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Acta Pharmaceutica Sinica B 2024年第2期14卷 897-899页

作者： Zekun li Yongchun Pan Shiyu Du yayao li Chao Chen Hongxiu Song Yueyao Wu Xiaowei Luan Qin Xu Xiaoxiang Guan Yujun Song Xin Han Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of Medicine&Holistic Integrative MedicineJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative MedicineNanjing University of Chinese MedicineNanjing 210023China College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional MaterialsState Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

The authors regret that there is an error in the article Fig.5E due to the mistake of copying and pasting in the process of assembling figures and negligence in the *** it does not affect the conclusion,it is an obvio... 详细信息

关键词： journal correction conclusion

Silicon-based inorganic-organic hybrid optoelectronic synaptic devices simulating cross-modal learning

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Science China(Information Sciences) 2021年第6期64卷 188-195页

作者： yayao li Yue WANG Lei YIN Wen HUANG Wenbing PENG Yiyue ZHU Kun WANG Deren YANG Xiaodong PI State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang University Advanced Semiconductor Research Institute ZJU-Hangzhou Global Scientific and Technological Innovation Center

With advances in Si-based technology infrastructures and the rapid integration of Si-based optoelectronics, Si-based optoelectronic synaptic devices have the potential to greatly facilitate the large-scale deployment of neuromorphic computing. The incorporation of solution-processable polymer semiconductors into Si-based optoelectronics may enable the cost-effective fabrication of optoelectronic synaptic ***(3-hexylthiophene)(P3HT) is a semiconducting polymer used to manufacture optoelectronic synaptic transistors with P3HT channels and Si gates. The gate dielectric between them consists of a *** inorganic-organic Si/P3HT optoelectronic synaptic transistors can mimic synapses when exposed to optical and electrical stimuli. The Si/P3HT synaptic devices can spatiotemporally integrate optical and electrical stimuli to mimic cross-modal learning.

关键词： poly(3-hexylthiophene) silicon optoelectronic synaptic devices cross-modal learning transistor

Intelligent nanotherapeutic strategies for the delivery of CRISPR system

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药学学报:英文版 2023年第6期13卷 2510-2543页

作者： Chao Chen Wu Zhong Shiyu Du yayao li Yunfei Zeng Kunguo liu Jingjing Yang Xiaoxiang Guan Xin Han Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization School of Medicine&Holistic Integrative MedicineNanjing University of Chinese MedicineNanjing 210023China Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province School of MedicineHunan Normal UniversityChangsha 410013China Department of Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

CRISPR, as an emerging gene editing technology, has been widely used in multiple fields due to its convenient operation, less cost, high efficiency and precision. This robust and effective device has revolutionized the development of biomedical research at an unexpected speed in recent years. The development of intelligent and precise CRISPR delivery strategies in a controllable and safe manner is the prerequisite for translational clinical medicine in gene therapy field. In this review, the therapeutic application of CRISPR delivery and the translational potential of gene editing was firstly discussed. Critical obstacles for the delivery of CRISPR system in vivo and shortcomings of CRISPR system itself were also analyzed. Given that intelligent nanoparticles have demonstrated great potential on the delivery of CRISPR system, here we mainly focused on stimuli-responsive nanocarriers. We also summarized various strategies for CIRSPR-Cas9 system delivered by intelligent nanocarriers which would respond to different endogenous and exogenous signal stimulus. Moreover, new genome editors mediated by nanotherapeutic vectors for gene therapy were also discussed. Finally, we discussed future prospects of genome editing for existing nanocarriers in clinical settings.

关键词： CRISPR system Intelligent delivery Gene editing Endogenous responsive Exogenous control Nanotherapeutic platforms Gene therapy Diseases correction

Subfield Codes of linear Codes from Perfect Nonlinear Functions and Their Duals

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Communications in Mathematical Research 2022年第2期38卷 157-183页

作者： Dabin Zheng Xiaoqiang Wang yayao li Mu Yuan Hubei Key Laboratory of Applied Mathematics and Faculty of Mathematics and StatisticsHubei UniversityWuhan 430062China

Let F_(p)^(m) be a finite field with p^(m) elements,where p is an odd prime and m is a positive ***,[17]and[35]determined the weight distributions of subfield codes with the form C f={((T r(a f(x)+b x)+c)_(x∈F_(p)^(m)),T r(a)):a,b∈F_(p)^(m),c∈F_(p)}for f(x)=x^(2) and f(x)=x p k+1,respectively,where Tr(⋅)is the trace function from F_(p)^(m) to F_(p),and k is a nonnegative *** this paper,we further investigate the subfield code C f for f(x)being a known perfect nonlinear function over F_(p)^(m) and generalize some results in[17,35].The weight distributions of the constructed codes are determined by applying the theory of quadratic forms and the properties of perfect nonlinear functions over finite *** addition,the parameters of the duals of these codes are also *** examples show that some of our codes and their duals have the best known parameters according to the code tables in[16].The duals of some proposed codes are optimal according to the Sphere Packing bound if p≥5.

关键词： Subfield code perfect nonlinear function quadratic form weight distribution Sphere Packing bound

Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy

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Acta Pharmaceutica Sinica B 2022年第11期12卷 4224-4234页

作者： Zekun li Yongchun Pan Shiyu Du yayao li Chao Chen Hongxiu Song Yueyao Wu Xiaowei Luan Qin Xu Xiaoxiang Guan Yujun Song Xin Han Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of Medicine&Holistic Integrative MedicineJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative MedicineNanjing University of Chinese MedicineNanjing 210023China College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional MaterialsState Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNajing 210023China Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

Near-infrared(NIR)-light-triggered nanomedicine, including photodynamic therapy(PDT)and photothermal therapy(PTT), is growing an attractive approach for cancer therapy due to its high spatiotemporal controllability and minimal invasion, but the tumor eradication is limited by the intrinsic anti-stress response of tumor cells. Herein, we fabricate a tumor-microenvironment responsive CRISPR nanoplatform based on oxygen-deficient titania(TiO_(2-x)) for mild NIR-phototherapy. In tumor microenvironment, the overexpressed hyaluronidase(HAase) and glutathione(GSH) can readily destroy hyaluronic acid(HA) and disulfide bond and releases the Cas9/sgRNA from TiO_(2-x) to target the stress alleviating regulators, i.e., nuclear factor E2-related factor 2(NRF2) and heat shock protein 90a(HSP90a), thereby reducing the stress tolerance of tumor cells. Under subsequent NIR light illumination, the TiO_(2-x) demonstrates a higher anticancer effect both in vitro and in vivo. This strategy not only provides a promising modality to kills cancer cells in a minimal side-effects manner by interrupting anti-stress pathways but also proposes a general approach to achieve controllable gene editing in tumor region without unwanted genetic mutation in normal environments.

关键词： Near infrared phototherapy Gene editing Nuclear factor E2-related factor 2 .Heat shock protein 90c TiO_(2-x) Sensitized phototherapy Nanoprodrug Tumor microenvironment

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光电神经突触器件研究进展

中国科学：信息科学 2020年第6期50卷 892-912页

作者：李雅瑶王越杨德仁皮孝东浙江大学硅材料国家重点实验室和材料科学与工程学院杭州310027

神经形态计算(类脑计算)以其自适应学习、高并行计算和低功耗等优点,被认为是最有希望解决冯·诺依曼(von Neumann)瓶颈的方法之一.实现神经形态计算的重要前提是开发能模拟生物突触行为的神经突触器件.电学神经突触器件是首先发展起来... 详细信息

神经形态计算(类脑计算)以其自适应学习、高并行计算和低功耗等优点,被认为是最有希望解决冯·诺依曼(von Neumann)瓶颈的方法之一.实现神经形态计算的重要前提是开发能模拟生物突触行为的神经突触器件.电学神经突触器件是首先发展起来的神经突触器件,但是它们在统筹考虑带宽、连接、密度等因素下的整体优化面临着很大的挑战.近年来,把光引入神经突触器件,研制光电神经突触器件,为神经突触器件的发展带来了新机遇.对神经突触器件而言,光不仅具备电难以实现的高带宽、低串扰、低功率和无延迟等特性,还可以直接模拟视觉等至关重要的神经行为.光电神经突触器件作为基于光电集成的人工神经网络的基础,有望有力促进高性能和低功耗的神经形态计算的发展.本文主要介绍了光电神经突触器件的基本性能和类别,展示了已经实现的光电神经突触器件的模拟应用,并展望了今后光电神经突触器件的发展.

关键词：光电神经突触器件突触可塑性能耗氧空位离化与去离化载流子俘获与释放

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一种融合语义特征的图卷积文本分类方法

计算机应用与软件 2024年第5期41卷 247-253,285页

作者：黎文杰洪嘉伟魏艳辉左亚尧广东工业大学计算机学院广东广州510006

随着文本分类领域相关研究的推进,基于深度学习的文本分类方法成为了该领域的重要研究方向之一。深度学习模型因其强大的特征提取能力,在文本分类任务上有着颇为优越的表现。但由于文本数据的高维性和自然语言的语义复杂性,现有的深度... 详细信息

随着文本分类领域相关研究的推进,基于深度学习的文本分类方法成为了该领域的重要研究方向之一。深度学习模型因其强大的特征提取能力,在文本分类任务上有着颇为优越的表现。但由于文本数据的高维性和自然语言的语义复杂性,现有的深度学习模型在复合语义信息的提取上仍有待进一步优化,其表现对文本分类效果产生不可忽视的影响。为此,该文提出一种基于LDA和GCN的文本分类模型LGCN。该模型利用LDA模型学习文档、单词和主题的关联信息,借助滑动窗口、PMI值计算等方式获取字符间的联系,采用TF-IDF得到单词和文档的联系,通过融合这些丰富的语义信息得到以节点形式构建的图,使用GCN模型学习图中语义信息并对图中文档节点进行分类从而完成文本分类任务。实验结果表明,在相同的数据集上,LGCN模型的文本分类效果优于LSTM等参照模型。

关键词：图卷积神经网络隐狄利克雷分布文本分类

A Value Classification of Electronic Product Reviews Based on Maximum Entropy

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Chinese Journal of Electronics 2016年第6期25卷 1071-1078页

作者： ZUO yayao li Jiejun TANG Yong SHU Zhongmei Faculty of Computer Guangdong University of Technology School of Computer Science South China Normal University School of Education Sun Yat-sen University

Reviews of electronic product are important resources for manufacturers to gather feedbacks from customers. They provide an important reference for customers to make a decision on product purchase. Electronic product reviews with high quality is valuable, and reviews analysis is becoming an open issue. Based on the binary feature function, a maximum entropy classification of electronic product reviews is proposed to identify the valuable reviews. Considering the simpleness of the theme in reviews, a text classifier integrated with the features of descriptive anaphor is provided to enhance the model’s fitting degree. Furthermore, the feature library is constructed by the Term frequency-inverse document frequency(TF-IDF)algorithm to locate the description, and the descriptive anaphors are identified by means of the minimum Inflectional phrase(IP) parsing tree. The experiment shows the proposed classifier has the relatively high stability and precision, which makes the reviews much more usable for manufacturers to make product strategy and for customers to make a decision.

关键词： Maximum entropy Binary feature function Electronic product reviews Review classification Anaphor identification

宁夏罗山4种典型森林群落植物-凋落物-土壤生态化学计量特征

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南京林业大学学报（自然科学版） 2024年第4期48卷 227-234页

作者：余雅尧徐雪蕾刘超刘佳欣杨天宇李树明宁夏大学农学院宁夏银川750021 宁夏罗山国家级自然保护区管理局宁夏吴忠751900

【目的】宁夏罗山是中部干旱带上唯一的生态安全屏障,研究该地区森林群落生态化学计量特征以揭示森林生态系统植被生长发育的主要限制性营养元素,为该地区植被恢复实践中群落的选择和森林经营管理提供理论依据。【方法】选择罗山保护区... 详细信息

【目的】宁夏罗山是中部干旱带上唯一的生态安全屏障,研究该地区森林群落生态化学计量特征以揭示森林生态系统植被生长发育的主要限制性营养元素,为该地区植被恢复实践中群落的选择和森林经营管理提供理论依据。【方法】选择罗山保护区4种主要的森林群落[青海云杉(Picea crassifolia)纯林、油松(Pinus tabuliformis)纯林、山杨(Populus davidiana)纯林、青海云杉×油松混交林]为研究对象,采取野外样地调查取样,室内测定森林群落乔木优势种植物各器官、凋落物及林地土壤的碳(C)、氮(N)、磷(P)含量,分析比较4种森林群落乔木优势种植物各器官、凋落物、土壤生态化学计量特征及环境因素,植物(各器官平均值)、凋落物和土壤三者化学计量特征的相关性。【结果】(1)乔木优势种植物叶和枝的C含量显著高于根的,叶的N、P含量显著高于枝和根,叶C/N显著低于枝和根;山杨纯林叶和枝的N含量显著高于其他森林群落,而叶的C/N显著低于其他森林群落;油松纯林根的N含量和枝、根的N/P显著低于其他森林群落,而枝和根的C/N显著高于其他森林群落。(2)山杨纯林凋落物N、P含量和N/P显著高于其他森林群落,C/N、C/P显著低于其他森林群落。(3)土壤C、N、P含量,C/N、C/P在不同森林群落间无显著差异,青海云杉纯林土壤N/P显著高于其他森林群落。(4)植物N与凋落物N含量,N/P存在显著正相关关系,两者的C/N则存在显著负相关关系;植物C/N与凋落物C含量存在显著正相关关系,两者的N/P则存在显著负相关关系;土壤C/N、N/P分别与植物P含量、凋落物C/P存在显著正相关关系,凋落物与植物的C/P存在显著负相关关系。植物P含量与土壤pH显著正相关。海拔与凋落物C/N、C/P呈显著正相关,与凋落物N含量、N/P呈显著负相关。土壤N/P与pH显著负相关,与海拔和土壤碱解氮呈显著正相关。土壤C、N、P含量、C/P、N/P与土壤有机质含量呈极显著正相关。【结论】罗山4种主要的森林群落中植物生长发育和凋落物分解的主要限制元素均为N元素,尤其该地区针叶林植被建设中需加强N元素的保护与利用;而山杨纯林生长速率最快且凋落物更易分解,在罗山的植被恢复中应优先选择和保护。

关键词：生态化学计量特征植物凋落物土壤宁夏罗山国家级自然保护区

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拉萨河抗生素耐药基因污染情况研究

公共卫生与预防医学 2024年第4期35卷 1-5页

作者：吕雅瑶陈梦秋李海北李淑娟刘淑杰张弋天津市第一中心医院药学部天津300192 天津科技大学天津300222

目的掌握拉萨河中抗生素耐药基因(antibiotic resistance genes,ARGs)的污染情况,为区域人群饮水安全和水环境污染的防治提供科学依据。方法 2022年7月在拉萨河流域内随机选取5个点进行河水采样,并利用荧光定量PCR技术检测和分析19种A... 详细信息

目的掌握拉萨河中抗生素耐药基因(antibiotic resistance genes,ARGs)的污染情况,为区域人群饮水安全和水环境污染的防治提供科学依据。方法 2022年7月在拉萨河流域内随机选取5个点进行河水采样,并利用荧光定量PCR技术检测和分析19种ARGs的污染情况,其中包括8种“最后防线”ARGs(last-resort ARGs,LARGs)。以SPSS 22.0软件进行统计学分析,两组间数据采用Student t检验比较分析。结果 19种ARGs都有较高程度的检出,其中氨基糖苷类耐药基因aadA浓度最高,磺胺类耐药基因sul1和大环内酯类耐药基因ermB次之。在8种LARGs中,碳青霉烯类耐药基因bla_(OXA-48)浓度最高。总体来看,LARGs的绝对浓度和相对浓度都低于“常规”ARGs,二者的绝对含量差异有统计学意义。结论拉萨河水中“常规”ARGs和LARGs都有检出,虽然和国内其它水域相比仍处于较低水平,但鉴于ARGs尤其是LARGs可能造成的严重不良影响,拉萨河中ARGs的污染应引起重视。

关键词：抗生素耐药基因 “最后防线”抗生素耐药基因拉萨河

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