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World Journal of Clinical Cases 2020年第2期8卷 377-381页

作者： You-Wen tan Yun ye Li Sun Department of Hepatology The Third Hospital of Zhenjiang Affiliated Jiangsu University

BACKGROUND Spinal metastasis of hepatocellular carcinoma(HCC) is rare, with an extremely poor prognosis and results in severe pain. Argon-helium cryotherapy is a local ablation method for *** SUMMARY A 54-year-old man was diagnosed with HCC related to hepatitis B one year ago and underwent surgical tumor resection and tenofovir antiviral ***, a new lesion developed on the right liver after 1 mo. Transarterial chemoembolization was performed four times. One month ago, the patient developed back pain, and metastasis on the 11 th thoracic vertebra was ***-helium cryoablation was performed to treat the right occupancy and metastatic lesion, which immediately alleviated the pain and prolonged *** The use of argon-helium cryoablation for thoracic vertebrae with metastasis of HCC achieved favorable results.

关键词： Cryoablation Metastasis Hepatocellular carcinoma Hepatitis B Case report

Characteristics of magnetic fabrics of Jiangshan-Shaoxing collision belt and its tectonic implications

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Chinese Science Bulletin 1999年第19期44卷 1819-1824页

作者： Zhongyue Shen Ying ye Dajun fang Xiaodong tan Zhejiang Univ Dept Earth Sci Hangzhou 310027 Peoples R China

The study of anisotropy of magnetic susceptibility (AMS) of rocks from the northern part of Jiangshan-Shaoxing collisional belt demonstrates that the minimum principal AMS axes are the most concentrated one in various types of rocks. The planar projection of the minimum axis shows that the main compressive stress lies on northwest 30°-60°, which trends domi-nantly in northwest-southeast of Chencai area and arc-like disperse towards both north

关键词： Jiangshan-Shaoxlng collision belt magnetic fabric paleomagnetism. Mesozoic.

Green Fluorescent Protein Recombinant Nisin as a Probe for Detection of Gram-Positive Bacteria

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Transactions of Tianjin University 2017年第4期23卷 334-339页

作者： Xiqian tan ye Han Huazhi Xiao Zhijiang Zhou School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

A great amount of foodborne pathogens were Gram-positive (G+) bacteria, a threat to public health. In this study, considering the binding ability of nisin towards G+ bacteria and the stable fluorescent ability of EGFP protein, a fluorescent nisin–EGFP protein probe was constructed by a gene engineering method. Nisin and EGFP were used as the receptor and fluorophore, respectively, to detect G+ bacteria. The nisin and egfp gene were amplified separately according to the sequence published in GenBank using unique primers. The two genes were cloned into a pET-28b(+) vector resulting in a pET-28b(+)–nisin–egfp vector. The vector was transferred into Escherichia coli (E. coli) BL21 (DE3) for expression. The expressed protein was extracted, purified by a Ni–NTA column, and then tested by the SDS-PAGE method to confirm its molecular weight. Listeria monocytogenes (L. monocytogenes), Staphylococcus aureus (S. aureus), and Micrococcus luteus (M. luteus) were used as the representations of G+ bacteria. E. coli O157, representing the gram-negative (G−) bacteria, was used as a negative control. The binding specificity of the recombinant protein was performed on two types of bacteria and then detected through fluorescent microscopy. The results indicated that the nisin–EGFP probe could detect G+ bacteria at 108CFU/mL. © 2017, Tianjin University and Springer-Verlag Berlin Heidelberg.

关键词： Antibiotics Bins Cloning Escherichia coli Fluorescence Genes Health risks Pathogens Probes Proteins Recombinant proteins

Synthesis and Properties of pH and Temperature Responsive Copolymer with Pesudorotaxane Structure

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Chemical Research in Chinese Universities 2012年第6期28卷 1101-1106页

作者： MA Qiang YANG Hui XU Wen-chao tan ye-bang Key Laboratory of Special Functional Aggregated Materials Ministry of EducationSchool of Chemistry and Chemical Engineering Shandong University Jinan 250100 P. R. China

pH and temperature responsive copolymers PNAM4VBCB of N-isopropyl acrylamide（NAM） and complex pseudorotaxane monomer N 1-（4-vinylbenzyl）-1,4-diaminobutane dihydrochloride with cucurbit[6]uril（CB[6]） threaded（4VBCB） were prepared via free-radical polymerization in aqueous *** copolymers were characterized by 1 H NMR,Fourier transform infrared（FTIR） spectrometry,elemental analysis,and static light *** thermodynamic properties of the copolymers were studied by thermogravimetric analysis（TGA）,and the effects of pH and the concentration of the copolymer on the average hydrodynamic radius（R h） were studied by dynamic light scattering（DLS）.In addition,the thermal sensitivities of the copolymers were studied by DLS and *** experiment data show that CB[6] beads are localized on 1,4-diaminobutane units in the side chains of the *** data show that thermal stability of the copolymers increases with the adding of CB[6] threaded because of the enhanced rigidity and the bulky steric hindrance of 4VBCB in the side chain of *** data show that the average hydrodynamic radius of copolymer increases with the increase of the copolymer concentration and has a jump with adjusting pH due to the existing of the small size CB[6] dethreaded from the copolymer with increasing *** pH and electrical conductivity curves of the solution of PNAM4VBCB-4 have a jump because CB[6] could dethread from the copolymers with the addition of *** addition,the copolymers have thermal sensitivity and their phase-change temperatures could be controlled by adjusting the molar ratio of NAM to 4VBCB in the copolymers.

关键词： Cucurbituril Thermal sensitivity Water soluble copolymer Polypseudorotaxane

Pediococcus Acidilactici Inhibit Biofilm Formation of Food-Borne Pathogens on Abiotic Surfaces

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Transactions of Tianjin University 2017年第1期23卷 70-77页

作者： Xiqian tan ye Han Huazhi Xiao Zhijiang Zhou School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

In this study, we aimed to examine the inhibitory effect of PA003, a Pediococcus acidilactici that produces lactic acid and antimicrobial peptides pediocin, on pathogenic biofilm formation on abiotic surfaces. PA003 and pathogens (Escherichia coli, Salmonella enterica serovar Typhimurium, Staphylococcus aureus and Listeria monocytogenes) were used to evaluate auto-aggregation, hydrophobicity, biofilm formation and biofilm formation inhibition on stainless steel, polyvinyl chloride and glass slides in terms of exclusion, displacement and competition. The results showed the highest auto-aggregation abilities were observed for one of the E. coli strains EAggEC (E58595) and the highest hydrophobic strain was observed with EPEC (E2348/69) (51.9%). The numbers of biofilm cells of E. coli, S. Typhimurium, S. aureus and L. monocytogenes on stainless steel, polyvinyl chloride and glass slide coupons were effectively reduced by approximately 4 log CFU/coupon. These results demonstrate that lactic acid bacteria can be used as an alternative to effectively control the formation of biofilms by food-borne pathogens. © 2016, Tianjin University and Springer-Verlag Berlin Heidelberg.

关键词： Bacteria Biofilms Enzyme inhibition Escherichia coli Glass Hydrophobicity Lactic acid Listeria Pathogens Polypeptides Polyvinyl chlorides Salmonella Stainless steel Strain

fabrication of homogeneously dispersed graphene/Al composites by solution mixing and powder metallurgy

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International Journal of Minerals,Metallurgy and Materials 2018年第1期25卷 102-109页

作者： Xiang Zeng Jie Teng Jin-gang Yu Ao-shuang tan Ding-fa Fu Hui Zhang School of Materials Science and Engineering Hunan University College of Chemistry and Chemical Engineering Hunan Provincial Key Laboratory of Efficient and Clean Utilization of Manganese ResourcesCentral South University

Graphene-reinforced aluminum （AI） matrix composites were successfully prepared via solution mixing and powder metallurgy in this study. The mechanical properties of the composites were studied using microhardness and tensile tests. Compared to the pure Al alloy, the graphene/Al composites showed increased strength and hardness. A tensile strength of 255 MPa was achieved for the graphene/Al com- posite with only 0.3wt% graphene, which has a 25% increase over the tensile strength of the pure Al matrix. Raman spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy were used to investigate the morphol- ogies, chemical compositions, and microstructures of the graphene and the graphene/A1 composites. On the basis of fractographic evidence, a relevant fracture mechanism is proposed.

关键词： graphene metal matrix composites solution mixing powder metallurgy mechanical properties

Deep adaptive control with online identification for industrial robots

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Science China(Technological Sciences) 2022年第11期65卷 2593-2604页

作者： SHEN tan QIAO XueChun DONG YunLong WANG YuRan ZHANG Wei YUAN ye School of Artificial Inteligence and Automation Huazhong University of Science and TechnologyWuhan 430074China Department of Mechanical and Energy Engineering Southerm University of Science and TechnologyShenzhen 518055China

Derivation of control equations from data is a critical problem in numerous scientific and engineering *** inverse dynamic control of robot manipulators in the field of industrial robot research is a key ***,researchers needed to obtain the robot dynamic model through physical modeling methods before developing ***,the robot dynamic model and suitable control methods are often elusive and difficult to tune,particularly when dealing with real dynamical *** this paper,we combine an enhanced online sparse Bayesian learning(OSBL)algorithm and a model reference adaptive control method to obtain a data-driven modeling and control strategy from data containing noise;this strategy can be applied to dynamical *** particular,we use a sparse Bayesian approach,relying only on some prior knowledge of its physics,to extract an accurate mechanistic model from the measured *** parameters are further identified from the modeling error through a deep neural network(DNN).By combining the identification model with a model reference adaptive control approach,a general deep adaptive control(DAC)method is obtained,which can tolerate unmodeled *** adaptive update law is derived from Lyapunov’s stability criterion,which guarantees the asymptotic stability of the ***,the Enhanced OSBL identification method and DAC scheme are applied on a six-degree-of-freedom industrial robot,and the effectiveness of the proposed method is verified.

关键词： industrial robots sparse Bayesian learning online identification adaptive control

Users Intention for Continuous Usage of Mobile News Apps:the Roles of Quality,Switching Costs,and Personalization

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Journal of Systems Science and Systems Engineering 2019年第1期28卷 91-109页

作者： Qiongwei ye Yumei Luo Guoqing Chen Xunhua Guo Qiang Wei Shuyan tan China Retail Research Center School of Economics and Management Tsinghua University Beijing 100084 China Business School Yunnan University of Finance and Economics Kunming 650032 China College of Business and Tourism Management Yunnan University Kunming 650091 China

Mobile news apps have emerged as a significant means for learning about latest news and trends. However, in light of numerous news apps and information overload, motivating users to adopt one app is a major concern for both the industry and academia. Therefore, considering the attributes of mobile news and the debate on switching costs in the Internet context, based on the expectation-confirmation model (ECM), this study suggests that switching costs still exist and have a significant moderating effect on user satisfaction and continuous usage of mobile news apps. Furthermore, the different influences of information quality, system quality and service quality on continuance intention, user satisfaction and switching costs are discussed, showing that quality of information has a significant impact on users’ continuous usage of mobile news apps through increasing perceived usefulness, whereas personalized service quality have stronger effects through increasing user satisfaction and switching costs.

关键词： Personalized recommendation switching costs mobile news apps expectation-confirmation model

Co-delivery of Andrographolide and Notch1-targeted siRNA to Macrophages with Polymer-based Nanocarrier for Enhanced Anti-inflammation

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Chinese Journal of Polymer Science 2018年第12期36卷 1312-1320页

作者： Teng Wu Min tan Heng-ye Gong Yong Wang Xin-Tao shuai PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat-Sen University Guangzhou 510275 China Center of Biomedical Engineering Zhongshan School of Medicine Sun Yat-sen University Guangzhou 510080 China

Chronic inflammatory responses induced by macrophages play a pivotal role in the progression of atherosclerosis. In the present study, a multifunctional nanocarrier based on poly（ethylene glycol）-block-poly（L-aspartic acid） grafted with diethylenetriamine, lysine and cholic acid （PEG-PAsp（DETA）-Lys-CA2） polymer was synthesized for co-delivery of andrographolide and siRNA targeting Notchl gene to alleviate the inflammatory response in macrophages. The nanocarrier exerted low cytotoxicity as well as high performance in drug/siRNA co-delivery. In vitro studies demonstrated the co-delivery of andrographolide and Notchl siRNA not only significantly inhibited lipopolysaccharide （LPS）-activated interleukin-6 （IL-6） and monocytes chemotactic protein 1 （MCP-1） expression as well as blocked nuclear factor-rd3 （NF-rd3） signal activation, but also interfered the Notchl gene expression and increased anti-inflammatory cytokines such as interleukin-10 （IL-10） and arginase-1 expression obviously in macrophages. These results suggested that the combination therapy based on Notchl siRNA and andrographolide co-delivered nanocarrier, i.e. suppressing the expression of proinflammatory cytokines while simultaneously increasing anti-inflammatory factors expression, be a feasible strategy for atherosclerosis treatment.

关键词： Macrophages Anti-inflamatory Andrographolide Notchl siRNA

Investigation on identification of structural anomalies from polluted data sets using an unsupervised learning method

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Frontiers of Structural and Civil Engineering 2024年第10期18卷 1479-1491页

作者： Junchen ye Zhixin ZHANG Ke CHENG Xuyan tan Bowen DU Weizhong CHEN School of Transportation Science and Engineering Beihang UniversityBeijing 100191China CCSE Lab Beihang UniversityBeijing 100191China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil Mechanics Chinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

Civil infrastructure is prone to structural damage due to high geo-stress and other natural disasters,so monitoring is *** collected by structural health monitoring(SHM)systems are easily affected by many factors,such as temperature,sensor fluctuation,sensor failure,which can introduce a lot of noise,increasing the difficulty of structural anomaly *** address this problem,this paper designs a new process of structural anomaly identification under noisy conditions and offers Civil Infrastructure Denoising Autoencoder(CIDAE),a denoising autoencoder-based deep learning model for SHM of civil *** a case study,the effectiveness of the proposed model is verified by experiments on deformation stress data of the Wuhan Yangtze River Tunnel based on finite element *** of the circumferential weld and longitudinal weld data of the case study is also *** is concluded that CIDAE is superior to traditional methods.

关键词： structural health monitoring deep learning anomaly detection