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Free-standing microscale photonic lantern spatial mode(De-)multiplexer fabricated using 3D nanoprinting

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Light(Science & Applications) 2024年第6期13卷 1170-1185页

作者： Yoav Dana yehudit Garcia Aleksei Kukin Lauren Dallachiesa Sterenn Guerrier Nicolas K.Fontaine Dan M.Marom Institute of Applied Physics Hebrew University of JerusalemJerusalemIsrael Nokia Bell Labs 600 Mountain AveNew ProvidenceNJ07974USA

Photonic lantern(PL)spatial multiplexers show great promise for a range of applications,such as future high-capacity mode division multiplexing(MDM)optical communication networks and free-space optical *** enable efficient conversion between multiple single-mode(SM)sources and a multimode(MM)waveguide of the same *** multiplexers operate by facilitating adiabatic transitions between the SM arrayed space and the single MM ***,current fabrication methods are forcing the size of these devices to multi-millimeters,making integration with micro-scale photonic systems quite *** advent of 3D micro and nano printing techniques enables the fabrication of freestanding photonic structures with a high refractive index contrast(photopolymer-air).In this work we present the design,fabrication,and characterization of a 6-mode mixing,375µm long PL that enables the conversion between six single-mode inputs and a single six-mode *** PL was designed using a genetic algorithm based inverse design approach and fabricated directly on a 7-core fiber using a commercial two-photon polymerization-based 3D printer and a *** the waveguides exhibit high index contrast,low insertion loss(−2.6 dB),polarization dependent(−0.2 dB)and mode dependent loss(−4.4 dB)were measured.

关键词： mode enable printing

An Example for Arc-Type Granitoids Along Collisional Zones:The Pertek Granitoid,Taurus Orogenic Belt,Turkey

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International Journal of Geosciences 2011年第3期2卷 214-226页

作者： Sevcan Kürüm Bünyamin Akgül Ayten Oztüfekci Onal Durmus Boztug yehudit harlavan Melek Ural University of Firat Engineering FacultyDepartment of GeleogyElazigTurkey University of Tunceli Engineering FacultyDepartment of GeleogyTunceliTurkey Geological Survey of Israel JerusalemIsrael

The Pertek granitoid consisting dominantly of diorite, quartz diorite, quartz monzodiorite, tonalite and lesser granite, adamellite and syenite, is considered to form the easternmost continuation of the Central Anatolian Crystalline Complex. Diorite and monzonites of this granitoid complex are cut by the granitic dykes. The Pertek granitoid, in the study area, is found in the Permo-Triassic Keban metamorphic sequence along intrusive and tectonic contacts. Along the intrusive contacts metasomatic mineralizations are common. Granitoids are, depending on the mineralogical composition, low-, middle- high-K subalkaline features. Major oxide-SiO2 variation diagrams show that fractionation (particularly plagioclase, hornblend, pyroxene and olivine fractionation) played an important role on the granitoid formation during a continuous crystallization process. Distribution of the samples from the Pertek granitoid in the tectonic setting diagrams, and their chondrite- and primordial mantle-normalized trace element patterns resemble to the of arc-type granitoids. Trace element and rare earth element compositions indicate that the magma, from which the Pertek granitoid crystallized, derived from a mantle that was enriched by the fluids derived from the subducted slab, however this magma was contaminated by the crust during its intrusion. These geochemical characteristics are also supported by the field observations. The field and geochemical characteristics of the Pertek Granitiod suggest that they are similar to the other granitoids cropping out in the central and eastern Anatolia and they form the lateral continuation of the same magmatic belt.

关键词： Pertek Tunceli Island Arc Granitoid Geochemistry

Alpha-1 Anti-trypsin Exerts a Hepatoprotective Effect on Immune-mediated Hepatitis and Acetaminophen-induced Liver Injury

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Journal of Clinical and Translational Hepatology 2018年第4期6卷 345-349页

作者： yehudit Shabat Ami Ben Ya'acov Yaron Ilan Gastroenterology and Liver Units Department of MedicineHebrew University-Hadassah Medical CenterJerusalemIsrael

Background and Aims:The serine proteinase inhibitor alpha-1 anti-trypsin(AAT)protects the body against protease *** functions of AAT beyond those attributed to its antiprotease activity have been described,among them immunomodulatory and anti-inflammatory *** present study aimed to determine the efficacy of AAT for the treatment of immune-mediated liver injury using the models of concanavalin A-induced immune-mediated hepatitis and acetaminophen-induced liver ***:AATwas administered to mice subjected to concanavalin A-induced immune-mediated hepatitis or 2 h after acetaminophen-induced liver *** were followed for changes in serum levels of liver enzymes,liver histology,and for interferon gamma serum ***:Treatment with AATalleviated concanavalin A-induced immunemediated liver damage,as demonstrated by a reduction in the serum levels of liver enzymes and interferon gamma,and an improved lymphocyte infiltration into the liver on liver ***,treatment with AAT was associated with alleviation of the acetaminophen-induced liver ***:AAT exerts an hepatoprotective effect on immune-mediated and drug-induced liver *** data support its potential use in patients with immune-associated liver disorders.

关键词： Alpha-1 anti-trypsin Chronic liver disease Acetaminophen Druginduced liver injury

Oral administration of a non-absorbable plant cellexpressed recombinant anti-TNF fusion protein induces immunomodulatory effects and alleviates nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2016年第39期22卷 8760-8769页

作者： Yaron Ilan Ami Ben Ya'acov yehudit Shabbat Svetlana Gingis-Velitski Einat Almon Yoseph Shaaltiel Gastro-enterology and Liver Units Department of MedicineHadassah Hebrew University Medical CenterJerusalem IL 91120Isreal Protalix Biotherapeutics Carmel 20100Israel

AIM To evaluate the immunomodulatory effect of oral administration of PRX-106 in the high-fat diet *** For 22 wk, C57BL/6 HFD-fed mice received daily oral treatments with BY-2 cells expressing recombinant antitumor necrosis factor alpha fusion protein(PRX-106). Mice were followed for serum liver enzyme and triglyceride levels, liver histology and intrahepatic and systemic *** The orally administered non-absorbable PRX-106 w a s b i o l o g i c a l l y a c t i v e. A l t e r e d d i s t r i b u t i o n o f CD4+CD25+Fox P3+ between the liver and spleen and an increase in the intrasplenic-to-intrahepatic CD4+CD25+Fox P3+ ratio and a decrease in the intrasplenic-to-intrahepatic CD8+CD25+Fox P3+ ratio were observed. An increase in intrahepatic NKT cells and a decrease in the intrasplenic-to-intrahepatic NKT ratio were noted. Assessment of the CD4-to-CD8 ratios showed sequestration of CD8+ lymphocytes in the liver. These effects were associated with a decrease in serum triglyceride levels, decrease in the aspartate aminotransferase levels, serum glucose levels, and HOMA-IR score. A decrease in hepatic triglycerides content was observed in the high dose-treated *** Orally administered PRX-106 shows biological activity and exerts an immunomodulatory effect, alleviating liver damage. The data suggest that PRX-106 may provide an oral immunotherapy for nonalcoholic steatohepatitis.

关键词：不含酒精的 steatohepatitis 不含酒精的脂肪肝疾病肿瘤坏死 alpha Enbrel 糖尿病

Oral Co-administration of Soy-derived Extracts with Alcohol or with Sugar-sweetened Beverages Exerts Liver and Sugar Protective Effects

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Journal of Clinical and Translational Hepatology 2017年第3期5卷 208-215页

作者： Tawfik Khoury Devorah Rotnemer-Golinkin yehudit Shabat Lidya Zolotarovya Yaron Ilan Gastroenterology and Liver Units Department of Medicine Hadassah-Hebrew University Medical CenterJerusalem Israel

Background and Aims:Both alcoholic drinks and high sugar-containing soft drinks cause major health problems *** administration of OS and M1 soy-derived extracts has been shown to alleviate liver injury in animal *** aim of the present study was to determine the liver-and sugar-protective effect of OS and M1 soy-derived extracts when added to alcohol and sugar-enriched ***:Mice were treated with alcohol or high sugarcontaining drinks,with and without administration of a combination of OS and M1 soy *** were observed for the effects on liver injury,glucose metabolism,and the immune ***:Co-administration of the soy extracts OS and M1 significantly alleviated the liver injury induced by acute alcohol,as evidenced by decreased liver *** beneficial effects were associated with promotion of subsets of regulatory T lymphocytes and with a trend towards a pro-inflammatory to an anti-inflammatory cytokine ***-administration of OS M1 soy extracts with sugar-sweetened beverages significantly alleviated the increases in serum sugar ***:OS and M1 extracts exert a synergistic hepato-and glucose-protective effect in models of alcohol-induced liver damage and soft drinks-associated increases in serum *** extracts may provide a solution to the two pressing health problems.

关键词： Soy Soda drinks Alcoholic liver disease T regulatory cells

Are Mikvehs Responsible for GBS Carriers among Orthodox Jewish Women?—A Prospective Observational Study

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Open Journal of Obstetrics and Gynecology 2020年第7期10卷 909-913页

作者： Jacky Herzlich Daniel Lubin yehudit Schindler Osnat Wittmann Ronella Marom Departments of Neonatology Mahayanei Hayeshua Center Bney Brak Israel Departments of Neonatology Lis Maternity Hospital Tel Aviv Sourasky Medical Center Tel Aviv Israel Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel Departments of Microbiology Mahayanei Hayeshua Center Bney Brak Israel

Background: Maternal colonization with group B streptococcus (GBS) is an important risk factor for neonatal sepsis. A “mikveh” is a pool of water for ritual immersion by Jewish women. It had been reported to be a risk factor for GBS colonization. Objective: To determine whether there is an association between ritual immersion in the mikveh pools and GBS carriership. Methods: Water samples and bacterial swabs were taken from eight mikveh pools centers at two separate occasions and tested for GBS growth. For determination of the total number of live, aerobic bacteria, each sample was grown on strep selective agar for 48 hours at 37°C and CO2 5%. Results: All the samples were tested. No trace of GBS was found in any of the samples. Conclusions: The findings of this study refute earlier findings and suggest that there is no association between ritual immersion in mikvehs and GBS carriership.

关键词： Group B Streptococcus Carrier Mikveh Colonization Religiosity Early on Set Sepsis

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保持低速,保持复杂

青年视觉 2018年第6期 146-163页

作者：示人 yehudit Sasportas 不详

黑色的森林,一处来自无名之域的荒芜沼泽,从黑色森林中树木上剥落的黑色径直地贯穿了由沼泽水塘构建出的视平线,无论是空间装置作品还是绘画或者视频影像,都充满了一种压制和紧张感,这些都是依浩特·莎丝波特丝(yehudit Sasportas)作品... 详细信息

黑色的森林,一处来自无名之域的荒芜沼泽,从黑色森林中树木上剥落的黑色径直地贯穿了由沼泽水塘构建出的视平线,无论是空间装置作品还是绘画或者视频影像,都充满了一种压制和紧张感,这些都是依浩特·莎丝波特丝(yehudit Sasportas)作品中经常出现的元素,也构成了她独特的艺术风格。莎丝波特丝是一位描述和呈现临界状态的高手,呈现“尚未出现”和“刚刚逝去”的不确定瞬间,呈现社会现实与个体的无意识混合空间是其艺术创作的核心内容。一方面,莎丝波特丝试图将景观的存在和人类感知相结合。

关键词：视频影像人类感知临界状态混合空间紧张感艺术创作视平线无意识

Altered distribution of regulatory lymphocytes by oraladministration of soy-extracts exerts a hepatoprotectiveeffect alleviating immune mediated liver injury,non-alcoholic steatohepatitis and insulin resistance

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World Journal of Gastroenterology 2015年第24期21卷 7443-7456页

作者： Tawfik Khoury Ami Ben Ya'acov yehudit Shabat Lidya Zolotarovya Ram Snir Yaron Ilan Tawfik Khoury Ami Ben Ya'acov Yehudit Shabat Lidya Zolotarovya Ram Snir Yaron Ilan Gastroeneterology and Liver Units Department of Medicine Hadassah-Hebrew University Medical Center Jerusalem IL-91120 Israel.

AIM To determine the immune-modulatory and thehepatoprotective effects of oral administration of twosoy extracts in immune mediated liver injury and nonalcoholicsteatohepatitis （NASH）.METHODS： Two soy extracts, M1 and OS, were orallyadministered to mice with concanavalin A （ConA）immune-mediated hepatitis, to high-fat diet （HFD） miceand to methionine and choline reduced diet combinedwith HFD mice. Animals were followed for disease andimmune ***： Oral administration of OS and M1 had anadditive effect in alleviating ConA hepatitis manifestedby a decrease in alanine aminotransferase and aspartateaminotransferase serum levels. Oral administration ofthe OS and M1 soy derived fractions, ameliorated liverinjury in the high fat diet model of NASH, manifested bya decrease in hepatic triglyceride levels, improvementin liver histology, decreased serum cholesterol andtriglycerides and improved insulin resistance. In themethionine and choline reduced diet combined withthe high fat diet model, we noted a decrease inhepatic triglycerides and improvement in blood glucoselevels and liver histology. The effects were associated with reduced serum tumor necrosis factor alpha andalteration of regulatory T cell ***： Oral administration of the combinationof OS and M1 soy derived extracts exerted an adjuvanteffect in the gut-immune system, altering the distributionof regulatory T cells, and alleviating immune mediatedliver injury, hyperlipidemia and insulin resistance.

关键词： Non-alcoholic steatohepatitis Fatty liver Regulatory T cells Soy Type 2 diabetes ConA hepatitis

Vestiges of the Cold War in Libya’s“Arab Spring”:Revisiting Libya’s Relations with the Soviet Union

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Asian Journal of Middle Eastern and Islamic Studies 2014年第2期8卷 66-95页

作者： yehudit RONEN Department of Political Studies Bar-Ilan UniversityIsrael

Although Muammar al-Qaddafi was known to fanatically adhere to a broad set of zealous principles,when threats and challenges to his political survival mounted,sporadic breaches in the country’s rigid wall of ideology in regard to Libya’s international relations appeared,evincing Qaddafi’s ability to demonstrate pragmatism when required in order to maintain his grip on *** article will explore Libya’s strategic-military alignment with the USSR and offer a retrospective analysis of one of the lesser-discussed chapters in Tripoli’s tempestuous and belligerent foreign policy during the height of the Cold war era,spanning the period of 1974-1989.

关键词： Cold War and post Cold War Arab Countries and the“Arab Spring” The Soviet Union Libya The Superpowers’Middle East Policy