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国外医学.耳鼻咽喉科学分册 1982年第5期 267-269页

作者： yee r D 王赋冰

先天性眼震是一种常见的眼运动失调症。本病缺少视固定反射机能,当患者企图固定注视某静止物体时,眼球作快速水平摆动,使物体在眼底黄斑部不能成像,造成严重的视觉功能缺陷。本病原因不明,近来采用灵敏而准确的眼震电图

关键词：眼震前庭患者暗室视动系统眼球运动

延迟增强磁共振成像预测心室内不同步患者对心脏再同步治疗的反应

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 53-54页

作者： White J.A. yee r. 刘少伟 Division of Cardiology Department of MedicineUniversity of Western OntarioLondonOnt.Canada Dr.

目的:本研究评估了延迟增强磁共振成像(DE-MrI)预测患者对心脏再同步治疗(CrT)临床反应性的能力。背景:在经选择的心力衰竭患者中,心脏再同步治疗可降低发病率和死亡率。

关键词：再同步磁共振成像临床反应射血分数心功能心肌梗死病史室壁运动基线水平室间隔无反应性

Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural regeneration research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman yee Hang Ethan Ma Nolan Fullenkamp Giles W.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

一项关于阻塞性睡眠呼吸暂停患者中生理性起搏的前瞻性随机交叉试验

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世界核心医学期刊文摘（心脏病学分册） 2006年第5期2卷 48-49页

作者： Krahn A.D yee r Erickson M.K. 王亭忠 London Health Sciences Center University Campus 339 Windermere Road London Ont. N6A 5A5 CanadaDr.

OBJECTIVES: This study was designed to assess the impact of prevention of bradycardia with physiologic pacing on the severity of obstructive sleep apnea. BACKGrOUND: Apneic episodes during sleep are associated with slowing of the heart rate during apnea and tachycardia with subsequent arousal. Patients with permanent pacemakers may have reduced episodes of sleep apnea when their pacemaker rate is set faster than their spontaneous nocturnal heart rate. METHODS: We conducted a prospective, randomized, single-blind crossover trial of temporary atrial pacing in obstructive sleep apnea to reduce the apnea hypopnea index(AHI). Fifteen patients(age 60± 13 years, 12 men) with moderate to severe obstructive sleep apnea(AHI 34± 14) underwent insertion of an externalized atrial permanent pacing system via the left subclavian vein. Patients underwent overnight respiratory sleep studies in hospital, during atrial pacing at 75 beats/min, and with pacing turned off. The order of pacing mode was randomized, with crossover the subsequent night to the other mode. Patients were blinded to pacing mode, and the analysis of sleep recordings was blind to pacing mode. rESULTS: Pacing was tolerated without complications in all patients. Overnight physiologic pacing did not affect the AHI(pacing 39± 21/h vs. control 42± 21/h, p=0.23, 95% confidence interval- 9.3 to 2.5 for difference), desaturation time(pacing 3.8± 6.0% vs. control 3.5± 4.3% , p=0.70), or the minimum SaO2(pacing 75± 10% vs. control 77± 11% , p=0.38). There was a borderline significant reduction in circulatory time with pacing(pacing 23.4± 3.2 s vs. control 25.5± 4.4 s, p=0.09). CONCLUSIONS: Temporary atrial pacing does not appear to improve respiratory manifestations of obstructive sleep apnea. Permanent atrial pacing in this patient population does not appear to be justified.

关键词：重度阻塞性睡眠呼吸暂停永久性起搏器植入患者随机交叉试验生理性起搏呼吸暂停低通气指数经左锁骨下静脉心率变慢心房起搏起搏器频率永久起搏器

Artificial Intelligence Based MPPT Techniques for Solar Power System: A review

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Journal of Modern Power Systems and Clean Energy 2020年第6期8卷 1043-1059页

作者： Kah Yung Yap Charles r.Sarimuthu Joanne Mun-yee Lim the Department of Electrical and Computer Systems Engineering(ECSE) School of EngineeringMonash UniversitySubang JayaMalaysia

In the last decade,artificial intelligence(AI)techniques have been extensively used for maximum power point tracking(MPPT)in the solar power *** is because conventional MPPT techniques are incapable of tracking the global maximum power point(GMPP)under partial shading condition(PSC).The output curve of the power versus voltage for a solar panel has only one GMPP and multiple local maximum power points(MPPs).The integration of AI in MPPT is crucial to guarantee the tracking of GMPP while increasing the overall efficiency and performance of *** selection of AI-based MPPT techniques is complicated because each technique has its own merits and *** general,all of the AI-based MPPT techniques exhibit fast convergence speed,less steady-state oscillation and high efficiency,compared with the conventional MPPT ***,the AI-based MPPT techniques are computationally intensive and costly to ***,the hybrid MPPT is favorable in terms of the balance between performance and complexity,and it combines the advantages of conventional and AI-based MPPT *** this paper,a detailed comparison of classification and performance between 6 major AI-based MPPT techniques have been made based on the review and MATLAB/Simulink simulation *** merits,open issues and technical implementations of AI-based MPPT techniques are *** intend to provide new insights into the choice of optimal AI-based MPPT techniques.

关键词： Maximum power point tracking(MPPT) artificial intelligence(AI) fuzzy logic control(FLC) artificial neural network(ANN) genetic algorithm(GA) swarm intelligence(SI) machine learning(ML)

Modelling for registration of remotely sensed imagery when reference control points contain error

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Science China Earth Sciences 2006年第7期49卷 739-746页

作者： Leung yee The Department of Geography and resource Management The Chinese University of Hong Kong Shatin Hong Kong China

reference control points (rCPs) used in establishing the regression model in the regis-tration or geometric correction of remote sensing images are generally assumed to be “perfect”. That is, the rCPs, as explanatory variables in the regression equation, are accurate and the coordinates of their locations have no errors. Thus ordinary least squares (OLS) estimator has been applied exten-sively to the registration or geometric correction of remotely sensed data. However, this assumption is often invalid in practice because rCPs always contain errors. Moreover, the errors are actually one of the main sources which lower the accuracy of geometric correction of an uncorrected image. Under this situation, the OLS estimator is biased. It cannot handle explanatory variables with errors and cannot propagate appropriately errors from the rCPs to the corrected image. Therefore, it is essential to develop new feasible methods to overcome such a problem. This paper introduces a consistent adjusted least squares (CALS) estimator and proposes relaxed consistent adjusted least squares (rCALS) estimator, with the latter being more general and flexible, for geometric correction or regis-tration. These estimators have good capability in correcting errors contained in the rCPs, and in propagating appropriately errors of the rCPs to the corrected image with and without prior information. The objective of the CALS and proposed rCALS estimators is to improve the accuracy of measure-ment value by weakening the measurement errors. The conceptual arguments are substantiated by a real remotely sensed data. Compared to the OLS estimator, the CALS and rCALS estimators give a superior overall performance in estimating the regression coefficients and variance of measurement errors.

关键词： error modelling, registration, ordinary least squares, relaxed consistent adjusted least squares, remote sensing images.

WAVE INDUCED OSCILLATOrY AND STEADY FLOWS IN THE ANNULUS OF A CATHETErIZED VISCOELASTIC TUBE

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Journal of Hydrodynamics 2010年第5期22卷 605-617页

作者： NG Chiu-On CHANG Yin-yee Department of Mechanical Engineering The University of Hong Kong

A perturbation analysis based on equations of motion in Lagrangian form is presented for the oscillatory and time-mean viscous flows induced by a propagating wave of small amplitude in an annulus with a viscoelastic outer wall. Owing to the steady streaming effect, the existence of a catheter in a blood vessel brings in an additional steady pressure gradient, a correction to that predicted by the linear theory, and an additional steady shear stress, which may increase the possibility of hemolysis of red blood cells.

关键词： annulus flow steady streaming catheterized artery

Challenges and Opportunities in the Practice of Chinese Medicine in Singapore

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Chinese Journal of Integrative Medicine 2024年第6期30卷 483-488页

作者： CHEW Sin yee National University Hospital Singapore119074Singapore

According to the World Health Oranization(WHO)Traditional Medicine Strategy 2014-2023,traditional medicine is defined as"the sum total of the knowledge,skill and practices based on the theories,beliefs,and experiences indigenous to different cultures,whether explicable or not,used in the maintenance of health as well as in the prevention,diagnosis,improvement or treatment of physical and mental illness.

关键词： theories prevention diagnosis

Design-space adaptation method for multiobjective and multidisciplinary optimization

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Chinese Journal of Aeronautics 2024年第8期37卷 166-189页

作者： Jongho JUNG Kwanjung yee Shinkyu JEONG Department of Aerospace Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Mechanical Engineering Kyunghee UniversityYoungin 17104Republic of Korea

This paper developed a new method that adaptively adjusts a design space by considering the actual solution distribution of a problem to overcome the conventional design-space adaptation method that assumes the solutions distribution to be a normal distribution because the distributions of solutions are rarely normal distributions for real-world *** developed method was applied to nineteen multiobjective test functions that are widely used to evaluate the characteristics and performance of optimization *** results showed that this method adapted the design space to an appropriate design space where the solution existence probability was *** optimization performance achieved using the developed method was higher than that of the conventional ***,the developed method was applied to the conceptual design of an unmanned spacecraft to confirm its validity in real-world design and multidisciplinaryoptimization *** results showed that the Pareto solutions of the developed method were superior to those of conventional ***,the optimization efficiency with the developed method was improved by more than 1.4 times over that of the conventional *** this regard,the developed method has the potential to be applied to complicated real-world optimization problems to achieve better performance and efficiency.

关键词： Multiobjective optimization Multiobjective genetic algorithm Design-space adaptation Multidisciplinary optimization Hypersonic vehicle

Intercellular and inter-organ crosstalk in browning of white adipose tissue:molecular mechanism and therapeutic complications

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Journal of Molecular Cell Biology 2021年第7期13卷 466-479页

作者： Lai yee Cheong Aimin Xu The State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina

Adipose tissue(AT)is highly plastic and heterogeneous in response to environmental and nutritional *** development of heat-dissipating beige adipocytes in white AT(WAT)through a process known as browning(or beiging)has garnered much attention as a promising therapeutic strategy for obesity and its related metabolic *** is due to its inducibility in response to thermogenic stimulation and its association with improved metabolic *** consists of adipocytes,nerves,vascular endothelial cells,various types of immune cells,adipocyte progenitor cells,and *** cells contribute to the formation of beige adipocytes through the release of protein factors that significantly influence browning *** addition,inter-organ crosstalk is also important for beige adipocyte ***,we summarize recent findings on fat depot-specific differences,secretory factors participating in intercellular and inter-organ communications that regulate the recruitment of thermogenic beige adipocytes,as well as challenges in targeting beige adipocytes as a potential anti-obese therapy.

关键词： adipose tissue browning circulating factors energy homeostasis adipose biology obesity