生，甚至还有可能导致合作或协议的终止。不过，从现在开始，你再也不用为此而担心了。认真学习本书，可以掌握各种电子邮件的必备表达，为日后写英语邮件打下坚实的基础，攻克电子邮件英语这一难关。随书附赠的MP3光盘对书中的“Key essions”、“强化串记”、“迷你测验”及“综合训练”四部分内容进行了朗读。

关键词：英语商务

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Targeted therapy of kidney disease with nanoparticle drug delivery materials

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Bioactive Materials 2024年第7期37卷 206-221页

作者： Shunlai Shang Xiangmeng Li Haoran Wang yena Zhou Keying Pang Ping Li Xiaomin Liu Min Zhang Wenge Li Qinggang Li Xiangmei Chen Department of Nephrology China-Japan Friendship HospitalBeijingChina Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province China Peking Union Medical College BeijingChina Department of Nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People’s Liberation ArmyNational Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijingChina School of Medicine Nankai UniversityTianjinChina College of Pharmacy Hebei University of Chinese MedicineShijiazhuangHebei ProvinceChina Department of Nephrology Affiliated Beijing Chaoyang Hospital of Capital Medical UniversityBeijingChina

With the development of nanomedicine,nanomaterials have been widely used,offering specific drug delivery to target sites,minimal side effects,and significant therapeutic *** kidneys have filtration and reabsorption functions,with various potential target cell types and a complex structural environment,making the strategies for kidney function protection and recovery after injury *** also lays the foundation for the application of nanomedicine in kidney ***,evidence in preclinical and clinical settings supports the feasibility of targeted therapy for kidney diseases using drug delivery based on *** prerequisite for nanomedicine in treating kidney diseases is the use of carriers with good biocompatibility,including nanoparticles,hydrogels,liposomes,micelles,dendrimer polymers,adenoviruses,lysozymes,and elastin-like *** carriers have precise renal uptake,longer half-life,and targeted organ distribution,protecting and improving the efficacy of the drugs they ***,attention should also be paid to the toxicity and solubility of the *** the carriers mentioned above have been used in preclinical studies for targeted therapy of kidney diseases both in vivo and in vitro,extensive clinical trials are still needed to ensure the short-term and long-term effects of nano drugs in the human *** review will discuss the advantages and limitations of nanoscale drug carrier materials in treating kidney diseases,provide a more comprehensive catalog of nanocarrier materials,and offer prospects for their drug-loading efficacy and clinical applications.

关键词： Nanomedicine Materials Targeted drugs Kidney disease

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Design of Evolutionary Algorithm Based Unequal Clustering for Energy Aware Wireless Sensor Networks

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Computer Systems Science & Engineering 2023年第10期47卷 1283-1297页

作者： Mohammed Altaf Ahmed T.Satyanarayana Murthy Fayadh Alenezi E.Laxmi Lydia Seifedine Kadry yena Kim Yunyoung Nam Department of Computer Engineering College of Computer Engineering&SciencesPrince Sattam Bin Abdulaziz UniversityAl-Kharj11942Saudi Arabia Chaitanya Bharathi Institute of Technology HyderabadTelanganaIndia Department of Electrical Engineering College of EngineeringJouf UniversitySakaka 72388Saudi Arabia Department of Computer Science and Engineering Vignan’s Institute of Information TechnologyVisakhapatnam530049India Department of Applied Data Science Noroff University CollegeKristiansandNorway Department of Electrical and Computer Engineering Lebanese American UniversityByblosLebanon Artificial Intelligence Research Center(AIRC) College of Engineering and Information TechnologyAjman UniversityAjmanUnited Arab Emirates Department of ICT Convergence Soonchunhyang UniversityAsan 31538Korea

Wireless Sensor Networks(WSN)play a vital role in several real-time applications ranging from military to *** the benefits of WSN,energy efficiency becomes a major part of the challenging issue in WSN,which necessitate proper load balancing amongst the clusters and serves a wider monitoring *** clustering technique for WSN has several benefits:lower delay,higher energy efficiency,and collision *** clustering protocol has several *** a large-scale network,cluster-based protocols mainly adapt multi-hop routing to save energy,leading to hot spot problems.A hot spot problem becomes a problem where a cluster node nearer to the base station(BS)tends to drain the energy much quicker than other nodes because of the need to implement more *** article introduces a Jumping Spider Optimization Based Unequal Clustering Protocol for Mitigating Hotspot Problems(JSOUCP-MHP)in *** JSO algorithm is stimulated by the characteristics of spiders naturally and mathematically modelled the hunting mechanism such as search,persecution,and jumping skills to attack *** presented JSOUCPMHP technique mainly resolves the hot spot issue for maximizing the network *** JSOUCP-MHP technique elects a proper set of cluster heads(CHs)using average residual energy(RE)to attain *** addition,the JSOUCP-MHP technique determines the cluster sizes based on two measures,i.e.,RE and distance to BS(DBS),showing the novelty of the *** proposed JSOUCP-MHP technique is examined under several experiments to ensure its *** comparison study shows the significance of the JSOUCPMHP technique over other models.

关键词： Wireless sensor networks energy efficiency cluster heads unequal clustering hot spot issue lifetime enhancement

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乡村振兴背景下楚剧文化的创造性传承

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华中师范大学学报（人文社会科学版） 2021年第4期60卷 107-113页

作者：韦也纳湖北第二师范学院艺术学院湖北武汉430205

在乡村文化振兴背景下,如何实现楚剧文化的创造性传承,让楚剧真正在荆楚大地传得开、唱得响、留得住,成为值得深入探讨的新时代文化课题。从新公共治理理论的“共同生产”这一核心概念出发,公共文化服务应实现从政府单一提供到多元主体... 详细信息

在乡村文化振兴背景下,如何实现楚剧文化的创造性传承,让楚剧真正在荆楚大地传得开、唱得响、留得住,成为值得深入探讨的新时代文化课题。从新公共治理理论的“共同生产”这一核心概念出发,公共文化服务应实现从政府单一提供到多元主体共治,供需关系主体重构和公共文化产品的多样化。基于此,楚剧文化的非遗保护和创造性传承的当代路径为:从“送戏下乡”到“乡村种戏”;普及楚剧文化知识,培育观众兴趣;多元化、本土化培养楚剧传承人才;在传统楚剧中增添现代元素;将楚剧表演融入乡村民俗节庆;以文化法治建设助力楚剧传承发展的制度化、规范化。

关键词：乡村振兴楚剧传承公共文化服务新公共治理共同生产

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Activated Human Hydroxy-Carboxylic Acid Receptor-2 Signals to Akt Signaling Cascades via the PKC-and EGFR-Dependent Pathways

Activated Human Hydroxy-Carboxylic Acid Receptor-2 Signals t...

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第11届全国脂质与脂蛋白学术会议

作者： Ying Shi yena Yu Qi Zhou Guo Li Ying Shi Naiming Zhou College of Life Sciences Zhejiang UniversityZijingang Campus

Nicotinic acid(niacin) has been widely used as a lipid-lowering drug for several decades,and recently,Human Hydroxy-Carboxylic Acid Receptor-2(HCA2) has been identified as a receptor for *** investigations have shown that,upon niacin activation,HCA2 couples to a Gi protein and inhibits adenylate cyclase activity, leading to inhibition of liberation of free fatty ***,the underlying molecular mechanisms for HCA2 signaling remain largely *** CHO-K1 cells stably expressing HCA2,and A431 cells,which is a human epidermoid cell line

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Right Internal Jugular Vein Ectasia in African Woman: A Report of 2 Cases

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Surgical Science 2015年第10期6卷 437-441页

作者： Seydou Togo Moussa Abdoulaye Ouattara Sékou Koumaré Mody Abdoulaye Camara Sadio yena Thoracic and Vascular Surgery Department Hospital of Mali Bamako Mali Surgery “A” Department Point G Hospital Bamako Mali Radiology Department Hospital of Mali Bamako Mali

Internal jugular vein (IJV) ectasia is a rare benign disease. It commonly presents as a unilateral, soft, compressible neck swelling that mostly involves the right side. It is usually a childhood disease and believed to be of congenital origin. Accurate diagnosis from careful history, physical examination and radiological study can be made. We report here two cases of IJV ectasia in African adults with right lateral neck mass dilating when increase intrathoracic pressure. Because of its rarity, this entity is frequently ignored or misdiagnosed. This case report intends to stress the importance of keeping IJV ectasia as differential diagnosis in mind in case of lateral neck swellings to avoid invasive investigations and inappropriate treatment. The asymptomatic case management of IJV ectasia is conservative with long-term surveillance.

关键词： Jugular Vein Ectasia Adults Management

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