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Inhibitory effects of Shuanghuanglian injection on nuclear factor-kappa B expression in mice with viral encephalitis in a time-and dose-dependent manner

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Neural Regeneration Research 2011年第24期6卷 1865-1869页

作者： ye tian caiping han naibing gu zhengli di gejuan zhang hui lei Department of Neurology Xi＇an Center Hospital Xi＇an 710003 Shaanxi Province China

Previous studies have confirmed that the anti-virus effects of Shuanghuanglian injection may be associated with nuclear factor-kappa B activity. This study observed nuclear factor-kappa B expression in mice with viral encephalitis, and showed significant decreases in nuclear factor-kappa B protein and mRNA levels following Shuanghuanglian injection. The inhibitory effect was more significant with prolonged intervention duration and increased treatment dose. These findings verify that Shuanghuanglian injection plays a therapeutic role in viral encephalitis by reducing expression of nuclear factor-kappa B in a time- and dose-dependent manner.

关键词： nuclear factor-kappa B viral encephalitis mice gene expression Shuanghuanglian injection neural regeneration

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Shuanghuanglian injection downregulates nuclear factor-kappa B expression in mice with viral encephalitis

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Neural Regeneration Research 2012年第33期7卷 2592-2599页

作者： naibing gu ye tian zhengli di caiping han hui lei gejuan zhang Department of Neurology Xi'an Center HospitalXi'an 710003Shaanxi ProvinceChina

A mouse model of viral encephalitis was induced by intracranial injection of a Coxsackie virus B3 suspension. Quantitative real-time reverse transcription-PCR and western blot assay were applied to detect mRNA and protein expression of intelectin-2 and nuclear factor-kappa B in the viral encephalitis and control groups. Nuclear factor-kappa B and intelectin-2 mRNA and protein expression were significantly increased in mice with viral encephalitis. After intraperitoneal injection of Shuanghuanglian at a dose of 1.5 mg/kg for 5 successive days, intelectin-2 and nuclear factor-kappa B protein and mRNA expression were significantly decreased. To elucidate the relationship between intelectin-2 and nuclear factor-kappa B, mice with viral encephalitis were administered an intracerebral injection of 107 pfu recombinant lentivirus expressing intelectin shRNA. Both protein and mRNA levels of intelectin and nuclear factor-kappa B in brain tissue of mice were significantly decreased. Experimental findings suggest that Shuanghuanglian injection may downregulate nuclear factor-kappa B production via suppression of intelectin production, thus inhibiting inflammation associated with viral encephalitis.

关键词： intelectin nuclear factor-kappa B viral encephalitis short hairpin RNA Shuanghuanglian injection mice lentivirus nervous system disease traditional Chinese medicine neural regeneration

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