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Computers, Materials & Continua 2024年第6期79卷 3435-3453页

作者： yehao long Jing Zhong Tongdi Zhang Li Chen Lijun Zhang State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China

Physical Vapor Deposited(PVD)TiAlN coatings are extensively utilized as protective layers for cutting tools,renowned for their excellent comprehensive *** optimize quality control of TiAlN coatings for cutting tools,a multi-scale simulation approach is proposed that encompasses the microstructure evolution of coatings considering the entire preparation and service lifecycle of PVD TiAlN *** scheme employs phase-field simulation to capture the essential microstructure of the PVD-prepared TiAlN ***,cutting simulation is used to determine the service temperature experienced during cutting processes at varying ***-Hilliard modeling is finally utilized to consume the microstructure and service condition data to acquaint the microstructure evolution of TiAlN coatings throughout the cutting *** methodology effectively establishes a correlation between service temperature and its impact on the microstructure evolution of TiAlN *** is expected that the present multi-scale numerical simulation approach will provide innovative strategies for assisting property design and lifespan prediction of TiAlN coatings.

关键词： Multiscale phase-field TiAlN coatings PVD cutting

Qingfei Zhisou oral liquid(清肺止嗽口服液) alleviates fever-induced inflammation by regulating arachidonic acid and lysophospholipids metabolism and inhibiting hypothalamus transient receptor potential ion channels expression

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Journal of Traditional Chinese Medicine 2024年

作者： GAO Jiaming ZHANG yehao CHEN Yuanyuan JIN long ZHAO Jianfeng GUO Hao FU Jianhua Institute of Basic Medical Sciences Xiyuan Hospital of China Academy of Chinese Medical Sciences Pharmaceutical R&D Department Taiyuan Yidavike Medical Technology Development Co. Ltd.

OBJECTIVE: To explore how Qingfei Zhisou oral liquid (清肺止嗽口服液， QFZS) adjusts body temperature bias and the interaction of inflammatory factors levels and metabolomic differences. METHODS: Dry yeast was subcutaneously injected at 10 mL/kg to establish the pyrexia model. We randomly divided 60 Sprague-Dawley rats into five groups: control， model， positive， low dose of QFZS and high dose of QFZS. Inflammatory proteins were evaluated by Western blotting and immunohistochemistry. For the examination of the endogenous metabolites， enzyme linked immunosorbent assay and ultra-high-performance liquid chromatography high-resolution mass spectrometry were employed. RESULTS: QFZS significantly reduced rats' body temperature within 6 h after dry yeast injection and reduced the secretion of the arginine vasopressin， cyclic adenosine monophosphate， prostaglandin E-2， tumor necrosis factor-α (TNF-α)， interleukin-6 (IL-6)， and interleukin-1β in serum. Meanwhile， we identified 41 metabolites between the model and QFZS groups， including arachidonic acid and lysophospholipids. QFZS restored normal arachidonic acid levels. Based on the differential metabolite enrichment analysis， QFZS's anti-inflammatory and anti-pyrexia effects might be related to the inflammatory pathway regulated by transient receptor potential. Additionally， QFZS treatment reduced transient receptor potential melastatin 2 ion channel expression and affected TNF-α， heat shock protein 70， and cyclooxygenase-2 expression in the hypothalamus. CONCLUSION: QFZS exerts its regulatory effects on fever by regulating the metabolism of lysophospholipids and arachidonic acid and the regulation of inflammation via transient receptor potential ion channels channels.

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Modulation on electrostatic potential to build a firm bridge at NiO_(x)/perovskite interface for efficient and stable perovskite solar cells

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Journal of Energy Chemistry 2024年第9期96卷 249-258页

作者： Xiangbao Yuan Xufeng Ling Hongyu Wang Chengxia Shen Ru Li yehao Deng Shijian Chen Chongqing Key Laboratory of Interface Physics in Energy Conversion College of PhysicsChongqing UniversityChongqing 401331China Key Laboratory of Optoelectronic Technology&Systems(Ministry of Education) College of Optoelectronic EngineeringChongqing UniversityChongqing 400044China Center of Modern Physics Institute for Smart City of Chongqing University in LiyangLiyang 213300JiangsuChina

The NiO_(x)/perovskite interface in NiO_(x)-based inverted perovskite solar cells(PSCs)is one of the main issues that restrict device performance and long-term stability,as the unwanted interfacial defects and undesirable redox reactions cause severe interfacial non-radiative recombination and open-circuit voltage(Voc)***,a series of self-assembled molecules(SAMs)are employed to bind,bridge,and stabilize the NiO_(x)/perovskite interface by regulating the electrostatic *** on systematically theoretical and experimental studies,4-pyrazolecarboxylic acid(4-PCA)is proven as an efficient molecule to simultaneously passivate the NiO_(x)and perovskite surface traps,release the interfacial tensile stress as well as quench the detrimental interface redox reactions,thus effectively suppressing the interfacial non-radiative recombination and enhancing the quality of perovskite ***,the PSCs with 4-PCA treatment exhibited an eminently increased Voc,leading to a significant increase in power conversion efficiency from 21.28%to 23.77%.Furthermore,the unencapsulated devices maintain 92.6%and 81.3%of their initial PCEs after storing in air with a relative humidity of 20%–30%for 1000 h and heating at 65℃for 500 h in a N_(2)-filled glovebox,respectively.

关键词： Perovskite solar cells Nickel oxide Interface defects passivation Redox reaction Nonradiative recombination

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中药干预神经递质治疗局灶性脑缺血研究进展

辽宁中医药大学学报 2024年第7期26卷 130-135页

作者：王苑张业昊刘光宇中国中医科学院西苑医院基础医学研究所中药药理北京市重点实验室北京100091

神经递质调控是研究局灶性脑缺血损伤机制的重要内容,近年来研究发现局灶性脑缺血损伤发生后神经递质发生变化,与钙超载、炎症反应、氧化应激等病理过程相互关联,相互影响,通过神经、内分泌、免疫等多种途径干预局灶性脑缺血损伤的发生... 详细信息

神经递质调控是研究局灶性脑缺血损伤机制的重要内容,近年来研究发现局灶性脑缺血损伤发生后神经递质发生变化,与钙超载、炎症反应、氧化应激等病理过程相互关联,相互影响,通过神经、内分泌、免疫等多种途径干预局灶性脑缺血损伤的发生、发展、预后。中医药历史悠久,源远流长,中药及其复方具有多成分、多靶点、不良反应小等特点,适用于局灶性脑缺血损伤复杂多样的病理机制,被广泛用于神经系统疾病的治疗。近年来研究发现中药可以调控神经递质及受体的传递,对于局灶性脑缺血的治疗具有重要的意义,其内在机制也成为研究热点。文章以神经递质的分类为主线,系统梳理了不同分类的神经递质与局灶性脑缺血损伤的相关性,分析了中药对其的影响,为局灶性脑缺血后神经递质变化的相关研究提供思路,对中医药防治缺血性脑损伤的前景进行展望。

关键词：局灶性脑缺血神经递质中医药

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Contextual and selective attention networks for image captioning

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Science China(Information Sciences) 2022年第12期65卷 142-156页

作者： Jing WANG yehao LI Yingwei PAN Ting YAO Jinhui TANG Tao MEI School of Computer Science and Engineering Nanjing University of Science and Technology JD Explore Academy

The steady momentum of innovations has convincingly demonstrated the high capability of attention mechanisms for the sequence to sequence learning. Nevertheless, the computation of attention across a sequence is often independent in either hard or soft mode, thereby resulting in undesired effects such as repeated modeling. In this paper, we introduce a new design to holistically explore the interdependencies between attention histories and locally emphasize the strong focus of each attention on image captioning. Specifically, we present a contextual and selective attention network(namely Co SA-Net) that novelly memorizes contextual attention and brings out the principal components from each attention. Technically,Co SA-Net writes/updates the attended image region features into memory and reads from memory when measuring attention in the next time step to leverage contextual knowledge. Only the regions with the top-k highest attention scores are selected, and each region feature is individually employed to compute an output distribution. The final output is an attention-weighted mixture of all k distributions. In turn, the attention is then upgraded by the posterior distribution conditioned on the output. Our Co SA-Net is appealing given that it is pluggable to the sentence decoder in any neural captioning model. Extensive experiments on the COCO image captioning dataset demonstrate the superiority of Co SA-Net. More remarkably, integrating Co SA-Net to a one-layer long short-term memory(LSTM) decoder increases CIDEr-D performance from 125.2% to 128.5% on the COCO Karpathy test split. When further endowing a two-layer LSTM decoder with Co SA-Net, the CIDEr-D score is boosted to 129.5%.

关键词： image captioning hybrid attention contextual attention

武汉典型城市交通因素对COVID-19传播的影响研究

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南方建筑 2022年第4期 78-87页

作者：彭然王竞钊刘业浩刘学良武汉工程大学土木工程与建筑学院、西部绿色建筑国家重点实验室武汉工程大学土木工程与建筑学院

在汇总2020年初受到COVID-19疫情严重冲击的武汉市3,397个居住区内共计25,244个确诊病例的地理分布信息,并结合多类型城市交通大数据的基础上,将武汉7个传统中心城区的93个街道作为研究对象,然后在空间异质性视角下构建OLS和GWR模型分... 详细信息

在汇总2020年初受到COVID-19疫情严重冲击的武汉市3,397个居住区内共计25,244个确诊病例的地理分布信息,并结合多类型城市交通大数据的基础上,将武汉7个传统中心城区的93个街道作为研究对象,然后在空间异质性视角下构建OLS和GWR模型分析各街道的路网密度、道路可达性、轨道交通站点分布以及公交站点分布等4个典型交通驱动因素对于疫情传播的影响特征,并得出如下结论:(1)路网密度对于疫情传播的影响不显著;(2)轨道交通站点分布与疫情传播之间存在着显著的正相关性,轨道交通线路极有可能成为城市中疫情传播的“高速走廊”,而公交站点分布与疫情传播之间也存在正相关性,但其相关程度低于轨道交通站点分布;(3)道路可达性与疫情传播之间存在负相关性。最后探讨了相关交通优化措施,提出构建有效的城市交通“平疫转换”体系,并基于此加强城市的韧性交通建设。

关键词：城市交通空间异质性地理加权模型交通驱动因素 COVID-19

单纯锥度固位种植体应用于后牙区即刻种植5~7年的临床疗效

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华西口腔医学杂志 2023年第3期41卷 341-349页

作者：任碧晖郭水根徐业豪戴婕婷魏洪武南昌大学第四附属医院口腔科南昌330009

目的评估单纯锥度固位种植体在后牙区即刻种植修复后5~7年的长期临床疗效。方法选取2015年1月—2017年12月于南昌大学第四附属医院口腔科就诊行后牙区即刻种植修复患者共38名,53枚种植体,均为深部植入(骨下≥2 mm),上部结构修复完成后,... 详细信息

目的评估单纯锥度固位种植体在后牙区即刻种植修复后5~7年的长期临床疗效。方法选取2015年1月—2017年12月于南昌大学第四附属医院口腔科就诊行后牙区即刻种植修复患者共38名,53枚种植体,均为深部植入(骨下≥2 mm),上部结构修复完成后,追踪观察60~90个月,记录并分析种植体周围骨组织健康状况。结果随访5~7年间,有1枚种植体失败脱落,种植体存留率为98.1%;种植体修复后5~7年近远中边缘骨吸收量分别为(0.16±0.94)、(−0.01±1.29)mm,种植体近远中边缘骨高度与修复后即刻比较差异均无统计学意义(P>0.05);牙周炎、种植位点炎症、吸烟对种植体周围边缘骨吸收的影响差异无统计学意义(P>0.05)。结论单纯锥度固位种植体扩宽了后牙区即刻种植适应证,其骨下深部植入方式(骨下≥2 mm)在一定程度上避免种植体受到外界刺激干扰及种植体颈部基台暴露,种植体周围边缘骨长期稳定性良好。

关键词：单纯锥度固位后牙区即刻种植骨吸收

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圆形悬挂轨道的二阶非线性扰动修正

西北工业大学学报 2013年第4期31卷 629-632页

作者：刘蕾和兴锁闫业毫西北工业大学工程力学系陕西西安710129

基于动力学原理,首先建立了圆形悬挂轨道的相对运动动力学模型,然后在C-W方程考虑非线性扰动情况下,推导出圆形悬挂轨道基于二阶非线性扰动的运动方程,分析研究了非线性因素对悬挂轨道的影响,并给出了具体的修正方法。仿真结果表明,基... 详细信息

基于动力学原理,首先建立了圆形悬挂轨道的相对运动动力学模型,然后在C-W方程考虑非线性扰动情况下,推导出圆形悬挂轨道基于二阶非线性扰动的运动方程,分析研究了非线性因素对悬挂轨道的影响,并给出了具体的修正方法。仿真结果表明,基于相对运动条件下,对圆形悬挂轨道进行的二阶非线性修正消除了Y-bar方向上的长期扰动,为今后的研究奠定了理论基础。

关键词：悬挂轨道非线性相对运动动力学分析模型分析

A High Speed Wireless Synchronous Exposure System Based on TDMA

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A High Speed Wireless Synchronous Exposure System Based on T...

井下煤矿工作不育患者的精子质量及辅助生殖妊娠结局研究

第40届中国控制会议

作者： yehao Wang Qinghua Yang Chuang Wang Xiaowei Tu School of Mechatronic Engineering and Automation Shanghai University

In a system composed of a line array CCD and multiple LEDs, it is necessary to accurately obtain the CCD exposure sequence and work on the exposure while the LEDs are lit, which makes time synchronization more difficult under wireless conditions. In this paper, a wireless synchronous exposure system based on time division multiple access（TDMA） timing is proposed. The method reduces the network load and hardware power consumption and avoids the use of signal lines for synchronization between nodes. The exposure errors are described, and the errors generation is theoretically analyzed and experimentally verified. The method of node clock synchronization is proposed, and through experiments and data analysis, it is shown that the exposure accuracy reaches 1μs and can operate stably for a long time.

关键词： Synchronous exposure wireless sensor networks line array CCD

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中国男科学杂志 2022年第4期36卷 68-73页

作者：管福来董业浩曹井贺梁鲁南刘贞辉孙宝刚潍坊医学院形态学实验室山东潍坊261053 济宁医学院附属医院山东济宁272029

目的研究分析井下煤矿工作不育患者的精液质量、精子功能、辅助生殖妊娠结局以及后代情况,探讨从事井下煤矿工作对精液质量、精子功能、辅助生殖妊娠结局以及出生后代的影响。方法回顾分析济宁医学院附属医院生殖医学中心2015年1月至202... 详细信息

目的研究分析井下煤矿工作不育患者的精液质量、精子功能、辅助生殖妊娠结局以及后代情况,探讨从事井下煤矿工作对精液质量、精子功能、辅助生殖妊娠结局以及出生后代的影响。方法回顾分析济宁医学院附属医院生殖医学中心2015年1月至2020年12月56例从事井下煤矿工作1年以上、因妻子输卵管因素不孕行辅助生殖助孕的男性患者作为实验组,将103例因妻子输卵管因素不孕,拟行辅助生殖助孕的健康男性患者作为对照组。对比以上两组精子质量、精子功能指标(如顶体酶、精子顶体完整性、精子核蛋白组型、精子-透明质酸结合率等)以及妊娠结局和出生后代指标。结果实验组与对照组男、女方患者的平均年龄、不孕年限、窦卵泡数,女方基础FSH(卵泡刺激素),女方基础LH(黄体生成素),HCG日(扳机日)E2(雌二醇)水平,HCG日子宫内膜厚度比较,差异均无统计学意义(P>0.05)。实验组与对照组相比,精液参数中,精液量、精液浓度无统计学意义(P>0.05)。对照组前向运动率、精子活动率、正常形态率组高于实验组,差异有统计学意义。实验组顶体酶活性、精子-透明质酸结合率与对照组相比差异无统计学意义,实验组的DNA碎片、核蛋白组型异常比例大于对照组,差异具有统计学意义;对照组的受精率、优质胚胎率高于实验组,差异有统计学意义。实验组的卵裂率、着床率、生化妊娠率、临床妊娠率与对照组相比差异无统计学意义。实验组的流产率、出生体重、早产率、双胎妊娠率、男婴比例、出生缺陷率与对照组相比差异无统计学意义。结论长期从事井下工作对男性精液质量、精子功能及辅助生殖妊娠结局有一定的影响,而对出生后代可能无明显不良影响。

关键词：不育男性矿工辅助生殖技术妊娠结局