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Drosophila adhesion GPCR Remoulade regulates axon growth, branching, and guidance by modulating Rac1 GTPase

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Journal of Genetics and Genomics 2024年第4期51卷 458-461页

作者： xi Yang Changkun pan Meitong ye Jinshuo liang Haoyang Cheng Qing liang Shu Huang Jianshu Wang Hoi yee Chow Haihuai He Cancer Center and State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China National Clinical Research Center for Geriatrics and State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China Department of Neurosurgery Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China

The assembly of neurons into complex circuits relies upon appropriate axonal navigation to distant *** considerable progress has been made toward understanding the regulation of the guidance and branching of axon extension,the molecular and cellular mechanisms underlying the coordination of the motility of the axon tip,axon growth,and branching remain largely unknown(Sudhof,2017).The Drosophila mushroom body(MB),the major site for associative learning and memory,is a powerful model system to investigate complex axon *** MB is a bilaterally symmetric central brain structure,mainly composed of Kenyon cells,MB output neurons,and dopaminergic neurons(Li et al.,2020).Among the seven neuronal subtypes of~2000 Kenyon cells,Y,a/β,and a/β'subtypes extend axons in a fascicle and bifurcate to produce two sister branches,one projecting into the dorsal lobe and the other into the medial lobe.

关键词： branching medial axon

Ultrahigh accelerating gradient and quality factor of CEPC 650 MHz superconducting radio-frequency cavity

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Nuclear Science and Techniques 2022年第10期33卷 33-40页

作者： Peng Sha Wei-Min pan Song Jin Ji-Yuan Zhai Zheng-Hui Mi Bai-Qi Liu Chao Dong Fei-Si He Rui Ge liang-Rui Sun Shi-Ao Zheng Ling-xi ye Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Acceleration Physics and Technology Chinese Academy of SciencesBeijing 100049China Center for Superconducting RF and Cryogenics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Two 650 MHz single-cell superconducting radio-frequency(SRF)cavities used for the Circular Electron Positron Collider(CEPC)were studied to achieve a high accelerating gradient(E_(acc))and high intrinsic quality factor(Q_(0)).The 650 MHz single-cell cavities were subjected to a combination of buffered chemical polishing(BCP)and electropolishing(EP),and their E_(acc) exceeded40 MV/*** a high E_(acc) may result from the cold EP with more uniform *** is easy,cheap,and rough,whereas EP is complicated,expensive,and precise Therefore,the combination of BCP and EP investigated in this study is suitable for surface treatments of mass SRF *** temperature(mid-T)furnace baking was also conducted,which demonstrated an ultrahigh Q_(0) of 8×10^(10) at 22 MV/m for both cavities,and an extremely low BCS resistance(R_(BCS))of~1.0 nΩwas achieved a2.0 K.

关键词： SRF cavity Accelerating gradient Quality factor Electropolishing Vertical test

Profibrogenic macrophage-targeted delivery of mitochondrial protector via exosome formula for alleviating pulmonary fibrosis

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Bioactive Materials 2024年第2期32卷 488-501页

作者： Wei Zhang Zhuo Wan Di Qu Wenqi Sun liang Zhang Yuan liang Lei pan Hua Jiang Zichen ye Mengying Wei Lijun Yuan Guodong Yang Faguang Jin Department of Pulmonary and Critical Care Medicine Tangdu HospitalFourth Military Medical UniversityXi’anShaanxi710038China Department of Hematology Tangdu HospitalFourth Military Medical UniversityXi’anShaanxi710038China Department of Cardiology Xijing HospitalFourth Military Medical UniversityXi’anShaanxi710032China Department of Clinical Pharmacy General Hospital of Western Theater CommandChengduSichuan610083China Department of Ultrasound Diagnostics Tangdu HospitalFourth Military Medical UniversityXi’anShaanxi710038China Department of Health Service Health Service Training BaseFourth Military Medical UniversityXi’anShaanxi710032China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Department of Biochemistry and Molecular BiologyFourth Military Medical UniversityXi’anShaanxi710032China

Pulmonary fibrosis(PF)is a devastating lung disease with limited treatment *** this pathological process,the profibrogenic macrophage subpopulation plays a crucial role,making the characterization of this subpopulation fundamentally *** present study revealed a positive correlation between pulmonary macrophages with higher mitochondrial mass(Mø^(mitohigh))and *** the Mø^(mitohigh)subpopulation of CD206^(+)M2,characterized by higher expression of dynamin 1-like(Drp1),as determined by flow cytometry and RNA-seq analysis,a therapeutic intervention was developed using an exosome-based formula composed of pathfinder and therapeutics.A pathfinder exosome called“exosome^(MMP19)(Exo^(MMP19))”,was constructed to display matrix metalloproteinase-19(^(MMP19))on the surface to locally break down the excessive extracellular matrix(ECM)in the fibrotic lung.A therapeutic exosome called“exosome therapeutics(Exo^(Tx))”,was engineered to display D-mannose on the surface while encapsulating siDrp1 *** delivery of Exo^(MMP19)degraded excessive ECM and thus paved the way for Exo^(Tx)to be delivered into Mø^(mitohigh),where Exo^(Tx)inhibited mitochondrial fission and alleviated *** study has not only identified Mø^(mitohigh)as profibrotic macrophages but it has also provided a potent strategy to reverse PF via a combination of formulated exosomes.

关键词： Pulmonary fibrosis Macrophages Mitochondrial fission Drp1 Exosomes

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模型精度对自控性能的影响及谨慎控制策略

计算机集成制造系统 2007年第10期13卷 1952-1957页

作者：叶亮潘尔顺奚立峰上海交通大学机械与动力工程学院上海200030

为消除过程模型精度对自动过程控制性能的影响,根据仿真分析了试验设计与回归模型精度之间的关系。针对较低精度模型会恶化自动控制性能的问题,将过程模型估计误差引入到控制模型的目标函数中,提出了谨慎控制策略,改善了过程控制性能对... 详细信息

为消除过程模型精度对自动过程控制性能的影响,根据仿真分析了试验设计与回归模型精度之间的关系。针对较低精度模型会恶化自动控制性能的问题,将过程模型估计误差引入到控制模型的目标函数中,提出了谨慎控制策略,改善了过程控制性能对模型精度的依赖程度。使用谨慎控制律,能够使过程质量在使用模型精度较高和较低的情况下都能保持在较好的水平,大大提高了自动过程控制对模型精度的鲁棒性,也降低了试验成本。

关键词：试验设计自动过程控制鲁棒参数设计谨慎控制

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基于鲁棒参数控制方法的可变控制线控制图

计算机集成制造系统 2007年第4期13卷 817-821页

作者：叶亮潘尔顺奚立峰上海交通大学机械与动力工程学院上海200030

针对在制造过程中应用鲁棒参数控制时,其过程均值和方差都会经常改变,且无法直接使用现有的控制图技术进行统计过程控制,提出了基于应用鲁棒参数控制的可变控制线控制图的设计方法。它不同于传统的适应性控制图设计方法,是该研究通过对... 详细信息

针对在制造过程中应用鲁棒参数控制时,其过程均值和方差都会经常改变,且无法直接使用现有的控制图技术进行统计过程控制,提出了基于应用鲁棒参数控制的可变控制线控制图的设计方法。它不同于传统的适应性控制图设计方法,是该研究通过对过程均值和方差变化的有效估计,给出了可变控制线的调节律算法,为控制图自动跟踪过程变化提供了一种可行的方法。通过实例分析,验证了上述方法的有效性和实用性。

关键词：鲁棒参数控制休哈特控制图可变控制线

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基于实验设计的健壮参数控制方法

上海交通大学学报 2006年第6期40卷 918-921页

作者：叶亮潘尔顺奚立峰上海交通大学机械与动力工程学院上海200240

针对复杂制造过程中无法应用自动过程控制理论,提出一种基于实验设计的参数健壮控制方法.该方法基于在线噪声变异的可观测且充分利用在线控制参数实时补偿变异的能力,在新的因素分类基础上,以田口损失函数最小为目标,建立了基于实验设... 详细信息

针对复杂制造过程中无法应用自动过程控制理论,提出一种基于实验设计的参数健壮控制方法.该方法基于在线噪声变异的可观测且充分利用在线控制参数实时补偿变异的能力,在新的因素分类基础上,以田口损失函数最小为目标,建立了基于实验设计的健壮参数控制模型.并针对该模型提出了一种优化分析方法,拓展了实验设计回归模型的应用范围,使之能够适用于自动过程控制,从而形成复杂制造过程健壮参数控制的新方法.通过实验分析,验证了上述方法是有效且实用的.

关键词：实验设计健壮参数控制自动过程控制回归模型

Expert consensus on difficulty assessment of endodontic therapy

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International Journal of Oral Science 2024年第1期16卷 15-25页

作者： Dingming Huang xiaoyan Wang Jingping liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou xinmei Chen Jiyao Li Ling ye Lei Cheng xin Xu Tao Hu Hongkun Wu Bin Guo Qin Su Zhi Chen Lihong Qiu Wenxia Chen xi Wei Zhengwei Huang Jinhua Yu Zhengmei Lin Qi Zhang Deqin Yang Jin Zhao Shuang pan Jian Yang Jiayuan Wu Yihuai pan xiaoli xie Shuli Deng xiaojing Huang Lan Zhang Lin Yue Xuedong Zhou State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Operative Dentistry and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghuaSchool of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhanChina Department of Operative Dentistry&Endodontics School of StomatologyThe Fourth Military Medical UniversityXi’anChina Department of Endodontics Beijing Stomatological HospitalSchool of StomatologyCapital Medical UniversityBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Preventive Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Geriatric dentistry West China Hospital of Stomatology

Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy(RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system’s anatomy intricacies and the technique sensitivity of RCT. Success in RCT hinges on factors like patients, infection severity, root canal anatomy, and treatment techniques. Therefore, improving disease management is a key issue to combat endodontic diseases and cure periapical lesions. The clinical difficulty assessment system of RCT is established based on patient conditions, tooth conditions, root canal configuration, and root canal needing retreatment, and emphasizes pre-treatment risk assessment for optimal outcomes. The findings suggest that the presence of risk factors may correlate with the challenge of achieving the high standard required for RCT. These insights contribute not only to improve education but also aid practitioners in treatment planning and referral decision-making within the field of endodontics.

关键词： anatomy difficulty treatment

A multicenter prospective study on the management of hepatoblastoma in children:a report from the Chinese Children's Cancer Group

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World Journal of Pediatrics 2024年第6期20卷 590-601页

作者： Meng-Jie Tang xiao-Li Ma xiang-Ling He Wei-Hua pan xiao-Hong Zhang Sha-Yi Jiang Ju Gao Fu Li Wei Yao Song Gu Wei-Ling Zhang Qiang Zhao Shi-Hao Huang Yong-Jun Fang Wei Liu Hui-Zhong Niu Chun-Mei Wang Li-Rong Sun Hui Gao Yun-Peng Dai Shun-Gen Huang Zhi-Yong Zhong xi-Ge Wang Zhong-Rong Li liang-Chun Yang ye-Ming Wu Huan-Min Wang xin Sun xiao-Jun Yuan Department of Pediatric Hematology/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang RoadYangpu DistrictShanghai 200092China Medical Oncology Department Pediatric Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Hematology/Oncology Children's Medical CenterHunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 41005China Department of Pediatric Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Hematology/Oncology Guangzhou Women and Children's Medical CenterNational Children's Medical Center for South Central RegionGuangzhou 510623China Department of Hematology Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China Department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041China Department of Hematology/Oncology Qilu Children's Hospital of Shandong UniversityJinan 250022China Department of Pediatric Surgery Children's Hospital of Fudan UniversityShanghai 201102China Department of General Surgery Shanghai Children's Medical Center(National Children's Medical Center-Shanghai)Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Pediatrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Hematology/Oncology Children's Hospital of Nanjing Medical UniversityNanjing 210008China Department of Hematology/Oncology Henan Children's HospitalZhengzhou 450018China Department of Pediatric General Surgery Hebei Children's Hospital of Hebei Medical UniversityShijiazhuang City 050031China Children's Hospital the First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Paediatric

Background This study aimed to identify survival risk factors in Chinese children with hepatoblastoma(HB)and assess the effectiveness of the new treatment protocol proposed by the Chinese Children's Cancer Group(CCCG)in *** A multicenter,prospective study that included 399 patients with HB from January 2015 to June 2020 was *** demographics,treatment protocols,and other related information were *** regression models and Kaplan-Meier curve methods were *** The 4-year event-free survival(EFS)and overall survival(OS)were 76.9 and 93.5%,*** 4-year EFS rates for the very-low-risk,low-risk,intermediate-risk,and high-risk groups were 100%,91.6%,81.7%,and 51.0%,*** 4-year 0S was 100%,97.3%,94.4%,and 86.8%,*** regression analysis found that age,tumor rupture(R+),and extrahepatic tumor extension(E+)were independent prognostic factors.A total of 299 patients had complete remission,and 19 *** with declining alpha-fetoprotein(AFP)>75%after the first two cycles of neoadjuvant chemotherapy had a better EFS and OS than those≤75%.Conclusions The survival outcome of HB children has dramatically improved since the implementation of CCCG-HB-2016 ***≥8 years,R+,and E+were independent risk factors for *** with a declining AFP>75%after the first two cycles of neoadjuvant chemotherapy had better EFS and OS.

关键词： Alpha-fetoprotein Hepatoblastoma Multicenter Prospective study Survival

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管内蒸汽射流凝结速度场特性研究

工程热物理学报 2016年第12期37卷 2577-2581页

作者：徐强郭烈锦常亮王晔春张西民于子文潘辉西安交通大学动力工程多相流国家重点实验室西安710049 北京宇航系统工程研究所北京100076

采用粒子图像测速仪(PIV)对圆管内横向蒸汽射流凝结速度场进行了测量。垂直圆管直径80 mm,喷嘴直径3.2 mm,喷嘴与管道壁面垂直,蒸汽射流雷诺数20192 详细信息

采用粒子图像测速仪(PIV)对圆管内横向蒸汽射流凝结速度场进行了测量。垂直圆管直径80 mm,喷嘴直径3.2 mm,喷嘴与管道壁面垂直,蒸汽射流雷诺数20192

关键词：蒸汽凝结射流速度场