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Prediction of risk factors for lymph node metastasis in early gastric cancer

World Journal of Gastroenterology 2013年第20期19卷 3096-3107页

作者： Gang Ren Rong Cai Wen-Jie Zhang jin-Ming Ou ye-ning jin Wen-Hua Li Department of Radiology Xinhua HospitalShanghai Jiaotong University Medical School Department of Radiochemotherapy Ruijin HospitalShanghai Jiaotong University Medical School Department of Surgery Xinhua HospitalShanghai Jiaotong University Medical School

AIM:To explore risk factors for lymph node metastases in early gastric cancer(EGC) and to confirm the appropriate range of lymph node ***:A total of 202 patients with EGC who underwent curative gastrectomy with lymphadenectomy in the Department of Surgery,Xinhua Hospital and Ruijin Hospital of Shanghai Jiaotong University Medical School between November 2003 and July 2009,were retrospectively *** the surgical procedure and the extent of lymph node dissection were based on the recommendations of the Japanese gastric cancer treatment *** macroscopic type was classified as elevated(type Ⅰ or Ⅱa),flat(Ⅱb),or depressed(Ⅱc or Ⅲ).Histopathologically,papillary and tubular adenocarcinomas were grouped together as differentiated adenocarcinomas,and poorly differentiated and signet-ring cell adenocarcinomas were regarded as undifferentiated *** and multivariate analyses of lymph node metastases and patient and tumor characteristics were ***:The lymph node metastases rate in patients with EGC was 14.4%.Among these,the rate for mucosal cancer was 5.4%,and 8.9% for submucosal *** analysis showed an obvious correlation between lymph node metastases and tumor location,depth of invasion,morphological classification and venous invasion(χ 2 = 122.901,P = 0.001;χ 2 = 7.14,P = 0.008;χ 2 = 79.523,P = 0.001;χ 2 = 8.687,P = 0.003,respectively).In patients with submucosal cancers,the lymph node metastases rate in patients with venous invasion(60%,3/5) was higher than in those without invasion(20%,15/75)(χ 2 = 4.301,P = 0.038).Multivariate logistic regression analysis revealed that the depth of invasion was the only independent risk factor for lymph node metastases in EGC [P = 0.018,Exp(B) = 2.744].Among the patients with lymph node metastases,29 cases(14.4%) were at N1,seven cases were at N2(3.5%),and two cases were at N3(1.0%).Univariate analysis of variance revealed a close relationship between the dep

关键词： Gastric neoplasm Lymph node metastasis Risk factors Gastrectomy Lymphadenectomy

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Lymph node metastasis in gastric cardiac adenocarcinoma in male patients

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World Journal of Gastroenterology 2013年第37期19卷 6245-6257页

作者： Gang Ren Ying-Wei Chen Rong Cai Wen-Jie Zhang Xiang-Ru Wu ye-ning jin Department of Radiology Xin Hua HospitalShanghai Jiaotong University Medical School Department of Gastroenterology Xin Hua HospitalShanghai Jiaotong University Medical School Department of Radiochemotherapy Rui Jin HospitalShanghai Jiaotong University Medical School Department of Surgery Xin Hua HospitalShanghai Jiaotong University Medical School Department of Pathology Xin Hua HospitalShanghai Jiaotong University Medical School

AIM:To reveal the clinicopathological features and risk factors for lymph node metastases in gastric cardiac adenocarcinoma of male ***:We retrospective reviewed a total of 146male and female patients with gastric cardiac adenocarcinoma who had undergone curative gastrectomy with lymphadenectomy in the Department of Surgery,Xin Hua Hospital and Rui jin Hospital of Shanghai Jiaotong University Medical School between November2001 and May *** the surgical procedure and extent of lymph node dissection were based on the recommendations of Japanese gastric cancer treatment *** and multivariate analyses of lymph node metastases and the clinicopathological features were ***:The rate of lymph node metastases in male patients with gastric cardiac adenocarcinoma was72.1%.Univariate analysis showed an obvious correlation between lymph node metastases and tumor size,gross appearance,differentiation,pathological tumor depth,and lymphatic invasion in male *** logistic regression analysis revealed that tumor differentiation and pathological tumor depth were the independent risk factors for lymph node metastases in male *** was an obvious relationship between lymph node metastases and tumor size,gross appearance,differentiation,pathological tumor depth,lymphatic invasion at pN1and pN2,and nerve invasion at pN3in male *** were no significant differences in clinicopathological features or lymph node metastases between female and male ***:Tumor differentiation and tumor depth were risk factors for lymph node metastases in male patients with gastric cardiac adenocarcinoma and should be considered when choosing surgery.

关键词： Gastric neoplasm Lymph node metastasis Risk factors Gastrectomy Lymphadenectomy

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Serum transforming growth factor-β1 level reflects disease status in patients with esophageal carcinoma after radiotherapy

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World Journal of Gastroenterology 2007年第39期13卷 5267-5272页

作者： Su-Ping Sun ye-ning jin Hong-Peng Yang Yi Wei Zhao Dong Department of Radiation Oncology Xuzhou Third Hospital and Xuzhou Cancer Hospital- Affiliated Hospital of Jiangsu University Xuzhou 221005 Jiangsu Province China Department of Radiation Oncology Ruijin Hospital Shanghai 200025 China Department of Radiation Oncology Changhai Hospital Shanghai 200433 China

AIM: To evaluate the relationship between changes in serum transforming growth factor β1 (TGFβ1) level and curative effect of radiotherapy (RT) in patients with esophageal carcinoma. METHODS: Ninety patients with histologically confi rmed esophageal carcinoma were enrolled. Serum samples for TGFβ1 analysis were obtained before and at the end of RT. An enzyme-linked immunosorbent assay was used to measure serum TGFβ1 level. Multivariate analysis was performed to investigate the relationship between disease status and changes in serum TGFβ1 level. RESULTS: Serum TGFβ1 level in patients with esophageal carcinoma before RT was signifi cantly higher than that in healthy controls (P years was 48.28% (42/87), 19.54% (17/87) and 12.64% (11/87), respectively. Main causes of death were local failure and regional lymph node metastasis. In patients whose serum TGFβ1 level decreased after RT, the survival rate at 1, 3 and 5 years was 61.02% (36/59), 28.81% (17/59) and 18.64% (11/59), respectively. The survival rate at 1 year was 17.86% (5/28) in patients whose serum TGFβ1 level increased after RT, and all died within 18 mo (P < 0.01). CONCLUSION: Serum TGFβ1 level may be a useful marker for monitoring disease status after RT in patients with esophageal carcinoma.

关键词： Esophageal carcinoma Prognosis Radio-therapy TGFβ1

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Clinical effects of phospholipase D2 in attenuating acute pancreatitis

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World Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： jin-Wei Niu Guo-Chao Zhang Wu ning Hai-Bin Liu Hua Yang Chao-Feng Li Department of General Surgery China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute *** To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute *** The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)*** data was collected for each *** blot analysis assessed PLD2 protein expression in patient ***-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil *** levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent *** migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil *** Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(P<0.05).The expression level of PLD2 in the moderate group was also lower than that in the mild group(P<0.05).The severity of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumo

关键词： Phospholipase D2 Neutrophil migration Acute pancreatitis Retrospective analysis Inflammatory response

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肠内营养制剂在直肠癌根治术前肠道准备中的应用

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中华胃肠外科杂志 2013年第11期16卷 1059-1062页

作者：陈剑辉叶锦宁宋武何裕隆中山大学附属第一医院胃肠胰外科广州510080

目的探讨直肠癌手术前使用肠内无渣整蛋白营养制剂替代传统机械肠道准备的可行性与安全性。方法前瞻性入组2011年6月至2012年3月间在中山大学附属第一医院胃肠胰外科行Dixon手术的直肠癌患者．采用完全随机1：1配对方法，将入组患者分... 详细信息

目的探讨直肠癌手术前使用肠内无渣整蛋白营养制剂替代传统机械肠道准备的可行性与安全性。方法前瞻性入组2011年6月至2012年3月间在中山大学附属第一医院胃肠胰外科行Dixon手术的直肠癌患者．采用完全随机1：1配对方法，将入组患者分为试验组和对照组．每组各30例。试验组患者术前连续3d口服无渣整蛋白肠内营养制剂，不行机械肠道准备：对照组术前口服泻药行机械肠道准备。比较两组患者术中及术后一般情况、肠道清洁程度、术后并发症及营养状况。结果两组患者的临床病理特征的差异均无统计学意义（均P〉0．05）。两组患者肠道清洁情况、手术时间、术中出血量及术后住院时间的差异均无统计学意义（均P〉0．05）；但试验组较对照组患者术后肛门排气时间[（2．53±0．91）d比（3．03±0．68）d，P〈0．05]和半流饮食时间[（3．95±0．83）d比（4．52±1．14）d，P〈0．05]明显缩短。两组均无围手术期死亡患者，术后并发症发生率的差异无统计学意义[16．7％（5／30）比20．0％（6／30），P〉0．05]。两组患者术后总蛋白、白蛋白及前白蛋白水平较术前明显下降（均P〈0．05）；但试验组较对照组患者白蛋白[（36．2±2．5）g／L比（33．5±2．6）g／L，P〈0．01]和前白蛋白[（325．4±28．2）mg／L比（302．5±34．2）mg／L，P〈0．01]水平明显升高。结论直肠癌患者术前服用肠内营养制剂以代替术前机械肠道准备，其清肠效果并不劣于传统方法，亦不增加手术风险，并能有效促进术后肠道功能恢复，改善患者术后营养状况。

关键词：直肠肿瘤外科手术肠道准备肠内营养

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Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi ye Runqing Liu Hangxing Wang Aizhen Zuo Cen jin Nan Wang Huiqi Sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

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Predictive value of a constructed artificial neural network model for microvascular invasion in hepatocellular carcinoma:A retrospective study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 88-100页

作者： Hai-Yang Nong Yong-Yi Cen Shan-jin Lu Rui-Sui Huang Qiong Chen Li-Feng Huang Jian-ning Huang Xue Wei Man-Rong Liu Lin Li Ke Ding Department of Radiology The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Radiology Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research Center for Hepatobiliary Diseases Affiliated Hospital of Youiiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Hepatobiliary Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina

BACKGROUND Microvascular invasion(MVI)is a significant risk factor for recurrence and metastasis following hepatocellular carcinoma(HCC)***,there is a paucity of preoperative evaluation approaches for *** To investigate the predictive value of texture features and radiological signs based on multiparametric magnetic resonance imaging in the non-invasive preoperative prediction of MVI in *** Clinical data from 97 HCC patients were retrospectively collected from January 2019 to July 2022 at our *** were classified into two groups:MVI-positive(n=57)and MVI-negative(n=40),based on postoperative pathological *** correlation between relevant radiological signs and MVI status was ***4.6 software and the mutual information method were employed to identify the top 10 dominant texture features,which were combined with radiological signs to construct artificial neural network(ANN)models for MVI *** predictive performance of the ANN models was evaluated using area under the curve,sensitivity,and *** models with relatively high predictive performance were screened using the DeLong test,and the regression model of multilayer feedforward ANN with backpropagation and error backpropagation learning method was used to evaluate the models’*** The absence of a pseudocapsule,an incomplete pseudocapsule,and the presence of tumor blood vessels were identified as independent predictors of HCC *** ANN model constructed using the dominant features of the combined group(pseudocapsule status+tumor blood vessels+arterial phase+venous phase)demonstrated the best predictive performance for MVI status and was found to be automated,highly operable,and very *** The ANN model constructed using the dominant features of the combined group can be recommended as a noninvasive method for preoperative prediction of HCC MVI status.

关键词： Hepatocellular carcinoma Texture analysis Magnetic resonance imaging Microvascular invasion Pseudocapsule Tumor blood vessels

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Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai Li Zhen Ma jin-Hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

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术后胃瘫的治疗进展

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消化肿瘤杂志（电子版） 2018年第3期10卷 134-139页

作者：李广华叶锦宁王昭何裕隆中山大学附属第一医院胃肠外科中心广东广州510080 中山大学附属第七医院胃肠外科广东深圳518000

术后胃瘫延长住院时间、增加医疗费用并造成很多不良后果。对胃正常生理运动功能的研究有助于指导术后胃瘫的治疗。很多机制参与术后胃瘫的发生发展,如神经-化学因素、炎症反应、阿片类麻醉药物、部分胃切除、补液过多、低血压和缩血管... 详细信息

术后胃瘫延长住院时间、增加医疗费用并造成很多不良后果。对胃正常生理运动功能的研究有助于指导术后胃瘫的治疗。很多机制参与术后胃瘫的发生发展,如神经-化学因素、炎症反应、阿片类麻醉药物、部分胃切除、补液过多、低血压和缩血管药物等等。术后胃瘫治疗应采取综合性的治疗,包括术前、术中和术后的一系列预防性措施。针对性治疗主要是药物治疗,目前新的治疗方法如内镜下内毒素及支架治疗、胃电起搏治疗的效果尚需进一步研究。腔镜下幽门成形术可用来治疗内科保守治疗无效的胃瘫。而以经口内镜下胃幽门肌切开术(gastric peroral endoscopic pyloromyotomy, G-POEM)为代表的微创治疗在难治性胃瘫中的作用日益受到推崇。

关键词：术后胃瘫功能性解剖药物治疗内毒素胃电起搏 G-POEM

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MECHANICAL PROPERTIES AND INTERFACIAL STRUCTURES OF ALUMINIUM BORATE WHISKER REINFORCED ALUMINIUM COMPOSITES

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Acta Metallurgica Sinica(English Letters) 1993年第12期6卷 465-471页

作者： PAN jin ning Xiaoguang HU Kuiyi ye Hengqiang Changsha Institute of Technology ChangshaChina Laboratory of Atomic Imaging of Solids Institute of Metal ResearchAcademia SinicaShenyangChina

Quality 9Al_2O_3-2B_2O_3 whisker reinforced 6061Al or Al composites have been prepared by technique of squeeze *** mechanical properties of the 9Al_2O_3·2B_2O_3(w)/6061Al composites could be hardly improved by T6 treatment,owing to cause the remarkable interracial *** observation under high resolution trans- mission electron microscope on interfaces shows that the serious chemical reaction occurs and the product is Al_2MgO_*** no such reaction is found at the interfaces of 9Al_2O_3. 2B_2O_3(w)/Al *** analysis on the interfaces shows that above mentioned interracial reaction may be resulted from the interracial segregation of Mg atoms in 6061Al matrix during sequeeze casting.

关键词： aluminium borate whisker Al matrix composite strength interracial structure

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