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变压器 2024年第6期61卷 22-25页

作者：张秀杰包锦盾陈坤周晔晖三变科技股份有限公司浙江台州317100

变压器油箱的机器人自动化焊接能够提升生产效率并确保焊缝品质,本文作者介绍了机器人自动化焊接在本公司主变油箱焊接中的应用,通过油箱结构和制作工艺的适当改进,适应了机器人自动化焊接的要求,提高了自动化焊接,提高了生产效率。

关键词：焊接机器人焊接数字化

壳聚糖/普鲁兰多糖/聚乙烯醇/胶原蛋白食品膜的理化性质及结构特征

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现代食品科技 2023年第5期39卷 81-88页

作者：刘磊孙卫东黄利华张友胜陈帅张业辉广西大学轻工与食品工程学院广西南宁530004 广州城市职业学院食品科学与美食养生学院广东广州510405 广东省农业科学院蚕业与农产品加工研究所农业农村部功能食品重点实验室广东省农产品加工重点实验室广东广州510610

为了研究壳聚糖(Chitosan,CS)/普鲁兰多糖(Pullulan,LP)/聚乙烯醇(Polyvinyl Alcohol,PVA)/胶原蛋白(Collagen,GL)食品包装膜理化性质及结构特征,该研究以CS、LP、PVA和GL为原料,按一定比例混合,采用流延成膜法制备多元复合膜,测定复合... 详细信息

为了研究壳聚糖(Chitosan,CS)/普鲁兰多糖(Pullulan,LP)/聚乙烯醇(Polyvinyl Alcohol,PVA)/胶原蛋白(Collagen,GL)食品包装膜理化性质及结构特征,该研究以CS、LP、PVA和GL为原料,按一定比例混合,采用流延成膜法制备多元复合膜,测定复合膜的机械性能、水溶性、溶胀率、色度和透光率等指标,并利用红外光谱、X衍射光谱和扫描电镜表征膜的结构。结果表明:CS、LP和CS-LP膜材分别添加到PVA-GL中,复合膜厚度逐渐增加,拉伸强度逐渐降低,而断裂伸长率呈递增的趋势,其中四元膜厚度为142.50μm,抗拉强度为11.21 MPa,断裂伸长率为169.24%;提高复合膜的膨胀率,降低了复合膜的溶解度,四元膜的膨胀率最高,溶解度最低,分别为368.16%,58.64%;色度及不透明度的测量发现,四元膜亮度较亮和色差小的特点,且该膜不透明度最小,为2.28 UA/mm;测量其波长在200~800 nm范围内紫外可见光的透光率发现,该膜具有良好的紫外线阻隔能力;红外光谱、X衍射光谱及扫描电镜分析结果显示,CS和LP能与PVA-GL相互作用,降低CS和LP的结晶度,形成结构致密的均相体系。研究结果为CS/PL/PVA/GL食品包装膜的进一步研究提供了可以借鉴的科学依据。

关键词：壳聚糖普鲁兰多糖聚乙烯醇胶原蛋白流延成膜法食品包装膜

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CRABP2在肿瘤发生发展中的作用研究

中国临床药理学与治疗学 2023年第1期28卷 86-92页

作者：刘佳佳高岩张业慧武静乐陵市人民医院药剂科山东乐陵253600 山东大学第二医院药学部山东济南250000 山东第一医科大学第一附属医院(山东省千佛山医院)药学部山东济南250014

视黄酸(retinoic acid,RA)是维生素A的代谢中间产物,在胚胎发育和细胞的生长及分化过程中发挥重要作用。细胞视黄酸结合蛋白2(cellular retinoic acid-binding proteins 2,CRABP2)是一组低相对分子质量的胞内蛋白,其主要生理功能之一是... 详细信息

视黄酸(retinoic acid,RA)是维生素A的代谢中间产物,在胚胎发育和细胞的生长及分化过程中发挥重要作用。细胞视黄酸结合蛋白2(cellular retinoic acid-binding proteins 2,CRABP2)是一组低相对分子质量的胞内蛋白,其主要生理功能之一是将RA运输到细胞核中,与视黄酸受体(retinoic acid receptor,RAR)结合,从而调控特定的下游信号通路来发挥作用。研究发现,CRABP2的异常表达与人类恶性肿瘤密切相关,能通过调节诸多生长或凋亡相关通路或关键生物学分子,影响肿瘤的发生、发展。因此,CRABP2或许可以作为新的肿瘤诊断和预后标志物,并作为恶性肿瘤新的治疗靶点。本文就CRABP2与肿瘤发生发展、耐药及预后的关系作一综述,为后续研究提供参考。

关键词： CRABP2 肿瘤发生转移耐药分子标志物

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Planaxidae(Mollusca, Gastropoda) from the South China Sea

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Journal of Oceanology and Limnology 2018年第2期36卷 548-555页

作者： CHEN Zhiyun zhang Junlong LIAN Xiping TAN yehui Marine Biodiversity Collections of South China Sea~Key Laboratory of Tropical Marine Bio-Resources and Biology South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China Department of Marine Organism Taxonomy and Phylogeny Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China

Abstract Planaxidae is a family of tropical and subtropical marine gastropods that are adapted to an intertidal, rocky environment. The present study deals with three species in the family Planaxidae from the South China Sea： Planaxis sulcatus （von Born, 1778）, Angiola longispira （Smith, 1872）, and Supplanaxis niger （Quoy and Gaimard, 1833）, based on specimens deposited in the Marine Biodiversity Collections of the South China Sea, Chinese Academy of Sciences. The taxonomic status, main morphological characteristics of the shell and radula, distribution, and habitat of these three planaxid species are presented. We also briefly discuss their morphological differences and the biogeographic distribution.

关键词： Planaxidae Planaxis sulcatus Angiola longispira Supplanaxis niger radula South China Sea

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一种小型半导体恒温控制系统的研制

计算机测量与控制 2006年第8期14卷 1044-1045,1048页

作者：万利峰徐晓洁陈嘉威崔志立张晔晖中国农业大学信息与电气工程学院北京100083 北京农学院基础科学系北京102206 北京恒瑞美联信息技术有限公司北京100085

为研究近红外光谱仪中的光源等核心部件受温度影响的特性,研制出一种专门的小型恒温控制系统,此系统采用先进的半导体制冷技术和数字PID算法,并巧妙地使用电机驱动芯片构成驱动电路,测试结果表明,该恒温系统工作稳定可靠,控制精度较高,... 详细信息

为研究近红外光谱仪中的光源等核心部件受温度影响的特性,研制出一种专门的小型恒温控制系统,此系统采用先进的半导体制冷技术和数字PID算法,并巧妙地使用电机驱动芯片构成驱动电路,测试结果表明,该恒温系统工作稳定可靠,控制精度较高,在微小型恒温系统研制方面有一定的实用和推广价值。

关键词：恒温系统半导体制冷数字PID 驱动电路 DS18B20

Oxidative stress, nutritional antioxidants and beyond

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Science China(Life Sciences) 2020年第6期63卷 866-874页

作者： Qiuping Guo Fengna Li yehui Duan Chaoyue Wen Wenlong Wang Lingyu zhang Ruilin Huang Yulong Yin Laboratory of Animal Nutritional Physiology and Metabolic Process Institute of Subtropical AgricultureChinese Academy of SciencesKey Laboratory of Agro-ecological Processes in Subtropical RegionHunan Provincial Engineering Research Center for Healthy Livestock and Poultry ProductionScientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-CentralMinistry of AgricultureChangsha 410125China University of Chinese Academy of Sciences Beiing 100039China Hunan Co-Innovation Center of Animal Production Safety Hunan Collaborative Innovation Center for Utilization of Botanical Functional IngredientsChangsha 410128China Laboratory of Animal Nutrition and Human Health School of BiologyHunan Normal UniversityChangsha 410018China

Free radical-induced oxidative stress contributes to the development of metabolic syndromes(Mets), including overweight,hyperglycemia, insulin resistance and pro-inflammatory state. Most free radicals are generated from the mitochondrial electron transport chain;under physiological conditions, their levels are maintained by efficient antioxidant systems. A variety of transcription factors have been identified and characterized that control gene expression in response to oxidative stress *** antioxidant compounds have been largely studied for their strong antioxidant capacities. This review discusses the recent progress in oxidative stress and mitochondrial dysfunction in Mets and highlights the anti-Mets, anti-oxidative, and antiinflammatory effect of polyphenols as potential nutritional therapy.

关键词： reactive oxygen species oxidative stress mitochondrial dysfunction signal transduction nutritional antioxidant polyphenols

温度对乌鳢鱼皮胶原蛋白肽聚集体结构及理化特性的影响

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肉类研究 2021年第6期35卷 1-9页

作者：刘炜熹张业辉张友胜焦文娟赵甜甜周东来黄利华钟伟锐广东省农业科学院蚕业与农产品加工研究所农业农村部功能食品重点实验室广东省农产品加工重点实验室广东广州510610 广州城市职业学院食品系广东广州510405 汕尾市五丰海洋生物技术有限公司广东汕尾516626

研究乌鳢鱼皮胶原蛋白肽在20~52℃低温诱导下自组装体的结构稳定性与理化性质,比较分析聚集体变化过程中圆二色谱、自组装动力学、微观结构、凝胶强度、粒径、黏度、变性温度和红外光谱的变化。结果表明:在20~30℃温度范围内,升温对乌... 详细信息

研究乌鳢鱼皮胶原蛋白肽在20~52℃低温诱导下自组装体的结构稳定性与理化性质,比较分析聚集体变化过程中圆二色谱、自组装动力学、微观结构、凝胶强度、粒径、黏度、变性温度和红外光谱的变化。结果表明:在20~30℃温度范围内,升温对乌鳢鱼皮胶原蛋白肽自组装速率及聚集体稳定性具有促进作用,组装成核时间缩短13.5 min,形成的三维网络致密性增强,平均粒径增大,凝胶强度从50.23 g/cm^(2)升高至212.55 g/cm^(2)(P<0.05),最大剪切黏度增加549.34%,β-折叠相对含量增加45.42%,胶原蛋白肽结构稳定性显著增强;在30~52℃温度范围内,升温促使纤维网络结构发生溶解和絮集,凝胶强度降低97.87%(P<0.05),粒径降低46.16%,最大剪切黏度和β-折叠相对含量降低;差示量热扫描测定结果表明,聚集体自组装程度越高,其热稳定性越强。因此,适宜的温度可有效改善乌鳢鱼皮胶原蛋白肽纤维网络的结构稳定性及理化性质。

关键词：乌鳢鱼皮胶原蛋白肽温度自组装微观结构理化特性

Engineered Bacillus subtilis alleviates intestinal oxidative injury through Nrf2-Keap1 pathway in enterotoxigenic Escherichia coli(ETEC) K88-infected piglet

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第6期24卷 496-509页

作者： Chaoyue WEN Hong zhang Qiuping GUO yehui DUAN Sisi CHEN Mengmeng HAN Fengna LI Mingliang JIN Yizhen WANG Institute of Feed Science Key Laboratory of Animal Feed and Nutrition of Zhejiang ProvinceKey Laboratory of Molecular Animal NutritionMinistry of EducationKey Laboratory of Animal Nutrition and Feed Science in Eastern ChinaMinistry of AgricultureCollege of Animal SciencesZhejiang UniversityHangzhou 310058China Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process CAS Key Laboratory of Agro-Ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China College of Advanced Agricultural Science University of Chinese Academy of SciencesBejing 100039China

Engineered probiotics can serve as therapeutics based on their ability of produce recombinant immune-stimulating *** this study,we built the recombinant Bacillus subtilis WB800 expressing antimicrobial peptide KR32(WB800-KR32)using genetic engineering methods and investigated its protective effects of nuclear factor-E2-related factor 2(Nrf2)-Kelch-like ECH-associated protein 1(Keap1)pathway activation in intestinal oxidative disturbance induced by enterotoxigenic Escherichia coli(ETEC)K88 in weaned ***-eight weaned piglets were randomly distributed into four treatment groups with seven replicates fed with a basal *** feed of the control group(CON)was infused with normal sterilized saline;meanwhile,the ETEC,ETEC+WB800,and ETEC+WB800-KR32 groups were orally administered normal sterilized saline,5×10^(10)CFU(CFU:colony forming units)WB800,and 5×10^(10)CFU WB800-KR32,respectively,on Days 1-14 and all infused with ETEC K881×10^(10)CFU on Days *** results showed that pretreatment with WB800-KR32 attenuated ETEC-induced intestinal disturbance,improved the mucosal activity of antioxidant enzyme(catalase(CAT),superoxide dismutase(SOD),and glutathione peroxidase(GPx))and decreased the content of malondialdehyde(MDA).More importantly,WB800-KR32 downregulated genes involved in antioxidant defense(GPx and SOD1).Interestingly,WB800-KR32 upregulated the protein expression of Nrf2 and downregulated the protein expression of Keap1 in the ***800-KR32 markedly changed the richness estimators(Ace and Chao)of gut microbiota and increased the abundance of Eubacterium_rectale_ATCC_33656 in the *** results suggested that WB800-KR32 may alleviate ETEC-induced intestinal oxidative injury through the Nrf2-Keap1 pathway,providing a new perspective for WB800-KR32 as potential therapeutics to regulate intestinal oxidative disturbance in ETEC K88 infection.

关键词： Engineered probiotics Intestine Oxidative injury Weaned piglets Nuclear factor-E2-related factor 2(Nrf2)-Kelch-like ECH-associated protein 1(Keap1)pathway

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3D虚拟仿真技术在功能解剖学教学的应用

中国中医药现代远程教育 2023年第5期21卷 23-25页

作者：杨春张业辉郭金华崔晓军李文漫张剑凯杜以宽孙艳芹广东医科大学解剖学教研室广东东莞523808 东莞市人民医院中心实验室广东东莞523059 广东医科大学病理学系广东东莞523808

功能解剖学是一门形态学课程,侧重于研究人体某一局部的层次结构以及血管、神经、肌肉和器官之间的位置和毗邻关系。此课程是康复学专业非常重要的基础课程,但是功能解剖学内容庞杂、枯燥乏味、难懂难记,导致学生学习积极性不高、学习困... 详细信息

功能解剖学是一门形态学课程,侧重于研究人体某一局部的层次结构以及血管、神经、肌肉和器官之间的位置和毗邻关系。此课程是康复学专业非常重要的基础课程,但是功能解剖学内容庞杂、枯燥乏味、难懂难记,导致学生学习积极性不高、学习困难,影响教学效果。3D数字虚拟仿真系统具有可视化、三维化、虚拟化和交互等特点,联合这些虚拟仿真重建、虚拟可视化等软件教学,克服了传统医学教学的局限性,提高了课堂授课效率,提升了标本利用率,既可以激发学生学习的积极性、主动性,又受到了师生的认可,可促进功能解剖学的教学改革和发展。

关键词：功能解剖学 3D虚拟仿真教学改革

Benefit of everolimus as a monotherapy for a refractory breast cancer patient bearing multiple genetic mutations in the PI3K/AKT/mTOR signaling pathway

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Cancer Biology & Medicine 2018年第3期15卷 314-321页

作者： yehui Shi Wenwen zhang Yingnan Ye Yanan Cheng Lei Han Pengpeng Liu Weipeng Zhao Zhongsheng Tong Jinpu Yu Medical Oncology Department of Breast Cancer Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China Cancer Molecular Diagnostics Core Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China Department of Immunology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China

A postmenopausal patient with a diagnosis of estrogen receptor(ER)(+), progesterone receptor(PR)(+), and human epidermal growth factor receptor-2(HER2)(-) breast cancer was reported. The patient refused surgery and was resistant to conventional chemotherapy regimens. Computed tomography and the circulating tumor cell test indicated that the patient's tumor burden increased rapidly even after several chemotherapy sessions. Multiple genetic aberrances in the phosphatidylinositol3-kinases(PI3 K) signaling pathway were detected via next-generation sequencing(NGS)-based liquid biopsy, including a p. G1007 R missense mutation in exon 21 of PIK3 CA(33.61%), a p.L70 fs frameshift mutation in exon 3 of phosphatase and tension homolog deleted on chromosome ten(PTEN)(49.14%), and a p. D1542 Y missense mutation in exon 32 of mammalian target of rapamycin(m TOR)(1.66%). Therefore, only the m TOR inhibitor everolimus was administered to the patient. Partial remission(PR) was observed after 2 months, and sustained stable disease(SD) was observed after a year and a half. Subsequent sequencing showed that the mutation ratio of PIK3 CA decreased to 4.17%, and that the PTEN and m TOR mutations disappeared, which revealed the significant curative effect of everolimus. We report the first case of successful monotherapy treatment using everolimus in a patient with advanced breast cancer bearing mutations in genes involved in the PI3 K/ARK/m TOR signaling pathway. The success of this case highlights the invaluable clinical contribution of NGS-based liquid biopsy, as it successfully provided an optimal therapeutic target for the patient with advanced breast cancer.

关键词： Breast cancer everolimus next-generation sequencing liquid biopsy PI3K/AKT/mTOR