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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-cheng ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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Report on Childhood Obesity in China (4) Prevalence and Trends of Overweight and Obesity in Chinese Urban School-age Children and Adolescents, 1985-2000

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Biomedical and Environmental Sciences 2007年第1期20卷 1-10页

作者： cheng-ye JI 无 Institute of Child and Adolescent Health Peking Medical University Health Science Center 38 Xueyuan Road Beijing 100083 China COOPERATIVE STUDY ON CHILDHOOD OBESITY： WORKING GROUP ON OBESITY IN CHINA （WGOC）

Objective To describe the nationwide prevalence of childhood overweight/obesity, and their group variations and trends over the past 20 years in the Chinese urban population. Methods Data sets of boys and girls at the age of 7-18 years collected from the series of Chinese national surveillance on students＇ constitution and health （CNSSCH） between 1985 and 2000 were divided into five socioeconomic and demographic groups, while BMI classification reference proposed by Working Group on Obesity in China （WGOC） was used as screening reference to calculate the prevalence and trends of overweight/obesity in these groups. Results In 2000, the prevalence of obesity and overweight in boys aged 7-18 years was 11.3% and 6.5% in Beijing, 13.2% and 4.9% in Shanghai, 9.9% and 4.5% in coastal big cities, and 5.8% and 2.0% in coastal medium/small-sized cities, respectively, while the prevalence of of obesity and overweight in girls of the same age group was 8.2% and 3.7% in Beijing, 7.3% and 2.6% in Shanghai, 5.9% and 2.8% in coastal big cities, and 4.8% and 1.7% in coastal medium/small-sized cities, respectively. The prevalence of obesity was low in most of the inland cities at an early stage of epidemic overweight. The epidemic manifested a gradient distribution in groups, which was closely related to status （SES） of the study population. However, a dramatic and steady increasing trend was witnessed among all sex-age subgroups in the five urban groups, and such a trend was stronger in boys than in girls, and much stronger in children than in adolescents. Conclusion Although China is at an early stage of epidemic obesity by and large, the prevalence of obesity in her urban population, particularly in coastal big cities has reached the average level of developed countries. The increasing trend has been rapid since early 1990s, and the increments in obesity and overweight are exceptionally high. The prospect of epidemic obesity in China is in no way optimistic. Therefore, preventive

关键词： Obesity Overweight Prevalence Epidemic changes Chinese urban areas School-age children and adolescents

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Gradient Estimates and Harnack Inequalities for Positive Solutions of ■ on Self-shrinkers

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Acta Mathematica Sinica,English Series 2019年第7期35卷 1217-1226页

作者： ye cheng ZHU Qing CHEN Department of Applied Mathematics Anhui University of Technology Maanshan 243002 P. R. China Department of Mathematics University of Science and Technology of China Hefei 230026 P. R. China

In this paper, we investigate the positive solutions of ■u =■υ/■t on self-shrinkers, then get some gradient estimates and Harnack inequalities for the positive solutions.

关键词： Harnack inequality self^shrinker ∞-Bakry-Emery Ricci tensor gradient estimate

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Autism and Mental Retardation of Young Children in China

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Biomedical and Environmental Sciences 2005年第5期18卷 334-340页

作者： XIN ZHANG cheng-ye JI Institute of Child and Adolescent Health Peking University Health Science Center No.38 Xueyuan Road Haidian District Beijing 100083 China Department of Child and Adolescent Health Public Health School lianjin Medical University lianjin 300070 China

To understand the prevalence and rehabilitation status of autism and mental retardation in China. Methods Screening test and clinical assessment were conducted for the diagnosis of autism and mental retardation. The assessment included investigation of the histories of medical conditions and development of these two disorders, utilization and needs for the rehabilitation service, and related intellectual and behavioral appraisal. Results Among the 7345 children investigated, the prevalence of autism disorder was 1.10 cases per 1000 children aged 2-6 years （95% CI=0.34 to 2.54）, and the prevalence of mental retardation was 10.76 cases per 1000 children （95% CI=8.40 to 13.12）. All the children suffering from autistic disorder were intellectually disabled, whereas 31.0% of the non-autism mental retardates had other disabilities. The medical conditions prior to birth and perinatal period were important potential factors for autism. Half of the autistic children and 84% of the children with non-autism mental retardation had never received any rehabilitative service. Conclusions The prevalence of autistic disorder in children aged 2-6 years in Tianjin is rather high. It is urgent to improve the status of the autistic and intelligently disabled young children in China. In order to upgrade the level of early diagnostic and improve the intervention to autism and mental retardation, public awareness and training courses should be heightened.

关键词： Autism Mental retardation Epidemiology China

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Malnutrition Prevalence in Lasa Xizang Children and Adolescents

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Biomedical and Environmental Sciences 2014年第8期27卷 614-626页

作者： YIN Xiao Jian JI cheng ye Key Laboratory of Adolescent Health Assessment and Exercise Intervention Ministry of Education College of Physical Education & Health East China Normal University Institute of Child and Adolescent Health Peking University Health Science Center

Objective To assess the prevalence of malnutrition among children and adolescents in Xizang （Tibet）. Methods We analyzed data from the Chinese National Survey on Students＇ Constitution and Health for the years 1995, 2000, 2005, and 2010 pertaining to Tibetan children and adolescents in Lase （Lhasa）, aged 7-18 years old. Numbers of survey subjects for these years were：2 393, 2 754, 2 397, and 2 643, respectively. Results Our results indicated that the rate of occurrence of stunting in Tibet has evidenced a gradual decline：for boys, from 26.8%in 2000 to 9.3%in 2010;and for girls, from 25.8%in 2000 to 10.8%in 2010. In general, the wasting rate for both boys and girls in Tibet has gradually decreased over time：for boys, from 17.7%in 1995 to 4.6%in 2005;and for girls from 12.5%in 1995 to 2.3%in 2005. The stunting rates of boys aged 7-13 years old and of girls aged 7-11 years old were 67.5%and 53.1%, respectively, while these rates for boys aged 14-18 years old and girls aged 12-18 years old were 32.5%and 46.9%, respectively. Conclusion Stunting and wasting rates of Tibetan children and adolescents indicate a gradual declining trend over time. The stunting rates of both boys and girls during early puberty were significantly higher than those during late puberty.

关键词： Tibetan children and adolescents Malnutrition Stunting Wasting

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Secular Change in Stature of Urban Chinese Children and Adolescents, 1985-2010

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Biomedical and Environmental Sciences 2013年第1期26卷 13-22页

作者： CHEN Tian Jiao JI cheng ye Institute of Child and Adolescent Health School of Public HealthPeking University Health Science Center

Objective Research evidence shows a secular trend in Chinese physical growth in recent *** aim of this study was to analyze and assess changes in stature of children and adolescents during the 25 years from 1985‐2010,using national *** Data came from successive cycles of the Chinese National Survey on Students＇ Constitution and Health（CNSSCH）.Subjects were 7‐ to 18‐year‐old children and *** An overall positive secular trend occurred in urban China during 1985‐*** overall average rates of increment were 2.4 and 1.7 cm/decade for boys and girls,*** increases in adult stature for boys and girls were 2.6 and 1.7 cm,yielding rates of 1.0 and 0.7 cm/decade,*** with different socioeconomic levels had different characteristic *** stature increases in big cities were larger than those in moderate and small cities,and boys and girls in moderate and small cities showed greater potential for growth in *** An overall positive secular growth trend was associated with socioeconomic progress and differed with area socioeconomic *** policies and strategies should be developed based on increased stature,and should continue narrowing the inequity between different socioeconomic populations.

关键词： Secular change Stature Growth Socioeconomic disparity Children and adolescents

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Secular Changes of Stature in Rural Children and Adolescents in China, 1985-2010

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Biomedical and Environmental Sciences 2014年第8期27卷 573-581页

作者： CHEN Tian Jiao JI cheng ye Institute of Child and Adolescent Health School of Public Health Peking University Health Science Center

Objective To analyze and assess secular change in stature in rural children and adolescents in China from 1985 to 2010. Methods Data were obtained from the 6 rounds of the Chinese National Survey on Student＇s Constitution and Health. The subjects enrolled in the study were children and adolescents aged 7-18 years in rural areas of provincial capitals. Results An overall positive secular trend in stature occurred in rural areas of provincial capitals in China from 1985 to 2010. The overall average increase rates were 3.1 and 2.4 cm/decade for boys and girls, respectively. The total body height increases for grown up boys and girls were 3.6 and 2.3 cm and the increase rates were 1.4 and 0.9 cm/decade, respectively. There were differences in body height increase among eastern, central and western regions. The average body height of the children or adolescents in eastern region was highest, followed by central region and western region. The overall increase rates in central region were highest among the three regions. The difference between eastern/central region and western region was obvious. 〈br〉 Conclusion Positive secular trend in stature of children or adolescents has occurred in rural area of China, and rural boys and girls showed a great potential for continuous growth. More attention should be paid to the differences in children＇s body height between western region and eastern/central region.

关键词： Secular change Stature Rural population Regional difference Child and adolescent

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Large negative hyperpolariza-bilities (β) of the protonated Schiff bases of the azulenic retinal analogues

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Chinese Science Bulletin 2001年第10期46卷 831-835页

作者： Peng Wang cheng ye Center for Molecular Science Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing China

The molecular first hyperpolarizabilities (β) and electronic properties of some azulenic retinal analogues and their derivatives have been investigated theoretically by employing semiempirical approaches. The results indicate that the protonated Schiff bases (PSB) of the 2-substituted azulenic retinal analogues possess extremely large negative β values and very good transparency. These can be attributed to the large difference between the ground state dipole moment and the first excited state dipole moment according to the electronic property analysis. The characteristic blue-shifted absorption in polar solvents of the 2-substituted PSB chromophores can be well explained by the negative solva-tochromic effects. The largest calculated |μβ| value can reach the magnitude of 10-44 esu, which is close to the highest reported values of synthesized chromophores.

关键词： molecular first hyperpolarizability nonlinear optics azulene retinal derivatives theoretical calculation.

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Report on Childhood Obesity in China (7) Comparison of NCHS and WGOC

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Biomedical and Environmental Sciences 2008年第4期21卷 271-279页

作者： YI-QUN XU cheng-ye JI 无 Institute of Child and Adolescent Health Peking University of Health Science Center Beijing 100083 China COOPERATIVE STUDY ON CHILDHOOD OBESITY： WORKING GROUP ON OBESITY IN CHINA

Objective To test the validity of Working Group on Obesity in China （WGOC） reference in screening childhood obesity using obesity-related metabolic syndrome （MS） and its components as disease risk evidence. Methods A total of 2020 adolescents （1007 boys and 1013 girls） aged 14-16 years were sampled in Beijing, China. Anthropometric and biochemical measurements, as well as blood pressure parameters were available. Prevalence of overweight/obesity and related MS risk factors were analyzed across different body mass index （BMI） categories. The sensitivity and specificity of the WGOC cut-offs were compared with those of National Central Health Statistics （NCHS）. Results Significantly high prevalence of MS and its components were found both in the obesity and overweight groups, which were classified by the WGOC and NCHS references. Similar distribution pattern of MS risk factors existed among different BMI categories, but the frequency and clustering of these factors in the obesity group classified by the NCHS were much higher. Owing to its irrelevant high cut-offs for overweight/obesity （especially for girls since the mid- adolescence）, the NCHS reference had a high specificity but a low sensitivity. By contrast, the WGOC reference with a high sensitivity （90.1% for boys and 89.2% for girls） and a relative high specificity （96.4% and 92.8% for obese boys and girls, 78.1% and 68.9% for overweight boys and girls respectively） was more suitable to support the need for early screening, intervention, and treatment of childhood obesity in China. Conclusion High sensitivity is more important than specificity in choosing appropriate screening tools for childhood obesity. Validity test demonstrates that it is rational to use the WGOC reference, established on the basis of the Chinese own reference population as a uniform screening tool for childhood obesity, which can effectively overcome the unnecessary treatment and psychosociai implications of stigmatization caused by misclas

关键词： Body mass index Childhood obesity Overweight Metabolic syndromes Validity

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Surface and Interface Engineering for Advanced Nanofiltration Membranes

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Chinese Journal of Polymer Science 2022年第2期40卷 124-137页

作者： Bian-Bian Guo cheng-ye Zhu Zhi-Kang Xu Ministry of Education Key Laboratory of Macromolecular Synthesis and FunctionalizationKey Laboratory of Adsorption and Separation Materials&Technologies of Zhejiang ProvinceDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Nanofiltration has been attracting great attention in alleviating the global water crisis because of its high efficiency,mild operation,and strong *** decades,it remains a challenge to break the upper limit of performance and establish the formation-structureproperty relationship for nanofiltration *** feature article summarizes our recent progress in the preparation of high-performance thin-film composite(TFC)nanofiltration membranes,focusing on the mussel-inspired deposition method and the optimized interfacial polymerization(IP).By accelerating the oxidation of polydopamine and equilibrating the rate of aggregation and deposition processes,the mussel-inspired deposition method realizes the rapid and uniform formation of selective coatings or *** deposition systems endow the selective layer with rich chemical structures and easy post-functionalization,highlighting its potential in water *** for optimizing the conventional IP,the rapid polycondensation of amine and acid chloride groups is slowed down to enable the controllability of IP at the water-organic *** homogeneity and integrity of the TFC membranes are improved by constructing a uniform reaction platform and introducing a viscous medium to control the amine diffusion,which facilitates the water permeability and promotes the separation *** have proposed a series of practical strategies for improving TFC membranes and might provide more inspiration for other nanofiltration techniques.

关键词： Nanofiltration Thin-film composite membranes Mussel-inspired deposition Interfacial polymerization

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