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BIM技术在建筑设计中的应用

有色金属设计 2024年第3期51卷 85-88页

作者：周思辰陈业天武汉自在生成建筑空间设计有限公司南宁分公司广西南宁530000 广西工程咨询集团有限公司广西南宁530000

BIM技术在建筑设计中的运用,为项目管理和施工效率提供了显著提升,通过建立三维数字模型该技术整合了设计、施工及安全分析等多方面信息,尽管BIM技术优化了设计流程,其推广仍面临诸如专业人才缺乏和跨领域整合的挑战。该研究聚焦于BIM... 详细信息

BIM技术在建筑设计中的运用,为项目管理和施工效率提供了显著提升,通过建立三维数字模型该技术整合了设计、施工及安全分析等多方面信息,尽管BIM技术优化了设计流程,其推广仍面临诸如专业人才缺乏和跨领域整合的挑战。该研究聚焦于BIM技术在建筑设计中的应用,探讨其带来的优势和面临的挑战,旨在促进建筑行业的数字化转型。

关键词： BIM技术建筑设计三维模型效率

Targeted Adversarial Examples Generating Method Based on cVAE in Black Box Settings

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Chinese Journal of Electronics 2021年第5期30卷 866-875页

作者： YU Tingyue WANG Shen ZHANG Chunrui WANG Zhenbang LI yetian YU Xiangzhan School of Cyberspace Science Harbin Institute of Technology Institute of Computer Application China Academy of Engineering Physics State Grid Heilongjiang Power Co. Ltd.

In recent years, adversarial examples has become one of the most important security threats in deep learning applications. For testing the security of deep learning models in adversarial environment,many researches focus on generating adversarial examples quickly and efficiently. In order to solve the problems of existing generative adversarial networks based methods which can not effectively generate the targeted adversarial examples in black box settings, and to improve the temporal performance of gradient-based generating methods,an adversarial examples generating method based on conditional Variational autoencoder(cVAE) is proposed in this paper, where a cVAE is designed elaborately to generate adversarial examples without most of the detailed information about the attacked deep learning models, of which the output can be controlled arbitrarily by these crafted inputs, used to test the robustness of deep learning models against adversarial examples. The experimental results show that the proposed method can achieve a comparable attack success rate and a better temporal performance than the existing gradient-based generating methods in black box environment.

关键词： Data security Neural nets Deep learning Image recognition Adversarial examples Conditional variational autoencoder

A systematic review of SARS-CoV-2 vaccine candidates

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Signal Transduction and Targeted Therapy 2020年第1期5卷 471-484页

作者： yetian Dong Tong Dai Yujun Wei Long Zhang Min Zheng Fangfang Zhou The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious diseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310058China Life Sciences Institute and Innovation Center for Cell Signaling Network Hangzhou 310058China Institutes of Biology and Medical Science Soochow UniversitySuzhou 215123China Anhui Anlong Gene Technology Co. LtdHefei 230041China

Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available ***,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced *** patients underwent six 21-day cycles of anti-PD-1 antibody(day 1),pegaspargase 2000 U/m2(day 1),gemcitabine 1 g/m2(days 1 and 8)and oxaliplatin 130 mg/m2(day 1),followed by anti-PD-1 antibody maintenance every 3 *** death-ligand 1(PD-L1)expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)*** were assessed using 18F-fluorodeoxyglucose positron emission tomography(18FDG-PET)and computed tomography or magnetic resonance *** patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 10.6 months,6/9 patients(66.7%)remained in complete *** most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and *** produced a high response rate in patients with positive PD-L1 expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1 alterations and ARID1A mutation were associated with immunochemotherapy *** in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1 might indicate a poor response to *** conclusion,the anti-PD-1 antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced ***-L1 expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy.

关键词： alterations chemotherapy regimen

柏木低效林林窗自然更新状态与人工更新状态植物多样性对比研究——以川中丘陵区为例

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绿色科技 2024年第11期26卷 69-75页

作者：潘业田陈玥吴茜刘朔张翠翠四川省林业和草原调查规划院四川成都610081 四川省农业科学院植物保护研究所四川成都610066

林窗是森林结构调整的重要方式,也是森林群落演替过程的重要环节,对生态系统发展有着举足轻重的推动作用。为研究柏木低效林林窗自然更新状态与人工更新状态生物多样性,2021年3月砍伐形成50、100、150、200 m24种面积的林窗,并设置CK对... 详细信息

林窗是森林结构调整的重要方式,也是森林群落演替过程的重要环节,对生态系统发展有着举足轻重的推动作用。为研究柏木低效林林窗自然更新状态与人工更新状态生物多样性,2021年3月砍伐形成50、100、150、200 m24种面积的林窗,并设置CK对照组。2021年7月、2022年7月2次采用样方调查法以林下植物为研究对象对不同大小林窗进行生物多样性调查和分析,在自然更新状态林窗中共记录植物11892株,49种,分属46属27科,在人工更新状态林窗中共记录植物15325株,56种,分属52属31科。分析结果表明,以人工更新状态下和自然更新状态林下植物多样性的物种丰富度Shannon-wiener指数、Pielou均匀度指数以及Simpson优势度为指标进行评价,柏木林窗林下植物的多样性在人工更新状态下优于自然更新状态下的林窗。因此,合理地进行间伐、树种引入、上层透光抚育等结构调控改善林分结构,有助于提高林分生物多样性,是柏木低效林经营的方向。

关键词：川中丘陵区林窗柏木低效林植物多样性

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KAI1/CD82 gene expression in benign prostatic hyperplasia and late-stage prostate cancer in Chinese

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Asian Journal of Andrology 2000年第3期2卷 221-224页

作者： Wei-LieHU Ying-QiuLI Hui-XuHE Qing-RongLI yetian Ri-QuanLAI HuaMEI DepartmentofUrology theGeneralHospitalofGuangJumMilitaryAreaChinesePeople＇sLiberationArmyGuangzhouChina LifeScienceCollege SunYat-SenUniversityGuangzhouChina FirstAffiliatedHospital SunYat-SenUniversityofMedicalSciencesGuangzhouChina DepartmentofUrology theGeneralHospitalofGuangJumMilitaryAreaChinesePeople＇sLiberationArmyGuangzhouChina

Aim: To evaluate KAII/CD82 expression in Chinese patients with benign prostatic hyperplasia (BPH) and late-stage carcinoma of prostate (CaP). Methods: Thirty Chinese patients with benign prostatic hyperplasia and 34 withCaP (adenocarcinoma clinical stage C and D) were analyzed by means of immunohistochemical methods. Results:The KAII/CD82 expression in BPH tissue was all positive, which was uniformly located on the glandular cell mem-brane at the cell-to-cell borders, but KAII/CD82 expression in metastasis CaP tissues was either significantly lower thanthat of BPH or negative, and the immunostaining pattern was not continuous. In late-stage CAP KAII/CD82 expressionwas correlated inversely to the pathological grade ( P 0.05). Conclusion:The authors believe that decreased and negative KAII/CD82 expression in late-stage CaP may be related to tumor pro-gression and metastasis, and appears to be a prognostic marker.

关键词： KAII/CD82 metastasis suppressor gene expression benign prostatic hyperplasia prostatic neoplasms immunohistochemistry

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在线燃烧离子色谱法测定环氧树脂中的氯和溴

环境化学 2024年第1期43卷 152-159页

作者：巢静波史乃捷王海峰周希蕊房叶天陈艳许峰朱天一中国计量科学研究院北京100029 北京化工大学化学工程学院北京100029 山东非金属材料研究所济南250031

建立了在线燃烧离子色谱同时测定环氧树脂中氯和溴的分析方法.采用高温裂解炉与离子色谱的在线联用装置,通过对样品进行高温燃烧裂解和气化,以100 mg·L^(-1)过氧化氢为吸收液,将产生的卤化氢气体吸收并转化为无机阴离子,离子色谱法进... 详细信息

建立了在线燃烧离子色谱同时测定环氧树脂中氯和溴的分析方法.采用高温裂解炉与离子色谱的在线联用装置,通过对样品进行高温燃烧裂解和气化,以100 mg·L^(-1)过氧化氢为吸收液,将产生的卤化氢气体吸收并转化为无机阴离子,离子色谱法进行样品的测定,以氯和溴的峰面积外标法进行定量.对影响燃烧效果和测定结果准确度的因素如燃烧时间、燃烧温度、吸收液体积、称样量、氧气和氩气流速等条件进行了选择优化.在(0.10—2.50)mg·L^(-1)和(0.02—0.50)mg·L^(-1)范围内,氯和溴离子的线性相关系数(r^(2))大于0.999,该方法对于氯和溴的定量下限分别为0.55 mg·kg^(-1)和2.60 mg·kg^(-1).采用建立的方法分别对环氧树脂和EC680k低密度聚乙烯标准物质中的氯和溴进行测定,并与传统的氧弹燃烧-离子色谱法进行了比较.结果表明:在线燃烧离子色谱法对于环氧树脂中氯和溴测定结果的相对标准偏差分别为1.28%和2.29%,测定值与氧弹燃烧-离子色谱法基本一致,EC680k的测定结果与标准值符合,证明该方法具有良好的准确度和精密度.该方法准确度和灵敏度高、重复性较好,能够满足批量树脂类样品中氯和溴的含量筛查和多批次产品的质量控制.

关键词：在线燃烧离子色谱环氧树脂氯溴

Amorphous MoS_(3) enriched with sulfur vacancies for efficient electrocatalytic nitrogen reduction

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Journal of Energy Chemistry 2021年第2期30卷 132-138,I0005页

作者： Ke Chu Haifeng Nan Qingqing Li Yali Guo yetian Wuming Liu School of Materials Science and Engineering Lanzhou Jiaotong UniversityLanzhou 730070GansuChina Department of Physics College of ScienceHebei North UniversityZhangjiakou 075000HebeiChina Institute of Physics Chinese Academy of SciencesBeijing 100190China

Developing low-priced,yet effective and robust catalysts for the nitrogen reduction reaction(NRR) is of vital importance for scalable and renewable electrochemical NH3 ***,we provide the first demonstration of MoS_3 as an efficient and durable NRR catalyst in neutral *** prepared amorphous MoS_3 naturally possessed enriched S vacancies and delivered an NH3 yield of 51.7 μg h^(-1) mg^(-1)and a Faradaic efficiency of 12.8% at-0.3 V(RHE) in 0.5 M LiClO_4,considerably exceeding those of MoS_2 and most reported NRR *** functional theory calculations unraveled that S vacancies involved in MoS_3 played a crucial role in activating the NRR via a consecutive mechanism with a low energetics barrier and simultaneously suppressing the hydrogen evolution reaction.

关键词： Electrocatalytic N_2 reduction Amorphous materials Vacancy N_(2)activation

The way of SARS-CoV-2 vaccine development:success and challenges

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3421-3434页

作者： yetian Dong Tong Dai Bin Wang Lei Zhang Ling-hui Zeng Jun Huang Haiyan Yan Long Zhang Fangfang Zhou School of Medicine Zhejiang University City CollegeHangzhou 310015 ZhejiangChina Life Sciences Institute and Innovation Center for Cell Signaling Network Zhejiang UniversityHangzhouZhejiang 310058China Department of Orthopaedic Surgery The Third Affiliated Hospital of Wenzhou Medical UniversityRui‘anChina Institutes of Biology and Medical Science Soochow UniversitySuzhou 215123China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative agent of coronavirus disease 2019(COVID-19).To halt the pandemic,multiple SARS-CoV-2 vaccines have been developed and several have been allowed for emergency use and rollout *** novel SARS-CoV-2 variants emerging and circulating widely,whether the original vaccines that were designed based on the wild-type SARS-CoV-2 were effective against these variants has been a contentious ***,some studies revealed the long-term changes of immune responses post SARS-CoV-2 infection or vaccination and the factors that might impact the vaccine-induced ***,in this review,we have summarized the influence of mutational hotspots on the vaccine efficacy and characteristics of variants of interest and *** have also discussed the reasons that might result in discrepancies in the efficacy of different vaccines estimated in different ***,we provided an overview of the duration of immune responses after natural infection or vaccination and shed light on the factors that may affect the immunity induced by the vaccines,such as special disease conditions,sex,and pre-existing immunity,with the aim of aiding in combating COVID-19 and distributing SARS-CoV-2 vaccines under the prevalence of diverse SARS-CoV-2 variants.

关键词： immunity vaccine respiratory

地塞米松用于LQLB对妇科腹腔镜患者术后QoR的影响

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云南医药 2024年第5期45卷 23-26页

作者：张富荣王玥李世阔汪杰杨也天尹建伟昆明医科大学附属延安医院麻醉科云南昆明650051 楚雄彝族自治州人民医院麻醉科云南楚雄675000

目的探讨地塞米松作为佐剂行LQLB对妇科腹腔镜患者术后QoR的影响。方法选取2022年10月-2023年1月本院择期行妇科腹腔镜良性肿瘤手术患者70例,随机分为LD组(地塞米松复合罗哌卡因,n=35)和L组(罗哌卡因,n=35)行LQLB,对比2组术后QoR、VAS... 详细信息

目的探讨地塞米松作为佐剂行LQLB对妇科腹腔镜患者术后QoR的影响。方法选取2022年10月-2023年1月本院择期行妇科腹腔镜良性肿瘤手术患者70例,随机分为LD组(地塞米松复合罗哌卡因,n=35)和L组(罗哌卡因,n=35)行LQLB,对比2组术后QoR、VAS评分、镇痛补救情况、PONV发生率及严重程度、镇吐补救次数、术后首次肛门排气时间。结果与L组相比,LD组患者术后1d QoR-40评分更高、术后24h及48h VAS评分更低、镇痛补救次数减少、首次镇痛药物使用时间更长、术后48h内PONV发生率和严重程度更低、术后首次肛门排气时间更短,差异有统计学意义(P<0.05)。结论地塞米松作为佐剂行LQLB镇痛效果更完善、PONV发生率及严重程度降低、胃肠功能恢复快,有效提高妇科腹腔镜手术患者的术后QoR。

关键词：腰方肌阻滞地塞米松恢复质量腹腔镜手术