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Acceleration of aging behavior and improvement of mechanical properties of extruded AZ80 alloy through(10–12) twinning

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Journal of Magnesium and Alloys 2023年第2期11卷 671-683页

作者： Hyun ji Kim ye jin Kim Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

The effects of pre-existing {10–12} extension twins on the precipitation behavior of an extruded AZ80 material during aging and on its mechanical properties after peak aging are investigated. The material containing {10–12} twins-which are formed by compression before aging(twinned material)-has a finer grain size and higher dislocation density than the extruded material. Although the peak hardnesses of the twinned and extruded materials are almost the same, the time to reach the peak hardness is considerably shorter in the former material than in the latter(4 h and 24 h, respectively). In the twinned material, the high dislocation density of the {10–12} twins promotes continuous precipitation, which results in the formation of numerous fine Mg17Al12precipitates within the twins in the early stage of *** formation of these continuous precipitates reduces the driving force for discontinuous precipitation, which consequently suppresses the formation and growth of coarse Mg17Al12precipitates at the grain boundaries. Despite its shorter peak-aging time, the 4 h-peak-aged twinned material shows higher tensile strength and elongation than the 24 h-peak-aged extruded material. These higher mechanical properties of the former material are attributed primarily to the presence of more abundant fine continuous precipitates, which are effective in strengthening the material, and less abundant coarse discontinuous precipitates, which can act as crack initiation sites. These results demonstrate that the introduction of {10–12} twins into wrought Mg–Al-based alloys can accelerate the Mg17Al12precipitation kinetics considerably and improve the strength and ductility of the peak-aged alloys simultaneously.

关键词： AZ80 alloy Twin Aging Precipitation Tensile properties

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Aβ-ketoacyl-CoA Synthase OsCUT1 Confers Increased Drought Tolerance in Rice

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Rice science 2022年第4期29卷 353-362页

作者： GAO Xiuying ZHANG ye ZHANG Hongsheng huANG ji State Key Laboratory of Crop Genetics and Germplasm Enhancement College of AgricultureNanjing Agricultural UniversityNanjing 210095China jiangsu Provincial Engineering Research Center of Seed Industry Science and Technology Nanjing 210095China Suzhou Chien-Shiung Institute of Technology Taicang 215411China

Drought stress is one of the major environmental factors affecting crop growth and *** wax plays essential roles in protecting plants from environmental stress via forming a hydrophobic barrier on leaf *** this study,we analyzed nine members(OsCUT1‒OsCUT9)ofβ-ketoacyl-CoA synthase,the rate-limiting key enzyme for cuticular wax synthesis in rice by homology search and domain *** expression levels of OsCUT genes under different abiotic stresses were investigated and OsCUT1 down-regulated by abiotic stress was selected for further function *** to the wild type,overexpression of OsCUT1(OX-OsCUT1)exhibited significantly increased drought *** wax was increased on the leaf surface of OX-OsCUT1 and the chlorophyll leaching experiment showed that the cuticular permeability was decreased in the OX-OsCUT1 ***,overexpression of OsCUT1 didn’t result in the significant changes of major agronomic *** total,these results suggested that OsCUT1 is a promising gene for engineering rice plants with enhanced drought tolerance.

关键词： rice β-ketoacyl-CoA synthase drought tolerance cuticular wax OsCUT1

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Preliminary analysis of stem cell-like cells in human neuroblastoma

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World Journal of Pediatrics 2015年第1期11卷 54-60页

作者： Li-Li Xing Yong-Liang Sha ye-Ming Wu ji-Meng hu Min Zhang Fan Lv Department of Pediatric Surgery Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

Background:Neuroblastoma is an embryonic neoplasm originating from the neural crest with cellular heterogeneity as one of its oncobiological *** study was undertaken to determine whether human neuroblastoma contains stem ell-like ***:Twenty patients with neuroblastoma who have been treated in our hospital since January 2005 were divided into pre-operative chemotherapy(10 patients)and non-chemotherapy(10)*** specimens of the patients were taken and paraffin sections were *** expressions of stem cell markers CD133,ABCG2,CD117 and nestin were immunohistochemically detected in the *** cells were stained with Hoechst 33342 and *** side population(SP)cells were analyzed by the fluorescence activated cell *** disparity drug resistance to cisplatin(DDP)of SP and non-SP cells was measured with MTT colorimetric *** oncogenicity of SP and non SP cells was identified in nude ***:There was no significant difference in the expression intensity of CD117 and nestin between the two groups of specimens(P>0.05).There was a significant difference between the two groups in terms of the expression intensity of CD133 and ABCG2(Phuman neuroblastoma cells and were decreased to 0.1%-0.5%after verapamil *** SP and non-SP cells showed disparity in cell growth experiment and drug resistance to *** experiment revealed that nude mice could erupt tumor by an injection of 1×10^(6)SH-SY5Y and WIV SP ***,the nude mice could not form tumor by an injection of 1×10^(6)non-SP ***:Neuroblastoma might contain cancer stem cell-like cells.

关键词： drug resitance immunohistochemically neuroblastoma oncogenicity side population cells

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Advances in epigenetic biomarker research in colorectal cancer

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World Journal of Gastroenterology 2014年第15期20卷 4276-4287页

作者： Xi Wang ye-ye Kuang Xiao-Tong hu Biomedical Research Center Sir Run Run Shaw HospitalZhejiang University and Key Laboratory of Biotherapy of Zhejiang Province

Colorectal cancer(CRC)causes approximately 600000deaths annually and is the third leading cause of cancer mortality *** significant advancements in treatment options,CRC patient survival is still poor owing to a lack of effective tools for early diagnosis and a limited capacity for optimal therapeutic decision *** there exists a need to find new biomarkers to improve diagnosis of CRC,the research on epigenetic biomarkers for molecular diagnostics encourages the translation of this field from the bench to clinical *** alterations are thought to hold great promise as tumor *** this review,we will primarily focus on recent advances in the study of epigenetic biomarkers for colorectal cancer and discuss epigenetic biomarkers,including DNA methylation,microRNA expression and histone modification,in cancer tissue,stool,plasma,serum,cell lines and *** studies have improved the chances that epigenetic biomarkers will find a place in the clinical practices of screening,early diagnosis,prognosis,therapy choice and recurrence surveillance for CRC ***,these studies have typically been small in size,and evaluation at a larger scale of well-controlled randomized clinical trials is the next step that is necessary to increase the quality of epigenetic biomarkers and ensure their widespread clinical use.

关键词： Colorectal cancer Epigenetic biomarker DNA methylation MicroRNA biomarker Histone modification

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Isolation and characterization of uric acid-lowering functional components from Polygonum cuspidatum

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FOOD BIOSCIENCE 2023年第3期53卷 949-959页

作者： hu, Qingqing ji, jian Xu, Deping ye, Yongli Sun, jiadi Sheng, Lina Zhang, Yinzhi Sun, Xiulan jiangnan Univ Natl Engn Res Ctr Funct Food Synerget Innovat Ctr Food Safety & Qual Control Sch Food Sci & TechnolState Key Lab Food Sci & Te Lihu Ave 1800 Wuxi 214100 Jiangsu Peoples R China Yixing Inst Food & Biotechnol Co Ltd Yixing 214200 Peoples R China Xinjiang Agr Univ Coll Food Sci & Pharm 311 Nongda Dong Rd Urumqi 830052 Xinjiang Uygur Peoples R China

Polygonum cuspidatum (P. cuspidatum) is an herbaceous perennial plant known as Asian knotweed that is used in Chinese medicine due to its active components. Recent studies of the uric acid-lowering activity of P. cuspidatum extracts have mainly focused on analysis of its crude extract or specific chemical components, with limited research about its uric acid-lowering activity in vivo. In present study, monomeric compounds with higher uric acid-lowering ability were isolated from P. cuspidatum extract by column chromatography and thin-layer chro-matography (TLC) and tested in a hyperuricemia mouse model and xanthine oxidase (XOD) inhibition assay in vitro. Structural characterization of the isolated components was performed by nuclear magnetic resonance (NMR) spectroscopy and the potential mechanism of decreasing uric acid was analyzed using untargeted metabolomics. Two main novel compounds were isolated and identified, 1-(4-hydroxy-2-methoxyphenyl)-2-(4-hydroxy-3,5-dimethylphenyl)butane-1,2,3-triol (compound 1) and 1-(4-hydroxy-2-methoxyphenyl)-2-(4-hy-droxy-3,5-dimethylphenyl)-3-methylbutane-1,2-diol (compound 2), and compounds 1 was proved more signif-icant inhibitory effect on the activity of XOD (p < 0.01) with inhibition of 49.80%. Metabolomics analysis indicated that the fractions (compound 1 and compound 2) affected hyperuricemic mice mainly through changes in galactose metabolism (p = 5.74E-4) and the effects were closely related to metabolic pathways of organic acid, carbohydrate, and lipid metabolism. These results contribute to providing theoretical support for the utilization of P. cuspidatum as a food and medicinal material, which can increase its use as an alternative treatment for hyperuricemia.

关键词： Polygonum cuspidatum Uric acid Nuclear magnetic resonance Metabonomics Xanthine oxidase

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Using Chebyshev polynomial interpolation to improve the computational efficiency of gravity models near an irregularly-shaped asteroid

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Research in Astronomy and Astrophysics 2017年第12期17卷 15-26页

作者： Shou-Cun hu jiang-hui ji CAS Key Laboratory of Planetary Sciences Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China

In asteroid rendezvous missions, the dynamical environment near an asteroid’s surface should be made clear prior to launch of the mission. However, most asteroids have irregular shapes,which lower the efficiency of calculating their gravitational field by adopting the traditional polyhedral method. In this work, we propose a method to partition the space near an asteroid adaptively along three spherical coordinates and use Chebyshev polynomial interpolation to represent the gravitational acceleration in each cell. Moreover, we compare four different interpolation schemes to obtain the best precision with identical initial parameters. An error-adaptive octree division is combined to improve the interpolation precision near the surface. As an example, we take the typical irregularly-shaped nearEarth asteroid 4179 Toutatis to demonstrate the advantage of this method; as a result, we show that the efficiency can be increased by hundreds to thousands of times with our method. Our results indicate that this method can be applicable to other irregularly-shaped asteroids and can greatly improve the evaluation efficiency.

关键词： minor planets,asteroids:individual(4179 Toutatis) methods:numerical Chebyshev polynomials

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Exact Boundary Controllability and Exact Boundary Observability for a Coupled System of Quasilinear Wave Equations

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Chinese Annals of Mathematics,Series B 2013年第4期34卷 479-490页

作者： Long hu Fanqiong ji Ke WANG School of Mathematical Sciences Fudan University

Based on the theory of semi-global classical solutions to quasilinear hyperbolic systems, the authors apply a unified constructive method to establish the local exact boundary(null) controllability and the local boundary(weak) observability for a coupled system of 1-D quasilinear wave equations with various types of boundary conditions.

关键词： Coupled system of quasilinear wave equations Exact boundary control-lability Exact boundary observability

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Hepatocellular carcinoma: Current situation and challenge

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 303-304页

作者： Zhao Li ji-ye Zhu Department of Hepatobiliary Surgery Peking University People’s HospitalBeijing 100044China Peking University Institute for Organ Transplantation Beijing 100044China Beijing Key Laboratory of Liver Cirrhosis and Liver Cancer Beijing 100044China

Hepatocellular carcinoma(HCC)ranks the fourth cause of cancer-related death worldwide[1].More than 50%newly diagnosed HCC patients are in China,while 70%of them are at advanced stage when they are diagnosed[2].These patients have lost the opportunity of radical surgery and can only receive palliative ***,the modality for these advanced stage HCC patients mainly include:targeted therapy,interventional therapy,chemotherapy,radiotherapy,and immunotherapy.

关键词： chemotherapy patients therapy

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AIE interfacial supramolecular polymers

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Chinese Chemical Letters 2024年第1期35卷 316-320页

作者： Qingyun Li Ziqing hu Xiaofan ji Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Material Chemistry and Service FailureHubei Engineering Research Center for Biomaterials and Medical Protective MaterialsSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China

High monomer concentration is a requisite for engendering the aggregation-induced emssion(AIE)phenomenon as well as the formation of supramolecular ***,this is supposed to ensure the generation of AIE supramolecular polymers,wherein the monomer soluability takes ***,parts of supramolecular monomers are considered as poessessing different soluability towards the same sovlent,through which the polymerzation process is thus hard to *** polymerzation gets over the soluabilty restriction,providing a facile method for propelling the reaction of ***,we had prepared M1 containing tetraphenylethene(TPE)functionalized with two terpyridine derivatives,then making M1 dissolving in CHCl3 to give ***^(2+)solutions were fabricated through dissolving CuCl_(2)into *** mixing those solutions,AIE interfacial supramolecular polymers(AIEISPs)displaying green fluorescence were generated at the interface of two phases on the basis of metal-coordination between terpyridine and Cu^(2+).These AIEISPs were certificated to possess the stimuli-responsiveness,for which the excessive addition of tetrabutylammonium hydroxide would cause the structure destruction owing to the stronger bonding ability with Cu^(2+)than that of *** fabricated AIEISPs had provided a new avenue to prepare AIE supramolecular polymers.

关键词： Aggregation-induced emission Interfaces Metal-coordination interactions Supramolecular polymers Stimuli-responsiveness

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Simultaneous Social Cost Minimization and Nash Equilibrium Seeking in Non-cooperative Games 36

Simultaneous Social Cost Minimization and Nash Equilibrium S...

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第36届中国控制会议

作者： Maojiao ye Guoqiang hu School of Electrical and Electronic Engineering Nanyang Technological University

ISBN: (纸本)9781538629185

An N-coalition non-cooperative game is formulated in this paper. In the considered game, there are N interacting coalitions and each of them includes a set of agents. Each coalition acts as a virtual player（VP） in the game that aims to minimize its own objective function, which is defined as the sum of the agents’ local objective functions in the coalition. However, the actual decision-makers are not the coalitions but the agents therein. That is, the agents within each coalition collaboratively minimize the coalition’s objective function while constituting an entity that serves as a self-interested player（i.e., the coalition）in the game among the interacting coalitions. A seeking strategy is designed for the agents to find the Nash equilibrium of the N-coalition non-cooperative games. The equilibrium seeking strategy is based on an adaptation of a dynamic average consensus protocol and the gradient play. The dynamic average consensus protocol is leveraged to estimate the averaged gradients of the coalitions’ objective functions. The gradient play is then implemented by utilizing the estimated information to achieve the Nash equilibrium seeking. Convergence results are established by utilizing Lyapunov stability analysis. A numerical example is given in supportive of the theoretical results.

关键词： Nash equilibrium seeking social cost minimization interacting coalitions non-cooperative game

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