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Anisotropy Engineering Edge Magnetism in Zigzag Honeycomb Nanoribbons

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Chinese Physics Letters 2019年第6期36卷 83-87页

作者： Baoyue Li Yifeng Cao Lin xu Guang Yang Zhi Ma Miao ye Tianxing Ma School of Physics and Electronic-Electrical Engineering Ningxia UniversityYinchuan 750021 Department of Physics Beijing Normal UniversityBeijing 100875 School of Science Hebei University of Science and TechnologyShijiazhuang 050018 College of Information Science and Engineering Guilin University of TechnologyGuilin 541004

It has been demonstrated that the zigzag honeycomb nanoribbons exhibit an intriguing edge magnetism. Here the effect of the anisotropy on the edge magnetism in zigzag honeycomb nanoribbons is investigated using two kinds of large-scale quantum Monte Carlo simulations. The anisotropy in zigzag honeycomb nanoribbons is characterized by the ratios of nearest-neighbor hopping integrals t_1 in one direction and t_2 in another direction. Considering the electron-electron correlation, it is shown that the edge ferromagnetism could be enhanced greatly as t_2/|t_1|increases from 1 to 3, which not only presents an avenue for the control of this magnetism but is also useful for exploring further novel magnetism in new nano-scale materials.

关键词： Anisotropy Engineering Edge Magnetism Zigzag Honeycomb Nanoribbons edge magnetism

Synthesis and Antitumor Activities of 26-O-tert-Butyldimethylsiliyl Protodisogenyl β-D-Glucopyranoside

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Chinese Chemical Letters 2006年第5期17卷 571-574页

作者： Liang ZHOU Shu Jie HOU Peng xu De Quan YU ping Sheng LEI Chuan Chun ZOU Key Laboratory of Bioactive Substance and Resources Utilization of Chinese Herbal Medicine（Peking Union Medical College） Ministry of Education Institute of Materia Medica Peking Union Medical College ＆ Chinese Academy of Medical Sciences Beijing 100050

New saponin 26-O-tert-butyldimethylsiliyl protodiosgenyl β-D-glucopyranoside 1 was synthesized and its cytotoxicity activity in vitro was evaluated by MTI＇. It showed potent antitumor activity to human cancer cells. E ring and C22-OH play important roles in the antitumor activity of 1. A method to selective removal of acetyl group in the presence of benzoyl group was reported.

关键词： Saponin glycosylation cytotoxicity activity structure-activity relationship.

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补肾活血法治疗精索静脉曲张性不育研究概况

江西中医药 2024年第2期55卷 81-84,88页

作者：张婷崔云叶有骏王莉钱鑫徐新宇浙江中医药大学第三临床医学院杭州310053 浙江中医药大学附属宁波中医院浙江宁波315010

临床发现男性不育症患者中精索静脉曲张有较高的患病率,在已知男性不育的致病因素中居首位,然而精索静脉曲张的发病机制暂未明确。中医根据不育多肾虚、筋瘤多血瘀的病机演变特点,以补肾活血法为基本原则借助四诊合参辨证论治,在消除症... 详细信息

临床发现男性不育症患者中精索静脉曲张有较高的患病率,在已知男性不育的致病因素中居首位,然而精索静脉曲张的发病机制暂未明确。中医根据不育多肾虚、筋瘤多血瘀的病机演变特点,以补肾活血法为基本原则借助四诊合参辨证论治,在消除症状、提升患者精子质量、提高受孕率和疏通患者心理状态等方面有较为显著的临床效果。就近年来以补肾化瘀法治疗精索静脉曲张性不育的研究进展进行梳理,为临床辨证施治提供一定参考。

关键词：精索静脉曲张性不育症补肾活血法综述研究进展

Bioassay-guided isolation of α-Glucosidase inhibitory constituents from Hypericum sampsonii

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Chinese Journal of Natural Medicines 2023年第6期21卷 443-453页

作者： TAO Linlan xu Shuangyu ZHANG Zizhen LI Yanan YANG Jue GU Wei YI ping HAO Xiaojiang YUAN Chunmao State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang 550025China Natural Products Research Center of Guizhou Province Guiyang 550014China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

This study employed the α-glucosidase inhibitory activity model as an anti-diabetic assay and implemented a bioactivity-guided isolation strategy to identify novel natural compounds with potential therapeutic *** sampsonii was investigated,leading to the isolation of two highly modified seco-polycyclic polyprenylated acylphloroglucinols(PPAPs)(1 and 2),eight phenolic derivatives(3-10),and four terpene derivatives(11-14).The structures of compounds 1 and 2,featuring an unprecedented octahydro-2H-chromen-2-one ring system,were fully characterized using extensive spectroscopic data and quantum chemistry *** compounds(1,5-7,9,and 14)exhibited potential inhibitory effects against α-glucosidase,with IC_(50) values ranging from 0.050±0.0016 to 366.70±11.08μg·mL^(-1).Notably,compound 5(0.050±0.0016μg·mL^(-1))was identified as the most potential α-glucosidase inhibitor,with an inhibitory effect about 6900 times stronger than the positive control,acarbose(IC_(50)=346.63±15.65μg·mL^(-1)).A docking study was conducted to predict molecular interactions between two compounds(1 and 5)and α-glucosidase,and the hypothetical biosynthetic pathways of the two unprecedented seco-PPAPs were proposed.

关键词： Hypericum sampsonii Chemical constituents Structure elucidation α-Glucosidase Molecular docking

Systematic review and meta-analysis of laparoscopy-assisted and open total gastrectomy for gastric cancer

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World Journal of Gastroenterology 2013年第32期19卷 5365-5376页

作者： Ke Chen Xiao-Wu xu Ren-Chao Zhang Yu Pan Di Wu Yi-ping Mou Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang University

AIM:To evaluate the safety and efficacy of laparoscopy-assisted total gastrectomy(LATG)and open total gastrectomy(OTG)for gastric ***:A comprehensive search of PubMed,Cochrane Library,Web of Science and BIOSIS Previews was performed to identify studies that compared LATG and *** following factors were checked:operating time,blood loss,harvested lymph nodes,flatus time,hospital stay,mortality and *** synthesis and statistical analysis were carried out using RevMan 5.1 ***:Nine studies with 1221 participants were included(436 LATG and 785 OTG).Compared to OTG,LATG involved a longer operating time[weighted mean difference(WMD)=57.68 min,95%CI:30.48-84.88;P<0.001];less blood loss[standard mean difference(SMD)=-1.71;95%CI:-2.48--0.49;P<0.001];earlier time to flatus(WMD=-0.76 d;95%CI:-1.22--0.30;P<0.001);shorter hospital stay(WMD=-2.67d;95%CI:-3.96--1.38,P<0.001);and a decrease in medical complications(RR=0.41,95%CI:0.19-0.90,P=0.03).The number of harvested lymph nodes,mortality,surgical complications,cancer recurrence rate and long-term survival rate of patients undergoing LATG were similar to those in patients undergoing ***:Despite a longer operation,LATG can be performed safely in experienced surgical centers with a shorter hospital stay and fewer complications than open surgery.

关键词： Laparoscopy Total gastrectomy Gastric cancer Complications Meta-analysis

过/降表达circSTON2的胰腺癌细胞增殖、迁移、侵袭能力观察

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山东医药 2024年第17期64卷 25-28页

作者：叶伟标郑银海李广柳李伟滔徐咏强南方医科大学附属第十医院东莞临床病理诊断中心广东东莞523059 广东医科大学附属医院病理科

目的观察过/降表达环状RNA-STON2(circSTON2)的胰腺癌细胞株增殖、迁移及侵袭能力变化,初步探讨circSTON2在胰腺癌中的生物学功能。方法体外传代培养人胰腺癌细胞株PANC-1,分为circSTON2过表达组、circSTON2降表达组及对照组,利用质粒... 详细信息

目的观察过/降表达环状RNA-STON2(circSTON2)的胰腺癌细胞株增殖、迁移及侵袭能力变化,初步探讨circSTON2在胰腺癌中的生物学功能。方法体外传代培养人胰腺癌细胞株PANC-1,分为circSTON2过表达组、circSTON2降表达组及对照组,利用质粒转染及siRNA干扰技术分别转染circSTON2过表达质粒、circSTON2-siRNA干扰质粒及空白对照质粒。采用CCK-8法检测培养24、36、48 h时细胞增殖情况,Transwell实验检测细胞迁移和侵袭能力。结果培养24、36、48 h时,细胞增殖能力circSTON2过表达组>对照组>circSTON2降表达组(P均对照组>circSTON2降表达组(P均<0.05)。结论circSTON2过表达可增强胰腺癌细胞的增殖、迁移和侵袭能力,而circSTON2降表达后作用与之相反。

关键词：环状RNA-STON2 胰腺癌 PANC-1细胞细胞迁移细胞侵袭

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白杨素脂质体的制备工艺优化及抗神经炎症活性研究

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中南药学 2024年第4期22卷 864-870页

作者：贾文丁文华汪凯康王丹徐维平安徽中医药大学药学院合肥230012 中国科学技术大学合肥230027 安徽省老年医学研究所中国科学技术大学附属第一医院老年医学科合肥230001

目的优化白杨素脂质体的制备工艺并研究其体外抗神经炎症活性。方法采用乙醇注入法制备白杨素脂质体,根据单因素实验结果,通过Box-Behnken响应面筛选最优处方并表征。细胞毒性实验确定白杨素及其脂质体的安全药物浓度范围,利用脂多糖(... 详细信息

目的优化白杨素脂质体的制备工艺并研究其体外抗神经炎症活性。方法采用乙醇注入法制备白杨素脂质体,根据单因素实验结果,通过Box-Behnken响应面筛选最优处方并表征。细胞毒性实验确定白杨素及其脂质体的安全药物浓度范围,利用脂多糖(LPS)诱导的BV2细胞分析白杨素脂质体的抗神经炎症活性。结果白杨素脂质体最佳制备工艺参数:磷脂与胆固醇比7.86∶1、搅拌速度615 r·min^(-1)、水浴温度60℃,制备的白杨素脂质体形态呈椭圆球形,包封率为(85.01±0.33)%,平均粒径为(141.43±0.5)nm,平均PDI为(0.240±0.021),体外释药具有明显的缓释特征。细胞实验结果显示,在0~100μmol·L^(-1)实验浓度范围内,空白脂质体对BV2细胞无明显的细胞毒性。抗炎性能分析表明,相较于游离白杨素,白杨素脂质体对LPS诱导的BV2细胞具有更强的抗炎效果,且在使用范围(<25μmol·L^(-1))内无细胞毒性。结论本研究成功制备并优化了白杨素脂质体,该制剂提高了白杨素的溶解度和体外释放性能,同时展现出良好的体外抗炎活性,为未来白杨素新剂型的开发提供了理论基础。

关键词：白杨素脂质体响应面法神经炎症

Report on Childhood Obesity in China (7) Comparison of NCHS and WGOC

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Biomedical and Environmental Sciences 2008年第4期21卷 271-279页

作者： YI-QUN xu CHENG-ye JI 无 Institute of Child and Adolescent Health Peking University of Health Science Center Beijing 100083 China COOPERATIVE STUDY ON CHILDHOOD OBESITY： WORKING GROUP ON OBESITY IN CHINA

Objective To test the validity of Working Group on Obesity in China （WGOC） reference in screening childhood obesity using obesity-related metabolic syndrome （MS） and its components as disease risk evidence. Methods A total of 2020 adolescents （1007 boys and 1013 girls） aged 14-16 years were sampled in Beijing, China. Anthropometric and biochemical measurements, as well as blood pressure parameters were available. Prevalence of overweight/obesity and related MS risk factors were analyzed across different body mass index （BMI） categories. The sensitivity and specificity of the WGOC cut-offs were compared with those of National Central Health Statistics （NCHS）. Results Significantly high prevalence of MS and its components were found both in the obesity and overweight groups, which were classified by the WGOC and NCHS references. Similar distribution pattern of MS risk factors existed among different BMI categories, but the frequency and clustering of these factors in the obesity group classified by the NCHS were much higher. Owing to its irrelevant high cut-offs for overweight/obesity （especially for girls since the mid- adolescence）, the NCHS reference had a high specificity but a low sensitivity. By contrast, the WGOC reference with a high sensitivity （90.1% for boys and 89.2% for girls） and a relative high specificity （96.4% and 92.8% for obese boys and girls, 78.1% and 68.9% for overweight boys and girls respectively） was more suitable to support the need for early screening, intervention, and treatment of childhood obesity in China. Conclusion High sensitivity is more important than specificity in choosing appropriate screening tools for childhood obesity. Validity test demonstrates that it is rational to use the WGOC reference, established on the basis of the Chinese own reference population as a uniform screening tool for childhood obesity, which can effectively overcome the unnecessary treatment and psychosociai implications of stigmatization caused by misclas

关键词： Body mass index Childhood obesity Overweight Metabolic syndromes Validity

Effects of temperature and wavelength choice on in-situ dissolution test of Cimetidine tablets

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Journal of Pharmaceutical Analysis 2013年第1期3卷 71-74页

作者： Xin-Xia Li Yan Wang ping-ping xu Qi-Zhou Zhang Kun Nie xu Hu Bin Kong Li Li Jian Chen Department of Pharmacy Xinjiang Medical University Xinjiang FOCS Bio-Tech Co. Ltd.

The effects of temperature and wavelength choice on in-situ dissolution test instrument of Cimetidine were studied. Absorbance （A）〈 1.0 is required when using a fiber-optic dissolution test system. The detection wavelength of 2 （218 nm） was replaced by 244 nm to carry out this test. The absorbance of Cimetidine solution at different temperature showed an obvious change. Calibration of Cimetidine solution should be tested at the same temperature （37° C） with the test solution. A suitable wavelength with smaller tangent slope could be chosen for in-situ dissolution test of Cimetidine tablets.

关键词： Cimetidine tablets Drug dissolution test In-situ dissolution test UV-vis