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Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman yee Hang Ethan Ma Nolan Fullenkamp Giles W.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

Modelling for registration of remotely sensed imagery when reference control points contain error

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Science China Earth Sciences 2006年第7期49卷 739-746页

作者： Leung yee The Department of Geography and Resource Management The Chinese University of Hong Kong Shatin Hong Kong China

Reference control points (RCPs) used in establishing the regression model in the regis-tration or geometric correction of remote sensing images are generally assumed to be “perfect”. That is, the RCPs, as explanatory variables in the regression equation, are accurate and the coordinates of their locations have no errors. Thus ordinary least squares (OLS) estimator has been applied exten-sively to the registration or geometric correction of remotely sensed data. However, this assumption is often invalid in practice because RCPs always contain errors. Moreover, the errors are actually one of the main sources which lower the accuracy of geometric correction of an uncorrected image. Under this situation, the OLS estimator is biased. It cannot handle explanatory variables with errors and cannot propagate appropriately errors from the RCPs to the corrected image. Therefore, it is essential to develop new feasible methods to overcome such a problem. This paper introduces a consistent adjusted least squares (CALS) estimator and proposes relaxed consistent adjusted least squares (RCALS) estimator, with the latter being more general and flexible, for geometric correction or regis-tration. These estimators have good capability in correcting errors contained in the RCPs, and in propagating appropriately errors of the RCPs to the corrected image with and without prior information. The objective of the CALS and proposed RCALS estimators is to improve the accuracy of measure-ment value by weakening the measurement errors. The conceptual arguments are substantiated by a real remotely sensed data. Compared to the OLS estimator, the CALS and RCALS estimators give a superior overall performance in estimating the regression coefficients and variance of measurement errors.

关键词： error modelling, registration, ordinary least squares, relaxed consistent adjusted least squares, remote sensing images.

WAVE INDUCED OSCILLATORY AND STEADY FLOWS IN THE ANNULUS OF A CATHETERIZED VISCOELASTIC TUBE

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Journal of Hydrodynamics 2010年第5期22卷 605-617页

作者： NG Chiu-On CHANG Yin-yee Department of Mechanical Engineering The University of Hong Kong

A perturbation analysis based on equations of motion in Lagrangian form is presented for the oscillatory and time-mean viscous flows induced by a propagating wave of small amplitude in an annulus with a viscoelastic outer wall. Owing to the steady streaming effect, the existence of a catheter in a blood vessel brings in an additional steady pressure gradient, a correction to that predicted by the linear theory, and an additional steady shear stress, which may increase the possibility of hemolysis of red blood cells.

关键词： annulus flow steady streaming catheterized artery

Challenges and Opportunities in the Practice of Chinese Medicine in Singapore

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Chinese Journal of Integrative Medicine 2024年第6期30卷 483-488页

作者： CHEW Sin yee National University Hospital Singapore119074Singapore

According to the World Health Oranization(WHO)Traditional Medicine Strategy 2014-2023,traditional medicine is defined as"the sum total of the knowledge,skill and practices based on the theories,beliefs,and experiences indigenous to different cultures,whether explicable or not,used in the maintenance of health as well as in the prevention,diagnosis,improvement or treatment of physical and mental illness.

关键词： theories prevention diagnosis

Design-space adaptation method for multiobjective and multidisciplinary optimization

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Chinese Journal of Aeronautics 2024年第8期37卷 166-189页

作者： Jongho JUNG Kwanjung yee Shinkyu JEONG Department of Aerospace Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Mechanical Engineering Kyunghee UniversityYoungin 17104Republic of Korea

This paper developed a new method that adaptively adjusts a design space by considering the actual solution distribution of a problem to overcome the conventional design-space adaptation method that assumes the solutions distribution to be a normal distribution because the distributions of solutions are rarely normal distributions for real-world *** developed method was applied to nineteen multiobjective test functions that are widely used to evaluate the characteristics and performance of optimization *** results showed that this method adapted the design space to an appropriate design space where the solution existence probability was *** optimization performance achieved using the developed method was higher than that of the conventional ***,the developed method was applied to the conceptual design of an unmanned spacecraft to confirm its validity in real-world design and multidisciplinaryoptimization *** results showed that the Pareto solutions of the developed method were superior to those of conventional ***,the optimization efficiency with the developed method was improved by more than 1.4 times over that of the conventional *** this regard,the developed method has the potential to be applied to complicated real-world optimization problems to achieve better performance and efficiency.

关键词： Multiobjective optimization Multiobjective genetic algorithm Design-space adaptation Multidisciplinary optimization Hypersonic vehicle

Intercellular and inter-organ crosstalk in browning of white adipose tissue:molecular mechanism and therapeutic complications

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Journal of Molecular Cell Biology 2021年第7期13卷 466-479页

作者： Lai yee Cheong Aimin Xu The State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina

Adipose tissue(AT)is highly plastic and heterogeneous in response to environmental and nutritional *** development of heat-dissipating beige adipocytes in white AT(WAT)through a process known as browning(or beiging)has garnered much attention as a promising therapeutic strategy for obesity and its related metabolic *** is due to its inducibility in response to thermogenic stimulation and its association with improved metabolic *** consists of adipocytes,nerves,vascular endothelial cells,various types of immune cells,adipocyte progenitor cells,and *** cells contribute to the formation of beige adipocytes through the release of protein factors that significantly influence browning *** addition,inter-organ crosstalk is also important for beige adipocyte ***,we summarize recent findings on fat depot-specific differences,secretory factors participating in intercellular and inter-organ communications that regulate the recruitment of thermogenic beige adipocytes,as well as challenges in targeting beige adipocytes as a potential anti-obese therapy.

关键词： adipose tissue browning circulating factors energy homeostasis adipose biology obesity

Engineering behaviour of in situ cored deep cement mixed marine deposits subjected to undrained and drained shearing

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1749-1760页

作者： Wei Li Chung yee Kwok Faculty of Engineering China University of GeosciencesWuhan430074China Department of Civil Engineering The University of Hong Kong999000Hong Kong SARChina

The deep cement mixing(DCM)is used to improve the capacity and reduce the settlement of the soft ground by forming cemented clay *** investigation on the mechanical behaviour of the DCM samples is limited to either laboratory-prepared samples or in-situ samples under unconfined *** this study,a series of drained and undrained triaxial shearing tests was performed on the in-situ cored DCM samples with high cement content to assess their mechanical *** is found that the drainage condition affects significantly the stiffness,peak and residual strengths of the DCM samples,which is mainly due to the state of excess pore water pressure at different strain levels,*** positive before the peak deviatoric stress and negative after the peak deviatoric stress,in the undrained *** slope of the failure envelope changes obviously with the confining pressures,being steeper at lower stress levels and flatter at higher stress *** strength parameters,effective cohesion and friction angle obtained from lower stress levels(c′0 andφ′0)are 400 kPa and 58°,respectively,which are deemed to be true for design in most DCM applications where the in-situ stress levels are normally at lower values of 50-200 ***,the computed tomography(CT)scanning system was adopted to visualize the internal structures of DCM *** is found that the clay pockets existing inside the DCM samples due to uneven mixing affect markedly their stress-strain behaviour,which is one of the main reasons for the high variability of the DCM samples.

关键词： Deep cement mixing(DCM) In-situ cored sample Triaxial shearing Drainage condition Confining pressure Computed tomography(CT)

Protection of bridge piers against scouring with tetrahedral frames

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International Journal of Sediment Research 2009年第4期24卷 385-399页

作者： yee-Meng CHIEW School of Civil and Environmental Engineering Nanyang Technological University

Armoring countermeasures, such as riprap stones, are the primary method used to protect bridge piers against scouring; however, these methods have not had definitive success. Recently, flow-altering countermeasures, such as sacrificial piles, have been tested as an alternative to armoring countermeasures. This study investigated the mechanics of an innovative flow-altering countermeasure device, frames in the shape of tetrahedrons that act as a pier-scour countermeasure. Results of measured characteristics for turbulence flow showed that the flow around the tetrahedral frames can be divided into three regions: (1) a deceleration region near the sediment bed; (2) an acceleration region in the middle of water depth region; and (3) a restoration region near the water surface. The velocity magnitudes, turbulent intensities and vorticities decreased in the deceleration region, increased in the acceleration region and reverted to that of the unprotected condition in the restoration region. This pier-scour countermeasure is innovative because of its ability to dissipate energy associated with the downflow and the horseshoes vortex generated around the bridge pier. The scour tests revealed that the frames protected the foundation of bridge piers against scour. The experimental results showed that the percentage reduction of scour depth decreased as the velocity ratio, U/U c , decreased, reaching a value of 50% for the range of parameters tested in this study. Moreover, its efficiency was dependent on the placement density of the frames. The data showed that the frames were more effective when η was larger. However, their influence becomes less significant when η≥ 0.16.

关键词： Bridge-pier scour Scour protection Tetrahedral frames protection Flow altering countermeasure

Early control of short hepatic portal veins in isolated or combined hepatic caudate lobectomy

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Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 377-382页

作者： Wan-yee Lau Faculty of Medicine The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina

BACKGROUND:Caudate lobectomy has long been considered technically *** study aimed to elaborate the significance of early control of short hepatic portal veins(SHPVs) in isolated hepatic caudate lobectomy or in hepatic caudate lobectomy combined with major partial hepatectomy,and to describe the anatomical characteristics of ***:The data of 117 patients who underwent either isolated or combined caudate lobectomy by the same team of surgeons from 2005 to 2009 were retrospectively *** 2005 to 2007(group A,n=55),we carried out early control of short hepatic veins(SHVs) only;from 2008 to 2009(group B,n=62),we carried out early control of both SHVs and *** two groups were compared to evaluate which surgical procedure was better.A detailed anatomical study was then carried out on the last 25 consecutive patients in group B to study the number and distribution of SHPVs during ***:Patients in group B had less intra-operative blood loss,less impairment of liver function,shorter postoperative hospital stay,fewer postoperative complications and required less blood transfusion(P<0.05).The number of SHPVs in the 25 patients was 183,with 7.3±2.7 per *** diameters of SHPVs were 1 to 4 *** average,3.4 SHPVs/patient came from the left portal vein,2.2 from the bifurcation,1.4 from the right portal vein,and 0.3 from the main portal *** average,3.3 SHPVs/patient supplied segment I of the liver,0.4 for segment II,2.1 for segment IV,1.4 for segment V and 0.1 for segment ***:Early control of SHPVs in isolated or combined hepatic caudate lobectomy may be a useful method to decrease surgical risk and improve postoperative recovery.

关键词： short hepatic portal vein caudate lobe anatomy