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Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting Liu Shiqi Huang Xiangliang Chen Shen Liu Junshan Zhou hongdong Zhao ye hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion injury.Low-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s disease.However,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic stroke.To address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke models.First,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting analysis.We observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/reoxygenation.Second,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated virus.Low-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective phenotype.Finally,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte phenotype.These findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

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Phosphine-catalyzed acyl-transfer of heteroaryl ketones for the construction of N-fused heterocycles

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Chinese Chemical Letters 2024年第3期35卷 252-256页

作者： Yu Zhang De-Rui Han Dan ye hong Lu Hao Wei Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry&Materials ScienceNorthwest UniversityXi'an 710069China

An inexpensive phosphine catalyst was used effectively for a transition-metal-free acyl-transfer of N-containing heteroaryl ketones for the rapid synthesis of N-fused heterocycles.The key pre-aromatic spirocyclic intermediate initialized by the single electron transfer(SET)process of Togni's reagentⅡpromoted by the tertiary phosphine resulted in an intriguing and alternative tactic for the cleavage of C–C bonds.By using inexpensive tertiary phosphine as the catalyst,this skeleton-reorganizing approach of N-containing heteroaryl ketones allows a streamlined assembly of complex N-fused heterocycles with broad functional group tolerance.

关键词： Phosphine catalysis Acyl-transfer N-Fused heterocycles C–C bond activation Aromatization

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UAV-assisted cooperative offloading energy efficiency system for mobile edge computing

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Digital Communications and Networks 2024年第1期10卷 16-24页

作者： Xue-Yong Yu Wen-Jin Niu ye Zhu hong-Bo Zhu Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and Telecommunications Nanjing210003China Engineering Research Centerof Health Service System Based on Ubiquitous Wireless Nework Ministyof EducationNanjng Universityof Posts and Telecommunication Nanjing210003China

Reliable communication and intensive computing power cannot be provided effectively by temporary hot spots in disaster areas and complex terrain ground infrastructure.Mitigating this has greatly developed the application and integration of UAV and Mobile Edge Computing(MEC)to the Internet of Things(loT).However,problems such as multi-user and huge data flow in large areas,which contradict the reality that a single UAV is constrained by limited computing power,still exist.Due to allowing UAV collaboration to accomplish complex tasks,cooperative task offloading between multiple UAVs must meet the interdependence of tasks and realize parallel processing,which reduces the computing power consumption and endurance pressure of terminals.Considering the computing requirements of the user terminal,delay constraint of a computing task,energy constraint,and safe distance of UAV,we constructed a UAV-Assisted cooperative offloading energy efficiency system for mobile edge computing to minimize user terminal energy consumption.However,the resulting optimization problem is originally nonconvex and thus,difficult to solve optimally.To tackle this problem,we developed an energy efficiency optimization algorithm using Block Coordinate Descent(BCD)that decomposes the problem into three convex subproblems.Furthermore,we jointly optimized the number of local computing tasks,number of computing offloaded tasks,trajectories of UAV,and offloading matching relationship between multi-UAVs and multiuser terminals.Simulation results show that the proposed approach is suitable for different channel conditions and significantly saves the user terminal energy consumption compared with other benchmark schemes.

关键词： Computation offloading Internet of things(IoT) Mobile edge computing(MEC) Block coordinate descent(BCD)

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A Non-Parametric Scheme for Identifying Data Characteristic Based on Curve Similarity Matching

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1424-1437页

作者： Quanbo Ge Yang Cheng hong Li Ziyi ye Yi Zhu Gang Yao School of Automation Nanjing University of Information Science&TechnologyJiangsu Provincial University Key Laboratory of Big Data Analysis and Intelligent SystemsNanjing University of Information Science&Technologyand the Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology(CICAEET)Nanjing University of Information Science&TechnologyNanjing 210044China School of Department of Logistics Engineering Shanghai Maritime UniversityShanghai 201306China China Classification Society Nantong Office Nantong 226006China Chinese Flight Test Establishment Xi’an 710089China School of Mathematics Tsinghua UniversityBeijing 100084China School of Automation Nanjing University of Information Science&TechnologyNanjing 210044China Department of Logistics Engineering Shanghai Maritime UniversityShanghai 201306China IEEE

For accurately identifying the distribution charac-teristic of Gaussian-like noises in unmanned aerial vehicle(UAV)state estimation,this paper proposes a non-parametric scheme based on curve similarity matching.In the framework of the pro-posed scheme,a Parzen window(kernel density estimation,KDE)method on sliding window technology is applied for roughly esti-mating the sample probability density,a precise data probability density function(PDF)model is constructed with the least square method on K-fold cross validation,and the testing result based on evaluation method is obtained based on some data characteristic analyses of curve shape,abruptness and symmetry.Some com-parison simulations with classical methods and UAV flight exper-iment shows that the proposed scheme has higher recognition accuracy than classical methods for some kinds of Gaussian-like data,which provides better reference for the design of Kalman filter(KF)in complex water environment.

关键词： Curve similarity matching Gaussian-like noise non-parametric scheme parzen window.

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BSTFNet:An Encrypted Malicious Traffic Classification Method Integrating Global Semantic and Spatiotemporal Features

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Computers, Materials & Continua 2024年第3期78卷 3929-3951页

作者： hong Huang Xingxing Zhang ye Lu Ze Li Shaohua Zhou School of Computer Science and Engineering Sichuan University of Science&EngineeringYibin644002China School of Mathematics and Statistics Sichuan University of Science&EngineeringYibin644002China

While encryption technology safeguards the security of network communications,malicious traffic also uses encryption protocols to obscure its malicious behavior.To address the issues of traditional machine learning methods relying on expert experience and the insufficient representation capabilities of existing deep learning methods for encrypted malicious traffic,we propose an encrypted malicious traffic classification method that integrates global semantic features with local spatiotemporal features,called BERT-based Spatio-Temporal Features Network(BSTFNet).At the packet-level granularity,the model captures the global semantic features of packets through the attention mechanism of the Bidirectional Encoder Representations from Transformers(BERT)model.At the byte-level granularity,we initially employ the Bidirectional Gated Recurrent Unit(BiGRU)model to extract temporal features from bytes,followed by the utilization of the Text Convolutional Neural Network(TextCNN)model with multi-sized convolution kernels to extract local multi-receptive field spatial features.The fusion of features from both granularities serves as the ultimate multidimensional representation of malicious traffic.Our approach achieves accuracy and F1-score of 99.39%and 99.40%,respectively,on the publicly available USTC-TFC2016 dataset,and effectively reduces sample confusion within the Neris and Virut categories.The experimental results demonstrate that our method has outstanding representation and classification capabilities for encrypted malicious traffic.

关键词： Encrypted malicious traffic classification bidirectional encoder representations from transformers text convolutional neural network bidirectional gated recurrent unit

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Unified deep learning model for predicting fundus fluorescein angiography image from fundus structure image

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Journal of Innovative Optical Health Sciences 2024年第3期17卷 105-113页

作者： Yiwei Chen Yi He hong ye Lina Xing Xin Zhang Guohua Shi Jiangsu Key Laboratory of Medical Optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163P.R.China School of Biomedical Engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of China Hefei 230026P.R.China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031P.R.China

The prediction of fundus fluorescein angiography(FFA)images from fundus structural images is a cutting-edge research topic in ophthalmological image processing.Prediction comprises estimating FFA from fundus camera imaging,single-phase FFA from scanning laser ophthalmoscopy(SLO),and three-phase FFA also from SLO.Although many deep learning models are available,a single model can only perform one or two of these prediction tasks.To accomplish three prediction tasks using a unified method,we propose a unified deep learning model for predicting FFA images from fundus structure images using a supervised generative adversarial network.The three prediction tasks are processed as follows:data preparation,network training under FFA supervision,and FFA image prediction from fundus structure images on a test set.By comparing the FFA images predicted by our model,pix2pix,and CycleGAN,we demonstrate the remarkable progress achieved by our proposal.The high performance of our model is validated in terms of the peak signal-to-noise ratio,structural similarity index,and mean squared error.

关键词： Fundus fluorescein angiography image fundus structure image image translation unified deep learning model generative adversarial networks

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High-order time-reversal symmetry breaking normal state

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 136-148页

作者： Meng Zeng Lun-Hui Hu hong-ye Hu Yi-Zhuang You Congjun Wu Department of Physics University of CaliforniaSan DiegoCalifornia 92093USA Department of Physics Zhejiang UniversityHangzhou 310058China New Cornerstone Science Laboratory Department of PhysicsSchoolof ScienceWestlake UniversityHangzhou 30024China Institute for Theoretical Sciences Westlake UniversityHangzhou 310024China Key Laboratory for Quantum Materials of Zhejiang Province School of ScienceWestlake UniversityHangzhou 310024China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China

Spontaneous time-reversal symmetry breaking plays an important role in studying strongly correlated unconventional superconductors.When two superconducting gap functions with different symmetries compete,the relative phase channel(θ_(-)≡θ_(1)-θ_(2))exhibits an Ising-type Z_(2) symmetry due to the second order Josephson coupling,where θ_(1,2) are the phases of two gap functions.In contrast,the U(1) symmetry in the channel of θ_(+)≡(θ_(1)+θ_(2))/2 is intact.The phase locking,i.e.,ordering of θ_(-),can take place in the phase fluctuation regime before the onset of superconductivity,i.e.,when θ_(+) is disordered.If θ_(-) is pinned at ±π/2,then timereversal symmetry is broken in the normal state,otherwise,if θ_(-)=0,or,π,rotational symmetry is broken,leading to a nematic normal state.In both cases,the order parameters possess a 4-fermion structure beyond the scope of mean-field theory,which can be viewed as a high order symmetry breaking.We employ an effective two-component XY-model assisted by a renormalization group analysis to address this problem.As a natural by-product,we also find the other interesting intermediate phase corresponds to ordering of θ_+ but with θ_(-)disordered.This is the quartetting,or,charge-4e,superconductivity,which occurs above the low temperature Z_(2)-breaking charge-2e superconducting phase.Our results provide useful guidance for studying novel symmetry breaking phases in strongly correlated superconductors.

关键词： superconductivity strong correlation time-reversal breaking charge-4e

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Orientational growth behavior and mechanism of delta(δ)phase precipitation in cold-rolled Inconel 718 alloy during heat treatment

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Journal of Iron and Steel Research(International) 2024年第1期31卷 264-274页

作者： Neng-yong ye Guang-liang Zhang Tian-yue Huang Ming Cheng Shi-hong Zhang Lei Wang School of Materials Science&Engineering Taizhou UniversityTaizhou318000ZhejiangChina Institute of Metal Research Chinese Academy of SciencesShenyang110016LiaoningChina

Due to the important role ofδphase's quantity and morphology in the mechanical and fatigue properties of Inconel 718 alloy and its components,it is necessary to renew insights into the effect of cold deformation on theδphase precipitation,especially on the morphology evolution.Therefore,the nucleation and growth behavior ofδphase in cold-rolled Inconel 718 alloy during aging were investigated.The results show that the precipitation rate and volume fraction ofδphase increase with increasing the cold rolling reduction from 10%to 50%.The volume fraction ofδphase reaches equilibrium after 5 h,remaining at 5.98%,6.52%,and 6.79%under different rolling reductions(10%,30%,and 50%),respectively.The nucleation ofδphase mainly occurs on different sites(grain boundaries,new twin boundaries and old twin boundaries)under 10%rolling reduction,whileδphase mainly nucleates on the new grain boundaries of static recrystallization due to 50%rolling reduction.And the growth ofδphase undergoes a process of alternate orientation growth from spherical(nucleation)→short rod(longitudinal orientation growth)→short rod(radial orientation growth)→dynamic equilib-rium.Under 10%rolling reduction,δphase tends to grow into the matrix,while under 50%rolling reduction,the orientation grows faster and is easily affected by the grain boundary curvature.

关键词： Inconel 718 alloy Cold rolling δphase Orientation growth Morphology evolution

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Responses of plant diversity and soil microorganism diversity to nitrogen addition in the desert steppe,China

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Journal of Arid Land 2024年第3期16卷 447-459页

作者： ye He hong Mei XU Xuehui LIANG Zhiwei JIANG Na TU Nare WU Zhendan College of Grassland Resources and EnvironmentInner Mongolia Agricultural UniversityInner Mongolia Key Laboratory of Soil Quality and Nutrient ResourcesHohhot 010018China Key Laboratory of Agricultural Ecological Security and Green Development at University of Inner Mongolia Hohhot 010018China

Nitrogen(N)deposition is a significant aspect of global change and poses a threat to terrestrial biodiversity.The impact of plant-soil microbe relationships to N deposition has recently attracted considerable attention.Soil microorganisms have been proven to provide nutrients for specific plant growth,especially in nutrient-poor desert steppe ecosystems.However,the effects of N deposition on plant-soil microbial community interactions in such ecosystems remain poorly understood.To investigate these effects,we conducted a 6-year N-addition field experiment in a Stipa breviflora Griseb.desert steppe in Inner Mongolia Autonomous Region,China.Four N treatment levels(N0,N30,N50,and N100,corresponding to 0,30,50,and 100 kg N/(hm2•a),respectively)were applied to simulate atmospheric N deposition.The results showed that N deposition did not significantly affect the aboveground biomass of desert steppe plants.N deposition did not significantly reduce the alfa-diversity of plant and microbial communities in the desert steppe,and low and mediate N additions(N30 and N50)had a promoting effect on them.The variation pattern of plant Shannon index was consistent with that of the soil bacterial Chao1 index.N deposition significantly affected the beta-diversity of plants and soil bacteria,but did not significantly affect fungal communities.In conclusion,N deposition led to co-evolution between desert steppe plants and soil bacterial communities,while fungal communities exhibited strong stability and did not undergo significant changes.These findings help clarify atmospheric N deposition effects on the ecological health and function of the desert steppe.

关键词： soil microorganisms plant-microbial community interaction plant diversity nitrogen deposition desert steppe

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Cardiac remodeling in patients with atrial fibrillation reversing bradycardia-induced cardiomyopathy:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1339-1345页

作者： De-Kui Gao Xiang-Lin ye Zhen Duan hong-Yang Zhang Tao Xiong Zheng-hong Li Hai-Feng Pei Department of Cardiology Jiangyou Second People's HospitalJiangyou 621701Sichuan ProvinceChina Department of Cardiology The General Hospital of Western Theater CommandChengdu 610083Sichuan ProvinceChina Department of Clinical Medicine Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Special Inspection Jiangyou Second People's HospitalJiangyou 621701Sichuan ProvinceChina

BACKGROUND Bradycardia-induced cardiomyopathy(BIC),which is a disease resulting from bradycardia,is characterized by cardiac chamber enlargement and diminished cardiac function.The correction of bradycardia can allow for significant improvements in both cardiac function and structure;however,this disease has been infrequently documented.In this case,we conducted a longitudinal followup of a patient who had been enduring BIC for more than 40 years to heighten awareness and prompt timely diagnosis and rational intervention.CASE SUMMARY A woman who presented with postactivity fatigue and dyspnea was diagnosed with bradycardia at the age of 7.Since she had no obvious symptoms,she did not receive any treatment to improve her bradycardia during the 42-year follow-up,except for the implantation of a temporary pacemaker during labor induction surgery.As time progressed,the patient's heart gradually expanded due to her low ventricular rate,and she was diagnosed with BIC.In 2014,the patient developed atrial fibrillation,her ventricular rate gradually increased,and her heart shape gradually returned to normal.This report describes the cardiac morphological changes caused by the heart rate changes in BIC patients older than 40 years,introduces another possible outcome of BIC,and emphasizes the importance of early intervention in treating BIC.CONCLUSION BIC can induce atrial fibrillation,causing an increased ventricular rate and leading to positive cardiac remodeling.

关键词： Bradycardia cardiomyopathy Heart rate Atrial fibrillation Cardiac dilatation Case report

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