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Multiparameter magnetic resonance imaging of liver fibrosis in a bile duct ligation mouse model

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World Journal of Gastroenterology 2021年第47期27卷 8156-8165页

作者： Jia-Yi Liu Zhu-yuan Ding Zi-Yi Zhou Sheng-Zhen Dai Jie Zhang Hao Li Qiu Du ye-yu cai Quan-LiangShang Yong-Heng Luo En-Hua Xiao Department of Radiology The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Department of Emergency Medicine First People's Hospital of Changde CityChangde 415000Hunan ProvinceChina Department of Urology Hunan Provincial People's HospitalFirst Affiliated Hospital of Hunan Normal UniversityChangsha 410005Hunan ProvinceChina

BACKGROUND Bile duct ligation(BDL)in animals is a classical method for mimicking cholestatic *** different surgical techniques have been described in rats and rabbits,mouse models can be more cost-effective and reproducible for investigating cholestatic *** resonance imaging(MRI)has made great advances for noninvasive assessment of liver *** comprehensive liver fibrotic features of BDL on MRI are ***,the utility of multiparameter MRI to detect liver fibrosis in a BDL mouse model has not been *** To evaluate the correlation between the pathological changes and multiparameter MRI characteristics of liver fibrosis in a BDL mouse *** Twenty-eight healthy adult male balb/c mice were randomly divided into four groups:sham,week 2 BDL,week 4 BDL,and week 6 *** MRI sequences,included magnetic resonance cholangiopancreatography,T1-weighted,T2-weighted,T2 mapping,and pre-and post-enhanced T1 mapping,were performed after sham and BDL *** blood and liver tissue were collected after *** statistical analysis,Student’s t-test and Pearson’s correlation coefficient were *** Four mice died after BDL surgery;seven,six,five and six mice were included separately from the four *** intensities of liver parenchyma showed no difference on TI-and T2-weighted *** duct volume,ΔT1 value,T2 value,and the rate of liver fibrosis increased steadily in week 2 BDL,week 4 BDL and week 6 BDL groups compared with those in the sham group(P<0.01).Alanine aminotransferase and aspartate transaminase levels initially surged after surgery,followed by a gradual decline over *** correlations were found between bile duct volume(r=0.84),T2 value(r=0.78),ΔT1 value(r=0.62),and hepatic fibrosis rate(all P<0.01)in the BDL *** The BDL mouse model induces changes that can be observed on *** MRI parameters correlate with the hepatic fibrosis rate and allow for detec

关键词： Liver Fibrosis Magnetic resonance imaging Pathology Animal model Bile duct ligation

早熟苹果新品种“洛阳红”生长发育及产量研究

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安徽农业科学 2009年第35期37卷 17835-17836页

作者：叶玉彩河南省偃师市林业技术推广站河南偃师471900

[目的]探明早熟新品种"洛阳红"的产量及结果性能。[方法]以"美国8号"为CK,通过实地试验,研究了"洛阳红"的生长发育、成花及结果习性、产量。[结果]综合评价,"洛阳红"的生长发育、结果习性表现好,果实成熟率、萌芽率、成枝力、成花株数... 详细信息

[目的]探明早熟新品种"洛阳红"的产量及结果性能。[方法]以"美国8号"为CK,通过实地试验,研究了"洛阳红"的生长发育、成花及结果习性、产量。[结果]综合评价,"洛阳红"的生长发育、结果习性表现好,果实成熟率、萌芽率、成枝力、成花株数、坐果率较高,均优于"美国8号"。就产量而言,"洛阳红"产量大小年现象不明显,"美国8号"有大小年现象。[结论]"洛阳红"的结果习性及产量均优于"美国8号"。

关键词：洛阳红美国8号生长发育产量

Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 39-48页

作者： Peng Li Meifeng cai Shengjun Miao yuan Li yu Wang Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress *** investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution *** results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with *** is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and ***,there is no obvious relationship between the rock quality designation(RQD)and *** maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same *** addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

关键词： overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification

模拟放射性废树脂的沸石和特种水泥混合物固化

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原子能科学技术 2006年第3期40卷 288-291页

作者：李俊峰王建龙叶裕才清华大学核能与新能源技术研究院环境技术研究室北京100084

利用特种水泥（ASC）和沸石的混合物研究固化放射性废树脂的行为。实验比较了不同的沸石添加量对固化体抗压强度和Cs浸出率的影响，并从微观角度分析了沸石添加量对固化体结构的影响。结果表明：沸石的添加使针状结晶向片状结晶发展；1... 详细信息

利用特种水泥（ASC）和沸石的混合物研究固化放射性废树脂的行为。实验比较了不同的沸石添加量对固化体抗压强度和Cs浸出率的影响，并从微观角度分析了沸石添加量对固化体结构的影响。结果表明：沸石的添加使针状结晶向片状结晶发展；10％～20％的沸石添加量可大幅降低Cs的浸出率，而固化体抗压强度降低却很少。

关键词：模拟放射性废树脂沸石水泥固化

Life-Cycle Bearing Capacity for Pre-Stressed T-beams Based on Full-Scale Destructive Test

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Structural Durability & Health Monitoring 2025年第1期19卷 145-166页

作者： yushan ye Tao Gao Liankun Wang Junjie Ma Yingchun cai Heng Liu Xiaoge Liu China Construction Seventh Engineering Division Corp. Ltd.Zhengzhou450004China School of Water Conservancy and Transportation Zhengzhou UniversityZhengzhou450001China

To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams,destructive tests were conducted on full-scale pre-stressed concrete *** on the measurement and ana-lysis of beam deﬂection,strain,and crack development under various loading levels during the research tests,combined with the veriﬁcation coefﬁcient indicators speciﬁed in the codes,the veriﬁcation coefﬁcients of bridges at different stages of damage can be *** results indicate that the T-beams experience complete,incom-plete linear,and non-linear stages during the destructive test *** the complete linear elastic stage,both the deﬂection and bottom strain veriﬁcation coefﬁcients comply with the speciﬁcations,indicating a good structural load-bearing capacity no longer adheres to the code’s *** the non-linear stage,both coefﬁcients exhi-bit a sharp increase,resulting in a further decrease in the structure’s load-bearing *** to the pro-visions of the current code,the beam can be in the incomplete linear stage when both values fall within the code’s speciﬁed *** strain veriﬁcation coefﬁcient sourced from the compression zone at the bottom of theﬂange is not recommended for assessing the bridge’s load-bearing capacity.

关键词： Pre-stressed T-beams whole process destructive test bearing capacity veriﬁcation coefﬁcient

Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting ye Yan Sun Jing cai Fubing yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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无机纳滤膜处理低水平放射性废水的试验研究

环境科学 2006年第7期27卷 1334-1338页

作者：白庆中陈红盛叶裕才李俊峰牟旭凤曹文清华大学环境科学与工程系北京100084 清华大学核能技术设计研究院北京100084 海军工程设计研究局北京100841

选择相对分子质量2000～5000的水溶性聚丙烯酸钠作为无机纳滤膜处理主要含^90Sr、^137Cs、^60Co放射性核素的低水平放射性废水的辅助药剂．重点考察了非放模拟废水的pH值及聚丙烯酸钠投加量对废水中锶、铯、钴等稳定核素截留率及膜通量... 详细信息

选择相对分子质量2000～5000的水溶性聚丙烯酸钠作为无机纳滤膜处理主要含^90Sr、^137Cs、^60Co放射性核素的低水平放射性废水的辅助药剂．重点考察了非放模拟废水的pH值及聚丙烯酸钠投加量对废水中锶、铯、钴等稳定核素截留率及膜通量的影响，并就影响机理做了初步探讨．得到较优的试验条件为：pH值7～8，聚丙烯酸钠体积浓度不低于0．1％．在优化的条件下，进行实际放射性废水的处理试验．结果表明，聚丙烯酸钠辅助无机纳滤膜处理低水平放射性废水是可行的，对总β和总γ的净化率均达到95％左右，且可得到满意的膜通量．

关键词：无机膜纳滤聚丙烯酸钠低水平放射性废水

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聚合物辅助陶瓷膜处理重金属废水

膜科学与技术 2005年第6期25卷 45-50页

作者：陈红盛叶裕才白庆中李俊峰曹文清华大学环境科学与工程系北京100084 清华大学核能与新能源技术研究院北京100084 海军工程设计研究局北京100841

研究了用聚丙烯酸辅助的陶瓷膜分离技术处理含锶、铯、钴的重金属废水.重点探讨了聚丙烯酸与锶、铯、钴离子的质量浓度比P:M值和溶液pH对重金属离子截留率和膜通量的影响,得到了三种重金属离子的最佳P:M值:锶为10,铯为33.5,钴为18和最... 详细信息

研究了用聚丙烯酸辅助的陶瓷膜分离技术处理含锶、铯、钴的重金属废水.重点探讨了聚丙烯酸与锶、铯、钴离子的质量浓度比P:M值和溶液pH对重金属离子截留率和膜通量的影响,得到了三种重金属离子的最佳P:M值:锶为10,铯为33.5,钴为18和最适pH为6～7.结果显示,同时提高溶液中聚丙烯酸和三种重金属离子的浓度,并保持溶液中的P:M值不变,溶液中三种重金属离子截留率不受其进水浓度的影响.研究表明,在最佳P:M值和最适pH时,用聚丙烯酸辅助陶瓷膜分离技术处理含锶、铯、钴的重金属废水,废水中三种重金属离子的截留率分别为99.7%、95.1%和99.9%,实验结果表明用聚丙烯酸辅助可以大大提高陶瓷膜对重金属废水中锶、铯、钴的去除效率.

关键词：陶瓷膜重金属废水锶铯钴

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2006～2015年中国标准化研究回顾

标准科学 2016年第10期 17-21页

作者：蒙永业蔡郁对外经济贸易大学

本文以CNKI所收录2006-2015年发表于《中国标准化》杂志的标准化研究文献为语料,结合计算机可视化分析软件Cite Space,并结合传统的文献计量方法,从年度、研究机构、支持基金、高频关键词等方面考察这十年中国标准化研究的现状、热点及... 详细信息

本文以CNKI所收录2006-2015年发表于《中国标准化》杂志的标准化研究文献为语料,结合计算机可视化分析软件Cite Space,并结合传统的文献计量方法,从年度、研究机构、支持基金、高频关键词等方面考察这十年中国标准化研究的现状、热点及未来发展趋势。研究发现:(1)中国标准化研究院、中国兵器标准化研究所、国家标准化委员会等机构相互合作,在标准化研究中发挥着主要作用;(2)研究主要集中在标准体系、技术标准、行业标准以及具体领域国内外标准概述、对比等方面;(3)食品安全、通信技术、循环经济、智慧城市是标准化紧密结合的研究热点;(4)标准化研究从前期理论探索到如今借鉴国外先进经验,开始翻译中国标准英文版,推动中国标准走向国际舞台。

关键词：标准化研究中国标准化研究热点标准化文献回顾可视化分析