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凯妮汀治疗妊娠期霉菌性阴道炎的疗效观察

河北医学 2000年第6期6卷 485-487页

作者：叶文珏范利北京铁路分局中心医院北京100071

目的 :观察凯妮汀治疗妊娠霉菌性阴道炎的疗效。方法 :将早孕期、中孕期及晚孕期合并霉菌性阴道炎的患者 4 6例 ,给予凯妮汀 50 0 mg阴道片剂放入阴道一粒 ,于用药后第 4 d,再次阴道用药 50 0 mg一粒 ,分别观察用药 3～ 7d及 2～ 3周时... 详细信息

目的 :观察凯妮汀治疗妊娠霉菌性阴道炎的疗效。方法 :将早孕期、中孕期及晚孕期合并霉菌性阴道炎的患者 4 6例 ,给予凯妮汀 50 0 mg阴道片剂放入阴道一粒 ,于用药后第 4 d,再次阴道用药 50 0 mg一粒 ,分别观察用药 3～ 7d及 2～ 3周时的临床症状改善情况及实验室真菌学检查。结果 :用药 3～ 7d时 ,临床治愈率为 80 .4 % ,有效率为 15.2 % ,总有效率为 95.6 % ,真菌学涂片治愈率为 91.3%。用药后第 2～ 3周临床治愈率为 91.3% ,有效率为 6 .5% ,总有效率为 97.8% ,真菌学涂片治愈率为 97.8%。结论

关键词：凯妮汀霉菌性阴道炎药物疗法妊娠合并症

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80例下呼吸道感染经验性治疗临床分析

河北医学 2000年第9期6卷 820-822页

作者：叶甫澄魏美红浙江省嘉兴市第二医院浙江嘉兴314000

目的 :分析经验性治疗在院内外下呼吸道感染中的价值。方法 :本文通过对 80例院内外下呼吸道感染患者采取经验性治疗 ,根据临床疗效并结合细菌培养及体外药敏试验 ( KB药敏纸片法 )结果作统计学处理、分析。结果 :经验性治疗在院外下呼... 详细信息

目的 :分析经验性治疗在院内外下呼吸道感染中的价值。方法 :本文通过对 80例院内外下呼吸道感染患者采取经验性治疗 ,根据临床疗效并结合细菌培养及体外药敏试验 ( KB药敏纸片法 )结果作统计学处理、分析。结果 :经验性治疗在院外下呼吸道感染组有效率为 89.6% ,院内下呼吸道感染组为 62 .5% ,二者有显著性差异 ( P<0 .0 1)。结论 :经验性治疗可作为院外下呼吸道感染的抗菌素选择方法 ,而院内下呼吸道感染治疗选择抗菌素应重视病原学检查 ,参考药敏试验结果 ,经验性治疗可作参考。

关键词：下呼吸道感染经验性治疗药敏试验

Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： Wei Xiong Xuan ye Hongzhang Cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro Letters 2025年第1期17卷 216-261页

作者： Jian‑En Zhou Yilin Li Xiaoming Lin Jiaye ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

Lithium-ion batteries(LIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with Li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(LIBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues Self-sacrificial template Lithium-ion batteries Sodium-ion batteries Potassium-ion batteries

Netrin-1 signaling pathway mechanisms in neurodegenerative diseases

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Neural Regeneration Research 2025年第4期20卷 960-972页

作者： Kedong Zhu Hualong Wang Keqiang ye Guiqin Chen Zhaohui Zhang Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurology The First Hospital of Hebei Medical UniversityBrain Aging and Cognitive Neuroscience Laboratory of Heibei ProvinceShijiazhuangHebei ProvinceChina Faculty of Life and Health Sciences Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal *** profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic *** amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of *** findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative *** a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.

关键词： Alzheimer’s disease axon guidance colorectal cancer Netrin-1 receptors Netrin-1 signaling pathways Netrin-1 neurodegenerative diseases neuron survival Parkinson’s disease UNC5C

The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying Wu Shan ye Xiangyi Liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

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Neural Regeneration Research 2025年第4期20卷 1178-1191页

作者： Wanxian Luo Chuanhui Xu Linxi Li Yunxiang Ji yezhong Wang Yingjia Li Yongyi ye Department of Medicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience Department of NeurosurgeryThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s *** perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity,but also exhibit remarkable anti-inflammatory ***,the role of perfluoropentane in microglia-mediated central inflammatory reactions remains poorly *** this study,we developed perfluoropentane-based oxygen-loaded nanodroplets(PFP-OLNDs)and found that pretreatment with these droplets suppressed the lipopolysaccharide-induced activation of M1-type microglia in vitro and in vivo,and suppressed microglial activation in a mouse model of Parkinson’s *** suppression led to a reduction in the inflammatory response,oxidative stress,and cell migration capacity in ***,the neurotoxic effects were mitigated,which alleviated neuronal ***,ultrahigh-performance liquid chromatography–tandem mass spectrometry showed that the anti-inflammatory effects of PFP-OLNDs mainly resulted from the modulation of microglial metabolic *** further showed that PFP-OLNDs regulated microglial metabolic reprogramming through the AKT-mTOR-HIF-1α***,our findings suggest that the novel PFP-OLNDs constructed in this study alleviate microglia-mediated central inflammatory reactions through metabolic reprogramming.

关键词： metabolic reprogramming microglia microglial migration nanotherapy neurodegenerative diseases neuroinflammation oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-performance liquid chromatography–mass spectrometry

ICA-Net: improving class activation for weakly supervised semantic segmentation via joint contrastive and simulation learning

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Optoelectronics Letters 2025年第3期 188-192页

作者： ye Zhuang LIU Ruyu SUN Bo School of Information Engineering Chengdu Aviation Vocational and Technical College School of Computer Science and Engineering Hangzhou Normal University Quanzhou Institute of Equipment Manufacturing Haixi Institutes Chinese Academy of Sciences

In the field of optoelectronics, certain types of data may be difficult to accurately annotate, such as high-resolution optoelectronic imaging or imaging in certain special spectral ranges. Weakly supervised learning can provide a more reliable approach in these situations. Current popular approaches mainly adopt the classification-based class activation maps (CAM) as initial pseudo labels to solve the task.

关键词：

ON NONLINEAR GALERKIN APPROXIMATION

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Journal of Computational Mathematics 1997年第1期15卷 23-35页

作者： Wang, bx Shi, K INST APPL PHYS & COMPUTAT MATH BEIJINGPEOPLES R CHINA LANZHOU UNIV DEPT MATHLANZHOU 730000PEOPLES R CHINA

Nonlinear Galerkin methods are numerical schemes adapted well to the long time integration of evolution partial differential equations. The aim of this paper is to discuss such schemes for reaction diffusion equations... 详细信息

关键词： Math ON NONLINEAR GALERKIN APPROXIMATION