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非视距环境中的无线网络残差加权定位算法

传感技术学报 2019年第5期32卷 749-755页

作者：尹烨佳华惊宇李枫张昱余旭涛浙江工业大学信息工程学院杭州310023 浙江工商大学信息与电子工程学院杭州310018 东南大学移动通信国家重点实验室南京210096

无线定位已成为物联网应用的重要研究内容,为减小非视距(NLOS)误差对传统定位算法的精度的影响。因此提出一种基于目标临时位置估计的残差幂次方加权定位算法。算法核心在于先利用分组定位得到不同目标节点估计位置,并将位置之间的差值... 详细信息

无线定位已成为物联网应用的重要研究内容,为减小非视距(NLOS)误差对传统定位算法的精度的影响。因此提出一种基于目标临时位置估计的残差幂次方加权定位算法。算法核心在于先利用分组定位得到不同目标节点估计位置,并将位置之间的差值定义为临时定位残差。然后区别于传统残差加权定位算法,本文提出用残差的高次幂作为加权函数,并通过仿真搜索最优的加权函数。仿真结果表明,当LOS-SN数目不小于2时,本文算法在定位精度上远高于传统的NLOS抑制定位算法。和传统的残差加权定位算法(RWGH)相比,本文所提算法的定位精度提高了近60%,同时降低了对LOS-SN个数的要求。和半正定规划(SDP)相比,定位精度提高了近38%,并降低了计算复杂度。

关键词：无线定位非视距误差临时定位残差残差加权

Therapeutic potential of TNFa inhibitors in chronic inflammatory disorders:Past and future

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Genes & Diseases 2021年第1期8卷 38-47页

作者： future Hongtao Zhang Nelson Shi Zhuo Diao Youhai Chen yejia Zhang Department of Pathology and Laboratory Medicine Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA Department of Orthopaedic Surgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA Department of Physical Medicine&Rehabilitation Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA Translational Musculoskeletal Research Center(TMRC) Corporal Michael J.Crescenz Veterans Affairs Medical CenterPhiladelphiaPAUSA

In the past 20 years,patients with rheumatoid arthritis(RA),Crohn’s disease(CD),and other immune diseases have witnessed the impact of a great treatment advance with the availability of biological TNFa *** 5 approved anti-TNFa biologics on the market and soon available biosimilars,patients have more treatment options and have benefited from understanding the biology of ***,many unmet needs remain for people living with TNFa-related diseases,namely some side effects and tolerance of current anti-TNFa biologics and resistance to ***,common diseases such as osteoarthritis and back/neck pain may respond to anti-TNFa therapies at early onset of *** of new TNFa inhibitors focusing on TNFR1 specific inhibitors,preferably small molecules that can be delivered orally,is much needed.

关键词： Antibodies Receptors Small molecule inhibitors TNFa TNFR1

A microwell-based impedance sensor on an insertable microneedle for real-time in vivo cytokine detection

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Microsystems & Nanoengineering 2021年第6期7卷 139-150页

作者： Naixin Song Pengfei Xie Wen Shen Hanju Oh yejia Zhang Flavia Vitale Mehdi Javanmard Mark G.Allen Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPAUSA Department of Electrical and Computer Engineering Rutgers UniversityPiscatawayNJUSA Department of Physical Medicine and Rehabilitation University of PennsylvaniaPhiladelphiaPAUSA Department of Orthopedic Surgery University of PennsylvaniaPhiladelphiaPAUSA Corporal Michael J.Crescenz Veterans Affairs Medical Center PhiladelphiaPAUSA Department of Bioengineering School of Engineering and Applied ScienceUniversity of PennsylvaniaPhiladelphiaPAUSA Department of Neurology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

Impedance-based protein detection sensors for point-of-care diagnostics require quantitative specificity,as well as rapid or real-time ***,microfabrication of these sensors can lead to the formation of factors suitable for in vivo ***,we present microfabricated needle-shaped microwell impedance sensors for rapid-sample-to-answer,label-free detection of cytokines,and other *** microneedle form factor allows sensors to be utilized in transcutaneous or transvascular sensing *** vitro,experimental characterization confirmed sensor specificity and sensitivity to multiple proteins of *** characterization demonstrated sufficient microneedle robustness for transcutaneous insertion,as well as preserved sensor function *** further utilized these sensors to carry out real-time in vivo quantification of human interleukin 8(hIL8)concentration levels in the blood of transgenic mice that endogenously express *** assess sensor functionality,hIL8 concentration levels in serum samples from the same mice were quantified by *** agreement between real-time in vivo sensor readings in blood and subsequent ELISA serum assays was observed over multiple transgenic mice expressing hIL8 concentrations from 62 pg/mL to 539 ng/mL.

关键词： needle utilized insertion

Impacts of COVID-19 on Informal Workers and National Policies in China

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Journal of Business Administration Research 2021年第4期4卷 15-22页

作者： Kadiriya Kaimaier yejia Zhang Insurance Southwestern University of Finance and EconomicsChengduSichuan611100China Accounting Tianfu college of Southwestern University of Finance and EconomicsChengduSichuan610052China

The impact of the epidemic on China's economy is *** analyzing the impact of the epidemic on the informal economy and consulting the measures taken by local governments in Sichuan to restore the stall economy in the post epidemic period,this paper classifies and refines the measures made by urban governments of different sizes of cities,puts forward relevant laws,and puts forward opinions and forecasts on the future trend of the stall economy and stall economy in the post epidemic *** to the impact of the epidemic,people's awareness of self-protection has increased,local governments have also strengthened prevention and control,and the business of vendors has been seriously *** Sichuan case shows that the government's encouragement is an important guarantee for the rapid recovery of the stall *** the same time,reasonable control is a necessary means to prevent the recurrence of the *** the future trend of the stall,it is a trend to set up permittedvending-places(shudaoqu).Selecting an address according to the nature of the commodity is the guarantee of sales.

关键词： Stall economy Post epidemic period Reasonable control Permitted-vending-place

ADAM8 inactivation retards intervertebral disc degeneration in mice

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Genes & Diseases 2024年第3期11卷 91-94页

作者： Zuozhen Tian Frances S.Shofer Mingyue Fan Alec Z.Sandroni Lutian Yao Lin Han Ling Qin Motomi Enomoto-lwamoto yejia Zhang Department of Physical Medicine&Rehabilitation Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA19146USA Department of Emergency Medicine Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Orthopedic Surgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA School of Biomedical Engineering Science&Health SystemsDrexel UniversityPhiladelphiaPA 19104USA Department of Orthopedics/Sports Medicine and Joint Surgery the First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Orthopedics University of Maryland School ofMedicineBaltimoreMD21201USA Section of Rehabilitation Medicine Corporal Michael J.Crescenz Veterans Affairs Medical CenterPhiladelphiaPA 19104USA

ADAM8 has been identified as the fibronectin-cleaving enzyme in human degenerative intervertebral disc(IVD)tissues.^(1)Increase of the active form of ADAM8 and its cleavage product,fibronectin fragment,correlated with an increased degree of IVD degeneration.1 Furthermore,fibronectin fragments have been shown to accelerate the progression of IVD degeneration.^(2)These findings suggest that ADAM8 may play a role in degenerative disc disease,a clinical problem with tremendous socioeconomic burdens in the United States.

关键词： ADAM8 degeneration intervertebral

Basic Physical Properties and Degradability of Tungsten Wire Fibers

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Journal of Donghua University(English Edition) 2020年第1期37卷 50-54页

作者： ZHU yejia MA Yanxue GUAN Guoping MENG Fenye LI Yuling Engineering Research Center of Technical Textiles Ministry of EducationShanghai 201620China College of Textiles Donghua UniversityShanghai 201620China

In order to explore the feasibility of tungsten filament as biomedical metal material,this article conducted a series of performance tests on two different thicknesses of black tungsten filament and two different thicknesses of white tungsten *** mainly tested the basic physical properties of the tungsten filament including the longitudinal cross-section of the fiber,the fiber diameter,the mechanical properties of the fiber and the biodegradability,and analyzed the *** results showed that the breaking force of tungsten filament was about *** whether it was black tungsten filament or white tungsten filament,the larger the diameter,the greater the breaking force,and the breaking strength of the tungsten filament was much larger than the breaking strength of the steel *** larger the diameter of the tungsten filament,the slower the degradation *** the two months,the mass loss rate of the thick black tungsten filament was 59.40%,thin black tungsten filament was 83.88%,thick white tungsten filament was 47.39%,thin white tungsten filament was 72.29%,the degradation rate of thick tungsten wire was nearly half of the thin,and degradation mainly occured in the first months.

关键词： tungsten filament degradation performance mechanical properties diameter

Upregulation of β-catenin signaling represents a single common pathway leading to the various phenotypes of spinal degeneration and pain

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Bone Research 2023年第2期11卷 316-327页

作者： Ke Lu Qingyun Wang Hua Jiang Jun Li Zhou Yao Yongcan Huang Jianquan Chen yejia Zhang Guozhi Xiao Xueyu Hu Zhuojing Luo Liu Yang Liping Tong Di Chen Research Center for Computer-aided Drug Discovery Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina Faculty of Pharmaceutical Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina Division of Spine Surgery the First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxiChina Department of Orthopedic Surgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA Institute of Orthopedics Xijing Hospitalthe Fourth Military Medical UniversityXi’anChina Department of Spine Surgery Peking University Shenzhen HospitalShenzhenChina Department of Clinical Medicine School of MedicineZhejiang University City CollegeHangzhouZhejiangChina Departments of Physical Medicine&Rehabilitation Perelman School of MedicineUniversity of PennsylvaniaPAUSA School of Medicine Southern University of Science and TechnologyShenzhenChina

Spine degeneration is an aging-related disease,but its molecular mechanisms remain unknown,although elevatedβ-catenin signaling has been reported to be involved in intervertebral disc ***,we determined the role ofβ-catenin signaling in spinal degeneration and in the homeostasis of the functional spinal unit(FSU),which includes the intervertebral disc,vertebra and facet joint and is the smallest physiological motion unit of the *** showed that pain sensitivity in patients with spinal degeneration is highly correlated withβ-catenin protein *** then generated a mouse model of spinal degeneration by transgenic expression of constitutively activeβ-catenin in Col2^(+) *** found thatβ-catenin-TCF7 activated the transcription of CCL2,a known critical factor in osteoarthritic *** a lumbar spine instability model,we showed that aβ-catenin inhibitor relieved low back *** study indicates thatβ-catenin plays a critical role in maintaining spine tissue homeostasis,its abnormal upregulation leads to severe spinal degeneration,and its targeting could be an avenue to treat this condition.

关键词： degeneration smallest homeostasis

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东莞市植物多样性及其保护对策

安徽农业科学 2007年第24期35卷 7595-7596页

作者：廖业佳广东省林业调查规划院广东广州510500

根据对东莞市植物资源现状分析,总结其植物资源和植被类型特点,提出植物多样性保护要加强社区宣传、资源保护、森林防火和科学研究等方面工作的建议。

关键词：东莞市植物资源多样性

A comprehensive study of long-term skeletal changes after spinal cord injury in adult rats

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Bone Research 2015年第3期3卷 164-172页

作者： Tiao Lin Wei Tong Abhishek Chandra Shao-Yun Hsu Haoruo Jia Ji Zhu Wei-Ju Tseng Michael A Levine yejia Zhang Shi-Gui Yan X Sherry Liu Dongming Sun Wise Young Ling Qin Department of Orthopaedic Surgery Perelman School of Medicine University of Pennsylvania Department of Musculoskeletal Oncology The First Affiliated Hospital of Sun Yat-sen University Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology W.M.Keck Center for Collaborative Neuroscience Rutgers The State University of New Jersey Department of Orthopaedic Surgery School of Medicine Shihezi University Division of Endocrinology and Diabetes The Children’s Hospital of Philadelphia and Department of Pediatrics Perelman School of Medicine University of Pennsylvania Department of Physical Medicine & Rehabilitation Perelman School of Medicine University of Pennsylvania and Translational Musculoskeletal Research Center Philadelphia Veterans Affairs Medical Center Department of Orthopaedic Surgery 2nd Affiliated Hospital School of Medicine Zhejiang University

Spinal cord injury（SCI）-induced bone loss represents the most severe osteoporosis with no effective *** animal studies have focused primarily on long bones at the acute stage using adolescent rodents. To mimic chronic SCI in human patients, we performed a comprehensive analysis of long-term structural and mechanical changes in axial and appendicular bones in adult rats after SCI. In this experiment, 4-month-old Fischer 344 male rats received a clinically relevant T13 contusion injury. Sixteen weeks later, sublesional femurs, tibiae,and L4 vertebrae, supralesional humeri, and blood were collected from these rats and additional non-surgery rats for micro-computed tomography（m CT）, micro-finite element, histology, and serum biochemical *** trabecular sites, extreme losses of bone structure and mechanical competence were detected in the metaphysis of sublesional long bones after SCI, while the subchondral part of the same bones showed much milder damage. Marked reductions in bone mass and strength were also observed in sublesional L4 vertebrae but not in supralesional humeri. At cortical sites, SCI induced structural and strength damage in both sub- and supralesional long bones. These changes were accompanied by diminished osteoblast number and activity and increased osteoclast number and activity. Taken together, our study revealed site-specific effects of SCI on bone and demonstrated sustained inhibition of bone formation and elevation of bone resorption at the chronic stage of SCI.

关键词： SCI bone A comprehensive study of long-term skeletal changes after spinal cord injury in adult rats