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浅析中医院静脉注射配药中心不合格处方

中国药事 2016年第1期30卷 89-92页

作者：叶又青江苏省第二中医院南京210017

目的:提高静脉注射配药中心审方能力,规范临床合理用药。方法:收集2014年1月1日至2015年8月31日期间我院病区住院病人373941张处方,对其进行系统的回顾性分析。结果:不合格处方71张,占总量的0.02%,不合格处方原因主要是配伍禁忌、选用... 详细信息

目的:提高静脉注射配药中心审方能力,规范临床合理用药。方法:收集2014年1月1日至2015年8月31日期间我院病区住院病人373941张处方,对其进行系统的回顾性分析。结果:不合格处方71张,占总量的0.02%,不合格处方原因主要是配伍禁忌、选用溶媒不合理、给药剂量不当等。结论:针对不合理处方给出改进的合理化建议和对策。应不断提高药学人员的专业水平,规范医生开具的处方,保证患者用药安全。

关键词：静配中心不合理处方分析点评建议

艾司西酞普兰添加治疗对帕金森病患者非运动症状的临床疗效

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药学进展 2014年第6期38卷 450-453页

作者：叶有清建德市第四人民医院精神科浙江建德311600

目的:考察普拉克索添加艾司西酞普兰治疗对帕金森病患者非运动症状的临床疗效。方法:将60例帕金森病患者按收治顺序单双号分为观察组和对照组,每组30例。对照组采用口服盐酸普拉克索治疗,观察组则在口服盐酸普拉克索基础上添加艾司西... 详细信息

目的:考察普拉克索添加艾司西酞普兰治疗对帕金森病患者非运动症状的临床疗效。方法:将60例帕金森病患者按收治顺序单双号分为观察组和对照组,每组30例。对照组采用口服盐酸普拉克索治疗,观察组则在口服盐酸普拉克索基础上添加艾司西酞普兰治疗,连续治疗8周后,分别以帕金森病综合评分量表(UPDRS)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、匹兹堡睡眠质量指数(PQSI)和生活质量综合评定量表(GQOLI-74)的评分为指标,对比考察2组患者的综合症状、抑郁和焦虑症状、睡眠和生活质量等的变化。结果 :与治疗前相比,2组患者治疗后,UPDRS总分、运动检查以及精神、行为和情感评分均显著降低(P0.05),其中观察组患者的UPDRS总分以及精神、行为和情感评分较对照组显著降低(P0.05);且2组患者治疗后,HAMD、HAMA和PQSI评分均显著降低(P<0.05),其中观察组患者的HAMD、HAMA和PQSI评分较对照组显著降低(P<0.05),而2组患者的GQOLI-74评分均显著升高(P<0.05),其中观察组患者GQOLI-74评分显著高于对照组(P<0.05)。结论 :普拉克索添加艾司西酞普兰治疗可有效改善帕金森病患者抑郁、焦虑、睡眠障碍等非运动症状,从而提高患者生活质量,具有重要的临床意义。

关键词：艾司西酞普兰普拉克索帕金森病非运动症状生活质量

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赣州市低质低效林改造策略

绿色科技 2018年第15期20卷 172-174页

作者：叶友青黄敬文江西省定南县云台山生态林场江西赣州341900

阐述了赣州市低质低效林的现状,分析了低质低效林形成原因,从加强组织领导,加强宣传引导,强化项目管理、科学制定方案等方面提出了低质低效林改造的对策与建议。

关键词：赣州市低质低效林现状成因策略

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理塘断裂带沙湾段的晚第四纪活动性

第四纪研究 2007年第1期27卷 45-53页

作者：周荣军叶友清李勇黎小刚何玉林戈天勇四川省地震局工程地震研究院成都610041 成都理工大学油气藏及开发工程国家重点实验室成都610059

理塘断裂带沙湾段展布于四川西南部的木里河流域,处于理塘断裂带的南东尾端,为左旋走滑运动性质。文章在航空照片判译的基础上,通过野外研究发现,该断裂段的断错地貌现象主要集中分布在绒龙沟-沙湾的木里河东岸坡麓地带,表现为断层陡坎... 详细信息

理塘断裂带沙湾段展布于四川西南部的木里河流域,处于理塘断裂带的南东尾端,为左旋走滑运动性质。文章在航空照片判译的基础上,通过野外研究发现,该断裂段的断错地貌现象主要集中分布在绒龙沟-沙湾的木里河东岸坡麓地带,表现为断层陡坎、断塞塘、断错冲沟、河流阶地及洪积扇等。由5个地点的断裂位错值和位错开始的年代学(TL和14C)测试结果,估计的该断裂段晚更新世以来的平均水平滑动速率为2.1±0.3mm/a。在该断裂上开挖的3个探槽资料表明,该断裂段存在史前强震的地质记录,最晚一次强震的发生时间介于1310±90～950±30aB.P.之间,强震所导致的垂直位错量约0.5m,同震水平位错1.30～1.45m左右。根据同震位错量及断裂长度估计的地震震级为7.0级左右。

关键词：理塘断裂带滑动速率断错地貌史前强震

Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： Wei Xiong Xuan ye Hongzhang Cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro Letters 2025年第1期17卷 216-261页

作者： Jian‑En Zhou Yilin Li Xiaoming Lin Jiaye ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

Lithium-ion batteries(LIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with Li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(LIBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues Self-sacrificial template Lithium-ion batteries Sodium-ion batteries Potassium-ion batteries

Netrin-1 signaling pathway mechanisms in neurodegenerative diseases

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Neural Regeneration Research 2025年第4期20卷 960-972页

作者： Kedong Zhu Hualong Wang Keqiang ye Guiqin Chen Zhaohui Zhang Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurology The First Hospital of Hebei Medical UniversityBrain Aging and Cognitive Neuroscience Laboratory of Heibei ProvinceShijiazhuangHebei ProvinceChina Faculty of Life and Health Sciences Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal *** profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic *** amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of *** findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative *** a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.

关键词： Alzheimer’s disease axon guidance colorectal cancer Netrin-1 receptors Netrin-1 signaling pathways Netrin-1 neurodegenerative diseases neuron survival Parkinson’s disease UNC5C

The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying Wu Shan ye Xiangyi Liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

舒糖康胶囊对糖尿病性周围神经病变大鼠坐骨神经传导速度的影响

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长春中医药大学学报 2014年第4期30卷 585-587页

作者：叶又青罗宇慧沈明勤彭蕴茹丁永芳南京中医药大学第二附属医院药剂科南京210017 江苏省中医药研究院药理室南京210028

目的观察舒糖康胶囊对糖尿病性周围神经病变(DPN)大鼠坐骨神经传导速度的影响及痛觉传导时间的影响。方法采用链脲菌素(STZ)造成大鼠糖尿病模型,给糖尿病大鼠连续25 d灌胃给予舒糖康胶囊8.0,2.0 g生药/kg,观察舒糖康胶囊对糖尿病性周围... 详细信息

目的观察舒糖康胶囊对糖尿病性周围神经病变(DPN)大鼠坐骨神经传导速度的影响及痛觉传导时间的影响。方法采用链脲菌素(STZ)造成大鼠糖尿病模型,给糖尿病大鼠连续25 d灌胃给予舒糖康胶囊8.0,2.0 g生药/kg,观察舒糖康胶囊对糖尿病性周围神经病变大鼠坐骨神经及尾神经感觉电生理的影响。结果舒糖康胶囊口服给药4周对糖尿病模型大鼠周围神经病变有明显的恢复作用,对痛觉的传导速度也有一定程度的恢复作用。结论舒糖康胶囊对糖尿病性周围神经病变大鼠有一定的治疗作用,对周围神经病变有明显的恢复作用,对痛觉的传导速度也有一定程度的恢复作用。

关键词：舒糖康胶囊糖尿病周围神经病变大鼠