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Exploring the correlation between temperature and crime:A case-crossover study of eight cities in America

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Journal of Safety Science and Resilience 2024年第1期5卷 13-36页

作者： jinming hu Xiaofeng hu xin’ge Han Yan lin huanggang Wu Bing shen School of Information Technology and Cyber Security People’s Public Security University of ChinaBeijing 100038China Center for Capital Social Safety People’s Public Security University of ChinaBeijing 100038China China Association for Public Safety Beijing 100084China School of Emergency Management and Safety Engineering China University of Mining and TechnologyBeijing 100083China School of International Police Studies People’s Public Security University of ChinaBeijing 100038China

Recent years have seen increasing academic interest in exploring the correlation between temperature and ***,it is uncertain whether similar long-term trends or seasonality(rather than causal effect)of temper-ature and crime is the major reason for the observed correlation between *** explore whether there is still a correlation between temperature and crime when long-term trends and seasonal cycles are filtered out,we use the Kalman filter to decompose the time series of temperature and crimes,and then the fast Fourier transform is used to calculate the exact circle of their seasonality *** on that,the box-plot method and linear regression are used to explore the correlation between temperature residuals and crime *** results show that more than half of the crime types have similar seasonal cycles(approximately 1 year)to that of ***,the daily residual analyses show that temperature residuals have a positive correlation with assault and robbery residuals in all cities,whose average slopes are more than *** other four types of crimes vary greatly from case to *** temperature residuals show a weak correlation with the residuals of some crime types.

关键词： Time series decomposition Crime Temperature Kalman filter Fast fourier transform

Sperm acrosin activity may be a useful factor in choosing between ICSI and IVF for infertile male patients

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Asian Journal of Andrology 2024年第1期26卷 85-90页

作者： ye-Na hu Liang hu xin-Yu Yin huan Zhang Yang-Qin Peng Gang liu Ge lin Wei-Na Li The Institute of Reproductive and Stem Cell Engineering School of Basic Medical ScienceCentral South UniversityChangsha 410008China Department of Andrology Reproductive and Genetic Hospital of CITiC-XiangyaChangsha 410013China Clinical Research Center for Reproduction and Genetics in hunan Province Changsha 410013China hunan Guangxiu Hi-tech Life Technology Co. Ltd.Changsha 410013China

The clinical applications of acrosin activity are *** analyzed 61578 male partners in infertile couples who visited the outpatient department of the Reproductive and Genetic Hospital of CITIC-Xiangya(Changsha,China)between August 2014 and December 2019 to determine the reference ranges and thresholds for acrosin activity in infertile Chinese men;to determine whether correlations exist between acrosin activity and age,sperm concentration,sperm morphology,or sperm motility;and to evaluate whether acrosin activity could serve as an effective prognostic indicator for choosing between in vitro fertilization(IvF)and intracytoplasmic sperm injection(icsl)in the *** cut-off value for the normal reference range of acrosin activity for male partners in infertile couples was 24.78μlU per 106 *** was no significant association between acrosin activity and age,sperm concentration,semen volume,total sperm count,progressive motility,or total motile spermatozoa.A weak positive correlation was found between acrosin activity and normal sperm *** was a statistically significant difference in abnormal acrosome morphology between the group with high acrosin activity(>24.78μlU per 106 sperm)and the group with low acrosin activity(<24.78μlU per 106 sperm).The group with a low IVF fertilization rate had a high index of abnormal acrosomal morphology at 21.2%,while the group with a high IVF fertilization rate had a low index of 0.2%.At an acrosin activity of<24.78μlU per 10 sperm,in one cycle of the same patient,the fertilization rate,normal fertilization rate,and good-quality embryo rate for Icsl were significantly higher than those for ***,the most promising application of acrosin activity could be in the selection of IcsI over IVF for infertile male patients with complete fertilization failure or a low fertilization rate.

关键词： acrosin activity fertilization rate ICSI IVF semen parameters

Risk Factors of Depression Screened by Two-Sample Mendelian Randomization Analysis:A Systematic Review

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Biomedical and Environmental Sciences 2024年第1期37卷 85-95页

作者： WANG Han lin XUE Yan Feng CUI Bao Qiu liu Hong shen xin xin Shandong Provincial Research Center for Bioinformatic Engineering and Technique School of Life SciencesShandong University of TechnologyZibo 255049ShandongChina Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013ShanxiChina State Key Laboratory of Infectious Disease Prevention and Control National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective This study explored the potentially modifiable factors for depression and major depressive disorder(MDD)from the MR-Base database and further evaluated the associations between drug targets with *** We analyzed two-sample of Mendelian randomization(2SMR)using genetic variant depression(n=113,154)and MDD(n=208,811)from Genome-Wide Association Studies(GWAS).Separate calculations were performed with modifiable risk factors from MR-Base for 1,001 *** MR analysis was performed by screening drug targets with MDD in the DrugBank database to explore the therapeutic targets for *** variance weighted(IVW),fixed-effect inverse variance weighted(FE-IVW),MR-Egger,weighted median,and weighted mode were used for complementary *** The potential causal relationship between modifiable risk factors and depression contained 459 results for depression and 424 for ***,the associations between drug targets and MDD showed that SLC6A4,GRIN2A,GRIN2C,SCN10A,and IL1B expression are associated with an increased risk of *** contrast,ADRB1,CHRNA3,HTR3A,GSTP1,and GABRG2 genes are candidate protective factors against *** This study identified the risk factors causally associated with depression and MDD,and estimated 10 drug targets with significant impact on MDD,providing essential information for formulating strategies to prevent and treat depression.

关键词： Risk factors Drug targets Depression Major depressive disorder Two-sample Mendelian randomization

A reweighted damped singular spectrum analysis method for robust seismic noise suppression

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Petroleum Science 2024年第3期21卷 1671-1682页

作者： Wei-lin huang Yan-xin Zhou Yang Zhou Wei-jie liu ji-Dong Li State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing2249China SINOPEC Petroleum Exploration and Production Research Institute Beijing102206China SINOPEC Geophysical Research Institute Nanjing211103jiangsuChina

(Multichannel)Singular spectrum analysis is considered as one of the most effective methods for seismic incoherent noise *** utilizes the low-rank feature of seismic signal and regards the noise suppression as a low-rank reconstruction ***,in some cases the seismic geophones receive some erratic disturbances and the amplitudes are dramatically larger than other *** presence of this kind of noise,called erratic noise,makes singular spectrum analysis(SSA)reconstruction unstable and has undesirable effects on the final *** robustify the low-rank reconstruction of seismic data by a reweighted damped SSA(RD-SSA)*** incorporates the damped SSA,an improved version of SSA,into a reweighted *** damping operator is used to weaken the artificial disturbance introduced by the low-rank projection of both erratic and random *** central idea of the RD-SSA method is to iteratively approximate the observed data with the quadratic norm for the first iteration and the Tukeys bisquare norm for the rest *** RD-SSA method can suppress seismic incoherent noise and keep the reconstruction process robust to the erratic *** feasibility of RD-SSA is validated via both synthetic and field data examples.

关键词： Singular spectrum analysis Damping operator Seismic erratic noise Seismic signal processing Robust low-rank reconstruction

Berberine Enhances Intestinal Mucosal Barrier Function by Promoting Vitamin D Receptor Activity

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Chinese Journal of Integrative Medicine 2024年第2期30卷 143-151页

作者： huANG Yong-quan liu jia-lin CHEN Geng-xin shen Dan-ting Zhu Wang CHEN xin-lin liu Feng-bin HOU Qiu-ke Graduate School Guangzhou University of Chinese MedicineGuangzhou(510405)China Department of Orthopedics the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Preventive Medicine and Health Statistics Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510405)China

Objective:To evaluate if berberine can act on vitamin D receptors(VDR)and thereby regulate the expression of tight junction proteins(TJPs)in irritable bowel syndrome-diarrhea-predominant(IBS-D)***:The newborn rats were induced into IBS-D rat model via neonatal maternal separation combined with acetic acid chemical *** modeling,the model was evaluated and rats were divided into the control group and berberine treatment groups(0.85,1.7 and 3.4 mg/kg,once a day for 2 weeks).The distal colon was obtained and colonic epithelial cells(CECs)were isolated and cultured after IBS-D model *** vitamin D receptor response element(VDRE)reporter gene was determined in the CECs of IBS-D rats to analyze the effect of berberine on the VDRE *** overexpression or silencing technology was used to analyze whether VDR plays a role in promoting intestinal barrier repair,and to determine which region of VDR plays a role in berberine-regulated intestinal ***:The IBS-D rat model was successfully constructed and the symptoms were improved by berberine in a dose-dependent manner(P<0.05).The activity of VDRE promoter was also effectively promoted by berberine(P<0.05).Berberine increased the expression of TJPs in IBS-D CECs(P<0.05).VDR expression was significantly increased after transfection of different domains of VDR when compared to normal control and basic plasmid groups(all P<0.05).RT-qPCR and Western blot results showed that compared with the blank group,expressions of occludin and zonula occludens-1 were significantly higher in VDR containing groups(all P<0.05).Berberine plus pCMV-Myc-VDR-N group exerted the highest expression levels of occludin and zonula occludens-1(P<0.05).Conclusion:Berberine enhances intestinal mucosal barrier function of IBS-D rats by promoting VDR activity,and the main site of action is the N-terminal region of VDR.

关键词： berberine Chinese medicine irritable bowel syndrome-diarrhea-predominant vitamin D receptors intestinal mucosal barrier tight junction proteins

Effect of Low-temperature Imidization on Properties and Aggregation Structures of Polyimide Films with Different Rigidity

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Chinese Journal of Polymer Science 2024年第8期42卷 1134-1146页

作者： Yan jia Lei Zhai Song Mo Yi liu Li-xin liu xin-Yu du Min-hui He lin Fan Key Laboratory of Science and Technology on High-tech Polymer Materials Institute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China

The traditional high-temperature preparation process of polyimide can cause many problems and limits the wider application in extreme *** important challenge to be solved urgently is the reduction of imidization *** this work,twelve kinds of polyimide films with different chain rigidity were prepared at low temperature of 200℃,in the absence or presence of imidazole used as the *** molecular rigidity and free volume were theoretically calculated,and relationship between structure and properties were systematically *** results show that imidization reaction under low temperatures is significantly affected by the rigidity of molecula r *** rigid structure of polyimide is not conducive to the low-temperature imidization,but this adverse effect can be eliminated by adding catalyst,resulting the notably increased imidization *** optical and thermal properties can be improved to a certain extent for the chemically catalyzed system,resulting in relatively higher heat resistance and thermal *** the mechanical performance could be determined by com plicating factors,greatly different from polyimide films prepa red by high temperature *** investigate aggregation structures of film s,the effect of chain rigidity and catalyst on the stacking or orientation of molecular chains was further *** wo rk can contribute to the understanding of chemically catalyzed imidization that is rarely reported in the existing research,and will provide guidance for the low-temperature preparation of high-performance polyimides.

关键词： Polyimide Imidization Catalyst Structure and properties Aggregation structures

Special electromyographic features in a child with paramyotonia congenita: A case report and review of literature

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World Journal of Clinical Cases 2024年第3期12卷 587-595页

作者： hui Yi Chen-Xiang liu Shu-xin ye Yu-lin liu Department of Neuroelectrophysiology Qilu Children’s Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina Department of Neuroelectrophysiology University of Health and Rehabilitation Sciences(Qingdao Municipal Hospital)Qingdao 266000Shandong ProvinceChina

BACKGROUND Paramyotonia congenita(PMC)stands as a rare sodium channelopaty of skeletal muscle,initially identified by *** identification of PMC often relies on electromyography(EMG),a diagnostic *** child’s needle EMG unveiled trains of myotonic discharges with notably giant amplitudes,alongside irregular wave trains of myotonic *** distinctive observation had not surfaced in earlier *** SUMMARY We report the case of a 3-year-old female child with PMC,who exhibited la-ryngeal stridor,muffled speech,myotonia from ***,exposure to cool water,crying,and physical activity exacerbated the myotonia,which was relieved in warmth,yet never *** myotonia was observable in bilateral *** symptoms remained unchanged after potassium-rich food consumption like *** periodic paralysis was *** magnetic resonance imaging yielded normal *** potassium remained within normal range,while creatine kinase showed slight ***-wide genetic testing pinpointed a heterozygous mutation on chromosome SCN4A:c.3917G>A(p.G1306E).After a six-month mexiletine regimen,symptoms *** In this case revealed the two types of myotonic discharges,and had not been documented in other *** underscore two distinctive features:Giant-amplitude potentials and irregular waves.

关键词： Paramyotonia congenita Channelopathy Electromyography Child Case report

Characteristics of bioaerosols under high-ozone periods,haze episodes,dust storms,and normal days in Xi'an,China

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Particuology 2024年第7期90卷 140-148页

作者： Yiming Yang liu Yang Xiaoyan hu Zhenxing shen Department of Environmental Science and Engineering Xi’an Jiaotong UniversityXi’an710049China Key Lab of Aerosol Chemistry&Physics SKLLQGInstitute of Earth EnvironmentChinese Academy of SciencesXi’an710049China

The characteristics of bioaerosols and their effects on human beings'health have become a major public concern in the recent *** study compared the characteristics of bioaerosols under different types of pollution(high-ozone[HO]episodes,haze episodes,and dust storms[DSs]),with those of bioaerosols on normal days(NDs)in Xi'an,*** concentrations,diurnal variations,and size distribution of bacteria,fungi,and total airborne microbes(TAMs)were *** results showed that the bacterial and fungal concentrations were the highest during DSs and on NDs,reaching 425.2 and 956.9 colony-forming units/m^(3),*** concentration of TAMs was the highest during HO episodes,reaching 10.7×10^(6)cells/m^(3),which was significantly higher than that during the other *** maximum concentrations of bacteria and fungi during HO episodes were observed in the morning,while they appeared separately in the morning and evening during haze *** and TAMs during DSs reached peak concentrations in the morning and evening,which is opposite to the particulate matter(PM)distribution *** NDs,temperature and relative humidity had significant effects on *** size distributions of airborne bacteria exhibited bimodal patterns,whereas unimodal distributions were observed for *** mainly attached in fine particles(during haze episodes and DSs,respectively,which means that fungi were easily penetrated into the human respiratory *** evaluation of influence factors revealed that PM_(2.5) and PM10 had negative effects on fungal concentration during DSs,and ozone concentration and temperature were inversely correlated with fungal concentration during HO *** results provide valuable reference data for elucidating the formation and evolution of bioaerosols under different types of pollution.

关键词： Bacteria Fungi Total airborne microbe Different air pollution types Influence factors

NF-κB in biology and targeted therapy:new insights and translational implications

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1322-1358页

作者： Qing Guo Yizi jin xinyu Chen Xiaomin ye xin shen Mingxi lin Cheng Zeng Teng Zhou jian Zhang Department of Medical Oncology Fudan University Shanghai Cancer CenterNo.270Dong'an RoadShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina State Key Laboratory of Oncogenes and Related Genes Renj-Med-X Stem Cell Research CenterShanghai Cancer Institute&Department of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127PR China Department of Cardiology the First Affiliated Hospital of Sun Yat-Sen University58 Zhongshan 2nd RoadGuangzhou 510080China Department of Neurology Rujin HospitalShanghai JiaoTong University Schoolof MedicineShanghaiChina

NF-κB signaling has been discovered for nearly 40 ***,NF-κB signaling was identified as a pivotal pathway in mediating inflammatory ***,with extensive and in-depth investigations,researchers have discovered that its role can be expanded to a variety of signaling mechanisms,biological processes,human diseases,and treatment *** this review,we first scrutinize the research process of NF-κB signaling,and summarize the composition,activation,and regulatory mechanism of NF-κB *** investigate the interaction of NF-κB signaling with other important pathways,including PI3K/AKT,MAPK,JAK-STAT,TGF-β,Wnt,Notch,Hedgehog,and TLR *** physiological and pathological states of NF-κB signaling,as well as its intricate involvement in inflammation,immune regulation,and tumor microenvironment,are also ***,we illustrate how NF-κB signaling is involved in a variety of human diseases,including cancers,inflammatory and autoimmune diseases,cardiovascular diseases,metabolic diseases,neurological diseases,and ***,we discuss the therapeutic approaches targeting NF-κB signaling,including IKK inhibitors,monoclonal antibodies,proteasome inhibitors,nuclear translocation inhibitors,DNA binding inhibitors,TKls,non-coding RNAs,immunotherapy,and ***,we provide an outlook for research in the field of NF-κB *** hope to present a stereoscopic,comprehensive NF-κB signaling that will inform future research and clinical practice.

关键词： PI3K/AKT diseases involvement