检索结果-南通市图书馆

Tunable hybrid hydrogels with multicellular spheroids for modeling desmoplastic pancreatic cancer

Bioactive Materials 2023年第7期25卷 360-373页

作者： Menekse Ermis Natashya Falcone Natan Roberto de Barros Marvin Mecwan Reihaneh Haghniaz Auveen Choroomi Mahsa Monirizad yeji lee Jihyeon Song Hyun-Jong Cho Yangzhi Zhu Heemin Kang Mehmet R.Dokmeci Ali Khademhosseini Junmin lee Han-Jun Kim Terasaki Institute for Biomedical Innovation(TIBI) Los AngelesCA90024USA Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH)PohangGyeongbuk37673Republic of Korea College of Pharmacy Kangwon National UniversityChuncheonGangwon24341Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul02841Republic of Korea Institute for Convergence Research and Education in Advanced Technology Yonsei UniversityIncheon 21983Republic of Korea College of Pharmacy Korea UniversitySejong30019Republic of Korea

The tumor microenvironment consists of diverse,complex etiological *** matrix component of pancreatic ductal adenocarcinoma(PDAC)plays an important role not only in physical properties such as tissue rigidity but also in cancer progression and therapeutic *** significant efforts have been made to model desmoplastic PDAC,existing models could not fully recapitulate the etiology to mimic and understand the progression of ***,two major components in desmoplastic pancreatic matrices,hyaluronic acid-and gelatin-based hydrogels,are engineered to provide matrices for tumor spheroids composed of PDAC and cancer-associated fibroblasts(CAF).Shape analysis profiles reveals that incorporating CAF contributes to a more compact tissue *** expression levels of markers associated with proliferation,epithelial to mesenchymal transition,mechanotransduction,and progression are observed for cancer-CAF spheroids cultured in hyper desmoplastic matrix-mimicking hydrogels,while the trend can be observed when those are cultured in desmoplastic matrix-mimicking hydrogels with the presence of transforming growth factor-β1(TGF-β1).The proposed multicellular pancreatic tumor model,in combination with proper mechanical properties and TGF-β1 supplement,makes strides in developing advanced pancreatic models for resembling and monitoring the progression of pancreatic tumors,which could be potentially applicable for realizing personalized medicine and drug testing applications.

关键词： Pancreatic cancer Desmoplasia Fibrosis Extracellular matrix Tumor microenvironment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Radioactivity level of the ambient environment of Anren bone-coal power station

引用

Nuclear Science and Techniques 2002年第1期13卷 50-56页

作者： yeji－Da LIUHong－Shi 等 ZhejingProvinceRadiationEnvronmentalMonitoringCenter Hangzhou310012

The radioactivity level of the ambient environment of Anren Bone-coal Power Station (BCPS) was investigated systematically. The γ radiation dose rate level in the environment, the content of 238U and 226Ra in the ambient soil and the farmland in the direction of downwind, the concentrations of 238U. 232Th. 226Ra 40K and 222Rn as well as α potential energy in air, and the concentrations of natural U and Th in effluent are all higher than the corresponding values of the reference site. The additional annual effective dose equivalent to the residents living in the houses made of bone-coal cinder brick is 2.7 mSv.

关键词：骨煤燃骨煤粉电厂放射性等级环境

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Image enhancement with intensity transformation on embedding space

引用

CAAI Transactions on Intelligence Technology 2024年第1期9卷 101-115页

作者： Hanul Kim yeji Jeon Yeong Jun Koh Department of Applied Artificial Intelligence Seoul National University of Science and TechnologySeoulSouth Korea Department of Computer Science and Engineering Chungnam National UniversityDaejeonSouth Korea

In recent times,an image enhancement approach,which learns the global transformation function using deep neural networks,has gained ***,many existing methods based on this approach have a limitation:their transformation functions are too simple to imitate complex colour transformations between low-quality images and manually retouched high-quality *** order to address this limitation,a simple yet effective approach for image enhancement is *** proposed algorithm based on the channel-wise intensity transformation is ***,this transformation is applied to the learnt embedding space instead of specific colour spaces and then return enhanced features to *** this end,the authors define the continuous intensity transformation(CIT)to describe the mapping between input and output intensities on the embedding ***,the enhancement network is developed,which produces multi-scale feature maps from input images,derives the set of transformation functions,and performs the CIT to obtain enhanced *** experiments on the MIT-Adobe 5K dataset demonstrate that the authors’approach improves the performance of conventional intensity transforms on colour space ***,the authors achieved a 3.8%improvement in peak signal-to-noise ratio,a 1.8%improvement in structual similarity index measure,and a 27.5%improvement in learned perceptual image patch ***,the authors’algorithm outperforms state-of-the-art alternatives on three image enhancement datasets:MIT-Adobe 5K,Low-Light,and Google HDRþ.

关键词： computer vision deep learning image enhancement image processing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Survey of radon concentrations in bone-coal mining areas and inside BCCB houses in five provinces

引用

Nuclear Science and Techniques 2005年第3期16卷 187-192页

作者： LIYing yeji-Da ZHANGLiang JIANGShan KONGLing-Li SHIJin-Hua EnvironmentalMonitoringCenterStationofJiangxiProvinceNanchang330029 EnvironmentalRadiationMonitoringStationofZhejiangProvince Hangzhou310012 EnvironmentalMonitoringCenterStationofHunanProvince Changsha410004 EnvironmentalRadiationSurveillanceStationofAnhuiProvince Hefei230061 EnvironmentalProtectionScienceInstituteofWuhanCity Wuhan430022

It was investigated that the radon concentrations in bone-coal mining areas,in outside and inside BCCB houses and ordinary red-brick (ORB) houses of the reference points in Hubei,Hunan,Jiangxi,Zhejiang and Anhui Provinces. It was shown that the average annual radon concentration inside BCCB houses in the bone-coal mining areas in the five provinces ranges from 85.7 to 303 Bq/m3,with an average of 151 Bq/m3,which is 3 times that inside ORB houses at the reference points. The average annual radon concentration outside BCCB houses in the bone-coal mining areas in the five provinces ranges from 12.0 to 73.8 Bq/m3,with an average of 34.9 Bq/m3,which is 1.5 times that outside ordinary ORB at the reference points. And the radon concentration in shafts of Hubei and Zhejiang Prov- ince is 9.51×103 Bq/m3 and 965 Bq/m3,respectively. This report also shows the changing patterns of radon concen- trations with day,season,height,etc.

关键词：骨煤矿煤渣砖房放射剂量辐射监测

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of macular changes according to the etiology of optic neuritis:a cross-sectional study

引用

International Journal of Ophthalmology(English edition) 2024年第4期17卷 686-692页

作者： yeji Moon Sung-Min Kim Jae Ho Jung Department of Ophthalmology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Department of Neurology Seoul National University HospitalSeoul 03080Republic of Korea Department of Ophthalmology Seoul National University HospitalSeoul 03080Republic of Korea Department of Ophthalmology Seoul National University College of MedicineSeoul 03080Republic of Korea

AIM:To compare the macular structure including foveal thickness among patients with optic neuritis(ON)according to the etiology and to investigate the possible correlation between structural and visual outcomes METHODS:In this retrospective cross-sectional study,the clinical data of patients with aquaporin-4 immunoglobulin G-related ON(AQP4 group,40 eyes),myelin oligodendrocyte glycoprotein IgG-related ON(MOG group,31 eyes),and multiple sclerosis-related ON(MS group,24 eyes)were *** retinal thickness of the foveal,parafoveal and perifoveal regions were *** acuity(VA),visual field index and mean deviation were measured as visual ***:The AQP4 group showed a significantly thinner fovea(226.4±13.4μm)relative to the MOG(236.8±14.0μm,P=0.015)and MS(238.9±14.3μm,P=0.007)*** thickness in the parafoveal area also was thinner in the AQP4 group,though the difference in perifoveal retinal thickness was not *** thickness was correlated with VA in the AQP4 group(coefficientρ=-0.418,P=0.014),but not in the MOG and MS groups(P=0.218 and P=0.138,respectively).There was no significant correlation between foveal thickness and visual field test in all three ***:The significant thinning in the fovea and parafoveal areas in the AQP4 group compared to the MOG and MS groups are ***,macular changes in AQP4-ON show a significant correlation with *** results provide the possibility that retinal structural damage could reflect functional damage in AQP4-ON,distinct from MOGON and MS-ON.

关键词： foveal thickness optic neuritis aquaporin-4 immunoglobulin myelin oligodendrocyte glycoprotein multiple sclerosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Investigation of environmental activity levels of bone-coal min-ing area in five provinces

引用

Nuclear Science and Techniques 2005年第3期16卷 181-186页

作者： yeji-Da KONGLing-Li LIYing JIANGShan ZHANGLiang SHIJin-Hua WUZong-Mei EnvironmentalRadiationMonitoringStationofZhejiangProvince Hangzhou310012 EnvironmentalProtectionScienceInstituteofWuhanCity Wuhan430022 EnvironmentalMonitoringCenterStationofJiangxiProvince Nanchang330029 EnvironmentalRadiationSurveillanceStationofAnhuiProvince Hefei230061 EnvironmentalMonitoringCenterStationofHunanProvince.Changsha410004

During 1991-1993,the activity levels of the bone-coal mines were investigated in Zhejiang,Hubei,Hunan,Jiangxi and Anhui Province,respectively,where the reserve of bone-coal is about 90% of our country’s total *** average of γ radiation doserate level measured for bone-coal,bone-coal cinder(BCC) and bone-coal cinder brick(BCCB) in these provinces is about 500 nGy/h,400 nGy/h and 700 nGy/h respectively,while that for fields,roads and houses made of BCCB in corresponding regions of these provinces is about 200 nGy/h,260 nGy/h and 300 nGy/h *** is shown that the environmental activity level of bone-coal mining area is about 3 times higher than the reference spots.

关键词：骨煤矿煤渣砖辐射级别放射剂量环境监测

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ovalicin attenuates atopic dermatitis symptoms by inhibiting IL-31 signaling and intracellular calcium influx

引用

The Journal of Biomedical Research 2021年第6期35卷 448-458页

作者： Sung-Hyun Hwang Yeseul Yang yeji Jeong Yongbaek Kim Laboratory of Clinical Pathology College of Veterinary MedicineSeoul National UniversitySeoul 08826Republic of Korea The Brain Korea 21 Future Veterinary Medicine Leading Education and Research Center College of Veterinary MedicineSeoul National UniversitySeoul 08826Republic of Korea Research Institute for Veterinary Science College of Veterinary MedicineSeoul National UniversitySeoul 08826Republic of Korea.

Atopic dermatitis(AD)is a common skin disorder difficult to be treated with *** study investigated the potential of ovalicin extracted from Cordyceps militaris for the treatment of AD using in vitro and in vivo *** found that,in canine macrophage cell line DH82,lipopolysaccharide(LPS)upregulated the expression of genes associated with inflammation and pruritic responses through activating calcium and interleukin-31(IL-31)signaling,and the upregulation could be suppressed by ovalicin,with an effect significantly stronger than *** also reduced the expression of IL-31 downstream genes,including JAK2(Janus kinase 2),TRPV1(transient receptor potential vanilloid receptor-1),and HRH2(histamine receptor H2).Ovalicin significantly alleviated the allergic symptoms in the AD mouse ***,the number of macrophages and mast cells infiltrated in the dermis was significantly reduced by ovalicin *** the skin tissue of AD mice,reduction of IL-31 receptor was observed in the ovalicin treated group compared to the group without ovalicin *** our knowledge,this is the first study to elucidate the anti-atopic mechanism of ovalicin,which could be an alternative to steroidal drugs commonly used for AD treatment.

关键词： ovalicin IL-31 pruritus inflammation calcium atopic dermatitis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Radiological monitoring results of the ambient environment around Qinshan Nuclear Power Plant

引用

Nuclear Science and Techniques 2004年第1期15卷 59-64页

作者： ZHANGRong-Suo ZENGGuang-Jian JIANGRang-Rong yeji-Da XIANGYuan-Yi HUANGRen-Jie CAOZhong-Gang ZhejiangProvinceEnvironmentalRadiationMonitoringCenter Hangzhou310012

A plan of surveillance monitoring Qinshan Nuclear Power Plant (QNPP) has been implemented since 1992, the objective of which is to establish the database of environmental radiation information around QNPP, and to detect any unplanned discharge of radioactive materials from QNPP. This paper presents the monitoring results for radionuclide concentrations in the environmental matrices before and after QNPP operation. The radionuclide con- centrations in vegetation, food, atmosphere, soil and littoral soil samples have been determined. After operation of QNPP, the mean values of 137Cs, Sr and H in water are 0.6, 4.9 mBq/L and 1.7 Bq/L, respectively; the mean values 90 3 of137Cs in soil and littoral soil are 3.5 and 2.7 Bq/kg, respectively; the mean values of137Cs in rice, green cabbage, meat, mullet, milk and tea are 0.033, 0.039, 0.081, 0.069, 0.018 and 0.62 Bq/kg, respectively; the mean values of 90 Sr in rice, green cabbage and tea are 0.081, 0.315 and 4.1 Bq/kg, respectively; gross β activity in fallout is 0.9 Bq·m-2·d-1. Compared with the data before QNPP’s operation, no significant difference has heen observed in the radioactivity of137Cs, Sr, H and the gross β activity in ambient environmental matrices from 1992 to 2001, and 90 3 there are only some fluctuations within the range of background.

关键词：辐射监测秦山核电站 QNPP 环境污染辐射防护

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gross β activity level of fallout in the environment around Qinshan Nuclear Power Plant

引用

Nuclear Science and Techniques 2005年第1期16卷 43-45页

作者： yeji-Da CHENBin WUZong-Mei ZhejiangProvinceEnvironmentalRadiationMonitoringCenter Hangzhou310012

This paper presents the measurement results of gross β activities in fallout samples collected from the en- vironment around Qinshan Nuclear Power Plant (NPP) during 1993-2002. The gross β activity of 191 samples col- lected at five monitoring spots were (0.11～3.64) Bq·m-2·d-1, with an average of (0.91±0.49) Bq·m-2·d-1. This value was lower than (1.02±0.35) Bq?m-2?d-1 , the average of the samples collected at the reference spot in Hangzhou. It indicated that no obvious rise in the gross β activity level of fallout was observed in ambience of Qinshan NPP.

关键词：秦山核电站放射性监测辐射微尘 β活性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

具有离散参数齐次随机场的线性预测((Ⅷ))

引用

工程数学学报 2001年第1期18卷 39-44页

作者：徐业基复旦大学管理学院统计运筹系上海200433

提出并研究了齐次随机场在半平面或不对称半平面上的观察中存在遗漏观察值情况下的预测问题 ,并对特殊的谱密度 ,求得了预测值及预测误差的明显表达式。

关键词：线性预测预测误差预测值齐次随机场离散参数谱密度预测问题

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：