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Overactivation of histone deacetylases and EZH2 in Wilms tumorigenesis

Genes & Diseases 2023年第5期10卷 1783-1786页

作者： Chao-Hui Chen Nguyen yen Nhi ngo Alun Wang Samir El-Dahr Hongbing Liu Department of Pediatrics Tulane University School of MedicineNew OrleansLA 70112USA Department of Pathology and Laboratory Medicine Tulane University School of MedicineNew OrleansLA 70112USA

Wilms tumor (WT) is the most common childhood kidney cancer. Although WT is largely curable, current treatments fail in up to 15 percent of patients. Moreover, survivors suffer from the complications and late effects of the aggressive treatments. Thus, there is a critical need to improve our understanding of tumorigenesis to develop novel therapies to reduce the treatment burden while maintaining excellent survival rates. WT is believed to arise from the immature kidney cells, nephron progenitor cells (NPCs), which have failed to differentiate properly. Previous studies revealed that Wilms cells share a transcriptional and epigenetic landscape with normal renal stem cells.1 Although several studies have shown the positive associations between WT in children and embryonic exposure to adverse environments, the underlying mechanisms remain unknown. Altered epigenetics is central to oncogenesis in many pediatric cancers. The critical contribution of epigenetic dysregulation to pediatric tumors provides a compelling rationale for the therapeutic potential of epigenetic drugs. Histone deacetylases (HDACs) and Enhancer of Zeste Homolog 2 (EZH2, a histone H3K27 methyltransferase), have been demonstrated to play a critical role in self-renewal and differentiation of mouse NPCs.2,3 In addition, altered expression and mutations of HDACs and EZH2 have been linked to many human cancers, including WT. Thus, they are among the most promising therapeutic targets for cancer treatment. We reasoned that WT would result from the unrestrained proliferation of progenitor cells due to overactive HDAC1/2 (HDAC1 and HDAC2), and EZH2. We tested this hypothesis by analyzing a clinical specimen received from the left kidney tumor of an 11-year-old male patient diagnosed with WT and four other human WT specimens. We have the approval from Tulane Human Research Protection Office & Institutional Review Boards (Study number: 2019–623) to study WT specimens. The tumor (9.5 cm × 8 cm × 7.5 cm) is cl

关键词： EZH2 Figure approval

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Applicability and variability of liver stiffness measurements according to probe position

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World Journal of Gastroenterology 2009年第27期15卷 3398-3404页

作者： Patrick Ingiliz Kim Pav Chhay Mona Munteanu Pascal Lebray yen ngo Dominique Roulot Yves Benhamou Dominique Thabut Vlad Ratziu Thierry Poynard Dominique Thabut Vlad Ratziu Thierry Poynard AP-HP Hospital Group Pitié-Salpêtrière Hepatology Department47-83 Hospital Boulevard Paris 75651 France BioPredictive 40 Bac street Paris 75007 France AP-HP Hepatology Department Avicenne hospitalBobigny 93000France AP-HP Hospital Group Pitié-Salpêtrière Hepatology Department47-83 Hospital Boulevard Paris 75651 France

AIM: To investigate the liver stiffness measurement (LSM) applicability and variability with reference to three probe positions according to the region of liver biopsy. METHODS: The applicability for LSM was defined as at least 10 valid measurements with a success rate greater than 60% and an interquartile range/median LSM < 30%. The LSM variability compared the inter-position concordance and the concordance with FibroTest. RESULTS: Four hundred and forty two consecutive patients were included. The applicability of the anterior position (81%) was significantly higher than that of the reference (69%) and lower positions (68%), (both P = 0.0001). There was a signif icant difference (0.5 kPa, 95% CI 0.13-0.89; P < 0.0001) between mean LSM estimated at the reference position (9.3 kPa) vs the anterior position (8.8 kPa). Discordance between positions was associated with thoracic fold (P = 0.008). The discordance rate between the reference position result and FibroTest was higher when the 7.1 kPa cutoff was used to define advanced fibrosis instead of 8.8 kPa (33.6% vs 23.5%, P = 0.03).CONCLUSION: The anterior position of the probe should be the fi rst choice for LSM using Fibroscan, as it has a higher applicability without higher variability compared to the usual liver biopsy position.

关键词： Fibroscan Fibrotest Liver fibrosis Variability Concordance

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Microplastic and nanoplastic exposure and risk of diabetes mellitus

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World Journal of Clinical Cases 2025年第3期13卷 24-29页

作者： Hui-Yi Hsiao Chung-Yi Nien Ruei-Feng Shiu Wei-Chun Chin Tzung-Hai yen Department of Biomedical Sciences College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina Center for Tissue Engineering Chang Gung Memorial HospitalLinkouTaoyuan 33305TaiwanChina Department of Life Sciences National Central UniversityZhongli 320317TaoyuanTaiwanChina Center of Excellence for The Oceans Taiwan Ocean UniversityKeelung 20224TaiwanChina Institute of Marine Environment and Ecology Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Chemical and Materials Engineering University of California MercedMercedCA 95343United States Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalLinkou 33305TaoyuanTaiwanChina School of Traditional Chinese Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

The issue of plastic pollutants has become a growing *** microplastics(MPs)(particle size<5 mm)and nanoplastics(NPs)(particle size<1μm)can cause DNA damage,cytotoxicity,and oxidative stress in various *** primary known impacts of microplastic/nanoplastic are observed in the liver and respiratory system,leading to hepatotoxicity and chronic obstructive pulmonary *** research on the effects of MPs and NPs on diabetes is still in its early stages,there are potential *** editorial highlights the risk to diabetics from co-exposure to contaminants and MPs/NPs,supported by evidence from animal studies and the various chemical compositions of MPs/NPs.

关键词： Microplastics Nanoplastics Plastic pollution,Diabetes mellitus Insulin resistance

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Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： yen-Shou Kuo Kuan-Hsun Lin Ying-Yi Chen Yuan-Ming Tsai Ti-Hui Wu Hsu-Kai Huang Tsai-Wang Huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

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Numerical Analysis of Deteriorated Sub-sea Pipelines under Environmental Loads

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Chinese Journal of Mechanical Engineering 2015年第6期28卷 1163-1170页

作者： GüCüyen Engin Department of Civil Engineering Faculty of Engineering Celal Bayar University

The significant point is the bidirectional interaction technique in FSI analysis while investigating subsea corrosion effect. By this way, pipe environment is accurately modelled and fluid effects are also considered. The effect of external corrosion defects on structural behaviour of a pipeline is studied by creating a nonlinear numerical model based on the finite element method according to ABAQUS analysis program. Corrosion losses of sections are obtained from experimental results and applied to the model. Numerical model is formed by a span of sub-sea pipeline that is subjected to environmental loads. Seismic and wind-generated irregular wave loads are considered as environmental loads. Irregular wave is represented with equivalent eight regular waves via FFT. The pipe is modelled according to two different types which are non-corroded（intact） and corroded（deteriorated） to demonstrate corrosion effects on it. The visible type of corrosion in marine environment is named ‘pitting＇ corrosion, in which the material loss is locally interpenetrated over the surface. By considering this situation, the corroded and non-corroded pipes are modelled as 3D solid elements. The main point is revealing how the subsea corrosion affects the structural behaviour of pipelines on the basis of implementation of experimental results to a model structure due to changes of stresses and displacement.

关键词： offshore pipelines environmental loads corrosion numerical analysis

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Classification of Lagrangian Surfaces of Curvatureε in Non-fiat Lorentzian Complex Space Form ■_1~2(4ε)

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Acta Mathematica Sinica,English Series 2009年第12期25卷 1987-2022页

作者： Bang yen CHEN Department of Mathematics Michigan State University East Lansing Michigan 48824-1027 USA

It is well known that a totally geodesic Lagrangian surface in a Lorentzian complex space form M12（4ε） of constant holomorphic sectional curvature 4s is of constant curvature 6. A natural question is ＂Besides totally geodesic ones how many Lagrangian surfaces of constant curvature εin M12（46） are there？＂ In an earlier paper an answer to this question was obtained for the case e = 0 by Chen and Fastenakels. In this paper we provide the answer to this question for the case ε≠0. Our main result states that there exist thirty-five families of Lagrangian surfaces of curvature ε in M12（4ε） with ε ≠ 0. Conversely, every Lagrangian surface of curvature ε≠0 in M12（4ε） is locally congruent to one of the Lagrangian surfaces given by the thirty-five families.

关键词： Lagrangian surfaces Lorentzian complex space form Legendre curve surfaces of constant curvature

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Solid codes and the uniform density of fd-domains

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Science China Mathematics 2007年第7期50卷 1026-1034页

作者： yen-Shung TSAI College of Science Chung Yuan Christian UniversityChung-Li 320TaiwanChina

By means of further investigation of solid codes,the problem“Is every fd-domain uni- formly dense”proposed by Yuqi Guo,*** and *** in 1988 is solved in this paper.

关键词： solid code fd-domain uniformly dense language 20M35 68Q70

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Emissions of C_2-C_(12) hydrocarbons in the Hsuehshan tunnel,Taiwan

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Journal of Environmental Sciences 2011年第6期23卷 941-948页

作者： Chia-Hsiang Lai yen-Ping Peng Department of Safety Health and Environmental EngineeringCentral Taiwan University of Science and Technology

The concentrations of 56 hydrocarbons from C2 to C12 were measured simultaneously in the southbound bore,the northbound bore and the exhaust air shafts of the Hsuehshan tunnel near Yilan,Taiwan for 12 days during 2007 and 2008.A total of 60 integrated air samples were collected using stainless steel canisters and analyzed using GC/FID and GC/*** five most abundant species in all samples were ethylene,acetylene,isopentane,propylene and *** exit/entrance ratios of total non-methane hydrocarbons（NMHC） concentration were 7.8 and 4.8 for the southbound and northbound bores,***,the exhaust from the vertical shafts a？ects air quality in the *** most abundant species of emission rate（ER） was toluene（21.93-42.89 mg/sec）,followed by isopentane,ethylene,propylene and 1-butene,with ER ranging from 2.50 to 9.31 mg/*** species in the three exhaust air shafts showed that the reactivities of these emissions are similar to those of vehicle ***,the control of emissions in the vertical shafts of the vehicle tunnel will be important in the future.

关键词： tunnel non-methane hydrocarbons vehicle emissions shaft rate

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Networking dual-surveillance/dual-pair-tele-paths for critical urban areas

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Journal of Southeast University(English Edition) 2008年第S1期24卷 114-119页

作者： Hsu Li-yen Department of Aviation Management China Institute of TechnologyHsinchu 31241

Providing a reliable and efficient communication infrastructure for critical regions is generally a strategy used to enhance regional safety or to sustain regional development. For such purposes, the spider-web network is prototyped as a cellular telecommunication infrastructure for its advantages including being interference-free, possessing fault-tolerance, having security management, and countering radio's multipath effects. Besides, it is used to develop area-based-street-SCADA (supervisory control and data acquisition) networks composed of regular optimal degree-3 prototyped sub-networks with the concepts of dual-surveillance, operational order and Hamiltonian laceability, and it flexibly fits various circulation configurations. Moreover, it can offer integrative response capabilities even after two paths' SCADA networks have been ruined.

关键词： supervisory control and data acquisition (SCADA) telecommunication transportation

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Tree species diversity and utilities in a contracting lowland hillside rainforest fragment in Central Vietnam

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Forest Ecosystems 2017年第3期4卷 182-200页

作者： yen Thi Van Roland Cochard Hue University of Agriculture and Forestry Hue University Institute of Integrative Biology Swiss Federal Institute of Technology

Background： Within the highly bio-diverse ‘Northern Vietnam Lowland Rain Forests Ecoregion＇ only small, and mostly highly modified forestlands persist within vast exotic-species plantations. The aim of this study was to elucidate vegetation patterns of a secondary hillside rainforest remnant（elevation 120–330 m, 76 ha） as an outcome of natural processes, and anthropogenic processes linked to changing forest ***： In the rainforest remnant tree species and various bio-physical parameters（relating to soils and terrain）were surveyed on forty 20 m × 20 m sized plots. The forest＇s vegetation patterns and tree diversity were analysed using dendrograms, canonical correspondence analysis, and other statistical ***： Forest tree species richness was high（172 in the survey, 94 per hectare）, including many endemic species（〉16%; some recently described）. Vegetation patterns and diversity were largely explained by topography, with colline/sub-montane species present mainly along hillside ridges, and lowland/humid-tropical species predominant on lower slopes. Scarcity of high-value timber species reflected past logging, whereas abundance of light-demanding species, and species valued for fruits, provided evidence of human-aided forest restoration and ‘enrichment＇ in terms of useful trees. Exhaustion of sought-after forest products, and decreasing appreciation of non-wood products concurred with further encroachment of exotic plantations in between 2010 and 2015. Regeneration of rare tree species was reduced probably due to forest ***： Despite long-term anthropogenic influences, remnant forests in the lowlands of Vietnam can harbor high plant biodiversity, including many endangered species. Various successive future changes（vanishing species, generalist dominance, and associated forest structural-qualitative changes） are, however, expected to occur in smal forest *** forest biodiversity can only be maintained if forest fragments m

关键词： Secondary evergreen monsoon forest Floristic patterns Tree species richness Timber NTFP Biodiversity conservation

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