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Elevated Arsenic Exposure Is Associated with an Increased Risk of Chronic Hepatitis B Virus Infection： NHANES （2003-2014） in U.S. Adults

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Current Medical Science 2018年第4期38卷 610-617页

作者： Wei-hua ZHANG Jiao HUANG Mei FENG ye-qing tong Xu-hua GUAN Hong-wei JIANG Sheng WEI Department of Epidemiology and Biostatistics Key Laboratory of Environment and Health of Ministry of Education School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Preventive Medicine School of Medicine Ningbo University Ningbo 315211 China Institute of Infectious Disease Control and Prevention Hubei Provincial Center for Disease Control and Prevention Wuhan 430079 China

Studies concerning the association between arsenic exposure and hepatitis B virus （HBV） infection have been lacking. The present study aimed to examine the association between total urinary arsenic （TUA） and infection ofHBV. A total of 5186 participants from National Health and Nutrition Examination Survey （NHANES） 2003-2014 were included in the analysis. We used logistic regression to evaluate the association. We defined two measures of TUA. TUA1 was the sum of arsenous acid, arsenicacid, monomethylarsonic acid and dimethylarsenic acid. TUA2 was defined as TUA minus arsenobetaine and arsenocholine. The results showed that the weighted overall prevalence of HBV infection was 6.08%. For NHANES 2003-2014, the medians （interquartile range） of TUA1 and TUA2 were 5.60 μg/L （3.97-8.09 μg/L） and 4.91 μg/L （2.36-9.11 μg/L）, respectively. Comparing the highest quartile to the lowest quartile after multivariable adjustment showed that the odds ratios （ORs） and 95% confidence intervals （CIs） for TUA1 and TUA2 were 2.44 （1.40-4.27） and 2.84 （1.60-5.05）, respectively. In conclusion, elevated urinary arsenic was associated with the risk of HBV infection. Further studies, especially prospective studies, are needed to confirm the causal relationship between arsenic exposure and HBV infection.

关键词： arsenic exposure hepatitis B infection National Health and Nutrition Examination Survey

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购房者信心与住宅价格的关联研究——以厦门市为例

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华侨大学学报（哲学社会科学版） 2016年第5期 57-67页

作者：叶青叶培桐楚建乐华侨大学土木工程学院

参考消费者信心指数的体系和编制方法,构建了购房者信心指数体系,确定了经济发展形势、政策因素、家庭收入和购房意愿这四个指标,选取了网络搜索数据来编制购房者信心指数。并以厦门市为例进行实证研究,发现购房者信心与住宅价格之间存... 详细信息

参考消费者信心指数的体系和编制方法,构建了购房者信心指数体系,确定了经济发展形势、政策因素、家庭收入和购房意愿这四个指标,选取了网络搜索数据来编制购房者信心指数。并以厦门市为例进行实证研究,发现购房者信心与住宅价格之间存在着相互影响的关系,但是购房者信心对于住宅价格的影响力要大于住宅价格对于购房者信心的影响力。

关键词：购房者信心住宅价格消费者信心指数

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北京市月季丽赤壳褐斑病病原菌鉴定

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植物病理学报 2021年第3期51卷 446-450页

作者：贾静怡孙倩张玮叶清桐乔广行燕继晔李兴红北京市农林科学院植物保护环境保护研究所北京100097

月季(Rosa chinensis)为北京市市花,蔷薇科(Rosaceae)蔷薇属(Rosa)多年生木本植物[1]。因其形态繁多、适应力强、便于管理、四季常开而成为园林绿化的重要植物[2]。北京市园林绿化局2018年统计显示,全市的月季种植面积已达1667 hm2。随... 详细信息

月季(Rosa chinensis)为北京市市花,蔷薇科(Rosaceae)蔷薇属(Rosa)多年生木本植物[1]。因其形态繁多、适应力强、便于管理、四季常开而成为园林绿化的重要植物[2]。北京市园林绿化局2018年统计显示,全市的月季种植面积已达1667 hm2。随着月季种植面积的不断扩大,月季病害发生普遍。黑斑病、白粉病、灰霉病、锈病及茎溃疡病等[3,4]是常见的月季病害。

关键词：园林绿化局病原菌鉴定病害发生灰霉病褐斑病白粉病蔷薇属适应力

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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma Ke ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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Fatty acid-binding protein gene is indispensable for molting process in Heortia vitessoides(Lepidoptera:Crambidae)

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Journal of Integrative Agriculture 2023年第2期22卷 495-504页

作者： ye qing-ya LI Zhi-xing CHEN qing-ling SUN Ming-xu YIN Ming-liang LIN tong College of Forestry and Landscape Architecture South China Agricultural UniversityGuangzhou 510642P.R.China

As intracellular fatty acid(FA) carriers,FA-binding proteins(FABPs) widely participate in the absorption,transport,and metabolism of *** is a key protein in insect lipid metabolism and plays an important role in various physiological activities of *** FABP gene(HvFABP) was cloned from the transcriptional library of Heortia vitessoides Moore(Lepidoptera:Crambidae),and its expression patterns were determined using reverse transcription quantitative PCR(RTqPCR).Stage-and tissue-specific expression profiles indicated that HvFABP highly expressed from prepupal to adult stages and in larval midgut and adult *** expression may be induced through starvation,mRNA expression was downregulated at 24 and 48 h and upregulated at 72 h after ***,20-hydroxyecdysone can induce the upregulation of its *** interference-mediated silencing of Hv FABP significantly inhibited HvFABP expression,resulting in delayed development,abnormal molting or lethal phenotypes,and a significantly reduced survival *** results indicate that HvFABP plays a key role in the molting of ***.

关键词： fatty acid-binding protein starvation 20-hydroxyecdysone RNA interference Heortia vitessoides Moore

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Effect of Semen vaccariae and Taraxacu mogono on Cell Adhesion of Bovine Mammary Epithelial Cells

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Journal of Integrative Agriculture 2012年第12期11卷 2043-2050页

作者： tong Jin-jin LI ye LIU Rong GAO Xue-jun LI qing-zhang Key Laboratory of Dairy Science Ministry of Education/College of Life Science Northeast Agricultural University

The aim of this study is to reveal the regulation mechanism of the effect of Semen vaccariae and Taraxacu mogono on the cell-cell adhersion molecule, E-cadherin and β-catenin on the proliferation role and secretion function of bovine mammary epithelial cells cultured in vitro. Firstly, the epithelial character of bovine mammary epithelial cells was authenticated using immunofluorescence, then the cell grow curve was observed and investigated after S. vaccariae and T. mogono treatment. On the effect of S. vaccariae and T. mogono, cell adhesion molecules E-cadherin, β-catenin and CycinD1 mRNA and protein were detected by qRT-PCR and Western blotting, respectively. The results showed that the cellular keratin 18 expressed positively and proliferfated vigorously after S. vaccariae and T. mogono treament. The mRNA and protein levels of E-cadherin and CycinD1 were remarkably higher （P〈0.05） in 36 h after S. vaccariae and T. mogono treatment. The cell proliferation at 36 h was increased significantly （P〈0.05）. In conclusion, S. vaccariae and T. mogono have a positive impact on the cell proliferation and an effect on the adhesion molecules E-cadherin, β-catenin and CycinD1 in the Wnt signaling pathway.

关键词： E-cadherin β-catenin Semen vaccariae Taraxacu mogono bovine mammary epithelial cells

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Rop plays conserved roles in the reproductive and digestive processes of spider mites

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Insect Science 2023年第2期30卷 351-364页

作者： Xue Xia Chang-Wu Peng qing-tong ye Xiao-Li Bing Xiao-Yue Hong Department of Entomology Nanjing Agricultural UniversityNanjingChina

Ras opposite(Rop)is known to play an essential role in regulating vesicle trafficking,including synaptic transmission and general *** fundamental roles of Rop have been confirmed by the observation that null mutations in many organisms generate lethal phenotypes during ***,the effects of Rop during the postembryonic stages,especially in non-model organisms,remain largely ***,we provide new data that enhance our understanding of Rop's roles in the adults of multiple species of Tetranychus spider mites(Acari:Tetranychidae),a class of notorious agricultural *** in silico and experimental evidence demonstrated that Rop is under purifying selection and is highly conserved in Tetranychus *** interference experiments showed that Rop is required for maintaining normal fecundity but has no significant effect on *** further demonstrate that knockdown of Rop darkens the body color of spider mites and blocks the excretion of fecal pellets,which is likely to be related to an abnormality in the excretion of food waste in the digestive ***,our findings clarify novel functions of a vesicle trafficking-related gene in the adult stage of multiple Tetranychus species and highlight the need to evaluate the roles of essential genes in various organisms.

关键词： body color reproduction Rop spider mites Tetranychus vesicle trafficking

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Upconversion luminescence and temperature sensing performance of Er^(3+) ions doped self-activated KYb(MoO_(4))_(2) phosphors

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Journal of Rare Earths 2024年第8期42卷 1507-1513,I0004页

作者： ye tong Wenpeng Liu Shoujun Ding School of Microelectronics and Data Science Anhui University of TechnologyMaanshan243002China Advanced Laser Technology Laboratory of Anhui Province Hefei230037China Anhui Institute of Optics and Fine Mechanics Chinese Academy of SciencesHefei230031China

In this work,a series of self-activated KYb(MoO_(4))_(2) phosphors with various x at% Er^(3+) doping concentrations(x=0.5,1,3,5,8,10,15) was synthesized by the solid-state reaction *** phase structure of the as-prepared samples was analyzed by X-ray diffraction(XRD),XRD Rietveld refinement and Fourier transform infrared(FT-IR) *** as-prepared samples retain the orthorhombic structure with space group of Pbcn even Er^(3+) doping concentration up to 15 at%.High-purity upconversion(UC) green emission with green to red intensity ratio of 55 is observed from the as-prepared samples upon the excitation of 980 nm semiconductor laser and the optimum doping concentration of Er^(3+) ions in the self-activated KYb(MoO_(4))_(2) host is revealed as 3 at%.The strong green UC emission is confirmed as a two-photon process based on the power-dependent UC *** addition,the fluorescence intensity ratios(FIRs) of the two thermally-coupled energy levels,namely ^(2)H_(11/2) and ^(4)S_(3/2).of Er^(3+) ions were investigated in the temperature region 300-570 K to evaluate the optical temperature sensor behavior of the *** maximum relative sensitivity(S_(R)) is determined to be 0.0069 K^(-1) at300 K and the absolute sensitivity(S_(A)) is determined to be 0.0126 K^(-1) at 300 *** S_(A) of self-activated KYb(MoO_(4))2:Er^(3+)is almost twice that of traditional KY(MoO_(4))2:Er^(3+)/Yb^(3+)codoping *** results demonstrate that Er^(3+) ions doped self-activated KYb(MoO_(4))2 phosphor has promising application in visible display,trademark security and optical temperature sensors.

关键词： Er^(3+)ions doped KYb(MoO_(4))_(2) Self-activated phosphors Upconversion luminescence Solid-state reaction method Optical temperature sensors Rare earths

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A comprehensive evaluation of diversity systems based on mimic defense

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Science China(Information Sciences) 2021年第12期64卷 258-259页

作者： qing tong Yunfei GUO National Digital Switching System Engineering and Technological R&D Center

Dear editor,Diversity systems increase attacking challenges through mechanisms such as system diversification design, redundancy, or dynamic rotation. They resist various external threats, including the unknown attacks on the system. Several research studies have been conducted to analyze and validate the security and effectiveness of diversity systems,

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Sparse Reconstruction Method for DOA Estimation Based on Dynamic Dictionary and Negative Exponent Penalty

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Chinese Journal of Electronics 2018年第2期27卷 386-392页

作者： QIAN tong CUI Wei SHEN qing School of Information and Electronic Beijing Institute of Technology

This paper proposes a novel sparse representation method for direction of arrival estimation based on dynamic dictionary and negative exponent penalty. The dynamic dictionary can eliminate the off-grid effect and the negative exponent penalty is capable of strengthening the sparse constraint to improve the performance. The basis is regarded as a part of the optimal target and the cross iteration is utilized to jointly update the dictionary and sparse support in this method. Based on the propositions of the penalty function, the penalty function is designed to replace of 1 norm because of its unbiasedness and stronger sparse constraint. The regularization parameter is simplified as a constant due to pre-white process, which greatly extends the application range of the proposed method. The simulation results show that the proposed method can efficiently reduce the off-grid effect and the over-complete rate of the original dictionary. Compared with the conventional sparse representation methods, it has better performance and lower computation complexity.

关键词： Direction of arrival(DOA) Sparse reconstruction Dynamic dictionary Penalty function

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