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Adjuvant hormone therapy after radical prostatectomy in highrisk localized and locally advanced prostate cancer: First multicenter, observational study in China

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Chinese Journal of Cancer Research 2019年第3期31卷 511-520页

作者： Dingwei ye Wei zhang Lulin Ma Chuanjun Du Liping Xie Yiran Huang qiang Wei zhangqun ye Yanqun Na Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Urology Jiangsu Province Hospital Nanjing 210029China Department of Urology Peking University Third HospitalBeijing 100191China Department of Urology the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China Department of Urology the First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003China Department of Urology Renji Hospital Shanghai Jiaotong University School of MedicineShanghai 200127China Department of Urology West China HospitalSichuan UniversityChengdu 610041China Department of Urology Tongji HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhan 430030China Department of Urology Peking University Shougang HospitalBeijing 100144China

Objective: Potential of combined androgen blockade(CAB) has not been explored extensively in Chinese males with prostate cancer(PCa). Therefore, this study evaluated the 2-year prostate-specific antigen(PSA) recurrence rate and quality of life(Qo L) in patients with high-risk localized and locally advanced PCa receiving adjuvant hormone therapy(HT) after radical prostatectomy(RP).Methods: This prospective, multicenter, observational study conducted in 18 centers across China enrolled patients with high-risk factor(preoperative PSA>20 ng/m L or Gleason score >7) or locally advanced PCa. Different adjuvant HT were administered after RP according to investigator’s decision in routine clinical *** of baseline and postoperative characteristics was assessed with recurrence rate. PSA recurrence rate and Functional Assessment of Cancer Therapy-Prostate(FACT-P) Qo L scores were recorded at 12 months and 24 months. Kaplan-Meier analysis was used to construct the PSA recurrence rate during ***: A total of 189 patients(mean age: 66.9±6.5 years) were recruited, among which 112(59.3%) patients showed serum PSA>20 ng/m L preoperatively. The highest postoperative pathological advancement noticed was from clinical T2(c T2) to pathological T3(p T3)(43.9%) stage. The majority of the patients(66.1%) received CAB as adjuvant HT, for a median duration of 20.0 months. The least recurrence(15.2%) was noticed in patients treated with CAB, followed by those treated with luteinizing hormone-releasing hormone agonist(LHRHa)(16.1%), and antiandrogen(19.0%), with non-significant difference noted among the groups. None of the baseline or postoperative characteristics was related with PSA recurrence in our study. The 24-month FACT-P Qo L score of119 patients treated for >12 months showed significant improvement above baseline compared with those treated for ≤12 ***: Adjuvant CAB therapy after RP showed reduction trend in 2-year PSA recurrence rate in

关键词： Adjuvant hormone therapy combined androgen blockade PSA recurrence quality of life radical prostatectomy

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A reconfigurable dynamic Bayesian network for digital twin modeling of structures with multiple damage modes

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Theoretical & Applied Mechanics Letters 2023年第4期13卷 251-260页

作者： Yumei ye qiang Yang Jingang zhang Songhe Meng Jun Wang Xia Tang School of Mechanical Technology Wuxi Institute of TechnologyWuxi 214121China National Key Laboratory of Science and Technology for National Defence on Advanced Composites in Special Environments Harbin Institute of TechnologyHarbin 150001China Beijing Institute of Astronautical Systems Engineering Beijing 100076China

Dynamic Bayesian networks(DBNs)are commonly employed for structural digital twin *** present,most researches only consider single damage mode *** is not sufficient for a reusable spacecraft as various damage modes may occur during its service life.A reconfigurable DBN method is proposed in this *** structure of the DBN can be updated dynamically to describe the interactions between different *** common damages(fatigue and bolt loosening)for a spacecraft structure are considered in a numerical *** results show that the reconfigurable DBN can accurately predict the acceleration phenomenon of crack growth caused by bolt loosening while the DBN with time-invariant structure cannot,even with enough *** definition of interaction coefficients makes the reconfigurable DBN easy to track multiple damages and be extended to more complex *** method also has a good physical interpretability as the reconfiguration of DBN corresponds to a specific *** predictions do not require precise knowledge of reconfiguration conditions,making the method more practical.

关键词： Dynamic Bayesian network Reusable spacecraft Damage Reconfiguration

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A thelytokous predatory mite is more cannibalistic towards distant kin

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Current Zoology 2023年第5期69卷 578-584页

作者： Keshi zhang Zhi-qiang zhang School of Biological Sciences University of Auckland3A Symonds StreetAuckland1072New Zealand and Manaaki Whenua-Landcare Research 231 Morrin RoadAuckland1072New Zealand

Kin recognition has been widely observed in various *** avoidance may be a strong driver for the evolution of kin recognition,as it may avoid a reduction in inclusive *** recognition has recently been observed in a generalist phytoseiid,Amblyseius herbicolus(Acari:Phytoseiidae).This study experimentally examined the degree of relatedness needed between prey larvae and cannibal adults of *** for the occurrence of kin *** adults were individually placed in enclosed arenas with two prey,a daughter and a more distant related larva,to observe their cannibalizing *** adults of *** did not discriminate between close relatives(daughter versus niece)but preferably cannibalized more distant kin(i.e.,first and second cousins once removed).Phenotype matching and familiarization seem prominent as recognition mechanisms used by *** *** effect of learning on kin recognition through prior contact in *** requires further *** on other adaptive functions of kin recognition of ***,such as cooperation and parental care,may provide meaningful insights.

关键词： Acari cannibalism choice test close kin discrimination kin recognition

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Synthesis, radiolabeling and biological evaluation of butene amine oxime containing nitrotriazole as a tumor hypoxia marker

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Nuclear Science and Techniques 2016年第2期27卷 35-43页

作者： qiang zhang Tai-Wei Chu Beijing National Laboratory for Molecular Sciences Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science College of Chemistry and Molecular Engineering Peking University

^(99m)Tc-BnAO, as a nonnitroaromatic hypoxia marker, is the subject of intensive research in recent years. In this study, a butene amine oxime–nitrotriazole(Bn AO–NT)was synthesized and radiolabeled with ^(99m)Tc in high *** uptakes of^(99m)Tc-Bn AO–NT and ^(99m)Tc-Bn AO were tested using murine sarcoma S180 and hepatoma H22 cell lines. The highest hypoxic cellular uptake of^(99m)TcBn AO–NT was 27.11 ± 0.73 and 14.85 ± 0.83 % for the S180 and H22 cell lines, respectively, whereas the normoxic cellular uptake of the complex was about 4–8 % for both cell lines. For^(99m)Tc-Bn AO, the highest hypoxic cellular uptake was 30.79 ± 0.44 and 9.66 ± 1.20 % for the S180 and H22 cell lines, respectively, while the normoxic cellular uptake was about 5 % for both cell lines. Both^(99m)Tc-Bn AO–NT and^(99m)Tc-Bn AO complexes showed hypoxic/normoxic differentials in the two cell lines, but the results were more significant for the S180 cell line. The in vitro results suggested that S180 may be better than H22 cell line in hypoxic biological evaluation of Bn AO complexes. The biodistribution study was tested using a S180 tumor model. The complex^(99m)Tc-Bn AO–NT showed a selective enrichment in tumor tissues: At 4 h, the tumor-to-muscle ratio was 3.79 ± 0.98 and the tumor-to-blood ratio was 2.31 ± *** with the results of ^(99m)Tc-Bn AO, the latter was at the same level. In vitro and in vivo studies demonstrated that ^(99m)Tc-Bn AO–NT could be a hypoxia-sensitive radiotracer for monitoring hypoxic regions in a sarcoma S180 tumor.

关键词：细胞缺氧肿瘤模型生物学评价标记合成胺肟丁烯 S180

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非厄米PT对称多通道光波导体系的调控及动力学

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原子与分子物理学报 2025年第1期42卷 108-117页

作者：孙武叶伏秋张光成吉首大学物理与机电工程学院吉首416000

宇称-时间(PARITY-TIME PT)对称光学波导系统中有关PT对称性的调控主要通过周期性变化的复折射率材料来实现.本文中我们给出了一种对于已耦合的双通道波导体系中额外引入周期调制的中性波导操纵PT对称性的构型,通过高频近似将系统转换... 详细信息

宇称-时间(PARITY-TIME PT)对称光学波导系统中有关PT对称性的调控主要通过周期性变化的复折射率材料来实现.本文中我们给出了一种对于已耦合的双通道波导体系中额外引入周期调制的中性波导操纵PT对称性的构型,通过高频近似将系统转换为重整化参数后的等效未调制系统后,发现可以通过额外引入单频周期调制的光波导去调控体系的PT对称性,并且讨论了周期调制的非厄米三通道波导体系的能谱特性.最后通过解析和数值的方法给出了光在非厄米三通道光学波导中的动力学演化.

关键词： PT对称非厄米三通道波导

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Chemical characteristics of aerosol particles (PM_(2.5)) at a site of Horqin Sand-land in northeast China

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Journal of Environmental Sciences 2006年第4期18卷 701-707页

作者： SHEN Zhen-xing CAO Jun-ji LI Xu-xiang WANG Ya-qiang JIE Dong-mei zhang Xiao-ye Department of Environmental Science and Engineering Xi＇an Jiaotong University Xi＇an 710049 China SKLLQG Institute of Earth Environment Chinese Academy of Sciences Xi＇an 710075 China Chinese Academy of Meteorological Sciences Beijing 100081 China Urban and Environment Science College Northeast Normal University Changchun 130024 China

The objective of this study was to characterize the mass concentration and chemical composition of aerosol particles（PM2.5） collected at Tongliao（Inner Mongolia Autonomous Region, China）, a site in Horqin Sand-land in northeast China. During spring 2005, the mass concentration for PM2.5 was （126±71）μg/m^3 in average. Five dust storm events were monitored with higher concentration of （255 ± 77）μg/m^3 in average than the non dusty days of （106 ± 44）μg/m^3. Concentrations for 20 elements were obtained by the PIXE method. Mass concentrations of ALl, Mg, Si, K, Ca, Ti, Mn, and V, which increased with the PM2.5 concentration, were higher than the pollution elements （S, Cl, Zn, Ar, Se, Br, and Pb）. Enrichment factor relative to crust material was also calculated, which showed dust trace elements were mainly from earth upper crust and pollution elements were dominated the anthropogenic aerosols. The Si/Al, Ca/Al, and Fe/Al ratios in PM2.5 samples at Tongliao were 4.07, 0.94, and 0.82, respectively, which were remarkably different with those on other source regions, such as ＂Western desert source region＂, ＂North desert source region＂ and central Asia source. Air mass back-trajectory analysis identified three kinds of general pathways were associated with the aerosol particle transport to Tongliao, but have the similar elemental ratios, implying that elemental signatures for dust aerosol from Horqin Sand-land were different with other regions.

关键词： dust aerosol mass concentration elemental composition transport pathway

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One stone two birds:Dual-effect kinetic regulation strategy for practical lithium–sulfur batteries

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Journal of Energy Chemistry 2022年第2期31卷 302-303页

作者： Xi-Yao Li qiang zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

Lithium–sulfur(Li–S)batteries are deemed as one of the most promising energy storage systems due to their ultrahigh theoretical energy density of 2600 Wh kg^(-1) far beyond the current lithium-ion battery technique[1].

关键词： battery lithium Dual

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Solution-processed lead-free bulk 0D Cs3Cu2I5 single crystal for indirect gamma-ray spectroscopy application

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Photonics Research 2021年第3期9卷 351-356页

作者： qiang Xu Juan Wang Qindong zhang Xiao Ouyang Maheng ye Weiting Xie Xuewen Yan Deyuan Li Xiaoping Ouyang Xiaobing Tang Xiaodong zhang Department of Nuclear Science and Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China Shaanxi Engineering Research Center of Controllable Neutron Source School of ScienceXijing UniversityXi'an 710123China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China China Institute for Radiation Protection Taiyuan 030012China Northwest Institute of Nuclear Technology Xi'an 710024China

Bulk scintillators that are with high density,low cost,and fine pulse-height energy spectral resolution,and are nonhygroscopic and user friendly,are desired for high-energy gamma-ray spectroscopy ***,low-cost solution-processed perovskite nanoscintillators have been demonstrated with outstanding performances for indirect low-energy X-ray detection;however,the stability and thickness are not suitable for high-energy gamma-ray ***,we report scintillation performances of a low-cost solution-processed bulk 0D Cs3Cu2I5 single *** self-trapped exciton emission results in a large Stokes shift (109 nm) that is reabsorption free.A broad X-ray excited emission matches well with the sensitivity of a silicon *** unique Cs+ surrounded isolated [Cu2I5]3-cluster scintillator provides ultra-stability in air and strong radiation hardness under high-dose gammaray exposure from a 60Co *** solution-processed Cs3Cu2I5 scintillator is expected with low-cost and has detection performances comparable to commercial alkali-halide scintillator products.

关键词： spectroscopy stability crystal

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miR-206 Inhibits Renal Cell Cancer Growth by Targeting GAK

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2016年第6期36卷 852-858页

作者： Chao WEI Shen WANG zhang-qun ye Zhi-qiang CHEN Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Renal cell cancer(RCC)remains one of the most lethal types of cancer in *** RNAs(mi RNAs)play key roles in the pathogenesis of *** role of mi R-206 in RCC has not been fully *** purpose of this study was to examine the role of mi R-206 in the regulation of proliferation and metastasis of RCC and the possible *** R-206 expression was detected by reverse transcription?quantitative polymerase chain reaction(RT-q PCR)in RCC cell lines(786-O and OS-RC-2 cells)and clinical ***[3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium]method,colony formation and transwell assay were used to detect the tumor-suppressing ability of mi R-206 in *** assay was performed to verify the precise target of mi *** results showed that the expression of mi R-206 was significantly down-regulated in RCC tissues and *** expression level of cyclin G-associated kinase(GAK),a master regulator of tumor proliferation and metastasis,was up-regulated with the decrease in mi R-206 in RCC tissues as well as RCC cell *** addition,the mi R-206 inhibitor promoted the proliferation,migration and invasion of 786-O and OS-RC-2 *** combined with luciferase and Western blot assays revealed that mi R-206 inhibited the expression of ***,mi R-206 regulates RCC cell growth partly through targeting *** study indicated that mi R-206 functions as a tumor suppressor in regulating the proliferation,migration and invasion of RCC by directly targeting GAK,and it holds promises as a potential therapeutic target for RCC.

关键词： miR-206 renal cell cancer G-associated kinase

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Effects and Mechanism of Action of Artemisinin on Mitochondria of Plasmodium berghei

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Chinese Journal of Integrative Medicine 2020年第4期26卷 277-282页

作者： HOU Hong-ping zhang Guang-ping MA Li-na SU Ping zhang Zhong-xiu DAI Bao-qiang ye Zu-guang Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing(100700)China

Objective:To study the antimalarial effects and mechanisms of artemisinin(Qinghaosu in Chinese,QHS)on mitochondria in mice infected with Plasmodium ***:A total of 108 C57 mice infected with Plasmodium berghei were randomly divided into 3 groups by weight:the control group,200 and 400 mg/kg QHS *** two QHS treatment groups were further divided into 4 sub-groups with 12 animals each time according to the treatment time,0.5,1,2,and 4 *** saline was intragastrically(i.g.)administered to the control *** other two groups received different doses of QHS by *** were treated once with QHS for different detection time as follows:0.5,1,2,and 4 *** mitochondrial energy metabolism,oxidative damage,membrane potential,and membrane permeability and other indexes were ***:After administration of 200 and 400 mg/kg QHS,adenosine triphosphate(ATP)levels in Plasmodium and its mitochondria were reduced(P<0.05),the levels of reactive oxygen species(ROS)and malondialdehyde(MDA)were in creased(P<0.05),and the activity of superoxide dismutase(SOD)was also increased(P<0.05).At the same time,the membrane potential of the mitochondria was reduced and the degree to which the membrane permeability transition pore was ope ned was irreversibly in creased(P<0.05).Conclusions:Mitoch on dria in Plasmodium were the targets of QHS,which can adversely affect mitochondrial energy metabolism,oxidative damage,membrane potential,and membrane opening,and ultimately exert an antimalarial effect.

关键词： Qinghaosu Clinese medicine Plasmodium mitochondria antimalarial effect

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