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Risk assessment of fault reactivation considering the heterogeneity of friction strength in the BZ34-2 Oilfield,Huanghekou Sag,Bohai Bay Basin,China

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Petroleum Science 2023年第5期20卷 2695-2708页

作者： ye-jun jin Ling-Dong Meng Ding-You Lyu Xiao-Fei Fu Jiang-Bo Huang Si-Jia Cao Jian-Da Li School of Earth Sciences Northeast Petroleum UniversityDaqing 163318HeilongjiangChina Key Laboratory of Oil&Gas Reservoir and Underground Gas Storage Integrity Evaluation of Heilongjiang Province Northeast Petroleum UniversityDaqing 163318HeilongjiangChina Bohai Rim Energy Research Institute Northeast Petroleum UniversityQinhuangdao066004HebeiChina CNOOC Tianjin Company Tianjin 300459China

The hazards of fault reactivation caused by fluid injection are a growing ***,traditional evaluation methods of fault stability are likely to underestimate the risk in fault segments with a high clay ***,an extended evaluation method of fault stability(ECPP)incorporating the heterogeneity in friction strength caused by variation in the clay content within the fault zone is established in this *** characterizing the current stress field of the BZ34-2 Oilfield in the Huanghekou Sag,Bohai Bay Basin,the reactivation potential of faults is evaluated using both traditional and ECPP *** evaluation of fault stability shows that all faults are stable in the present stress *** oriented ENE have a relatively high *** maximum sustainable fluid pressure Δp is approximately 8.8-8.9 MPa and 9.3-9.9 *** considering the heterogeneity in fault friction strength,the fault stability is clearly controlled by the clay content of the *** high-risk fault segments assessed using traditional methods are no longer obvious,which reflects the importance of incorporating friction strength heterogeneity in the process of fault ***,the results also show that most fault segments are activated when the fault zone is dominated by montmorillonite,reflecting the strong influence of clay mineral types on fault *** factors influencing the heterogeneity of fault friction strength are very complicated in actual ***,future work should focus on establishing a database through a large number of experiments and investigating the relationship between the friction coefficient and the main controlling factors.

关键词： Faultreactivation In-situ stress Strength heterogeneity of fault friction Huanghekou Sag

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Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin Zheng Zi-Yu ye jun-Ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum jun Kim Seungyon Koh Hyo jin Cho Xuelian jin Byung Gon Kim jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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电磁阀性能测试脉冲电源的设计

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自动化与仪表 2010年第4期25卷 57-60页

作者：章泰周凤星叶进军武汉科技大学冶金自动化及检测技术教育部工程研究中心武汉430081

为了测试电磁阀在各种工作状态下(即在不同的输入脉冲供电的情况下)的性能,研制了一种模拟电磁阀工作状态的PWM脉冲电源。该电源依靠CPLD构成数字PWM发生器,由单片机控制,具有短路保护和浪涌保护功能。系统软件部分以模块化的方式实现,... 详细信息

为了测试电磁阀在各种工作状态下(即在不同的输入脉冲供电的情况下)的性能,研制了一种模拟电磁阀工作状态的PWM脉冲电源。该电源依靠CPLD构成数字PWM发生器,由单片机控制,具有短路保护和浪涌保护功能。系统软件部分以模块化的方式实现,能够连续地输出不同的PWM脉冲。目前,该电源已经在武汉东江阀业有限公司投入使用。

关键词：测试脉冲电源数字PWM 保护设计模块化

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杉木全同胞家系的遗传分析及重要树冠因子的筛选

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西北林学院学报 2020年第3期35卷 68-74,89页

作者：齐明王海蓉叶金俊何贵平中国林业科学研究院亚热带林业研究所浙江富阳311400 浙江省林木育种技术研究重点实验室浙江富阳311400 浙江省遂昌县林业技术推广总站浙江遂昌323300

通过对5年生杉木6×6全双列杂交(GriffingⅢ)试验林的调查与分析,研究杉木若干性状的遗传与变异规律,并筛选决定理想株型的重要树冠结构因子,为杂交育种和杉木理想株型无性系选育提供科学依据。运用转化分析法来处理不平衡试验数据,结... 详细信息

通过对5年生杉木6×6全双列杂交(GriffingⅢ)试验林的调查与分析,研究杉木若干性状的遗传与变异规律,并筛选决定理想株型的重要树冠结构因子,为杂交育种和杉木理想株型无性系选育提供科学依据。运用转化分析法来处理不平衡试验数据,结合配合力分析法、相关分析法和通径分析法,研究杉木遗传变异、基因作用方式和重要树冠因子的选择。通过对杉木若干性状进行研究,获得了不同性状遗传变异大小。结果表明,杉木材积、枝下高和饱满度等性状具有中度遗传变性,树高、胸径具有窄的遗传变异性,同时杉木改良性状具有中度以上的遗传力,因此杉木生长形质性状宜采用连续多世代改良;在杉木生长、形质性状和树冠结构性状中,12个研究性状有8个重要性状的基因作用方式以非加性遗传基因效应为主,杉木高世代育种亲本是多世代与高强度选择的产物,杂合体居多,杉木的多性状、高世代遗传改良以杂交育种为主;生长、形质和树冠结构性状间具有明显的遗传相关性,通径分析揭示:决定杉木理想株型育种中重要树冠结构性状是冠形率和树冠表面积大小。由此可见:杉木多性状、多世代连续改良以杂交育种为主,杉木无性系理想株型选择时,应注重冠形率和树冠表面积的作用。

关键词：杉木双列杂交遗传变异性基因作用方式遗传相关

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Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi ye Runqing Liu Hangxing Wang Aizhen Zuo Cen jin Nan Wang Huiqi Sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

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胰腺炎微循环障碍加重过程中血管内皮生长因子的表达及意义

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中国现代普通外科进展 2012年第9期15卷 679-682页

作者：叶进军戴璟瑜深圳市龙岗中心医院普外科广东深圳518116

目的:探讨在胰腺炎微循环障碍加重的过程中,血管内皮生长因子(VEGF)的表达情况及其意义。方法:选取实验用大鼠共30只,其中15只大鼠处理为急性水肿型胰腺炎(AEP),另外15只大鼠则处理为胰腺炎微循环障碍加重后的急性坏死型胰腺炎(ANP),测... 详细信息

目的:探讨在胰腺炎微循环障碍加重的过程中,血管内皮生长因子(VEGF)的表达情况及其意义。方法:选取实验用大鼠共30只,其中15只大鼠处理为急性水肿型胰腺炎(AEP),另外15只大鼠则处理为胰腺炎微循环障碍加重后的急性坏死型胰腺炎(ANP),测量2组大鼠血清中VEGF的含量,检测VEGF在胰腺组织中的表达情况,同时将胰腺置于光学显微镜下,观察病理改变。结果:2组血清中均有较高的VEGF含量,ANP组高于AEP组(P<0.05);ANP组大鼠胰腺组织中的VEGF表达明显升高,与AEP组相比差异有统计学意义(P<0.01);光学显微镜下观察2组大鼠的胰腺组织,AEP组间质充血,存在坏死的腺泡灶,而ANP组则出现间质的出血,腺泡灶也存在大范围的坏死,同时大量红细胞沉积,坏死更加明显。结论:在胰腺炎微循环障碍加重之后,VEGF出现明显的高表达,在临床上可以作为疾病加重的指标之一。

关键词：胰腺炎微循环障碍症状加重血管内皮生长因子

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腹腔镜完全腹膜外双侧腹股沟疝修补术中留置负压引流管预防术后血清肿的临床体会

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腹腔镜外科杂志 2018年第12期23卷 931-933,939页

作者：辛乐叶进军阎玉矿深圳市龙岗中心医院广东深圳518116

目的:探讨腹腔镜完全腹膜外双侧腹股沟疝修补术(TEP)中留置负压引流管预防术后血清肿的应用价值。方法:回顾分析2013年1月至2016年12月为115例双侧腹股沟疝患者行TEP的临床资料,根据术中是否留置负压引流管分为引流组(n=48)与对照组(n=6... 详细信息

目的:探讨腹腔镜完全腹膜外双侧腹股沟疝修补术(TEP)中留置负压引流管预防术后血清肿的应用价值。方法:回顾分析2013年1月至2016年12月为115例双侧腹股沟疝患者行TEP的临床资料,根据术中是否留置负压引流管分为引流组(n=48)与对照组(n=67),对比分析两组患者围手术期数据。结果:两组患者年龄、病程、双侧疝分型、手术时间、出血量、疝囊处理方式、手术后前3 d疼痛评分、术后住院时间差异无统计学意义;引流组术后血清肿发生率(4.17%vs. 22.39%)低于对照组,差异有统计学意义(P<0.05)。结论:腹膜外间隙留置负压引流管可有效减少腹腔镜TEP术后血清肿的发生。

关键词：疝,腹股沟双侧全腹膜外疝修补术腹腔镜检查负压引流血清肿

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一种用于汽车电磁阀质量测试电源的设计

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现代电子技术 2010年第19期33卷 201-203页

作者：叶进军周凤星武汉科技大学湖北武汉430081

设计一种用于模拟汽车电磁阀工作状态的PWM电源,该电源以单片机为控制核心,采用DDS芯片AD9851和PWM控制芯片SG3525为波形发生设备,键盘和液晶显示作为人机接口,输出频率在0～25 000 Hz,占空比在0～100%,幅度在0～36 V范围内可任意设置... 详细信息

设计一种用于模拟汽车电磁阀工作状态的PWM电源,该电源以单片机为控制核心,采用DDS芯片AD9851和PWM控制芯片SG3525为波形发生设备,键盘和液晶显示作为人机接口,输出频率在0～25 000 Hz,占空比在0～100%,幅度在0～36 V范围内可任意设置和实时显示的PWM信号。该电源运行稳定、精度高,已成功应用到汽车、电磁阀的生产企业。

关键词：电磁阀 PWM 单片机 DDS

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Enhanced solid-electrolyte interface efficiency for practically viable hydrogen-air fuel cell systems

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Journal of Energy Chemistry 2025年第1期100卷 356-368页

作者： Venkitesan Sakthivel Dong jin Yoo Graduate School Department of Energy Storage/Conversion Engineering (BK21 FOUR) Hydrogen and Fuel Cell Research Center Jeonbuk National University Jeonju Department of Life Science Jeonbuk National University

Proton exchange membrane fuel cells （PEMFCs） provide an appealing sustainable energy system,with the solid-electrolyte membrane playing a crucial role in its overall ***,sulfonated poly（1,4-phenylene ether-ether sulfone）(SPEES),an aromatic hydrocarbon polymer,has garnered considerable attention as an alternative to Nafion ***,the long-term durability and stability of SPEES present a significant *** this context,we introduce a potential solution in the form of an additive,specifically a core–shell-based amine-functionalized iron titanate （A–Fe2TiO5）,which holds promise for improving the lifetime,proton conductivity,and power density of SPEES in *** modified SPEES/A–Fe2TiO5composite membranes exhibited notable characteristics,including high water uptake,enhanced thermomechanical stability,and oxidative ***,the SPEES membrane loaded with 1.2 wt%of A–Fe2TiO5demonstrates a maximum proton conductivity of 155 mS cm-1,a twofold increase compared to the SPEES membrane,at 80°C under 100%relative humidity （RH）.Furthermore,the 1.2 wt%of A–Fe2TiO5/SPEES composite membranes exhibited a maximum power density of 397.37 mW cm-2and a current density of 1148 mA cm-2at 60°C under 100%RH,with an opencircuit voltage decay of 0.05 m V/h during 103 h of continuous *** study offers significant insights into the development and understanding of innovative SPEES nanocomposite membranes for PEMFC applications.

关键词： Acid-base Hybrid membrane Proton conductivity Polymer electrolyte fuel cell Single-cell performance

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