检索结果-南通市图书馆

Schisandra lignans ameliorate nonalcoholic steatohepatitis by regulating aberrant metabolism of phosphatidylethanolamines

引用

Acta Pharmaceutica Sinica B 2023年第8期13卷 3545-3560页

作者： Lijuan xue Keanqi Liu Caixia Yan Junling Dun yexin xu Linlin Wu Huizhu Yang Huafang Liu Lin Xie Guangji Wang Yan Liang Key Lab of Drug Metabolism&Pharmacokinetics State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research Department of Clinical Pharmacythe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Analytical Applications Center Shimadzu(China)Co.Ltd.Shanghai 200233China

Nonalcoholic steatohepatitis(NASH)is a spectrum of chronic liver disease characterized by hepatic lipid metabolism disorder.Recent reports emphasized the contribution of triglyceride and diglyceride accumulation to NASH,while the other lipids associated with the NASH pathogenesis remained unexplored.The specific purpose of our study was to explore a novel pathogenesis and treatment strategy of NASH via profiling the metabolic characteristics of lipids.Herein,multi-omics techniques based on LC—Q-TOF/MS,LC—MS/MS and MS imaging were developed and used to screen the action targets related to NASH progress and treatment.A methionine and choline deficient(MCD)diet-induced mouse model of NASH was then constructed,and Schisandra lignans extract(SLE)was applied to alleviate hepatic damage by regulating the lipid metabolism-related enzymes CES2A and CYP4A14.Hepatic lipidomics indicated that MCD-diet led to aberrant accumulation of phosphatidylethanolamines(PEs),and SLE could significantly reduce the accumulation of intrahepatic PEs.Notably,exogenous PE(18:0/18:1)was proved to significantly aggravate the mitochondrial damage and hepatocyte apoptosis.Supplementing PE(18:0/18:1)also deteriorated the NASH progress by up regulating intrahepatic proinflammatory and fibrotic factors,while PE synthase inhibitor exerted a prominent hepatoprotective role.The current work provides new insights into the relationship between PE metabolism and the pathogenesis of NASH.

关键词： Nonalcoholic steatohepatitis Multi-omics Schisandra lignans extract Phosphatidyle thanolamine PE(18:0/18:1)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

回归日常生活:农业文化遗产研究与保护的再思考

引用

中国农史 2024年第2期43卷 131-140页

作者：徐业鑫薛伟芃山西农业大学公共管理学院山西晋中030831 南京师范大学新闻传播学院江苏南京210023

农业文化遗产是人类与其所处环境长期协调形成的农业生产生活系统,遗产地居民的意义世界、生存情境以及实践逻辑是理解农业文化遗产的重要索引。因此,农业文化遗产研究不仅要关注遗产本身的系统特征,而且要将遗产地居民的日常生活实践... 详细信息

农业文化遗产是人类与其所处环境长期协调形成的农业生产生活系统,遗产地居民的意义世界、生存情境以及实践逻辑是理解农业文化遗产的重要索引。因此,农业文化遗产研究不仅要关注遗产本身的系统特征,而且要将遗产地居民的日常生活实践纳入视野,在对遗产地居民生活世界的文化阐释路径下,分析其独特的意义网络与表达动力。在此基础上,修复遗产地居民与农业文化遗产互嵌的共生关系,重塑遗产地居民在农业文化遗产中的行动主体地位,进而使保护农业文化遗产成为遗产地居民日常生产与生活中的自觉行动。

关键词：农业文化遗产遗产地居民日常生活

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Possible change on the runoff in the upper Yellow River basin under global climate change

引用

Research in Cold and Arid Regions 2009年第2期1卷 157-164页

作者： YongChao Lan Jun Wen JunJie Chang yexin xu YongPing Shen XingLin Hu JinQi Lu Key Laboratory of Ecohydrology and Integrated River Basin Science Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of SciencesLanzhouGansu 730000China Institute of the Riverhead Region of the Yellow River Water Conservancy Committee of the Yellow River BasinLanzhouGansu 730000China Institute of the Riverhead Region of the Yellow River Water Conservancy Committee of the Yellow River BasinLanzhouGansu 730030China

In this study, the characteristics and changing trends of temperature, precipitation, and runoff in the upper Yellow River basin up Tangnag station are analyzed by using hydrological and meteorological data in the past 50 years from observation stations in the basin. Further, in this study, the evolving trend of runoff in the future decades is forecasted in the basin based on the method of suppositional climate scenes combination. The results indicate temperature variation in the basin has an evident positive relation with global warming, and the precipitation variations are quite complicated in the basin because of differences of located geographic positions during the past 50 years. Runoff in the basin has been decreasing continually since the end of the 1980s because the mean temperature in the basin has been rising and precipitation in the main areas of runoff formation in the basin has been decreasing. Runoff will largely decrease if precipitation decreases and temperature rises continuously, whereas runoff will increase if temperature is invariable and precipitation increases largely; the increase magnitude of runoff may be more than that of precipitation because of the synchronously increasing supply of meltwater from snow, glacier, and frozen soils in future several decades.

关键词： global climate change upper Yellow River runoff variation circulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mapping out the reaction network of humin formation at the initial stage of fructose dehydration in water

引用

Green Energy & Environment 2024年第6期9卷 1016-1026页

作者： Xing Fu yexin Hu Ping Hu Hui Li Shuguang xu Liangfang Zhu Changwei Hu Key Laboratory of Green Chemistry and Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengduSichuan610064China State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengduSichuan611137China

The formation of humins hampers the large-scale production of 5-hydroxymethylfurfural(HMF)in biorefinery.Here,a detailed reaction network of humin formation at the initial stage of fructose-to-HMF dehydration in water is delineated by combined experimental,spectroscopic,and theoretical studies.Three bimolecular reaction pathways to build up soluble humins are demonstrated.That is,the intermolecular etherification of β-furanose at room temperature initiates the C12 path,whereas the C-C cleavage of a-furanose at 130-150℃ leads to C11 path,and that of open-chain fructose at 180℃ to C11' path.The successive intramolecular dehydrations and condensations of the as-formed bimolecular intermediates lead to three types of soluble humins.We show that the C12 path could be restrained by using HCl or AlCl_(3) catalyst,and both the C12 and C110 paths could be effectively inhibited by adding THF as a co-solvent or accelerating heating rate via microwave heating.

关键词： Carbohydrates 5-hydroxymethylfurfural Reaction network Soluble humins Tautomer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Riverine sulfate sources and behaviors in arid environment,Northwest China:Constraints from sulfur and oxygen isotopes

引用

Journal of Environmental Sciences 2024年第3期137卷 716-731页

作者： Yifu xu Wenjing Liu Bing xu Zhifang xu Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

The fate of riverine sulfate ion (SO_(4)^(2-)) and its environmental effects in arid environment are difficult to evaluate due to its complicated sources and strongly coupled behaviors with water cycle which is significantly modified by humans.To understand the sulfur cycle in aquatic systems in arid environment,the chemical and sulfur and oxygen isotopic compositions (δ^(34)S_(SO4)and δ^(18)O_(SO4)) of major rivers around the Badain Jaran Desert,northwestern China,were investigated.These rivers had averaged SO_(4)^(2-)content at 1336μmol/L,over 10times higher than the global average.The δ^(34)S_(SO4)and δ^(18)O_(SO4)values ranged from-5.3‰to+11.8‰and+1.6‰to+12.8‰,respectively.The end-member analysis and the inverse model showed that riverine sulfate was mainly derived from evaporites dissolution (0-87%),sulfide oxidation (13%-100%) and precipitation (0-33%),indicating heterogeneity in sulfur sources and behaviors along the river drainage with the lithology variations and climate gradients.Multiple isotopic tools combining with hydro-chemistry compositions could be applied to reveal sulfur cycle in arid environment.Based on the calculation,sulfide oxidation plays the primary role in the headwater and upstream in the Qilian-Mountains area,where sulfide is widely exposed.While the proportion of evaporites dissolution contributing to riverine sulfate is much higher in downstream in a drier environment.Besides,less precipitation and higher temperature can lead to more intensive evaporation,affecting the process of sulfide oxidation and enhancing the rates of evaporites dissolution and sulfate precipitation in the basin.

关键词： Sulfur and oxygen isotopes Source apportionment Inverse model Arid environment Inland rivers Northwestern China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

结构参数对不锈钢织物透光与电磁屏蔽的影响

引用

丝绸 2024年第3期61卷 77-83页

作者：池烨馨俞科静徐阳江南大学纺织科学与工程学院江苏无锡214122

为实现不锈钢织物高透明与强电磁屏蔽性能相兼容的目标,文章采用数值计算与理论分析相结合的方法,在分析不锈钢织物主要结构参数(线径与线距)对其透光与电磁屏蔽性能影响的基础上,引入TOPSIS评价方法,探讨了线径与线距对不锈钢织物光学... 详细信息

为实现不锈钢织物高透明与强电磁屏蔽性能相兼容的目标,文章采用数值计算与理论分析相结合的方法,在分析不锈钢织物主要结构参数(线径与线距)对其透光与电磁屏蔽性能影响的基础上,引入TOPSIS评价方法,探讨了线径与线距对不锈钢织物光学与电磁学综合性能的影响。结果表明,由于电磁衍射的存在,结构参数对透光与电磁屏蔽性能的影响呈现非线性规律。其中,不锈钢织物的线距变化对总体性能的影响最为密切。当线径在0.02~0.05 mm且线距在0.4~1.0 mm时,不锈钢织物在90%高透光率的前提下,可达到至少30 dB的屏蔽效能,为高透光电磁屏蔽材料的结构设计提供了理论指导。

关键词：不锈钢织物结构参数透光性能屏蔽效能综合分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

生鲜电子商务供应链质量控制与保鲜努力决策研究

引用

济南大学学报（自然科学版） 2023年第6期37卷 752-757,765页

作者：陆芬吴小畅徐烨昕武汉科技大学管理学院湖北武汉430081 武汉科技大学服务科学与工程研究中心湖北武汉430081

为了研究生鲜电商供应链成员最优决策和利润状况,考虑1个生鲜供应商和1个生鲜零售商构成的二级供应链,其中供应商采取保鲜努力,零售商在此基础上采取质量控制,运用Stackelberg博弈理论,分别构建集中决策模型、分散决策模型和基准模型,... 详细信息

为了研究生鲜电商供应链成员最优决策和利润状况,考虑1个生鲜供应商和1个生鲜零售商构成的二级供应链,其中供应商采取保鲜努力,零售商在此基础上采取质量控制,运用Stackelberg博弈理论,分别构建集中决策模型、分散决策模型和基准模型,分析供应链成员最优决策和利润的变化,分析保鲜努力需求弹性、保鲜努力成本系数等因素对最优决策的影响。结果表明:生鲜供应商和生鲜零售商的“搭便车”心理对保鲜努力水平和质量控制水平起到一定的抑制作用;集中决策、分散决策模型中保鲜努力和质量控制的差异分别随各自的成本效率的提升而增大;当质量控制成本效率和保鲜努力成本效率高于一定水平时,零售商会制定低于集中决策的零售价格来吸引消费者购买;制定的成本分担-补偿契约可提高供应商的保鲜努力水平并鼓励零售商进行质量控制,同时协调供应链。

关键词：电子商务保鲜努力质量控制 Stackelberg博弈

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biohythane production from two-stage anaerobic digestion of food waste:A review

引用

Journal of Environmental Sciences 2024年第5期139卷 334-349页

作者： Xiaona An Ying xu Xiaohu Dai State Key Laboratory of Pollution Control and Resource Reuse School of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

The biotransformation of food waste(FW)to bioenergy has attracted considerable research attention as a means to address the energy crisis and waste disposal problems.To this end,a promising technique is two-stage anaerobic digestion(TSAD),in which the FW is transformed to biohythane,a gaseous mixture of biomethane and biohydrogen.This review summarises the main characteristics of FW and describes the basic principle of TSAD.Moreover,the factors influencing the TSAD performance are identified,and an overview of the research status;economic aspects;and strategies such as pre-treatment,co-digestion,and regulation of microbial consortia to increase the biohythane yield from TSAD is provided.Additionally,the challenges and future considerations associated with the treatment of FW by TSAD are highlighted.This paper can provide valuable reference for the improvement and widespread implementation of TSAD-based FW treatment.

关键词： Two-stage anaerobic digestion(TSAD) Food waste(FW) Methane production Hydrogen production

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identification of high oxygen-consuming substances in stormwater drainage systems illicitly connected with sewage system

引用

Journal of Environmental Sciences 2024年第4期138卷 132-140页

作者： Chen xu Zuxin xu Wenhai Chu Shanshan Wu Rong Xiao Lei Su State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Ministry of Education Key Laboratory of Yangtze River Water Environment Tongji UniversityShanghai 200092China Guangzhou Resource Environmental Protection Technology Co. Ltd.Guangzhou 510030China

The dissolved oxygen content in water is an important indicator for assessing the quality of the water environment,and maintaining a certain amount of dissolved oxygen is essential for the healthy development of the ecological environment.When a water body is anoxic,the activity of anaerobic microorganisms increases and organic matter is decomposed to produce a large number of blackening and odorizing substances,resulting in black and odorous water bodies,which is a very common and typical phenomenon in China.Presently,there is still a relatively universal occurrence of illicitly connected stormwater and sewage pipes in the urban drainage pipe network in China,which makes oxygen-consuming substances be directly discharged into rivers through stormwater pipes and consume the dissolved oxygen in the water bodies,resulting in an oxygen deficiency of the water.This induces seasonal or year-round black and stink phenomena in urban rivers.Hence,identifying high oxygen-consuming substances,which lays the foundation for the subsequent removal of oxygen-consuming substances,is essential.Through a series of comparisons of water quality indicators and analysis of organic characteristics,it was found that the oxygen consumption capacity of domestic sewage was higher than that of industrial wastewater in the selected area of this study,and the oxygen-consuming substances of domestic sewage were small molecular amino acids.By comparing 20 conventional free amino acids,it was found that seven of them consumed oxygen easily,and compared with chemical oxygen consumption,biological oxygen consumption was in a leading position.

关键词： Urban drainage system Oxygen-consuming substances Domestic sewage Amino acid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aldehyde oxidase mediated enantioselective metabolic health risk of dinotefuran

引用

Science China Chemistry 2024年第6期67卷 2079-2091页

作者： Liwei xu Xinxin xu Hua Kuang Chuanlai xu Xiaoling Wu State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi214122China International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and Technology Jiangnan UniversityWuxi214122China Collaborative Innovation center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityWuxi214122China

Chiral pollutants often pose significant differential environmental health risks.In this study,the biotransformation of chiral dinotefuran(DIN)and its enantioselective metabolic toxicity mechanisms have been systemically investigated.Firstly,reversedphase chromatography-high resolution mass spectrometry was developed to quantify the content of DIN R/S chiral enantiomer with pg level sensitivity,revealing a lower elimination rate constant(K_(e))of S-DIN(0.730 h^(-1))than R-DIN(0.746 h^(-1)).Secondly,the interaction mechanism between DIN metabolism and important endogenous bioactive molecules,such as aldehyde oxidase(AOX)and neurotransmitters,was revealed.The DIN nitro-group was converted into a guanidine group by the reducing site of nearby flavin adenine dinucleotide(FAD)in AOX with the preferred higher affinity of S-configuration.Meanwhile,the endogenous tryptophan(Trp)aldehyde metabolic intermediate,5-hydroxyindoleacetaldehyde(5-HIAL),provides a persistent electron donor for DIN reduction via the oxidation-catalyzed site in AOX,resulting in remarkable up-regulation of monoamine neurotransmitters such as serotonin and dopamine.Thirdly,the higher level of neurotransmitters further mediated dysregulation of oxylipin homeostasis via the serotonergic pathway,where S-DIN exhibited more pronounced liver lipid damage and environmental health risk with the accumulated lipid biomarkers,oxidized triglyceride(OxTG)and oxidized sphingomyelin(OxSM).This study elucidates the AOX-mediated enantioselectivity metabolic pathway of DIN,providing a new analytical method for chiral pollutants and paves the way for their health risk assessments.

关键词： neonicotinoid dinotefuran enantiomer aldehyde oxidase metabolomics health risk

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：