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预测翻车华尔街错在哪儿了?

商业周刊（中文版） 2024年第1期 20-21页

作者： Alexandra Semenova Sagarika Jaisinghani Liz Capo McCormick Selcuk Gokoluk ye xie Sujata Rao-Coverley Matt Turner 孟洁冰(译) 不详

回顾2022年底,不管是股票部门还是债券部门,无论是大公司还是小机构,整个华尔街的气氛都很低落。当时似乎大家都在未雨绸缪,认为经济衰退即将到来。在摩根士丹利(Morgan Stanley),看跌美股的策略师迈克·威尔逊(Mike Wilson)迅速成为市... 详细信息

回顾2022年底,不管是股票部门还是债券部门,无论是大公司还是小机构,整个华尔街的气氛都很低落。当时似乎大家都在未雨绸缪,认为经济衰退即将到来。在摩根士丹利(Morgan Stanley),看跌美股的策略师迈克·威尔逊(Mike Wilson)迅速成为市场宠儿,他预测标准普尔500指数即将大跌。

关键词：摩根士丹利经济衰退标准普尔500指数美股华尔街债券股票未雨绸缪

DELLA Proteins Promote Anthocyanin Biosynthesis via Sequestering MYBL2 and JAZ Suppressors of the MYB/bHLH/WD40 Complex in Arabidopsis thaliana

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Molecular Plant 2016年第5期9卷 711-721页

作者： ye xie Huijuan Tan Zhaoxue Ma Jirong Huang National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and EcologyShanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China University of the Chinese Academy of Sciences Beijing 100049 China

Anthocyanin accumulation is recognized as a visible biomarker of plants that have suffered from environmental stresses. However, the molecular mechanisms underlying stress-induced anthocyanin biosynthesis remain unclear. Expression of anthocyanin-specific genes is regulated by the conserved MBW complex, which is composed of the MYB, bHLH, and WD40 subunRs in higher plants. MBW activity is repressed by MYBL2 and the JAZ family proteins, which bind competitively to bHLH and MYB/bHLH, respectively. Here, we found that MYBL2 and JAZs mediate gibberellic acid-inhibRed anthocyanin biosynthesis in Arabidopsis. Competitive pull-down and dual-lucifarase assays showed that DELLA proteins directly sequester MYBL2 and JAZ repressors, leading to the release of bHLH/MYB subunits and subsequently to the formation of active MBW complex, which then activates the anthocyanin biosynthetic pathway. The JAZ-DELLA-MYBL2 module also plays an Important role in abiotic stress-induced anthocy- anin biosynthesis. Furthermore, we found that the DELLA protein RGA accumulates upon plant exposure to abiotic stresses. Altogether, our data reveal that DELLA-promoted anthocyanin biosynthesis is mediated at least in part by MYBL2 and JAZ regulatory proteins, providing new insights into the coordinated regulation of plant growth and defense through metabolic pathway regulation.

关键词： DELLA MYBL2 JAZ anthocyanin biosynthesis abiotic stresses

An ubiquitin-like protein SDE2 negatively affects sucrose-induced anthocyanin biosynthesis in Arabidopsis

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Science Bulletin 2017年第23期62卷 1585-1592页

作者： ye xie Yulei Zhao Huijuan Tan Qin Chen Jirong Huang National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China University of the Chinese Academy of Sciences Beijing 100049 China School of Life Sciences Shanghai University Shanghai 200444 China College of Life and Environmental Sciences Shanghai Normal University Shanghai 200234 China

Anthocyanin biosynthesis is regulated by a conserved transcriptional MBW complex composed of MYB,b HLH and WD40 subunits. However, molecular mechanisms underlying transcriptional regulation of these MBW subunits remain largely elusive. In this study, we isolated an Arabidopsis mutant that displays a constitutive red color in aboveground tissues with retarded growth phenotypes. In the presence of sucrose, the mutant accumulates more than 3-fold anthocyanins of the wild type(WT), but cannot produce anthocyanins as WT in the absence of sucrose. Map-based cloning results demonstrated that the mutation occurs in the locus At4 G01000, which encodes a conserved nuclear-localized ubiquitin-like(UBL) superfamily protein, silencing defective 2(SDE2), in eukaryotes. SDE2 is ubiquitously expressed in various tissues. In the sucrose-induced anthocyanin biosynthesis, SDE2 expression was not responded to sucrose treatment at the early stage but was enhanced at the late stage. SDE2 mutations result in upregulation of anthocyanin biosynthetic and regulatory genes. yeast-two hybrid analysis indicated that SDE2 has no direct interaction with the MYB transcription factor PAP1 and b HLH factor TT8, indicating that SDE2 is a indirect factor to affect anthocyanin accumulation. Taking together, our data suggest that SDE2 may play a role in finely coordinating anthocyanin biosynthesis with other biological processes.

关键词： Anthocyanin biosynthesis Sucrose SDE2 PAP1 Arabidopsis

Review of hybrid electric powered aircraft,its conceptual design and energy management methodologies

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Chinese Journal of Aeronautics 2021年第4期34卷 432-450页

作者： ye xie Al SAVVARISAL Antonios TSOURDOS Dan ZHANG Jason GU Intelligent Robot Research Centre Zhejiang LabHangzhou311100China School of Aerospace Transport and ManufacturingCranfield UniversityBedford MK430ALUnited Kingdom York University North YorkToronto M3J 1P3Canada Dalhousie University HalifaxNova Scotia B3H 4R2Canada

The paper overviews the state-of-art of aircraft powered by hybrid electric propulsion systems.The research status of the design and energy management of hybrid aircraft and hybrid propulsion systems are further reviewed.The first contribution of the review is to demonstrate that,in the context of relatively underdeveloped electrical storage technologies,the study of mid-scale hybrid aircraft can contribute the most to both theoretical and practical knowledge.Meanwhile,the profits and potential drawbacks of applying hybrid propulsion to mid-scale hybrid airplanes have not been thoroughly illustrated.Secondly,as summed in the overview of design methodologies,the multi-objective optimization transcends the single-objective one.The potential of the hybrid propulsion system can be thoroughly evaluated in only one optimization run,if several objectives optimized simultaneously.yet there are few researches covering the conceptual design of hybrid aircraft using multi-objective optimization.The review of the most popular energy management strategies discloses the third research gap—current methodologies favoured in hybrid ground vehicles do not consider the aircraft safety.Additionally,both non-causal and causal energy management are needed for performing a complicated flight mission with several sub-tasks.

关键词： Aircraft Convex optimization Energy management Fuzzy logic control Hybrid electric propulsion system Non-dominated sorting genetic algorithm Sizing

Arogenate Dehydratase Isoforms Differentially Regulate Anthocyanin Biosynthesis in Arabidopsis thaliana

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Molecular Plant 2016年第12期9卷 1609-1619页

作者： Qingbo Chen Cong Man Danning Li Huijuan Tan ye xie Jirong Huang National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Sciences 300 Fenglin Road Shanghai 200032 China These authors contributed equally to this article

Anthocyanins, a group of L-phenylalanine （Phe）-derived flavonoids, have been demonstrated to play impor- tant roles in plant stress resistance and interactions between plants and insects. Although the anthocyanin biosynthetic pathway and its regulatory mechanisms have been extensively studied, it remains unclear whether the level of Phe supply affects anthocyanin biosynthesis. Here, we investigated the roles of arogenate dehydratases （ADTs）, the key enzymes that catalyze the conversion of arogenate into Phe, in sucrose-induced anthocyanin biosynthesis in Arabidopsis. Genetic analysis showed that all six ADT isoforms function redundantly in anthocyanin biosynthesis but have differential contributions. ADT2 contributes the most to anthocyanin accumulation, followed by ADT1 and ADT3, and ADT4-ADT6. We found that anthocyanin content is positively correlated with the levels of Phe and sucrose-induced ADT transcripts in seedlings. Consistently, addition of Phe to the medium could dramatically increase anthocyanin content in the wild-type plants and rescue the phenotype of the adtl adt3 double mutant regarding the anthocyanin accumulation. Moreover, transgenic plants overexpressing ADT4, which appears to be less sensitive to Phe than overexpression ofADT2, hyperaccumulate Phe and produce elevated level of antho- cyanins. Taken together, our results suggest that the level of Phe is an important regulatory factor for sus- taining anthocyanin biosynthesis.

关键词： phenylalanine metabolic flux ADT anthocyanin Arabidopsis

A Crucial Role of GA-Regulated Flavonol Biosynthesis in Root Growth of Arabidopsis

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Molecular Plant 2019年第4期12卷 521-537页

作者： Huijuan Tan Cong Man ye xie Jijun Yan Jinfang Chu Jirong Huang National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China University of the Chinese Academy of Sciences Beijing 100049 China National Center for Plant Gene Research (Beijing) Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Shanghai Key Laboratory of Plant Molecular Sciences College of Life Sciences Shanghai Normal University Shanghai 200234 China

Flavonols have been demonstrated to play many important roles in plant growth, development, and communication with other organisms. Flavonol biosynthesis is spatiotemporally regulated by the subgroup 7 R2R3-MYB (SG7 MYB) transcription factors including MYB11/MYB12/MYB111. However, whether SG7- MYB activity is subject to post-translational regulation remains unclear. Here, we show that gibberellic acid (GA) inhibits flavonol biosynthesis via DELLA proteins in Arabidopsis. Protein-protein interaction analyses revealed that DELLAs (RGA and GAI) interacted with SG7 MYBs (MYB12 and MYB111) both in vitro and in vivo, leading to enhanced affinity of MYB binding to the promoter regions of key genes for flavonol biosynthesis and thus increasing their transcriptional levels. We observed that the level of auxin in the root tip was negatively correlated with root flavonol content. Furthermore, genetic assays showed that loss-of-function mutations in MYB 12, which is predominantly expressed in roots, partially rescued the short-root phenotype of the GA-deficient mutant ga1-3 by increasing root meristem size and mature cell size. Consistent with these observations, exogenous application of the flavonol quercetin restored the root meristem size of myb12 ga1-3 to that of ga1-3. Taken together, our data elucidate a molecular mechanism by which GA promotes root growth by directly reducing flavonol biosynthesis.

关键词： gibberellin flavonol root growth auxin stress

THF_1 mutations lead to increased basal and wound-induced levels of oxylipins that stimulate anthocyanin biosynthesis via COI_1 signaling in Arabidopsis

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Journal of Integrative Plant Biology 2014年第9期56卷 916-927页

作者： Yi Gan Hong Li ye xie Wenjuan Wu Maoyin Li Xuemin Wang Jirong Huang National Key Laboratory of Plant Molecular Genetics Shanghai Institute of Plant Physiology and EcologyShanghai Institutes for Biological Sciencesthe Chinese Academy of Sciences School of Agricultural and Food Science Zhejiang A&F University Department of Biology University of Missouri Donald Danforth Plant Science Center

Mutants defective in chloroplast development or photosynthesis are liable to accumulate higher levels of anthocyanin in photo-oxidative stress.However,regulatory mechanisms of anthocyanin biosynthesis in the mutants remain unclear.Here,we investigated the mechanism by which the deletion of thylakoid formation1（THF1） leads to an increased level of anthocyanin in Arabidopsis thaliana L.Physiological and genetic evidence showed that the increased level of anthocyanin in thf1 is dependent on coronatine-insensitive1（COM）signaling.Our data showed that thf1 had higher levels of basalα-linolenic acid（α-LeA）,and methyl jasmonate（JA）-induced α-LeA and 12-oxophytodienoic acid（OPDA） than the wild type（WT）.Consistently,expression levels of phospholipase genes including pPLAIIα and PLA-Iγ1 were elevated in thf1.Furthermore,inhibition of lipase activity by bromoenol lactone,a specific inhibitor of plant pPLA,led to producing identical levels of anthocyanins in WT and thf1 plants.Interestingly,OPDA biosynthesis was triggered by light illumination in isolated chloroplasts,indicating that new protein import into chloroplasts is not required for OPDA biosynthesis.Thus,we conclude that the elevated anthocyanin accumulation in thf1 is attributed to an increase in JA levels.This JA-mediated signaling to coordinate plant metabolism and growth in stress may be conserved in other photosensitive mutants.

关键词： Anthocyanin Arabidopsis jasmonates photo-oxidative stress retrograde signaling THF1

关节镜下“Chinese way”治疗老年肩关节脱位合并巨大肩袖撕裂的临床疗效

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中国临床解剖学杂志 2024年第3期42卷 316-321页

作者：孙晟轩谢晔沈光思周海斌苏州大学附属第二医院骨科江苏苏州215004

目的评估“Chinese way”技术行上关节囊重建在关节镜下治疗老年肩关节脱位合并巨大肩袖撕裂的临床效果。方法回顾性分析2019年5月至2022年1月在苏州大学附属第二医院收治的老年肩关节脱位后合并巨大肩袖撕裂的患者资料,纳入36例,男16... 详细信息

目的评估“Chinese way”技术行上关节囊重建在关节镜下治疗老年肩关节脱位合并巨大肩袖撕裂的临床效果。方法回顾性分析2019年5月至2022年1月在苏州大学附属第二医院收治的老年肩关节脱位后合并巨大肩袖撕裂的患者资料,纳入36例,男16例,女20例,年龄52~73岁,平均(62.3±4.7)岁,术中行肱二头肌长头腱转位,加强肩袖缝合。统计分析术前、术后的疼痛、肩关节活动度及肩关节功能评分,通过MR评估肩袖再撕裂率。结果所有患者均获得随访,随访时间为17.6±4.5个月。末次随访时肩关节前屈、外展、体侧外旋、体侧内旋活动度较术前均有显著增加(P<0.05);末次随访VAS评分、ASES评分、Constant-Murley评分、UCLA评分较术前均有明显改善(P<0.05);无肩关节再次脱位发生,MR依据Sugaya标准提示5例(13.9%)肩袖再撕裂,UCLA评分优9例,良23例,差4例,优良率为88.9%。结论关节镜下处理老年肩关节脱位合并巨大肩袖损伤时,采用“Chinese way”技术重建上关节囊,加强缝合肩袖组织,可有效避免肩袖再撕裂,解除肩关节疼痛,恢复肩关节功能并防止再次脱位。

关键词：关节镜巨大肩袖损伤肩关节脱位修复外科手术

Identification of a LMNA (c.646C>T) variant by whole-exome sequencing in combination with a dilated cardiomyopathy (DCM) related gene filter in a family with familiar DCM

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The Journal of Biomedical Research 2018年第4期32卷 314-316页

作者： Liang Chen Zhongyin Zhou Huihe Lu ye xie Gang Li Jianfei Huang Dongsheng Zhao Department of Cardiology The Second Affiliated Hospital of Nantong University Department of Cardiology The First Affiliated hospital of Hubei University of Technology Department of Cardiology The Third Affiliated Hospital of Nantong University

Dilated cardiomyopathy（DCM）is characterized by the dilated heart chambers and reduced systolic function in the absence of specific aetiology[1].Approximately one third of DCM cases are hereditary.In recent years,DCM... 详细信息