检索结果-南通市图书馆

Rare Metals 2024年第7期43卷 3329-3340页

作者： Zi-Yue Yu Liang-Liang Wei Xing-ye guo Bao-Peng Zhang Qing He Hong-Bo guo School of Materials Science and Engineering Beihang UniversityBeijing100191China Key Laboratory of High-Temperature Structure Materials and Protective Coatings(Ministry of Industry and Information Technology) Beihang UniversityBeijing 100191China Surface Engineering Research Institute Chinese Academy of Agricultural Mechanization SciencesBeijing 100083China

Thermal barrier coatings(TBCs) applied in aeroengines tend to be attacked by molten calcia-magnesiaalumino-silicate(CMAS) at high operating ***-stabilized zirconia(YSZ) coatings with quasicolumnar microstructure were fabricated by plasma spray physical vapor deposition(PS-PVD) *** chemic al changes,micros tructural transform ation,mechanical properties and degradation mechanisms of the CM AS-interacted TBCs in the thermal cycling tests were *** YSZ grains were dissolved in the CMAS melts,and then the ZrO_(2) grains were reprecipitated with spherical shape,accompanying with phase transformation from tetragonal(t) to monoclinic(m).The thermal cycling tests reveal that the YSZ coating fails at the early stage due to the attack of *** fractures in intracolumns lead to partial spallation of the *** failure of the coating occurs at the interfaces between thermally grown oxides(TGO) layer and YSZ topcoat;especially,the hardness and Young's modulus of the YSZ coatings increase intensively,as the coatings were infiltrated by the CMAS for a long time.

关键词： CMAS Thermal barrier coatings Young's modulus Thermal cycling behavior PS-PVD

Functional characterization,structural basis,and protein engineering of a rare flavonoid 2′-O-glycosyltransferase from Scutellaria baicalensis

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第8期14卷 3746-3759页

作者： Zilong Wang Xueqing Du guo ye Haotian Wang Yizhan Liu Chenrui Liu Fudong Li HansÅgren Yang Zhou Junhao Li Chao He De-An guo Min ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Anhui Key Laboratory of Modern Biomanufacturing and School of Life Sciences Anhui UniversityHefei 230601China National Science Center for Physical Sciences at Microscale Division of Molecular&Cell Biophysics and School of Life Sciences University of Science and Technology of ChinaHefei 230026China Department of Physics and Astronomy Uppsala UniversityUppsala SE-75120Sweden School of Pharmacy Jinan UniversityGuangzhou 510632China Shanghai Research Center for Modernization of Traditional Chinese Medicine Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Glycosylation is an important post-modification reaction in plant secondary metabolism,and contributes to structural diversity of bioactive natural *** plants,glycosylation is usually catalyzed by *** 2′-O-glycosides are rare ***,no UGTs have been reported,thus far,to specifically catalyze 2′-O-glycosylation of *** this work,UGT71AP2 was identified from the medicinal plant Scutellaria baicalensis as the first flavonoid 2′-*** could preferentially transfer a glycosyl moiety to 2′-hydroxy of at least nine flavonoids to yield six new *** of the 2′-O-glycosides showed noticeable inhibitory activities against cyclooxygenase *** crystal structure of UGT71AP2(2.15Å)was solved,and mechanisms of its regio-selectivity was interpreted by pKa calculations,molecular docking,MD simulation,MM/GBSA binding free energy,QM/MM,and hydrogen‒deuterium exchange mass spectrometry *** structure-guided rational design,we obtained the L138T/V179D/M180T mutant with remarkably enhanced regio-selectivity(the ratio of 7-O-glycosylation byproducts decreased from 48%to 4%)and catalytic efficiency of 2′-O-glycosylation(kcat/Km,0.23 L/(s·μmol),12-fold higher than the native).Moreover,UGT71AP2 also possesses moderate UDP-dependent de-glycosylation activity,and is a dual function *** work provides an efficient biocatalyst and sets a good example for protein engineering to optimize enzyme catalytic features through rational design.

关键词： Glycosyltransferase Regio-selectivity Crystal structure De-glycosylation Catalytic mechanisms

Molecular classification of small cell lung cancer subtypes:Characteristics,prognostic factors,and clinical translation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第2期137卷 130-139页

作者： Hanfei guo Wenqian Li ye guo Naifei Chen Jiuwei Cui Cancer Center The First Hospital of Jilin UniversityChangchunJilin 130021China

Small cell lung cancer(SCLC)is a highly malignant tumor with a very poor prognosis;therefore,more effective treatments are urgently needed for patients afflicted with the *** recent years,emerging molecular classifications based on key transcription factors of SCLC have provided more information on the tumor pathophysiology,metastasis,immune microenvironment,and acquired therapeutic resistance and reflected the intertumoral heterogeneity of the various SCLC ***,advances in genomics and single-cell sequencing analysis have further revealed the high intratumoral heterogeneity and plasticity of the ***,we review and summarize these recent lines of evidence and discuss the possible pathogenesis of SCLC.

关键词： Small cell lung carcinoma Molecular classification Tumor heterogeneity Drug resistance Transcription factors Genomics Phenotype Prognosis

Real-time Risk-averse Dispatch of an Integrated Electricity and Natural Gas System via Condi-tional Value-at-risk-based Lookup-table Ap-proximate Dynamic Programming

在线全文

学校读者我要写书评

暂无评论

Protection and Control of Modern Power Systems 2024年第2期9卷 47-60页

作者： Jianquan Zhu Guanhai Li ye guo Jiajun Chen Haixin Liu Yuhao Luo Wenhao Liu School of Electric Power Engineering South China University of Tech-nologyGuangzhou 510640China South China University of Technology GuangzhouChina

The real-time risk-averse dispatch problem of an integrated electricity and natural gas system(IEGS)is studied in this *** is formulated as a real-time conditional value-at-risk(CVaR)-based risk-averse dis-patch model in the Markov decision process *** of its stochasticity,nonconvexity and nonlinearity,the model is difficult to analyze by traditional algorithms in an acceptable *** address this non-deterministic polynomial-hard problem,a CVaR-based lookup-table approximate dynamic programming(CVaR-ADP)algo-rithm is proposed,and the risk-averse dispatch problem is decoupled into a series of tractable *** line pack is used as the state variable to describe the impact of one period’s decision on the *** facilitates the reduction of load shedding and wind power *** the proposed method,real-time decisions can be made according to the current information,while the value functions can be used to overview the whole opti-mization horizon to balance the current cost and future risk *** simulations indicate that the pro-posed method can effectively measure and control the risk costs in extreme ***,the decisions can be made within 10 s,which meets the requirement of the real-time dispatch of an *** Terms—Integrated electricity and natural gas system,approximate dynamic programming,real-time dispatch,risk-averse,conditional value-at-risk.

关键词： Integrated electricity and natural gas system approximate dynamic programming real-time dispatch risk-averse conditional value-at-risk

Sustainability-oriented prioritization of nuclear fuel cycle transitions in China:a holistic MCDM framework under uncertainties

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第9期35卷 196-212页

作者： Lei Wang Ru-Xing Gao Hyo On Nam Hong Jang Won Il Ko Chun-Dong Zhang guo-An ye Wen-Heng Jing State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China School of Energy Science and Engineering Nanjing Tech UniversityNanjing 211816China Korea Atomic Energy Research Institute 989-111 Daedeok-daeroYuseong-GuDaejeon 34057Republic of Korea China Institute of Atomic Energy P.O.Box 275-1Beijing 102413China

A sustainability-oriented assessment of the nuclear energy system can provide informative and convincing decision-making support for nuclear development strategies in *** our previous study,four authentic nuclear fuel cycle(NFC)transi-tion scenarios were proposed,featuring different development stages and exhibiting distinct environmental,economic,and technical ***,because of the multiple and often conflicting criteria embedded therein,determining the top-priority NFC alternative for a sustainability orientation remains *** address this issue,this study proposed a novel hybrid multi-criteria decision-making framework comprising fuzzy AHP,PROMETHEE GAIA,and ***,an improved fuzzy AHP weighting model was developed to determine criteria weights under uncertainty and investigate the influence of various weight aggregation and defuzzification ***,PROMETHEE GAIA was used to address conflicts among the criteria and prioritize alternatives on a visualized k-dimensional GAIA *** a result,the alternative for direct recycling PWR spent fuel in fast reactors is considered the most ***,a sensitivity analysis was conducted to examine the influence of criteria weight variation and validate the screening ***,using MOORA,some significant optimization ideas and valuable insights were provided to support decision-makers in shaping nuclear development strategies.

关键词： Nuclear energy systems Nuclear fuel cycle Fuzzy AHP PROMETHEE GAIA

在线全文

学校读者我要写书评

暂无评论

新时代能动司法的理论与实践逻辑

法律科学（西北政法大学学报） 2024年第2期42卷 30-43页

作者：郭晔北京师范大学法学院北京100875

新时代新征程的能动司法不是既往能动司法的翻版,而是具有深刻的理论和实践逻辑:一是,能动司法是新时代坚持党的全面领导之政治逻辑使然,是坚持党对司法的领导的重要表现,是加强和改善党的领导、提高党执政能力和执政水平、巩固党长期... 详细信息

新时代新征程的能动司法不是既往能动司法的翻版,而是具有深刻的理论和实践逻辑:一是,能动司法是新时代坚持党的全面领导之政治逻辑使然,是坚持党对司法的领导的重要表现,是加强和改善党的领导、提高党执政能力和执政水平、巩固党长期执政地位的现实需要。二是,能动司法是新时代以人民为中心发展理念的司法镜像,不仅可以保障人民的诉讼权益、促进矛盾纠纷的实质性化解,而且能够有效回应人民群众的正义需求。三是,能动司法是对中国式现代化时代主题的法治回应,不仅能够应对中国式现代化发展新变化、接纳现代化发展新成果,而且可以促进国家治理体系和治理能力现代化。四是,新时代能动司法创造中华司法文明新形态,延续了“法理情融合”的中华司法文明传统,传承了“马锡五审判方式”等司法文明,弘扬了“人民司法”的崇高理念,以尊重人权、维护公正、定分止争、促进和谐、保障发展、服务大局,创造性实践开辟了人类司法文明新境界。

关键词：新时代能动司法中国式现代化司法文明

在线全文

学校读者我要写书评

暂无评论

中国式法治现代化概念的逻辑构造及其展开

法学研究 2024年第2期46卷 3-19页

作者：郭晔北京师范大学法学院

中国式法治现代化是在中国式现代化范式下形成的标识性概念。法治、中国式、现代化三个关键词的相互关系,深蕴着中国式法治现代化概念的法理逻辑,即法治是现代化事业的内在构成、法治是实现现代化的外在保障、中国式现代化是法治变革的... 详细信息

中国式法治现代化是在中国式现代化范式下形成的标识性概念。法治、中国式、现代化三个关键词的相互关系,深蕴着中国式法治现代化概念的法理逻辑,即法治是现代化事业的内在构成、法治是实现现代化的外在保障、中国式现代化是法治变革的强大动力。这一法理逻辑,在历史道路上体现为逐层展开的“实践三问”,即要法治还是要人治、走什么样的法治道路、创造什么样的法治形态;在新征程上,要求中国式法治现代化建设从促进和保障社会公平正义、培育中国式现代化的法治有机体、全面推进国家各方面工作法治化等角度持续推进;在价值意蕴上揭示出中国式法治现代化的文明表征,即以幸福生活权彰显人权文明、以法典化彰显制度文明、以法治体系彰显治理文明、以“两个结合”为路径方法推进中华法治文明发展进步。

关键词：习近平法治思想中国式现代化法治现代化法治文明 “两个结合”

在线全文

学校读者我要写书评

暂无评论

省间电力现货交易优化设计与定价机制

电力系统自动化 2024年第4期48卷 76-85页

作者：刘昊郭烨孙宏斌清华-伯克利深圳学院清华大学深圳国际研究生院电力规划设计总院电力系统及大型发电设备安全控制和仿真国家重点实验室(清华大学) 清华大学电机工程与应用电子技术系

在“碳达峰·碳中和”的目标驱动下，受新能源地理分布与随机性影响，以跨区域交易为媒介的区域间电能与灵活性互济重要性凸显。目前，中国正处于构建全国统一电力市场体系的关键阶段，需要有效的市场机制来管理省间电力现货交易。基于... 详细信息

在“碳达峰·碳中和”的目标驱动下，受新能源地理分布与随机性影响，以跨区域交易为媒介的区域间电能与灵活性互济重要性凸显。目前，中国正处于构建全国统一电力市场体系的关键阶段，需要有效的市场机制来管理省间电力现货交易。基于上述背景，设计了一种不依赖于跨区域投标者的省间电力现货交易方法。首先，提出了基于报价区的市场出清模型，采用分区边际定价的方法计算每个报价区的结算价格；然后，基于等效双边配对方法,按潮流贡献计算得到各区域间交易所需承担的输电费用；最后，采用算例验证了所提方法的有效性。与已有方法相比，所提方法在不依赖于跨区域投标者的前提下完成了跨区跨省电力交易，充分利用了输电线路容量，且市场出清过程中保护了各区域内部网架信息隐私。

关键词：省间电力现货交易市场出清结算方法输电费用定价机制

环境规制、短期失败容忍与企业绿色创新——来自绿色信贷政策实践的证据

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

经济研究 2024年第3期59卷 112-129页

作者：郭俊杰方颖郭晔中南财经政法大学会计学院 430073 厦门大学王亚南经济研究院 361005 厦门大学经济学院 361005

已有文献大多支持环境规制促进企业绿色创新的论断。本文基于中国绿色信贷政策的实践,发现当绿色信贷政策缺乏短期失败容忍时,绿色信贷政策的实施将对企业的绿色创新产生负面影响。具体而言,当绿色信贷政策对企业短期创新失败缺乏足够... 详细信息

已有文献大多支持环境规制促进企业绿色创新的论断。本文基于中国绿色信贷政策的实践,发现当绿色信贷政策缺乏短期失败容忍时,绿色信贷政策的实施将对企业的绿色创新产生负面影响。具体而言,当绿色信贷政策对企业短期创新失败缺乏足够容忍时,政策的实施不仅未能激励污染企业增加绿色创新,反而导致了创新抑制效应,且政策短期失败容忍越低,对污染企业的绿色创新抑制作用则越强。值得注意的是,提高专利保护执法力度在一定程度上能够缓解这种负面影响。此外,环境规制对企业短期创新失败的容忍会对企业的环境行为选择产生重要影响,进而对不同影响机制的作用产生影响。由于对企业短期创新失败的容忍不足,中国绿色信贷政策通过“挤出”效应和资源约束效应抑制了污染企业的绿色创新投入。研究结果表明,对企业短期创新失败的容忍是环境规制促进企业绿色创新的重要条件。

关键词：绿色创新绿色信贷短期失败容忍环境投资

复发/转移性头颈部鳞癌免疫检查点抑制剂治疗专家共识(2024年版)

在线全文

学校读者我要写书评

暂无评论

中国癌症杂志 2024年第4期34卷 425-438页

作者：郭晔张陈平中国临床肿瘤学会头颈肿瘤专家委员会中国抗癌协会头颈肿瘤专业委员会

头颈部鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)是头颈部肿瘤最为常见的一种类型,具有较高的发病率和死亡率。随着帕博利珠单抗和纳武利尤单抗在国内相继获批用于复发/转移性(recurrent/metastatic,R/M)HNSCC的一线及... 详细信息

头颈部鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)是头颈部肿瘤最为常见的一种类型,具有较高的发病率和死亡率。随着帕博利珠单抗和纳武利尤单抗在国内相继获批用于复发/转移性(recurrent/metastatic,R/M)HNSCC的一线及后线治疗,免疫治疗已然成为R/MHNSCC的标准治疗。随着免疫检查点抑制剂(immunecheckpoint inhibitor,ICI)在临床中的广泛应用,生物标志物检测、不同人群免疫治疗方案的选择、免疫治疗效果的评估、免疫治疗不良反应(immunotherapy-related adverse event,irAE)的处理等也在不断规范和完善。中国临床肿瘤学会(Chinese Society of Clinical Oncology,CSCO)头颈肿瘤专家委员会和中国抗癌协会(China Anti-Cancer Association,CACA)头颈肿瘤专业委员会组织专家组进行深入探讨,共同制定了《复发/转移性头颈部鳞癌免疫检查点抑制剂治疗专家共识》,旨在形成相对规范统一的认识,更好地指导临床实践。经过多轮商议和探讨,专家组汇总出以下推荐意见。程序性死亡受体-配体1(programmed death-ligand 1,PD-L1)表达是抗程序性死亡受体1(programmed death-1,PD-1)单抗一线治疗R/M HNSCC的疗效预测生物标志物,推荐患者治疗前常规进行PD-L1联合阳性评分(combined positive score,CPS)检测。对于PD-L1CPS≥1的患者,推荐帕博利珠单抗联合铂类药物和5-FU,或者帕博利珠单抗单药作为一线治疗方案。关于帕博利珠单抗单药或联合化疗方案的选择,需结合患者的PD-L1 CPS评分(如CPS评分是否≥20)、肿瘤负荷或临床症状进行综合判断。对于PD-L1表达情况未知或PD-L1 CPS<1的患者,可选择帕博利珠单抗联合铂类药物和5-FU作为一线治疗方案。对于不适合使用5-FU的患者,可选择帕博利珠单抗联合铂类药物和紫杉类药物作为一线治疗方案。对于铂类药物耐药或复发/转移阶段含铂类药物治疗失败且既往未接受过抗PD-1单抗治疗的患者,推荐纳武利尤单抗或帕博利珠单抗作为后线治疗。对于无法耐受化疗且不适合接受抗PD-1单抗单药治疗的患者,可选择帕博利珠单抗或纳武利尤单抗联合西妥昔单抗作为一线或后线治疗方案。对于接受ICI的患者,推荐在治疗全程密切监测免疫相关不良反应的症状并及时作出判断,必要时进行多学科联合诊治。

关键词：免疫检查点抑制剂复发/转移性头颈部鳞状细胞癌共识