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心理应激对皮肤屏障功能的不良影响

生理科学进展 2024年第3期55卷 207-214页

作者：付梦丽高爽叶佳滨张凯妮赵文刚许诺温州大学生命与环境科学学院温州325035 温州医科大学药学院温州325035

皮肤是机体和外界环境之间的第一道保护性屏障,在保护机体免受外界环境等危险因素造成的损伤方面起着重要的作用。心理应激是人在面对各种压力和挑战时产生的情绪和心理反应,多种因素都可以作为心理应激的应激源。长期的心理应激会造成... 详细信息

皮肤是机体和外界环境之间的第一道保护性屏障,在保护机体免受外界环境等危险因素造成的损伤方面起着重要的作用。心理应激是人在面对各种压力和挑战时产生的情绪和心理反应,多种因素都可以作为心理应激的应激源。长期的心理应激会造成机体内环境稳态失衡,甚至疾病发生。迄今为止有众多研究表明心理应激可通过神经内分泌反应,导致皮肤细胞功能减弱或异常,从而深刻影响皮肤局部生理功能,引起皮肤屏障功能的显著变化,导致皮肤健康问题产生。本文主要综述心理应激影响皮肤屏障功能的相关研究进展。

关键词：心理应激皮肤健康皮肤屏障功能交感神经-肾上腺髓质系统下丘脑-垂体-肾上腺轴

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非均布压力作用下纯弯曲孔道预应力摩阻损失

科学技术与工程 2024年第12期24卷 5170-5178页

作者：杨雅勋刘寒柴文浩吴富勇叶家乐长安大学公路学院西安710064

为获得更准确的孔道预应力摩阻损失计算方法,保证桥梁结构设计的有效预应力和桥梁结构的安全运行。根据赫兹接触理论,综合考虑摩擦力、接触压力与张拉力间的相互作用,导出了纯弯曲孔道在非均匀压力作用下摩阻损失公式。通过有限元软件... 详细信息

为获得更准确的孔道预应力摩阻损失计算方法,保证桥梁结构设计的有效预应力和桥梁结构的安全运行。根据赫兹接触理论,综合考虑摩擦力、接触压力与张拉力间的相互作用,导出了纯弯曲孔道在非均匀压力作用下摩阻损失公式。通过有限元软件分析不同参数对摩阻损失计算值的影响。通过实际工程的摩阻试验探究纯弯曲孔道在非均匀压力下预应力摩阻损失的具体分布规律,并通过规范公式、推导公式的理论计算值与现场实测数据的偏差,验证公式的合理性。结果表明:弯曲角度小于120°、摩擦系数为0.2~0.4范围内,推导公式计算值更接近实际情况;随着张拉应力和弯曲角度的增加,利用推导公式计算得到的摩阻损失值更接近实测结果。

关键词：预应力摩阻损失弯曲孔道有限元模拟接触压力

Buyang Huanwu Decoction ameliorates ischemic stroke by modulating multiple targets with multiple components: In vitro evidences

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Chinese Journal of Natural Medicines 2018年第3期16卷 194-202页

作者： ZHANG Wei-Wei XU Feng WANG Ding ye jia CAI Shao-Qing Department of Molecular and Cellular Pharmacology School of Pharmaceutical Sciences Peking University Department of Clinical Pharmacy Beijing Tsinghua Changgung Hospital Medical Center Tsinghua University State Key Laboratory of Natural and Biomimetic Drugs Peking University

Buyang Huanwu Decoction （BYHWD） is a well-known traditional Chinese medicine prescription which is used to treat ischaemic stroke and stroke-induced disabilities. However, the exact mechanism underlying BYHWD＇s amelioration of ischaemic stroke and its effective constituents remain unclear. The present study aimed to identify the effective constituents of BYHWD and to further explore its action mechanisms in the amelioration of ischaemic stroke by testing the activities of 15 absorbable chemical constituents of BYHWD with the same methods under the same conditions. The following actions of these 15 compounds were revealed： 1） Ferulic acid, calycosin, formononetin, astrapterocarpan-3-O-β-D-glucoside, paeonol, calycosin-7-O-β-D-glucoside, astraisofla- van-7-O-β-D-glucoside, ligustrazine, and propyl gallate significantly suppressed concanavalin A （Con A）-induced T lymphocyte proliferation; 2） Propyl gallate, calycosin-7-O-β-D-glucoside, paeonol, and ferulic acid markedly inhibited LPS-induced apoptosis in RAW264.7 cells; 3） Propyl gallate and formononetin significantly inhibited LPS-induced NO release; 4） Hydroxysaffior yellow A and inosine protected PC12 cells against the injuries caused by glutamate; and 5） Formononetin, astragaloside IV, astraisofiavan-7-O-β-D- glucoside, inosine, paeoniflorin, ononin, paeonol, propyl gallate, ligustrazine, and ferulic acid significantly suppressed the constriction of the thoracic aorta induced by KCI in rats. In conclusion, the results from the present study suggest that BYHWD exerts its ischaemic stroke ameliorating activities by modulating multiple targets with multiple components.

关键词： Buyang Huanwu Decoction Chemical constituents Ischemic stroke Anti-inflammatory-immunity Neuroprotection Vasodilation

PyCIL: a Python toolbox for class-incremental learning

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Science China(Information Sciences) 2023年第9期66卷 291-292页

作者： Da-Wei ZHOU Fu-Yun WANG Han-jia ye De-Chuan ZHAN State Key Laboratory for Novel Software Technology Nanjing University

With the rapid development of deep learning, current deep models can learn a fixed number of classes with high performance. However, in our ever-changing world, data often come from the open environment, which is with stream format or available temporarily due to privacy issues. As a result, the classification model should learn new classes incrementally instead of restarting the training process.

关键词：

Photonic generation of microwave signals with tunabilities

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Chinese Science Bulletin 2014年第22期59卷 2672-2683页

作者： Hengyun jiang Lianshan Yan jia ye Wei Pan Bin Luo Xihua Zou Center for Information Photonics and Communications School of Information Science and Technology Southwest Jiaotong University

Microwave photonic signal generation schemes based on the frequency to time mapping and external modulation are *** concentrate on those configurations that can provide tunability of frequency,phase of signal,modulati... 详细信息

关键词：微波信号光子产生可调频率调制格式微波光子时间映射 2PSK 2FSK

Extraordinary transmission and reflection in PT-symmetric two-segment-connected triangular optical waveguide networks with perfect and broken integer waveguide length ratios

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Chinese Physics B 2019年第10期28卷 367-375页

作者： jia-ye Wu Xu-Hang Wu Xiang-Bo Yang Hai-Ying Li Guangzhou Key Laboratory for Special Fiber Photonic Devices School of Information and Optoelectronic Science and EngineeringSouth China Normal UniversityGuangzhou 510006China Laboratory of Nonlinear Fiber Optics School of Electronic and Computer EngineeringPeking UniversityShenzhen 518055China

By adjusting the waveguide length ratio, we study the extraordinary characteristics of electromagnetic waves propagating in one-dimensional(1D) parity-time-symmetric(PT-symmetric) two-segment-connected triangular optical waveguide networks with perfect and broken integer waveguide length ratios respectively. It is found that the number and the corresponding frequencies of the extremum spontaneous PT-symmetric breaking points are dependent on the waveguide length ratio. Near the extremum breaking points, ultrastrong extraordinary transmissions are created and the maximal can arrive at, respectively, 2.4079 × 10^14 and 4.3555 × 10^13 in both kinds of networks. However, bidirectional invisibility can only be produced by the networks with broken integer waveguide length ratio, whose mechanism is explained in detail from the perspective of photonic band structure. The findings of this work can be useful optical characteristic control in the fabrication of PT-symmetric optical waveguide networks, which possesses great potential in designing optical amplifiers,optical energy saver devices, and special optical filters.

关键词： parity-time symmetry optical waveguide network integer broken ratios

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模块化建筑(MiC)技术的研究综述与进展

广州建筑 2024年第1期52卷 113-117页

作者：叶嘉彬汤序霖何炳泉黄狄昉广州机施建设集团有限公司广州510725 华南理工大学土木与交通学院广州510641

装配式建筑作为重要抓手,推动着建筑工业化和行业转型升级的持续深化。高度符合“标准化设计、工厂化生产、低碳绿色建造、集成化装修”理念与特点的模块化建筑(MiC),正成为当下国内发展装配式建筑的又一重要方向,现已逐步在实际工程中... 详细信息

装配式建筑作为重要抓手,推动着建筑工业化和行业转型升级的持续深化。高度符合“标准化设计、工厂化生产、低碳绿色建造、集成化装修”理念与特点的模块化建筑(MiC),正成为当下国内发展装配式建筑的又一重要方向,现已逐步在实际工程中推广应用。本文对模块化建筑的研究历程与进展进行梳理和总结,包括模块间连接安装技术,混凝土MiC物流运输、吊重设备布置规划及智能建造等施工技术方面的研究进展。最后,搜集了相关混凝土MiC项目发展历程与应用案例,总结模块化建筑现有研究的不足和发展趋势。

关键词：建筑工业化预制模块化建筑 MiC 施工技术

Effect of Cu Addition on the Microstructure and Mechanical Properties of U-MIG Welds on Galvanized Steel Sheets

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Journal of Shanghai jiaotong university(Science) 2021年第6期26卷 757-764页

作者： YU Xiaokang ye jia WU Chunxiang MA Guohong Key Laboratory of Lightweight and High Strength Structural Materials of jiangxi Province School of Mechanical EngineeringNanchang UniversityNanchang 330031China Applied Materials Inc.Santa ClaraCA 95054-3299USA

Ultrasonic-assisted metal inert gas(U-MIG)welding experiments were performed to analyze the effect of Cu addition on the microstructure and mechanical properties of galvanized steel sheet welds,and first-principles calculations were undertaken to predict the effect of Cu on the mechanical properties ofα-Fe based *** shown by scanning electron microscopy analysis,Cu is conducive to the refinement and uniformity of the microstructure in the weld ***-dispersive spectrometry data indicated the presence of Cu in the welds after welding with Cu *** elastic moduli of the welds without and with Cu powder,obtained from nanoindentation tests,were(217.66±5.11)GPa and(223.13±9.12)GPa,respectively,which were close to the calculated *** mechanical properties of the crystal structures ofα-Fe andα-Fe_(1.9)Cu_(0.1)were calculated using Materials Studio *** the experimental and calculated results showed that Cu doping reduced the bulk modulus of the weld but increased its shear modulus.

关键词： weld Cu powder first-principles calculations galvanized steel sheet microstructure properties

Accumulation of cadmium and its effects on growth, development and hemolymph biochemical compositions in Boettcherisca peregrina larvae （Diptera： Sarcophagidae）

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Insect Science 2006年第1期13卷 31-39页

作者： GUO-XING WU GONG-YIN ye CUI HU jia-AN CHENG Institute of Applied Entomology College of Agriculture and Biotechnology Zhejiang University Hangzhou China

Newly emerged larvae of the fleshfly, Boettcherisca peregrina were exposed to two different CdCl2 concentrations of 100μg/g and 400 mg/g diet fresh weight （DFW）. They were administered in the diets until the end of larval stage. Cd-exposed larvae accumulated significant amounts of Cd and this accumulation increased with the exposure dose and time. The body weights were lightened and lengths of larvae were shortened considerably after Cd exposure, especially at the higher Cd concentration. The total larval duration was also extremely affected due to Cd exposure. The average duration was prolonged significantly by 14 h at the lower Cd concentration, while it was increased by 33.7 h over controls at the higher Cd concentration. A significant decrease in contents of either soluble proteins, total lipids or caloric values in the hemolymph occurred due to Cd exposure throughout the entire tested period but after 120 h of Cd exposure. In contrast, when exposed to Cd with its higher concentration, total sugar contents in the hemolymph were increased strikingly over the whole tested time, except after 96 h of Cd exposure, while they were not apparently altered except after 24 h of Cd exposure at the lower concentration. Thus, it is suggested that Cd exposure shows significant adverse impact on the growth and development, as well as metabolism, in larvae of this fleshfly, depending on its exposure time and dose.

关键词： Boettcherisca peregrina cadmium caloric value growth and development,lipids proteins total sugar