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Identification of LRRC46 as a novel candidate gene for high myopia

Science China Life Sciences 2024年

作者： Lingxi Jiang Chao Dai Yao Wei Bo Zhao Qi Li Zhengzheng Wu Liang zou Zimeng ye Zhenglin Yang Lulin Huang Yi Shi Sichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics Department of Laboratory Medicine Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Department of Ophthalmology Sichuan Provincial People's Hospital University of Electronic Science and Technology of China School of Food and Bioengineering Chengdu University School of Medicine University of Sydney Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026) Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Jinfeng Laboratory

High myopia(HM) is the primary cause of blindness, with the microstructural organization and composition of collagenous fibers in the cornea and sclera playing a crucial role in the biomechanical behavior of these tissues. In a previously reported myopic linkage region,MYP5(17q21–22), a potential candidate gene, LRRC46(c.C235T, p.Q79X), was identified in a large Han Chinese pedigree. LRRC46 is expressed in various eye tissues in humans and mice, including the retina, cornea, and sclera. In subsequent cell experiments, the mutation(c.C235T) decreased the expression of LRRC46 protein in human corneal epithelial cells(HCE-T). Further investigation revealed that Lrrc46–/–mice(KO) exhibited a classical myopia phenotype. The thickness of the cornea and sclera in KO mice became thinner and more pronounced with age, the activity of limbal stem cells decreased, and microstructural changes were observed in the fibroblasts of the sclera and cornea. We performed RNA-seq on scleral and corneal tissues of KO and normal control wild-type(WT) mice, which indicated a significant downregulation of the collagen synthesis-related pathway(extracellular matrix, ECM) in KO mice. Subsequent in vitro studies further indicated that LRRC46, a member of the important LRR protein family, primarily affected the formation of collagens. This study suggested that LRRC46 is a novel candidate gene for HM, influencing collagen protein VIII(Col8a1) formation in the eye and gradually altering the biomechanical structure of the cornea and sclera, thereby promoting the occurrence and development of HM.

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Bone Research 2024年第1期12卷 122-136页

作者： Nan-Yu zou Ran Liu Mei Huang Yu-Rui Jiao Jie Wei Yangzi Jiang Wen-Zhen He Min Huang Yi-Li Xu Ling Liu Yu-Chen Sun Mi Yang Qi Guo Yan Huang Tian Su ye Xiao Wei-Shan Wang Chao Zeng Guang-Hua Lei Xiang-Hang Luo Chang-Jun Li Department of Endocrinology Endocrinology Research CenterXiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Orthopaedics Xiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangshaChina Hunan Key Laboratory of Joint Degeneration and Injury ChangshaHunan 410008China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment Ministry of EducationXiangya HospitalCentral South UniversityChangshaChina School of Biomedical Sciences Institute for Tissue Engineering and Regenerative MedicineFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Orthopaedics The First Affiliated Hospital of Shihezi UniversityShiheziXinjiangChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain unclear.In this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs fracture healing.Local injection of human rGCA in young mice induced SSPC senescence and delayed fracture repair.Genetic deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC senescence.Mechanistically,GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular senescence.Depletion of Plxnb2 in SSPCs impaired fracture healing.Administration of GCA-neutralizing antibody enhanced fracture healing in aged mice.Thus,our study revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals.

关键词： healing union senescence

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异质中心角距离约束的多粒度跨模态行人重识别

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计算机工程与设计 2024年第4期45卷 1210-1217页

作者：邹业欣蒋敏江南大学人工智能与计算机学院江苏无锡214122

针对红外光和可见光图像之间巨大差异导致的跨模态行人重识别正确匹配图像异常困难的问题,提出一种多粒度特征学习的跨模态行人重识别网络(CM-MGN)。有效结合全局特征和不同粒度的局部特征,学习更具判别性的行人特征。为有效减小模型的... 详细信息

针对红外光和可见光图像之间巨大差异导致的跨模态行人重识别正确匹配图像异常困难的问题,提出一种多粒度特征学习的跨模态行人重识别网络(CM-MGN)。有效结合全局特征和不同粒度的局部特征,学习更具判别性的行人特征。为有效减小模型的计算复杂度和解决传统三元组损失中异常样本选取的问题,提出基于角距离的异质中心三元组损失(HCAT)。在RegDB和SYSU-MM01数据集上的实验结果表明,该方法的Rank-1精度分别达到了92.33%和62.83%,较其它方法取得了更优性能。

关键词：跨模态行人重识别多粒度局部特征异质中心角距离深度学习

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时变卡车—无人机协同配送路径建模研究

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现代信息科技 2024年第9期8卷 110-113页

作者：邹晔湖南工商大学湖南长沙410205

在人口稠密城区的卡车—无人机协同配送场景中,设计人员在设计已有配送路径规划模式时粗略地认为卡车的行驶速度恒定不变,但随着城市交通日益拥堵,卡车的行驶速度产生时变性。考虑到城区实际交通环境下卡车速度的时变性,对卡车和无人机... 详细信息

在人口稠密城区的卡车—无人机协同配送场景中,设计人员在设计已有配送路径规划模式时粗略地认为卡车的行驶速度恒定不变,但随着城市交通日益拥堵,卡车的行驶速度产生时变性。考虑到城区实际交通环境下卡车速度的时变性,对卡车和无人机的协同配送路径的建模进行分析。在分析问题根源的基础上,分别从模型假设、目标函数及约束条件等方面进行了探讨。

关键词：卡车—无人机协同配送无人机配送时变路径优化建模

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Thermoelectric properties of metal-(Z)-1,2-dihydroselenoethene-1,2-dithiol coordination polymers

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Science Bulletin 2018年第13期63卷 814-816页

作者： Yutao Cui Jie Yan Yue Sun ye zou Yimeng Sun Wei Xu Daoben Zhu Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Thermoelectric(TE)materials can realize mutual energy conversion between heat and electricity and are applied broadly in energy harvesting,local cooling or heating,and thermal sensing[1].TE devices are crucial to solve the global energy crisis with renewable energy resources.Currently,most of the research works are focused on inorganic TE materials because of their superior performance.Very recently,due to the growing demands

关键词：热电聚合物性质金属协作设备供应精力材料

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Design of S-band photoinjector with high bunch charge and low emittance based on multi-objective genetic algorithm

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Nuclear Science and Techniques 2023年第3期34卷 93-105页

作者： Ze-Yi Dai Yuan-Cun Nie Zi Hui Lan-Xin Liu Zi-Shuo Liu Jian-Hua Zhong Jia-Bao Guan Ji-Ke Wang Yuan Chen ye zou Hao-Hu Li Jian-Hua He The Institute for Advanced Studies Wuhan UniversityWuhan 430072China

High-brightness electron beams are required to drive LINAC-based free-electron lasers(FELs)and storage-ring-based synchrotron radiation light sources.The bunch charge and RMS bunch length at the exit of the LINAC play a crucial role in the peak current;the minimum transverse emittance is mainly determined by the injector of the LINAC.Thus,a photoin-jector with a high bunch charge and low emittance that can simultaneously provide high-quality beams for 4th generation synchrotron radiation sources and FELs is desirable.The design of a 1.6-cell S-band 2998-MHz RF gun and beam dynamics optimization of a relevant beamline are presented in this paper.Beam dynamics simulations were performed by combining ASTRA and the multi-objective genetic algorithm NSGA II.The effects of the laser pulse shape,half-cell length of the RF gun,and RF parameters on the output beam quality were analyzed and compared.The normalized transverse emittance was optimized to be as low as 0.65 and 0.92 mm·mrad when the bunch charge was as high as 1 and 2 nC,respectively.Finally,the beam stability properties of the photoinjector,considering misalignment and RF jitter,were simulated and analyzed.

关键词： Electron linear accelerator Photoinjector Beam dynamics Multi-objective genetic algorithm

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Few-layered organic single-crystalline heterojunctions for high-performance phototransistors

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Nano Research 2022年第3期15卷 2667-2673页

作者： Xinzi Tian Jiarong Yao Lijuan Zhang Bin Han Jianwei Shi Jianwei Su Jie Liu Chunlei Li Xinfeng Liu Tianyou Zhai Lang Jiang Fangxu Yang Xiaotao Zhang ye zou Rongjin Li Wenping Hu Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin UniversityTianjin 300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207China CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074China National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China

Photogating and electrical gating are key physical mechanisms in organic phototransistors(OPTs).However,most OPTs are based on thick and polycrystalline films,which leads to substantially low efficiency of both photogating and electrical gating and thus reduced photoresponse.Herein,high-performance OPTs based on few-layered organic single-crystalline heterojunctions are proposed and the obstacle of thick and polycrystalline films for photodetection is overcome.Because of the molecular scale thickness of the type I organic single-crystalline heterojunctions in OPTs,both photogating and electrical gating are highly efficient.By synergy of efficient photogating and electrical gating,key figures of merit of OPTs reach the highest among those based on planar heterojunctions so far as we know.The production of few-layered organic single-crystalline heterojunctions will provide a new type of advanced materials for various applications.

关键词： two-dimensional(2D)molecular crystals organic single crystals organic heterojunctions organic phototransistors

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Electronic structure engineering in organic thermoelectric materials

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Journal of Energy Chemistry 2021年第11期30卷 204-219,I0005页

作者： Xiaojuan Dai Qing Meng Fengjiao Zhang ye zou Chong-an Di Daoben Zhu Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China

Electronic structures, which play a key role in determining electrical and optical properties of π-conjugated organic materials, have attracted tremendous interest. Efficient thermoelectric (TE) conversion of organic materials has rigorous requirements on electronic structures. Recently, the rational design and precise modulation of electronic structures have exhibited great potential in exploring state-of-the-art organic TE materials. This review focuses on the regulation of electronic structures of organic materials toward efficient TE conversion. First, we present the basic knowledge regarding electronic structures and the requirements for efficient TE conversion of organic materials, followed by a brief introduction of commonly used methods for electronic structure characterization. Next, we highlight the key strategies of electronic structure engineering for high-performance organic TE materials. Finally, an overview of the electronic structure engineering of organic TE materials, along with current challenges and future research directions, are provided.

关键词： Organic thermoelectric materials Electronic structure Organic semiconductors

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基于沟槽结构的泵喷推进器导管脉动压力控制研究

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船舶力学 2024年第2期28卷 191-203页

作者：叶金铭吴原润孙大鹏邹笑宇海军工程大学舰船与海洋学院武汉430033

本文借鉴航空发动机中的压气机“处理机匣”技术,在泵喷推进器导管内壁开设一定数量的轴向沟槽结构,用于减弱泵喷推进器的梢涡,从而减小泵喷推进器导管内壁上的脉动压力。结合分离涡模拟(DES)方法和滑移网格方法对椭圆形水翼的梢涡流场... 详细信息

本文借鉴航空发动机中的压气机“处理机匣”技术,在泵喷推进器导管内壁开设一定数量的轴向沟槽结构,用于减弱泵喷推进器的梢涡,从而减小泵喷推进器导管内壁上的脉动压力。结合分离涡模拟(DES)方法和滑移网格方法对椭圆形水翼的梢涡流场进行数值模拟,数值计算结果与试验值吻合度较高,验证了数值计算方法的可靠性与适用性。在此基础上,分别对有无沟槽结构的泵喷推进器进行数值模拟,对比分析沟槽结构对梢涡涡核压力、导管内壁脉动压力和水动力性能的影响。结果表明:沟槽结构可以显著增大梢涡涡核压力,并对导管内壁面上脉动压力幅值有明显的降低效果,且对水动力性能影响较小。

关键词：泵喷推进器沟槽结构梢涡脉动压力

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人工智能增强多模态电子皮肤用于心理压力评估

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Science Bulletin 2024年第9期69卷 1173-1175页

作者：栗乾明邹旷怡张晔 National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artiﬁcial Functional MaterialsChemistry and Biomedicine Innovation CenterCollaborative Innovation Center of Advanced MicrostructuresCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210023China

Mental health has gradually become a focus of attention, especially with the significant increase in stress-related psychological disorders such as anxiety and depression [1,2]. This has led to an increasing demand for effective methods to assess mental health.However, current methods for assessing psychological stress are mostly limited to subjective surveys and clinical questionnaires。

关键词：人工智能多模态电子皮肤

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