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Link between pharyngeal acid reflux episodes and the effectiveness of proton pump inhibitor therapy

World Journal of Gastroenterology 2024年第48期30卷 5162-5173页

作者： yen-yang chen chen-Chi Wang Chun-Yi Chuang Yung-An Tsou yen-Chun Peng Chi-Sen Chang Han-Chung Lien Division of Gastroenterology Taichung Veterans General HospitalTaichung 402TaiwanChina Department of Otolaryngology Taichung Veterans General HospitalTaichung 402TaiwanChina School of Medicine National Yang Ming Chiao Tung UniversityTaipei 112TaiwanChina School of Speech Language Pathology and Audiology Chung Shan Medical UniversityTaichung 402TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 402TaiwanChina Department of Otolaryngology Chung Shan Medical University HospitalTaichung 402TaiwanChina Department of Otorhinolaryngology-Head and Neck Surgery China Medical University HospitalTaichung 400TaiwanChina Division of Gastroenterology and Hepatology Department of Internal MedicineTungs’Taichung Metro Harbor HospitalTaichung 435TaiwanChina Division of Gastroenterology Center for Functional Esophageal DisordersTaichung Veterans General HospitalTaichung 402TaiwanChina Department of Post-Baccalaureate Medicine College of MedicineNational Chung Hsing UniversityTaichung 402Taiwan

BACKGROUND Diagnosing laryngopharyngeal reflux(LPR)is challenging due to overlapping *** proton pump inhibitors(PPIs)are commonly prescribed,reliable predictors of their responsiveness are *** monitoring techno-server *** hypothesized that PAR episodes alone might also predict PPI *** To investigate whether PAR episodes alone predict a positive response to PPI *** Patients suspected of having LPR were prospectively recruited from otolaryngologic clinics in three Taiwan residents tertiary *** underwent a 24-hour esophagopharyngeal pH test using either 3-pH-sensor or hypopha-ryngeal MII-pH catheters while off medication,followed by a 12-week esomeprazole course(40 mg twice daily).Participants were categorized into four groups based on pH results:PAR alone,EAR alone,both pH(+),and both pH(-).The primary outcome was a≥50%reduction in primary laryngeal symptoms,with observers blinded to group *** A total of 522 patients(mean age 52.3±12.8 years,54%male)were *** these,190(mean age 51.5±12.4 years,61%male)completed the treatment,and 89(47%)responded to PPI *** rates were highest in the PAR alone group(73%,n=11),followed by EAR alone(59%,n=68),both pH(+)(56%,n=18),and both pH(-)(33%,n=93).Multivariate analysis adjusting for age,sex,body mass index,and endoscopic esophagitis showed that participants with PAR alone,EAR alone,and both pH(+)were 7.4-fold(P=0.008),4.2-fold(P=0.0002),and 3.4-fold(P=0.03)more likely to respond to PPI therapy,respectively,compared to the both pH(-)*** analyses using the definition of≥1 PAR episode were less *** In the absence of proven hypopharyngeal predictors,this post-hoc analysis found that baseline≥2 PAR episodes alone are linked to PPI responsiveness,suggesting the importance of hypopharyngeal reflux monitoring.

关键词： Pharyngeal acid reflux episodes Laryngopharyngeal reflux Hypopharyngeal multichannel intraluminal impedance-pH 3-pH-sensor Proton pump inhibitors

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Sunitinib for Taiwan Residents patients with gastrointestinal stromal tumor after imatinib treatment failure or intolerance

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World Journal of Gastroenterology 2011年第16期17卷 2113-2119页

作者： yen-yang chen Chun-Nan Yeh Chi-Tung cheng Tsung-Wen chen Kun-Ming Rau Yi-Yin Jan Miin-Fu chen Division of Hematology-Oncology Department of Internal MedicineChang Gung Memorial HospitalKaohsiung Medical Center GIST team Department of SurgeryChang Gung Memorial Hospital and University

AIM:To report preliminary results of the efficacy and safety of sunitinib in the management of Taiwan Residents gastrointestinal stromal tumors (GIST) patients facing imatinib mesylate (IM) intolerance or ***:Between 2001 and May 2010,199 Taiwan Residents patients with metastatic GIST were treated at Chang Gung Memorial *** them,23 (11.6%) patients receiving sunitinib were ***:Sixteen male and 7 female patients with a median age of 59 years (range:24-83 years) received ***-two GIST patients changed to sunitinib because of IM failure and 1 because of *** median duration of sunitinib administration was 6.0 mo (range:2-29 mo).The clinical benefit was 65.2% [2 complete response (CR),4 partial response (PR),and 9 stationary disease (SD);15/23].In 12 patients harboring mutations of the kit gene at exon 11,the clinical benefit rate (CR,PR,and SD) was 75.0% and 6 patients with tumors containing kit exon 9 mutations had a clinical benefit of 50.0% (not significant,P=0.344).The progression free survival (PFS) and overall survival (OS) did not differ between patients whose GISTs had wild type,KIT exon 9,or KIT exon 11 ***-foot syndrome was the most common cause of grade Ⅲ adverse effect (26.1%),followed by anemia (17.4%),and neutropenia (13.0%).During the median 7.5-mo follow-up after sunitinib use,the median PFS and OS of these 23 GIST patients after sunitinib treatment were 8.4 and 14.1 mo,***:Sunitinib appears to be an effective treatment for Taiwan Residents with IM-resistant/intolerant GISTs and induced a sustained clinical benefit in more than 50% of Taiwan Residents advanced GIST patients.

关键词： Suintinib Gastrointestinal stromal tumors Imaitinib Failure or intolerance

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Proton beam therapy for downstaging hepatocellular carcinoma with lobar portal vein tumor thrombosis to living donor liver transplantation

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 966-974页

作者： Chao-Long chen Leona Bettina PDungca Chee-Chien Yong Itsuko Chih-Yi chen Yu-Fan cheng Jen-Yu cheng yen-yang chen Liver Transplantation Center Department of SurgeryKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung Liver Transplantation Center Department of Diagnostic RadiologyKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung Liver Transplantation Center Department of Radiation OncologyKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung Liver Transplantation Center Department of Hematology-OncologyKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung

Introduction Liver transplantation(LT)is considered as the definitive standard treatment for hepatocellular carcinoma(HCC)with the advantage of addressing both malignancy and the underlying cirrhosis,thus,providing th... 详细信息

关键词： Proton beam therapy(PBT) hepatocellular carcinoma(HCC) portal vein tumor thrombosis(PVTT) living donor liver transplantation(LDLT) downstaging therapy

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Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： yen-Shou Kuo Kuan-Hsun Lin Ying-Yi chen Yuan-Ming Tsai Ti-Hui Wu Hsu-Kai Huang Tsai-Wang Huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

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Mechanically driven assembly of biomimetic 2D-material microtextures with bioinspired multifunctionality

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Nano Research 2024年第2期17卷 663-678页

作者： yang Li Lin Jing Joshua M.Little Haochen yang Tsai-Chun Chung Po-yen chen Department of Chemical and Biomolecular Engineering University of MarylandCollege ParkMD 20740USA Maryland Robotics Center University of MarylandCollege ParkMD 20742USA School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Nature provides a wealth of bio-inspiration for advanced material *** various nanomaterials into biomimetic microtextures with bioinspired functionalities has spurred increasing research interests and facilitated technological advances in various *** recent years,two-dimensional materials(2DMs)have emerged as important building block units in the biomimicry field due to their distinct chemical,physical,electrical,electrochemical,and catalytic *** this review article,various mechanically driven assembly approaches are summarized to fabricate various genealogies of biomimetic 2DM microtextures with bio-inspired ***,sequential deformation strategies are discussed to programmably construct higher dimensional 2DM microtextures,ranging from wrinkles/crumples(one-time deformation)to multiscale hierarchies(multiple deformations).Next,the current progress using higher dimensional 2DM microtextures to imitate different biological structures and/or induce bio-inspired multifunctionality is systematically *** showcases of bio-inspiration and biomimicry using different 2DM nanosheets are highlighted:(1)wrinkle patterns of an earthworm that spur the design of strain sensors with programmable working ranges and sensitivities,(2)wrinkle appearance of a Shar-Pei dog that motivates the fabrication of stretchable energy storage devices,(3)hierarchical scale textures of a desert lizard that inspire cation-induced gelation platforms for 2DM aerogels,and(4)wrinkle skin of an elephant that influences the development of 2DM protective skin for soft ***,challenges and future opportunities of adopting 2DM nanosheets to assemble biomimetic microstructures with synergistic functionalities are discussed.

关键词： two-dimensional(2D)materials mechanically driven assembly biomimetic microtextures functional nanocomposite bio-inspired multifunctionality

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Classification of Lagrangian Surfaces of Curvatureε in Non-fiat Lorentzian Complex Space Form ■_1~2(4ε)

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Acta Mathematica Sinica,English Series 2009年第12期25卷 1987-2022页

作者： Bang yen chen Department of Mathematics Michigan State University East Lansing Michigan 48824-1027 USA

It is well known that a totally geodesic Lagrangian surface in a Lorentzian complex space form M12（4ε） of constant holomorphic sectional curvature 4s is of constant curvature 6. A natural question is ＂Besides totally geodesic ones how many Lagrangian surfaces of constant curvature εin M12（46） are there？＂ In an earlier paper an answer to this question was obtained for the case e = 0 by chen and Fastenakels. In this paper we provide the answer to this question for the case ε≠0. Our main result states that there exist thirty-five families of Lagrangian surfaces of curvature ε in M12（4ε） with ε ≠ 0. Conversely, every Lagrangian surface of curvature ε≠0 in M12（4ε） is locally congruent to one of the Lagrangian surfaces given by the thirty-five families.

关键词： Lagrangian surfaces Lorentzian complex space form Legendre curve surfaces of constant curvature

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CO_2 sequestration utilizing basic-oxygen furnace slag:Controlling factors,reaction mechanisms and V–Cr concerns

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Journal of Environmental Sciences 2016年第3期28卷 99-111页

作者： Tung-Hsin Su Huai-Jen yang yen-Hong Shau Eiichi Takazawa Yu-chen Lee Department of Earth Sciences National Cheng-Kung UniversityTainan 70101Taiwan Department of Marine Biotechnology and Resources National Sun Yat-Sen UniversityKaohsiung 80424Taiwan Department of Geology Niigata University8050Ikarashi 2-no-choNishi-kuNiigata 950-2182Japan China Steel Corporation 1Chung-Kang Rd.Kaohsiung 81233Taiwan

Basic-oxygen furnace slag（BOF-slag） contains 〉35%CaO,a potential component for CO_*** this study,slag-water-CO_2 reaction experiments were conducted with the longest reaction duration extending to 96 hr under high CO_2 pressures of 100-300 kg/cm2 to optimize BOF-slag carbonation conditions,to address carbonation mechanisms,and to evaluate the extents of V and Cr release from slag *** slag carbonation degree generally reached the maximum values after 24 hr slag-water-CO_2 reaction and was controlled by slag particle size and reaction *** maximum carbonation degree of 71%was produced from the experiment using fine slag of〈0.5 mm under 100℃and a CO_2 pressure of 250 kg/cm^2 with a water/slag ratio of *** release from the slag to water was significantly enhanced（generally 〉2 orders） by slag *** contrast,slag carbonation did not promote chromium release until the reaction duration exceeded 24 ***,the water chromium content was generally at least an order lower than the vanadium concentration,which decreased when the reaction duration exceeded 24 ***,long reaction durations of 48-96 hr are proposed to reduce environmental impacts while keeping high carbonation *** textures and water compositions indicated that Mg-wustite,in addition to CaO-containing minerals,can also be ***,the conventional expression that only considered carbonation of the CaO-containing minerals undervalued the CO_2 sequestration capability of the BOF-slag by^20%.Therefore,the BOF-slag is a better CO_2 storage medium than that previously recognized.

关键词： Mineral CO_2 sequestration BOF-slag Carbonation

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Robust Watermarking Algorithm for Medical Images Based on Non-Subsampled Shearlet Transform and Schur Decomposition

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Computers, Materials & Continua 2023年第6期75卷 5539-5554页

作者： Meng yang Jingbing Li Uzair Aslam Bhatti Chunyan Shao yen-Wei chen School of Information and Communication Engineering Hainan UniversityHaikou570228China State Key Laboratory of Marine Resource Utilization in the South China Sea Hainan UniversityHaikou570228China Graduate School of Information Science and Engineering Ritsumeikan UniversityKyoto5258577Japan

With the development of digitalization in healthcare,more and more information is delivered and stored in digital form,facilitating people’s lives *** the meanwhile,privacy leakage and security issues come along with *** watermarking can solve this problem *** protect the security of medical information and improve the algorithm’s robustness,this paper proposes a robust watermarking algorithm for medical images based on Non-Subsampled Shearlet Transform(NSST)and Schur ***,the low-frequency subband image of the original medical image is obtained by NSST and ***,the Schur decomposition of low-frequency blocks to get stable values,extracting the maximum absolute value of the diagonal elements of the upper triangle matrix after the Schur decom-position of each low-frequency block and constructing the transition matrix from ***,the mean of the matrix is compared to each element’s value,creating a feature matrix by combining perceptual hashing,and selecting 32 bits as the feature ***,the feature vector is exclusive OR(XOR)operated with the encrypted watermark information to get the zero watermark and complete registration with a third-party copyright certification *** data show that the Normalized Correlation(NC)values of watermarks extracted in random carrier medical images are above 0.5,with higher robustness than traditional algorithms,especially against geometric attacks and achieve watermark information invisibility without altering the carrier medical image.

关键词： Non-Subsampled Shearlet Transform(NSST) Schur decomposition perceptual hashing chaotic mapping zero watermark

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Thalidomide-based multidisciplinary treatment for patients with advanced hepatocellular carcinoma:A retrospective analysis

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World Journal of Gastroenterology 2012年第5期18卷 466-471页

作者： yang-Yuan chen Hsu-Heng yen Kun-Ching Chou Shun-Sheng Wu Department of Gastroenterology ChinaMedical University Hospital China Medical University Taic-hung 40000 Taiwan China Depart-ment of Gastroenterology Changhua Christian Medical CenterChanghua 50000 Taiwan China

AIM： To evaluate the efficacy of thalidomide in com- bination with other therapies to treat patients with ad- vanced hepatocellular carcinoma （HCC）. METHODS： We performed a retrospective analysis of all patients with HCC who were treated with thalido- mide for at least two months. The medical records of patients with HCC who were treated at our institution between April 2003 and March 2008 were reviewed. Image studies performed before and after treatment, tumor response, overall survival, and the decrease in o-fetoprotein （AFP） levels were evaluated. RESULTS： A total of 53 patients with HCC received either 100 or 200 mg/d of thalidomide. The patient population consisted of 9 women and 44 men with a median age of 61 years. Thirty patients （56.6%） were classified as Child-Pugh A, and 12 patients （22.6%） were classified as Child-Pugh B. Twenty-six patients had portal vein thrombosis （49.1%）, and 25 patients had extrahepatic metastasis （47.1%）. The median duration of thalidomide treatment was 6.0 mo. Six of the 53 patients achieved a confirmed response （11.3%）, one achieved a complete response （1.9%） and 5 achieved a partial response （9.4%）. The disease control rate （CR ＋ PR ＋ SD） was 28.3% （95% CI： 17.8-42.4）, and the median overall survival rate was 10.5 too. The 1- and 2-year survival rates were 45% and 20%, respectively. Only one complete response patient showed an im- proved overall survival rate of 66.8 mo. Sixteen patients （30.2%） showed more than a 50% decrease in their serum AFP levels from baseline, indicating a better re- sponse rate （31.3%）, disease control rate （43.8%）, and overall survival time （20.7 mo）. The therapy was well tolerated, and no significant toxicities were observed. CONCLUSION： Thalidomide was found to be safe for advanced HCC patients, demonstrating anti-tumor ac- tivity including response, survival, and AFP decreases of greater than 50% from baseline.

关键词： Thalidomide Hepatocellular carcinoma

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Clinical impact of multidetector computed tomography before double-balloon enteroscopy for obscure gastrointestinal bleeding

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World Journal of Gastroenterology 2012年第7期18卷 692-697页

作者： Hsu-Heng yen yang-Yuan chen Chia-Wei yang Chi-Kuang Liu Maw-Soan Soon Departmentof Gastroenterology Endoscopy Center Changhua ChristianHospital 500 Changhua Taiwan China Department of Gastroenterology China Medi-cal University Hospital 40402 Taichung Taiwan China Department of Radiology Changhua ChristianHospital 500 Changhua Taiwan China

AIM： To evaluate the clinical impact of multidetector computed tomography （MDCT） before double-balloon endoscopy （DBE） for patients with obscure gastrointestinal bleeding （OGIB）.

关键词： Multidetector computed tomography Cap-sule endoscopy Double-balloon endoscopy Obscuregastrointestinal bleeding

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