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Molecular classification of small cell lung cancer subtypes:Characteristics,prognostic factors,and clinical translation

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Chinese Medical Journal 2024年第2期137卷 130-139页

作者： Hanfei guo Wenqian li ye guo Naifei Chen Jiuwei Cui Cancer Center The First Hospital of Jilin UniversityChangchunJilin 130021China

Small cell lung cancer(SCLC)is a highly malignant tumor with a very poor prognosis;therefore,more effective treatments are urgently needed for patients afflicted with the *** recent years,emerging molecular classifications based on key transcription factors of SCLC have provided more information on the tumor pathophysiology,metastasis,immune microenvironment,and acquired therapeutic resistance and reflected the intertumoral heterogeneity of the various SCLC ***,advances in genomics and single-cell sequencing analysis have further revealed the high intratumoral heterogeneity and plasticity of the ***,we review and summarize these recent lines of evidence and discuss the possible pathogenesis of SCLC.

关键词： Small cell lung carcinoma Molecular classification Tumor heterogeneity Drug resistance Transcription factors Genomics Phenotype Prognosis

Improving the value of molecular testing:current status and opportunities in colorectal cancer precision medicine

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Cancer Biology & Medicine 2024年第1期21卷 21-28页

作者： Haiyun li linwei guo Chenchen Wang Xin Hu ye Xu Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Gastrointestinal Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Precision Cancer Medical Center Affiliated with Fudan University Shanghai Cancer Center Shanghai 201315China

Colorectal cancer(CRC)is the second leading cause of cancer-related deaths *** radical resection with adjuvant chemotherapy remains the primary treatment choice for CRC,but the 5-year postoperative survival rate is only approximately 60%,and approximately one-third of patients with CRC experience recurrence within 2 years of ***,the transformation of high-throughput sequencing has accelerated the development of precision *** example,KRAS mutations indicate resistance to anti-epidermal growth factor receptor(EGFR)-targeted therapies in ***,molecular-guided individualized therapy has brought new promise in major clinical areas and challenges,such as novel biomarkers predicting sensitivity and resistance to immunotherapy for microsatellite stable(MSS)CRC.

关键词： cancer chemotherapy colorectal

Polyethylene interfacial dielectric layer for organic semiconductor single crystal based field-effect transistors

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Chinese Chemical Letters 2024年第4期35卷 431-435页

作者： Min Chen Boyu Peng Xuyun guo ye Zhu Hanying li Department of Polymer Science and Engineering MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationInternational Research Center for X PolymersShanxi-Zheda Institute of Advanced Materials and Chemical EngineeringZhejiang UniversityHangzhou 310027China Department of Applied Physics Research Institute for Smart EnergyThe Hong Kong Polytechnic UniversityHong Kong 999077China

Organic semiconductor single crystals(OSSCs) have shown their promising potential in high-performance organic field-effect transistors(OFETs). The interfacial dielectric layers are critical in these OFETs as they not only govern the key semiconductor/dielectric interface quality but also determine the growth of OSSCs by their wetting properties. However, reported interfacial dielectric layers either need rigorous preparation processes, rely on certain surface chemistry reactions, or exhibit poor solvent resistance, which limits their applications in low-cost, large-area, monolithic fabrication of OSSC-based OFETs. In this work, polyethylene(PE) thin films and lamellar single crystals are utilized as the interfacial dielectric layers, providing solvent resistive but wettable surfaces that facilitate the crystallization of 6,13-bis(tri-isopropylsilylethynyl)pentacene(TIPS-PEN) and 6,13-bis(triisopropylsilylethynyl)-5,7,12,14-tetraazapentacene(TIPS-TAP). As evidenced by the presence of ambipolar behavior in TIPS-PEN single crystals and the high electron mobility(2.3 ± 0.34 cm^(2)V^(-1)s^(-1)) in TIPS-TAP single crystals, a general improvement on electron transport with PE interfacial dielectric layers is revealed, which likely associates with the chemically inertness of the saturated C-H bonds. With the advantages in both processing and device operation, the PE interfacial dielectric layer potentially offers a monolithic way for the enhancement of electron transport in solution-processed OSSC-based OFETs.

关键词： Polyethylene Interfacial dielectric layer Organic semiconductor Single crystal Organic field-effect transistors

Deep learning for joint channel estimation and feedback in massive MIMO systems

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Digital Communications and Networks 2024年第1期10卷 83-93页

作者： Jiajia guo Tong Chen Shi Jin Geoffrey ye li Xin Wang Xiaolin Hou National Mobile Communications Research Laboratory Southeast UniversityNanjing210096China Department of Electrical and Electronic Engineering Imperial College LondonLondonSW72AZUK DOCOMO Beijing Communications Laboratories Co. LtdBeijingChina

The great potentials of massive Multiple-Input Multiple-Output(MIMO)in Frequency Division Duplex(FDD)mode can be fully exploited when the downlink Channel State Information(CSI)is available at base ***,the accurate CsI is difficult to obtain due to the large amount of feedback overhead caused by massive *** this paper,we propose a deep learning based joint channel estimation and feedback framework,which comprehensively realizes the estimation,compression,and reconstruction of downlink channels in FDD massive MIMO *** networks are constructed to perform estimation and feedback explicitly and *** explicit network adopts a multi-Signal-to-Noise-Ratios(SNRs)technique to obtain a single trained channel estimation subnet that works well with different SNRs and employs a deep residual network to reconstruct the channels,while the implicit network directly compresses pilots and sends them back to reduce network *** module is also designed to generate data-bearing *** results show that the two proposed networks exhibit excellent performance of reconstruction and are robust to different environments and quantization errors.

关键词： Channel estimation CSI feedback Deep learning Massive MIMO FDD

Mitochondrial energy metabolism in diabetic cardiomyopathy:Physiological adaption,pathogenesis,and therapeutic targets

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Chinese Medical Journal 2024年第8期137卷 936-948页

作者： Wanlin ye Kun Han Maodi Xie Sheyu li guo Chen Yanyan Wang Tao li Department of Anesthesiology Laboratory of Mitochondria and MetabolismNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Anesthesiology West China Second University HospitalSichuan UniversityChengduSichuan 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan UniversityMinistry of EducationChengduSichuan 610041China Department of Endocrinology and Metabolism Division of Guideline and Rapid RecommendationCochrane China CenterMAGIC China CenterChinese Evidence-Based Medicine CenterWest China HospitalSichuan UniversityChengduSichuan 610041China Nursing Key Laboratory of Sichuan Province West China HospitalSichuan UniversityChengduSichuan 610041China

Diabetic cardiomyopathy is defined as abnormal structure and function of the heart in the setting of diabetes,which could eventually develop heart failure and leads to the death of the *** blood glucose control and medications to heart failure show beneficial effects on this disease,there is currently no specific treatment for diabetic *** the past few decades,the pathophysiology of diabetic cardiomyopathy has been extensively studied,and an increasing number of studies pinpoint that impaired mitochondrial energy metabolism is a key mediator as well as a therapeutic *** this review,we summarize the latest research in the field of diabetic cardiomyopathy,focusing on mitochondrial damage and adaptation,altered energy substrates,and potential therapeutic targets.A better understanding of the mitochondrial energy metabolism in diabetic cardiomyopathy may help to gain more mechanistic insights and generate more precise mitochondria-oriented therapies to treat this disease.

关键词： Mitochondria Mitochondrial energy metabolism Diabetic cardiomyopathies Physiology Physiological adaption Pathogenesis Therapeutics

Instantaneous preparation of gold-carbon dot nanocomposites for on-site SERS identification of pathogens in diverse interfaces

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Photonics Research 2024年第6期12卷 1303-1312页

作者： YANXIAN guo ye liU CHAOCAI LUO YUE ZHANG YANG li FEI ZHOU ZHOUYI guo ZHENGFEI ZHUANG ZHIMING liU School of Electronic Engineering and Intelligentization Dongguan University of TechnologyDongguan 523808China Department of Physics University of Science and Technology of ChinaHefei 230026China MOE Key Laboratory of Laser life Science&Guangdong Provincial Key Laboratory of Laser life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China

Rapid detection of pathogens present on contaminated surfaces is crucial for food safety and public health due to the high morbidity and mortality of bacterial ***,a sensitive and efficient method for on-site identification of foodborne pathogens on anisotropic surfaces was developed by using an in situ instantaneously prepared surface-enhanced Raman scattering(SERS)*** achieve this,molybdenum-doped gallic acidderived carbon dots(MCDs)are utilized as the reductant for synthesizing Au@MCDs nanohybrids within just 3 s at ambient *** synergistic effect of the electromagnetic enhancement and charge transfer of Au@MCDs enables excellent SERS performance 10 times stronger than bare Au *** bioassay platform requires less than 5 min to complete the quantitative detection of foodborne pathogens on various microbial-contaminated interfaces with a sensitivity of 10 CFU/m *** innovative strategy breaks the long-standing limitations of SERS substrates in practical use,such as the time-consuming process,interference of residual surfactants,poor surface stability,and few application scenarios,providing a promising tool for widespread applications in biomedical research and clinical diagnostics.

关键词： temperature molybdenum consuming

Experimental Study on Soot Suppression of Acetylene Diffusion Flame by Acoustic-Excited Oscillation in Rijke-Type Burner

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Journal of Thermal Science 2024年第1期33卷 235-248页

作者： ZHU Yibin guo Hui SUO Yan'ge WU Minle ye Yanghui li guoneng ZHANG Zhiguo School of Mechanical and Energy Engineering Zhejiang University of Science and TechnologyHangzhou 310023China

This work reports that the flame oscillation induced by acoustic excitation can effectively suppress soot generation in Rijke-type *** the acoustic frequency is close to the natural frequency of the burner system,it can produce resonance resulting in intense oscillation of the *** relationship between the soot suppression efficiency and the acoustic field of standing wave at different flame positions is *** with that under self-excited oscillation,when there is external forced acoustic force introduced to the flame,oscillation combustion occurred in a lager zone in the glass *** fundamental cause of different soot suppression efficiency at different positions is that the standing wave acoustic field causes the particles to move at different speeds in different positions of the glass *** axial particle velocity difference results in the formation of acoustic vortexes and the change of the flame *** high particle velocity causes the air in the glass tube to turn into the turbulent condition and make the flame temperature *** results show that the surface growth rate of soot is reduced,while the oxidation rate of soot is enhanced,which result in the soot suppression under acoustic *** study can provide some reference for the practical application of oscillate combustion in soot suppression.

关键词： soot suppression acetylene diffusion flame acoustic-excited oscillation standing wave

A portable,auxiliary photovoltaic power system for electric vehicles based on a foldable scissors mechanism

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Energy and Built Environment

Energy and Built Environment 2024年第1期5卷 81-96页

作者： Zhou Jin Dongyang li Daning Hao Zutao Zhang liang guo xiaoping Wu Yanping Yuan China Railway Wuhan Electrification Bureau Group Shanghai Electric Co. LtdShanghai 201799PR China School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031PR China

In recent years,countries worldwide have actively advocated electric vehicles for environmental ***-ever,restrictions on the driving range and charging have hampered the promotion of electric *** study proposes a portable,auxiliary photovoltaic power system based on a foldable scissors mechanism for electric *** system includes a photovoltaic power generation module and an electricity transfer *** photovoltaic power generation module built based on a foldable scissors mechanism is five times smaller than in its unfolded state,improving its portability in its folded *** electricity transfer module transfers electricity into the cabin via wireless power transfer units and stores electricity in *** simulation exper-iments were conducted to evaluate the system’s performance:maximum output power of 1.736 W is measured when the load is 5Ω,while maximum wireless power transfer efficiency is up to 57.7% with 10Ω *** elec-tric vehicle in Chengdu city was simulated for a case *** results show that the annual output of a single photovoltaic power system can drive the MINIEV for 423.625 km,indicating that the proposed system would be able to supply power for electric vehicles as an auxiliary power supply system.

关键词： Auxiliary photovoltaic power system Energy harvesting Scissors mechanism Solar collector Electric vehicle

Structural Evolution of Ultra-High Molecular Weight Polyethylene Low-Entangled Films with Reserved Shish Crystals During Hot Stretching

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Chinese Journal of Polymer Science 2024年第8期42卷 1227-1242页

作者： Jia-Wei Gao li Chen ye-Shun Zhong Chao-Wei Xing Yi-guo li Zong-Bao Wang School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China

Shish crystals are crucial to achieving high performance low-dimensional ultra-high molecular weight polyethylene(UHMWPE)***,high stretch and shear flow fields are necessary for the formation of shish *** this study,UHMWPE gel films with reserved shish crystals were prepared by gel molding,the structural evolution and properties of UHMWPE films stretched at temperatu res of 100,110,120and 130℃were investigated by in situ small-angle X-ray scattering(SAXS)/ultra-small-angle X-ray scattering(USAXS)/wide-angle X-ray diffraction(WAXD)measu rements as well as scanning electron microscopy(SEM)and differential scanning calorimetry(DSC)*** findings showed that the reserved shish crystals can facilitate the formation and structural evolution of shish-kebab crystals during the hot ***,the reserved shish crystals promote the structu ral evolution of UHMWPE films to a greater extent when stretched at 120 and 130℃,compared to 100 and 110℃,resulting in higher crystallinity,orientation,thermal properties,breaking strength and Young's *** pared to UHMWPE high-entangled films with reserved shish crystals prepared by compression molding,UHMWPE low-entangled films with reserved shish crystals prepared by gel molding are more effective in inducing the formation and evolution of shish-kebab crystals during the hot stretching,resulting in increased breaking strength and Young's modulus.

关键词： UHMWPE low-entangled films Reserved shish crystals Structural evolution Hot stretching