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Wan-yee Joseph Lau:the promoter of modernization and internationalization of Chinese surgery

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Oncology and Translational Medicine 2024年第1期10卷 1-3页

作者： Wan-yee Joseph Lau Faculty of Medicine The Chinese University of Hong KongHong KongChina

To my knowledge,there have been 3 books[1–3]and 2 book chapters written about me.[4–5]For those who are interested in the details of my life,please refer to these books/book *** title of this article is an English translation of the title of the book I refer to as reference 1,which I find appropriate to describe the role that I play in China.

关键词： please details translation

Is Blumensaat Inclination Angle (BIA) and Angle between Blumensaat line and Tibal Slope (BATS) a Risk Factor for ACL Injury?

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Journal of Biosciences and Medicines 2024年第7期12卷 314-324页

作者： Shri Kapilan leong Yung Chin Zulkifli Hassan Department of Orthopedic Hospital Sultan Ismail (KKM) Johor Bharu Johor Malaysia

Introduction: Femoral and tibial morphology posted as anatomical risk factors for ACL injuries. Samora *** found out that a decreased BIA was associated with ACL rupture. Alentorn-Geli et al. found that the angle between the Blumensaat line and the anterior tibial slope (BATS angle) was significantly greater in men with ACL injury. However, other authors were not able to reproduce the similar findings. Our study aimed to determine the Blumensaat inclination angle (BIA) and angle between Blumensaat line and tibial slope (BATS) in patients with or without anterior cruciate ligament injury. We also explored the factors influence them. Method: We elavuated 142 MRI knee done in Hospital Sultan Ismail from January 2017 to November 2020. Study group was patient with ACL injuries, with or without meniscus and cartilage injuries. Control group was patient with no ACL injuries. 57 patients with history of fracture around the knee joint, multiligamentous injuries, inflammatory arthritis and tumour were excluded from the study. We recorded their age, gender, BIA, and BATS angle. BIA and BATS angle were measured in sagittal plane MRI as described by Koji Iswasaki et al. and Alentorn-Geli et al. Result: 54 patients were in study group and 31 years in control group. The mean age for study group was 32.7 (8.95) year old, and for control group was 42.5 (14.54). The mean BIA for study group was 36.20 (4.542) degree, and control group was 37.25 (4.941). The mean BATS for study group was 36.33 (5.78) degree, and control group was 25.26 (6.047) degree. BIA and BATS angle did not differ in both groups, age and gender. Conclusion: Our study did not show BIA and BATS angle as an anatomical risk factor for ACL injuries. Age and gender did not affect these angles.

关键词： BIA Anterior Tibial Slope ACL

A converged ubiquitin-proteasome pathway for the degradation of TOC and TOM tail-anchored receptors

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Journal of Integrative Plant Biology 2024年第5期66卷 1007-1023页

作者： Meijing Yang Shuai Chen Shey-Li Lim Lang Yang Jia Yi Zhong Koon Chuen Chan Zhizhu Zhao Kam-Bo Wong Junqi Wang Boon leong Lim School of Biological Sciences University of Hong KongPokfulam 999077Hong KongChina Department of Biology Southern University of Science and TechnologyShenzhen 518055China School of Biomedical Engineering Shenzhen UniversityShenzhen 518060China School of Life Sciences The Chinese Universityof Hong KongShatin 999077HongKongChina State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongShatin 999077Hong KongChina HKU Shenzhen Institute of Research and Innovation Shenzhen 518052China

In plants,thousands of nucleus-encoded proteins translated in the cytosol are sorted to chloroplasts and mitochondria by binding to specific receptors of the TOC(translocon on the outer chloroplast membrane)and the TOM(translocon on the outer mitochondrial membrane)complexes for import into those *** degradation pathways for these receptors are ***,we discovered a converged ubiquitin-proteasome pathway for the degradation of Arabidopsis thaliana TOC and TOM tail-anchored *** receptors are ubiquitinated by E3 ligase(s)and pulled from the outer membranes by the AAA+adenosine triphosphatase CDC48,after which a previously uncharacterized cytosolic protein,transmembrane domain(TMD)-binding protein for tail-anchored outer membrane proteins(TTOP),binds to the exposed TMDs at the C termini of the receptors and CDC48,and delivers these complexes to the 26S proteasome.

关键词： 26S proteasome CDC48 SP1 TOC TOM ubiquitination

Drosophila adhesion GPCR Remoulade regulates axon growth, branching, and guidance by modulating Rac1 GTPase

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Journal of Genetics and Genomics 2024年第4期51卷 458-461页

作者： Xi Yang Changkun Pan Meitong Ye Jinshuo Liang Haoyang Cheng Qing Liang Shu Huang Jianshu Wang Hoi yee Chow Haihuai He Cancer Center and State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China National Clinical Research Center for Geriatrics and State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China Department of Neurosurgery Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China

The assembly of neurons into complex circuits relies upon appropriate axonal navigation to distant *** considerable progress has been made toward understanding the regulation of the guidance and branching of axon extension,the molecular and cellular mechanisms underlying the coordination of the motility of the axon tip,axon growth,and branching remain largely unknown(Sudhof,2017).The Drosophila mushroom body(MB),the major site for associative learning and memory,is a powerful model system to investigate complex axon *** MB is a bilaterally symmetric central brain structure,mainly composed of Kenyon cells,MB output neurons,and dopaminergic neurons(Li et al.,2020).Among the seven neuronal subtypes of~2000 Kenyon cells,Y,a/β,and a/β'subtypes extend axons in a fascicle and bifurcate to produce two sister branches,one projecting into the dorsal lobe and the other into the medial lobe.

关键词： branching medial axon

THE SPARSE REPRESENTATION RELATED WITH FRACTIONAL HEAT EQUATIONS

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Acta Mathematica Scientia 2024年第2期44卷 567-582页

作者：曲伟钱涛梁应德李澎涛 College of Sciences China Jiliang UniversityHangzhou310018China Macao Center for Mathematical Science Macao University of Science and TechnologyMacao999078China Department of Mathematics Faculty of Science and TechnologyUniversity of MacaoMacao999078China School of Mathematics and Statistics Qingdao UniversityQingdao266071China

This study introduces a pre-orthogonal adaptive Fourier decomposition(POAFD)to obtain approximations and numerical solutions to the fractional Laplacian initial value problem and the extension problem of Caffarelli and Silvestre(generalized Poisson equation).As a first step,the method expands the initial data function into a sparse series of the fundamental solutions with fast convergence,and,as a second step,makes use of the semigroup or the reproducing kernel property of each of the expanding *** show the effectiveness and efficiency of the proposed series solutions.

关键词： reproducing kernel Hilbert space dictionary sparse representation approximation to the identity fractional heat equations

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经典电路网络中奇异束缚态的实验观察

Science Bulletin 2024年第14期69卷 2194-2204页

作者：邹德源陈天孟海瑜 yee Sin Ang 张向东李庆华 Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of TechnologyBeijing 100081China School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China Department of Physics National University of SingaporeSingapore 117542Singapore Science Mathematics and Technology ClusterSingapore University of Technology and DesignSingapore 487372Singapore Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207China

Exceptional bound(EB)states represent a unique new class of robust bound states protected by the defectiveness of non-Hermitian exceptional *** distinct from the more well-known topological states and non-Hermitian skin states,they were recently discovered as a novel source of negative entanglement entropy in the quantum entanglement ***,EB states have been physically elusive,being originally interpreted as negative probability eigenstates of the propagator of nonHermitian Fermi *** this work,we show that EB states are in fact far more ubiquitous,also arising robustly in broad classes of systems whether classical or *** hinges crucially on a newlydiscovered spectral flow that rigorously justifies the EB nature of small candidate lattice *** a highlight,we present their first experimental realization through an electrical circuit,where they manifest as prominent stable resonant voltage *** work brings a hitherto elusive but fundamentally distinctive quantum phenomenon into the realm of classical metamaterials,and provides a novel pathway for the engineering of robust modes in otherwise sensitive systems..

关键词： Exceptional bound states Classical circuit network Non-Hermitian Robustness Exceptional point

Recent Expedition in Pd-Catalyzed Sonogashira Coupling and Related Processes

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Chinese Journal of Chemistry 2023年第9期41卷 1099-1118页

作者： Pui Ying Choy Kin Boon Gan Fuk yee kwong Department of Chemistry and State Key Laboratory of Synthetic Chemistry The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina Shenzhen Center of Novel Functional Molecules Shenzhen Municipal Key Laboratory of Chemical Synthesis of Medicinal Organic MoleculesCUHK Shenzhen Research InstituteNo.10.Second Yuexing RoadShenzhenGuangdong 518507China

Sonogashira cross-coupling protocol,typically showing the reaction between aryl/vinyl halide and terminal alkyne,has been a widely used protocol for constructing C(sp2)-C(sp)*** resulting internal alkynes are highly versatile for reaching differently function-alized alkyne-containing scaffolds or serving as valuable synthetic synthons to many other functional *** is worth noting that products originated from this coupling reaction are mostly applicable to be transformed into corresponding Z-alkene,alkane,or het-erocyclic moieties in natural product *** reaction conditions and catalyst systems are able to be tweaked in order to facil-itate the activation of steric hindered and/or electron-rich ***-catalyzed copper-free Sonogashira coupling reaction has caught increasing attention as the improved method can be more environmentally *** is more,the conditions of the cou-pling reaction can be readily amended to allow the fusion of other carbonylation or decarboxylation step in the catalytic cycle,and thus allow more complex yet versatile convergent synthesis to proceed in an operationally simple one-pot manner.

关键词： Sonogashira Alkynylation Palladium Multicomponent reactions Cross-Coupling

Excess non-COVID-19-related mortality among inflammatory bowel disease decedents during the COVID-19 pandemic

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World Journal of Gastroenterology 2024年第20期30卷 2677-2688页

作者： Sarah Rotondo-Trivette Xin-Yuan He Jamil S Samaan Fan Lv Emily Truong Michaela Juels Anthony Nguyen Xu Gao Jian Zu yee Hui Yeo Fan-Pu Ji Gil Y Melmed Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Infectious Disease The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Karsh Division of Gastroenterology and Hepatology Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049Shaanxi ProvinceChina David Geffen School of Medicine University of CaliforniaLos AngelesLos AngelesCA 90095United States Division of Gastroenterology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Key Laboratory of Surgical Critical Care and Life Support(Xi’an Jiaotong University) Ministry of EducationXi’an 710004Shaanxi ProvinceChina

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic disrupted healthcare in the United *** To investigate COVID-19-related and non-COVID-19-related death and characteristics associated with excess death among inflammatory bowel disease(IBD)*** We performed a register-based study using data from the National Vital Statistics System,which reports death data from over 99%of the United States population,from January 1,2006 through December 31,***-related deaths among adults 25 years and older were stratified by age,sex,race/ethnicity,place of death,and primary cause of *** and actual age-standardized mortality rates(ASMRs)per 100000 persons were *** 49782 IBD-related deaths occurred during the study ***-COVID-19-related deaths increased by 13.14%in 2020 and 18.12%in 2021[2020 ASMR:1.55 actual vs 1.37 predicted,95%confidence interval(CI):1.26-1.49;2021 ASMR:1.63 actual vs 1.38 predicted,95%CI:1.26-1.49].In 2020,non-COVID-19-related mortality increased by 17.65%in ulcerative colitis(UC)patients between the ages of 25 and 65 and 36.36%in non-Hispanic black(NHB)Crohn’s disease(CD)*** the pandemic,deaths at home or on arrival and at medical facilities as well as deaths due to neoplasms also *** IBD patients suffered excess non-COVID-19-related death during the *** death was associated with younger age among UC patients,and with NHB race among CD *** death at home or on arrival and due to neoplasms suggests that delayed presentation and difficulty accessing healthcare may have led to increased IBD mortality.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease COVID-19 Excess death Race Sex Disparities

A prospective cohort of men with localized prostate cancer on active surveillance protocol in Hong Kong,China:what did we learn?

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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan Ching-Ho Ko Cindy Yeuk-Lam Hong Samuel Chi-Hang yee Jeremy Yuen-Chun Teoh Samson Yun-Sang Chan Ho-Man Tam Chi-Kwok Chan Chi-Fai Ng Peter Ka-Fung Chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,Hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer