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Surface and Interface Engineering for Advanced Nanofiltration Membranes

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Chinese Journal of Polymer Science 2022年第2期40卷 124-137页

作者： Bian-Bian Guo cheng-ye zhu Zhi-Kang Xu Ministry of Education Key Laboratory of Macromolecular Synthesis and FunctionalizationKey Laboratory of Adsorption and Separation Materials&Technologies of Zhejiang ProvinceDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Nanofiltration has been attracting great attention in alleviating the global water crisis because of its high efficiency,mild operation,and strong *** decades,it remains a challenge to break the upper limit of performance and establish the formation-structureproperty relationship for nanofiltration *** feature article summarizes our recent progress in the preparation of high-performance thin-film composite(TFC)nanofiltration membranes,focusing on the mussel-inspired deposition method and the optimized interfacial polymerization(IP).By accelerating the oxidation of polydopamine and equilibrating the rate of aggregation and deposition processes,the mussel-inspired deposition method realizes the rapid and uniform formation of selective coatings or *** deposition systems endow the selective layer with rich chemical structures and easy post-functionalization,highlighting its potential in water *** for optimizing the conventional IP,the rapid polycondensation of amine and acid chloride groups is slowed down to enable the controllability of IP at the water-organic *** homogeneity and integrity of the TFC membranes are improved by constructing a uniform reaction platform and introducing a viscous medium to control the amine diffusion,which facilitates the water permeability and promotes the separation *** have proposed a series of practical strategies for improving TFC membranes and might provide more inspiration for other nanofiltration techniques.

关键词： Nanofiltration Thin-film composite membranes Mussel-inspired deposition Interfacial polymerization

基于LiCl调控界面聚合的聚酰胺薄层复合纳滤膜制备与性能研究

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高分子学报 2024年第9期55卷 1145-1154页

作者：徐知源朱城业徐志康浙江省吸附分离材料与应用技术重点实验室浙江大学高分子科学与工程学系杭州310058

针对传统界面聚合反应可控性差、相应聚酰胺薄层复合膜结构和性能难以调控的问题,本研究以经典的哌嗪/均苯三甲酰氯在烷烃-水界面发生的聚合反应为研究对象,以氯化锂为哌嗪水溶液的添加剂,调控了反应生成聚酰胺分离层的结构,提升了聚酰... 详细信息

针对传统界面聚合反应可控性差、相应聚酰胺薄层复合膜结构和性能难以调控的问题,本研究以经典的哌嗪/均苯三甲酰氯在烷烃-水界面发生的聚合反应为研究对象,以氯化锂为哌嗪水溶液的添加剂,调控了反应生成聚酰胺分离层的结构,提升了聚酰胺薄层复合纳滤膜的分离性能.在氯化锂最适浓度为1.25 g·L^(-1)时,所制备聚酰胺分离层的调和酰胺键密度有所降低,孔径则由0.51 nm增大到0.59 nm,而其表面形貌、化学组成、表面亲水性及荷电性没有受到明显影响.薄层复合纳滤膜的水通量提升了17%,达到216 L·m^(-2)·h^(-1)·MPa^(-1),同时对Na_(2)SO_(4)的截留率维持在98.8%以上.此外,所制备的纳滤膜具有优异的耐压性、较宽的处理料液浓度范围以及较好的长期运行稳定性.

关键词：界面聚合聚酰胺氯化锂薄层复合膜纳滤

Netrin-1 signaling pathway mechanisms in neurodegenerative diseases

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Neural Regeneration Research 2025年第4期20卷 960-972页

作者： Kedong zhu Hualong Wang Keqiang ye Guiqin Chen Zhaohui Zhang Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurology The First Hospital of Hebei Medical UniversityBrain Aging and Cognitive Neuroscience Laboratory of Heibei ProvinceShijiazhuangHebei ProvinceChina Faculty of Life and Health Sciences Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal *** profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic *** amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of *** findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative *** a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.

关键词： Alzheimer’s disease axon guidance colorectal cancer Netrin-1 receptors Netrin-1 signaling pathways Netrin-1 neurodegenerative diseases neuron survival Parkinson’s disease UNC5C

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao Jing-Wen Li Hui ye Xue-Zhi Zhang Jian-Xiang Liu Hong cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali Chen Yiyong Wei Jin Liu Tao zhu cheng Zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava:A retrospective cohort study

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World Journal of Gastroenterology 2025年第1期31卷 42-57页

作者： Kun Huang zhu Chen Heng Xiao Hai-Yang Hu Xing-Yu Chen cheng-You Du Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of General Surgery Mianyang Hospital of Traditional Chinese MedicineMianyang 621000Sichuan ProvinceChina

BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under *** the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ *** To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional *** The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively *** novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the ***,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a ***,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic *** short-term postoperative outcomes and oncological results of the two approaches were evaluated and *** A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel *** novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)comp

关键词： Laparoscopic liver resection Inferior vena cava Retrohepatic tunnel Short hepatic veins Complex liver tumors Intraoperative bleeding control

层状MoS_(2)复合膜的制备及其纳滤与光热抗菌性能研究

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高分子学报 2021年第5期52卷 505-513页

作者：俞炯弛马梦琪朱城业胡登峰计剑徐志康浙江省吸附分离材料与应用技术重点实验室浙江大学高分子科学与工程学系杭州310027

二维纳米片构建的层状纳滤膜在工业染料和含盐废水的净化处理中显示出广泛的应用前景,但纳米片间松散的层状结构会影响过滤通道的稳定性,导致对盐类的截留效果不理想.本文以均苯三甲酰氯(TMC)交联单宁酸(TA)官能化的二硫化钼(MoS2)纳米... 详细信息

二维纳米片构建的层状纳滤膜在工业染料和含盐废水的净化处理中显示出广泛的应用前景,但纳米片间松散的层状结构会影响过滤通道的稳定性,导致对盐类的截留效果不理想.本文以均苯三甲酰氯(TMC)交联单宁酸(TA)官能化的二硫化钼(MoS2)纳米片构建薄层复合纳滤膜,以解决二维材料构建层状纳滤膜的常见问题.所制备的纳滤膜不仅对荷负电染料(伊文思蓝,分子量960.8)有很高的截留率(>98.5%),也能很好地选择性分离染料-盐混合溶液(NaCl截留率<15%).同时,该膜还能在严苛环境中保持优秀的稳定性.此外,在近红外光照射下,MoS2纳米片显著的光热转换效应赋予薄层复合纳滤膜一定的抗菌能力,使得该膜在实际应用中具有巨大潜力.

关键词：二硫化钼薄层复合膜纳滤光热转换效应抗菌

An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna Sun Pei cheng Zhaoyang Yao Ning Li Long ye Lijian Zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

Distribution of the Classification Traits in the F2 Progeny of Two Crosses of indica/japonica in Rice （Oryza sativa）

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Rice Science 2003年第Z1期 23-28页

作者： ZHANG Zai-jun~(1,2), LIANG cheng-ye~2, zhu Ying-guo~1 (~1 Key Laboratory of MOE for Plant Developmental Biology, Wuhan University, Wuhan 430072, China ~2 South China Institute of Botany, Chinese Academy of Sciences, C, uangzhou 510650, China)

Comparison of seed setting rate, plant height and cheng's morphological traits were made between the F2progeny of indica-japonica hybrids, 02428/Pei'ai 64 and Taichung 65/Teqing. There existed resemblance normal distribution in plant height, and the distribution had no relationship with the seed setting rate and plant height in F1progeny, suggesting that there were no gametic selection for the plant height in the F2progeny of indica-japoniea hybrids. An average seed setting rate of the F2was equal to the F1populations in the recombination of 02428/Pei'ai 64 in which there was an excellent cross compatibility, but the remarkable increase in the seed setting rate from the F1to F2in Taichung 65/Teqing, indicating that gametic selection only took place in the indica-japonica crosses with low cross compatibility while null or little in the hybrids with high compatibility. There were many intermediate types among the leaf pubescence, color of hull at heading, and length of the first and second panicle internode, and these cheng's morphological traits was distributed normally; there were also a little intermediate types in hull hairness and phenol reaction with bi-peak distribution; while length to width ratio of grain was inclined to the japonica types obviously showing a skewed distribution in the F2 population. Although cheng's morphological traits in F2populations had inconsistent distribution types, cheng's morphological traits index showed normal distribution, which suggested that intermediate types, i.e. indicalinous or japonicalinous, were primary in F2population.

关键词： rice indica-japonica crosses genetic effect generations distribution morphological traits seed setting rate plant height