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Nanomanufacturing and Metrology 2020年第2期3卷 112-122页

作者： Chun Jin Wang Chi Fai Cheung Lai Ting Ho yee man loh State Key Laboratory of Ultra-precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Fluid jet polishing(FJP)is a versatile polishing process that has many advantages compared to other polishing ***-off distance(SOD)is one of the key parameters in flu id jet polishi ***,relatively little research work has been carried out to investigate its effect of SOD on material removal characteristics and surface generation in *** this paper,a systematic investigation of the effect of SOD on the tool influence function and surface topography in FJP was *** were designed for FJP two kinds of materials corresponding to ductile and brittle *** are nickel copper(NiCu)alloy and BK7 optical glass,*** this study,the SOD was varied from 2 to 35 *** and discussions were made on its effect on the shape of TIF,material removal rate,and surface *** is interesting to note that the TIF shape becomes a Gaussian-like shape with large SOD both on NiCu and BK7,which provides a novel way to optimize the TIF in *** variation of the material removal rate and surface roughness versus SOD on NiCu and BK7 were also determined from the experimental ***,the surface topography of NiCu and BK7 were characterized from the results measured from the white light interferometer and scan electron *** outcome of the study provides a better understanding of the material removal characteristics and surface generation mechanism in FJP.

关键词： Fluid jet polishing Material removal characteristics Stand-off distance Tool influence function Surface generation Ultra-precision machining

Synthesis of a highly recoverable 3D MnO2/rGO hybrid aerogel for efficient adsorptive separation of pharmaceutical residue

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Journal of Environmental Sciences 2022年第8期34卷 194-203页

作者： Billie Yan Zhang Hiew Wan Ting Tee Nicholas Yung Li loh Kar Chiew Lai Svenja Hanson Suyin Gan Suchithra Thangalazhy-Gopakumar Lai yee Lee Department of Chemical and Environmental Engineering University of Nottingham MalaysiaJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia Department of Chemical and Environmental Engineering University of Nottingham Ningbo ChinaNingbo 315100China

Water contamination by non-steroidal anti-inflammatory drugs,such as acetaminophen,is an emerging ecological *** this study,a newthree-dimensionalmanganese dioxideengrafted reduced graphene oxide(3D MnO_(2)/rGO)hybrid aerogel was developed for acetaminophen *** synthesis involved firstly the self-assembly of GO aerogel,followed by thermal reduction and in-situ MnO_(2) growth by *** aerogel demonstrated interlinked planes with smooth surfaces deposited with MnO_(2) nanospheres and pores of 138.4–235.3μm *** influences of adsorbent dosage,initial pH,acetaminophen concentration,temperature and contact time were *** was determined that the adsorption of acetaminophen occurred on uniform sorption sites in the aerogel,as suggested by the best fit of data to the Langmuir isotherm,yielding a maximum adsorption capacity of 252.87 mg/*** highest adsorption performance of the 3D MnO_(2)/rGO aerogel was attained at a dosage of 0.6 g/L,initial pH of 6.2 and temperature of 40℃.The process kinetics were in-line with the pseudo-first-order and pseudo-second-order kinetics at 10 and 20–500 mg/L concentrations,*** assay showed the spontaneity and endothermicity features of the 3D MnO_(2)/rGO-acetaminophen *** acetaminophen adsorption mechanisms were mainly hydrogen bonding and pore ***,the as-synthesised aerogel was effectively regenerated using acetone and re-utilised in four adsorption-desorption ***,the results highly recommend the implementation of the 3D MnO_(2)/rGO hybrid aerogel for purification of wastewater polluted by acetaminophen residue.

关键词： Acetaminophen Adsorption Adsorption mechanism 3D reduced graphene oxide manganese oxide nanoparticles Regeneration

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Engineering immunosuppressive drug-resistant armored(IDRA)SARS-CoV-2 T cells for cell therapy

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Cellular & Molecular Immunology 2023年第11期20卷 1300-1312页

作者： Qi Chen Adeline Chia Shou Kit Hang Amy Lim Wee Kun Koh Yanchun Peng Fei Gao Jili Chen Zack Ho Lu-En Wai Kamini Kunasegaran Anthony Tanoto Tan Nina Le Bert Chiew yee loh Yun Shan Goh Laurent Renia Tao Dong Anantharaman Vathsala Antonio Bertoletti Emerging Infectious Disease Program Duke-NUS Medical SchoolSingaporeSingapore National University Centre for Organ Transplantation National University HospitalSingaporeSingapore MRC Human Immunology Unit MRC Weatherall Institute of Molecular MedicineRadcliffe Department of MedicineUniversity of OxfordOxfordUK Lion TCR Pte Ltd SingaporeSingapore A*STAR ID labs Agency for ScienceTechnology and ResearchSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Singapore Immunology Network A*STARSingaporeSingapore

Solid organ transplant(SOT)recipients receive immunosuppressive drugs(ISDs)and are susceptible to developing severe ***,we analyze the Spike-specific T-cell response after 3 doses of mRNA vaccine in a group of SOT patients(n=136)treated with different *** demonstrate that a combination of a calcineurin inhibitor(CNI),mycophenolate mofetil(MMF),and prednisone(Pred)treatment regimen strongly suppressed the mRNA vaccine-induced Spike-specific cellular *** defects have clinical consequences because the magnitude of vaccine-induced Spike-specific T cells was directly proportional to the ability of SOT patients to rapidly clear SARS-CoV-2 after breakthrough *** then compensate for the T-cell defects induced by immunosuppressive treatment and to develop an alternative therapeutic strategy for SOT patients,we describe production of 6 distinct SARS-CoV-2 epitope-specific ISD-resistant T-cell receptor(TCR)-T cells engineered using the mRNA electroporation method with reactivity minimally affected by mutations occurring in Beta,Delta,Gamma,and Omicron *** strategy with transient expression characteristics marks an improvement in the immunotherapeutic field and provides an attractive and novel therapeutic possibility for immunosuppressed COVID-19 patients.

关键词： T cell therapy Transplantation SARS-CoV-2 Immunosuppressive drug resistant T cells

Study Protocol to Investigate the Efficacy of Participation in Qi-Gong by Breast Cancer Survivors

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Journal of Cancer Therapy 2011年第5期2卷 715-724页

作者： Shing yee Lee Siew Yim loh Liam Murray 不详

Background: Physical activity improves quality of life and reduces the risks of breast cancer up to 30 - 40 percent. Qi-Gong is a form of exercise widely acknowledged by Asian survivors as health promoting, despite a lack of research evidence. This study aimed to investigate the efficacy of Qi-Gong on the Quality of Life (QOL) of survivors. Methods/ Design: A total of 114 women who had been treated for stage I or II breast cancer at least 12 months previously were randomly assigned to supervised aerobic exercise (n = 38), Qi-Gong exercise (n = 38), or usual care (n = 38). Supervised 1.5 hour exercise sessions took place three times per week for 8 weeks (face to face—once a week and home follow up twice a week). Outcomes included QoL (FACT-G), Functional Assessment of Cancer Therapy-Breast (FACT-B)], distress [Depression Anxiety Stress Scale (DASS)] assessed at baseline and at the 8-week follow-up. Secondary measures included exercise Self Efficacy Scale (ESS), Functional Assessment of Cancer Therapy-Fatigue (FACT-F) and exercise behavior (log) Two way (group × time) repeated measures ANOVA will examine differences between groups over time. Discussion: This research will provide insights on the efficacy of a 8 weeks structured Qi-Gong program designed for quality of life. The details of the Qi-Gong and the placebo (line dancing) over 8 weeks are delineated, with the study protocol for researcher’s replication. The result of the study can contribute towards understanding how Qi-Gong over other physical activity can be used for self managing physical health for people with breast cancer, an increasingly acknowledged chronic condition. Conclusion: Women with breast cancer need to start engaging in physically healthy-active living on a day-to-day basis for prevention of recurrence, mortality and wellbeing. However, many requires professional support with a structured intervention. This design of this study provides a protocol for 8 weeks Qi-Gong with implications on heal

关键词： Cancer Qi-Gong Physical Activity Protocol

Real world experience with Pegylated Interferon and ribavirin in Hepatitis C Genotype 1 population with favourable IL28B polymorphism

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Gastroenterology Report 2017年第3期5卷 208-212,I0002页

作者： Victoria Ekstrom Rajneesh Kumar Yi Zhao Mei Ling yee Cynthia Sung Dorothy Toh Poh Yen loh Jessica Tan Eng Kiong Teo Wan Cheng Chow Department of Gastroenterology and Hepatology Singapore General HospitalSingapore Department of Clinical Translational Research Singapore General HospitalSingapore Department of Pharmacy Singapore General HospitalSingapore Health Products Regulation Group Health Sciences AuthoritySingapore Emerging Infectious Disease Programme Duke-NUS Medical SchoolSingapore Department of Gastroenterology and Hepatology Changi General HospitalSingapore

背景与目的:丙型肝炎(HCV)的传统治疗是应用聚乙二醇干扰素(FEG-IFN)和病毒唑,但副作用明显。IL28B基因多态性可以预测治疗反应,CC基因型者效果更好。ITPA基因缺失能对治疗引起的临床贫血起到保护作用。本研究目的是检测接受FEG-IFN和... 详细信息

背景与目的:丙型肝炎(HCV)的传统治疗是应用聚乙二醇干扰素(FEG-IFN)和病毒唑,但副作用明显。IL28B基因多态性可以预测治疗反应,CC基因型者效果更好。ITPA基因缺失能对治疗引起的临床贫血起到保护作用。本研究目的是检测接受FEG-IFN和病毒唑治疗的1型HCV患者中IL28B基因多态性和ITPA基因突变情况,并分析其与持续病毒学应答(SVR)的相关性。方法:通过病历记录查询过去10年所有接受FEG-IFN和病毒唑治疗的1型HCV患者,通过信函邀请其参加本次研究。采集患者血液标本用以IL28B和ITPA基因检测。从病历记录中提取治疗反应、贫血发生及治疗中断情况。结果:共有61例1型HCV患者接受了FEG-IFN和病毒唑治疗,其中42例同意参加本次研究。治疗时平均年龄为(45.6±12.9)岁,男性患者占83.3%。33例(78.6%)检测为IL28B CC基因型,其中25例(75.8%)获得SVR,而9例非CC基因型患者中仅3例(33.3%)获得SVR(P=0.041)。11例患者检测为ITPA AC基因型,30例为CC基因型。ITPA AC与CC基因型患者的临床贫血发生率的差异无统计学意义(45.5%vs.63.3%,P=0.302)。即便在出现临床贫血的患者中,仍有70.8%最终获得了SVR。治疗中断对SVR亦无影响。结论:对于IL28B CC基因型的1型HCV患者,在考虑新的治疗选择前,应告知其FEG-IFN和病毒唑具有良好的治疗效果。

关键词：丙型肝炎聚乙二醇干扰素 IL28B基因多态性持续病毒学应答

Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study

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National Science Review 2022年第3期9卷 96-109页

作者： Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow Division of Pathology National Cancer Institute Department of Surgery Faculty of Medicine University of Malaya Department of Surgery and Center for Liver Disease management and Transplantation The Medical City 13. Department of Laboratories The Medical City Department of Pathology Singapore General Hospital Institute for Infocomm Research ASTAR Department of Pathology National University Health System Translational Immunology Institute (TII) Sing Health Duke-NUS Academic Medical Centre Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Genome Institute of Singapore Agency for Science Technology and Research Cancer Science Institute of Singapore National University of Singapore Division of Medical Oncology National Cancer Center Singapore Cardiovascular Research Institute National University of Singapore National University Healthcare System Singhealth-Duke-NUS Academic Surgery Program Duke-NUS Graduate Medical School Institute of Molecular and Cell Biology Agency for Science Technology and Research Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences School of Biological Sciences Nanyang Technological University Division of Biosciences Faculty of Life Sciences Division of Surgery and Surgical Oncology National Cancer Centre Department of Hepato-Pancreato-Biliary and Transplant Surgery Singapore General Hospital Division of Hepatobiliary and Pancreatic Surgery Department of Surgery University Surgical Cluster National University Health System Hepato-Pancreato-Biliary Surgery Unit Department of Surgery National Cancer Institute

Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types.

关键词： hepatocellular carcinoma intra-tumor heterogeneity phenotypic evolution tumor evolution

补肾益精丸治疗肾阴虚型精液活动力异常不育症的临床研究

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国际中医中药杂志 2014年第1期36卷 24-26页

作者：卢金玉卢锦燕新加坡同济医院不孕组 169874

目的观察补肾益精丸治疗男性精液活动力异常的临床疗效.方法收集60例肾阴虚型男性不育症患者,均采用补肾益精丸治疗,3个月为1个疗程,共治疗2个疗程.比较患者治疗前、后临床症状的改善情况,并对10例有完整精液常规检测资料的患者进行... 详细信息

目的观察补肾益精丸治疗男性精液活动力异常的临床疗效.方法收集60例肾阴虚型男性不育症患者,均采用补肾益精丸治疗,3个月为1个疗程,共治疗2个疗程.比较患者治疗前、后临床症状的改善情况,并对10例有完整精液常规检测资料的患者进行了统计分析.结果本组60例肾阴虚型男性不育症患者治疗后,痊愈20例,受孕率为33.3%.统计10例患者治疗后配偶受孕情况,其中痊愈5例,受孕率为50.0%.疗程结束后,患者五心烦热、盗汗口干、腰膝酸软、舌红少苔、脉细数等症状明显改善[治疗前分别为（2.67±0.57）分、（2.38±0.56）分、（2.43±0.54）分、（2.46±0.52）分、（2.96±0.53）分,治疗后分别为（0.67±0.24）分、（0.60±0.23）分、（0.52±0.23）分、（0.86±0.24）分、（0.91±0.22）分,P＜0.05].此外,治疗后精子活动力A级、B级、C级也较治疗前明显提高[治疗前分别为（22.6±2.36）%、（13.3±1.25）%、（3.1±0.58）%,治疗后分别为（35.1±3.15）%、（17.6±3.01）%、（11.1±1.26）%,P＜0.05].结论补肾益精丸可有效改善肾阴虚型男性不育症患者的临床症状及精子活动力,提高其配偶怀孕率.

关键词：男性精液活动力异常肾阴虚型补肾益精丸

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The Efficacy of Plant-Based Ionizers in Removing Aerosol for COVID-19 Mitigation

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Research 2021年第1期2021卷 70-80页

作者： Ady Suwardi Chin Chun Ooi Dan Daniel Chee Kiang Ivan Tan Hongying Li Ou Yang Zhong Liang Yuanting Karen Tang Jing yee Chee Anton Sadovoy Shu-Ye Jiang Srinivasan Ramachandran Enyi Ye Chang Wei Kang Wun Chet Davy Cheong Keng Hui Lim Xian Jun loh Institute of Materials Research and Engineering 2 Fusionopolis WayAgency for ScienceTechnology and ResearchSingapore 138634 Institute of High Performance Computing 1 Fusionopolis WayAgency for ScienceTechnology and ResearchSingapore 138632 Temasek Life Sciences Laboratory 1 Research LinkNational University of SingaporeSingapore 117604

Small-sized droplets/aerosol transmission is one of the factors responsible for the spread of COVID-19,in addition to large droplets and surface contamination(fomites).While large droplets and surface contamination can be relatively easier to deal with(i.e.,using mask and proper hygiene measures),aerosol presents a different challenge due to their ability to remain airborne for a long *** calls for mitigation solutions that can rapidly eliminate the airborne ***-COVID-19,air ionizers have been touted as effective tools to eliminate small *** this work,we sought to evaluate the efficacy of a novel plant-based ionizer in eliminating *** was found that factors such as the ion concentration,humidity,and ventilation can drastically affect the efficacy of aerosol *** aerosol removal rate was quantified in terms of ACH(air changes per hour)and CADR-(clean air delivery rate-)equivalent unit,with ACH as high as 12 and CADR as high as 141 ft^(3)/minute being achieved by a plant-based ionizer in a small isolated *** work provides an important and timely guidance on the effective deployment of ionizers in minimizing the risk of COVID-19 spread via airborne aerosol,especially in a poorly-ventilated environment.

关键词： aerosol eliminate sized

Study Protocol to Investigate the Efficacy of Participation in Qi-Gong by Breast Cancer Survivors

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异菸酰肼的 N-氯乙酰衍生物及2,6-二氨基异菸酸衍生物的合成及其抗结核作用

Journal of Cancer Therapy 2011年第5期

作者： Shing yee Lee Siew Yim loh Liam Murray

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化学学报 1956年第6期 566-571页

作者：高怡生翁尊尧陆顺兴中国科学院药物研究所

1.合成了三种异烟酰肼的衍生物,即 sym-氯乙酰基-异烟醯基肼、sym-三氯乙酰基-异烟酰基肼及 sym-一氯乙酰基-异烟酰肼盐酸(?)菜碱。这三种衍生物对 ***-gmatis 的抗菌作用分别为1∶16,000;1∶8,000;1∶8,000。2.制备了八种2,6-二氨基异... 详细信息

1.合成了三种异烟酰肼的衍生物,即 sym-氯乙酰基-异烟醯基肼、sym-三氯乙酰基-异烟酰基肼及 sym-一氯乙酰基-异烟酰肼盐酸(?)菜碱。这三种衍生物对 ***-gmatis 的抗菌作用分别为1∶16,000;1∶8,000;1∶8,000。2.制备了八种2,6-二氨基异烟酸酯,即甲酯、乙酯、正丙酯、异丙酯、正丁酯、异丁酯、正戊酯、异戊酯。其中甲酯为已知物,馀为新化合物。其抗 *** 的作用均为1∶2000。3.2,6-二氨基-异烟酰肼的抗 ***为1∶2000;2,6-二氨基-异烟酰胺及2,6-二氨基-异烟酸均无抗 *** 作用。

关键词：二氨基异烟酸酰肼酸衍生物衍生物