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The genetic basis and process of inbreeding depression in an elite hybrid rice

Science China(Life Sciences) 2024年第8期67卷 1727-1738页

作者： Xiaodong Xu yawen Xu Jian Che Xu Han Zhengji wang Xianmeng wang Qinghua Zhang Xu Li Qinglu Zhang Jinghua Xiao Xianghua Li Qifa Zhang Yidan Ouyang National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research(Wuhan) Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China

Inbreeding depression refers to the reduced performance arising from increased homozygosity,a phenomenon that is the reverse of heterosis and exists among plants and *** a natural self-pollinated crop with strong heterosis,the mechanism of inbreeding depression in rice is largely *** understand the genetic basis of inbreeding depression,we constructed a successive inbreeding population from the F_(2)to F_(4)generation and observed inbreeding depression of all heterotic traits in the progeny along with the decay of heterozygosity in each *** expected depression effect was largely explained by 13 QTLs showing dominant effects for spikelets per panicle,11 for primary branches,and 12 for secondary branches,and these loci constitute the main correlation between heterosis and inbreeding ***,the genetic basis of inbreeding depression is also distinct from that of heterosis,such that a biased transmission ratio of alleles for QTLs with either dominant or additive effects in four segregation distortion regions would result in minor effects in expected ***,two-locus interactions may change the extent and direction of the depression effects of the target loci,and overall interactions would promote inbreeding depression among *** an F_(2:3)variation population,the actual performance of the loci showing expected depression was evaluated considering the heterozygosity decay in the background after *** found inconsistent or various degrees of background depression from the F_(2)to F_(3)generation assuming different genotypes of the target locus,which may affect the actual depression effect of the locus due to *** results suggest that the genetic architecture of inbreeding depression and heterosis is closely linked but also differs in their intrinsic mechanisms,which expand our understanding of the whole-genome architecture of inbreeding depression.

关键词： rice inbreeding depression spikelet development dominance segregation distortion epistasis

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BIM技术在机电安装专业施工中的应用研究

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中国厨卫 2024年第4期23卷 312-314页

作者：廖强徐利阳王亚文北京城建集团有限责任公司北京100000 临沂西城建设项目管理有限公司山东临沂276000

BIM技术通过整合各种信息资源,为建筑项目的各个阶段提供支持,从而加快了建筑项目施工进度,降低了建设成本,确保了工程质量。机电安装作为建筑项目中的一个重要部分,由于其施工的复杂性和特殊要求,需要采用更先进、更高效的技术方法。... 详细信息

BIM技术通过整合各种信息资源,为建筑项目的各个阶段提供支持,从而加快了建筑项目施工进度,降低了建设成本,确保了工程质量。机电安装作为建筑项目中的一个重要部分,由于其施工的复杂性和特殊要求,需要采用更先进、更高效的技术方法。文章主要研究了BIM技术在机电安装专业施工中的应用,分析并解决了施工过程中土建施工与管线综合遇到的复杂性问题,避免了管线综合时的“碰撞现象”,探讨了其在设计、施工、运营和维护等阶段为建设项目提供的增值服务。

关键词： BIM技术机电安装管线综合进度成本质量

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南北地震带地震台网监测能力评估的不同方法比较研究

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地震学报 2017年第3期39卷 315-329页

作者：王亚文蒋长胜中国地震局地球物理研究所中国北京100081

为探讨不同地震台网监测能力评估方法的结果差异性及其原因,本文选用目前国际上比较前沿的"基于概率的完整性震级"(PMC)方法和"完整性震级范围"(EMR)方法,以及中国地震台网常规采用的"震级-最大距离"方法,对2008年10月1日—2015年9月17... 详细信息

为探讨不同地震台网监测能力评估方法的结果差异性及其原因,本文选用目前国际上比较前沿的"基于概率的完整性震级"(PMC)方法和"完整性震级范围"(EMR)方法,以及中国地震台网常规采用的"震级-最大距离"方法,对2008年10月1日—2015年9月17日南北地震带地区表征地震监测能力的最小完整性震级进行了比较研究.研究中考虑了以往关注不够的地震观测质量一致性问题,统一采用至少3个台站记录的地震资料.结果显示,3种方法的结果差异显著,最小完整性震级的差值在南北地震带个别地区甚至可达ML2.0,其中,PMC方法获得的最小完整性震级Mp值在32°N以北地区显著低于其它两种方法,震级-最大距离方法获得的最小完整性震级Mr低值结果仅与高台站密度地区有关,与包括EMR方法获得的最小完整性震级McEMR相比较在统计均值上则呈McEMR

关键词：最小完整性震级Mc 地震检测能力基于概率的完整性震级(PMC)方法完整性震级范围(EMR)方法

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Impact of climate change on dengue fever epidemics in South and Southeast Asian settings:A modelling study

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Infectious Disease Modelling 2023年第3期8卷 645-655页

作者： yawen wang Shi Zhao Yuchen Wei Kehang Li Xiaoting Jiang Conglu Li Chao Ren Shi Yin Janice Ho Jinjun Ran Lefei Han Benny Chung-ying Zee Ka Chun Chong Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong Kong Special Administrative RegionChina Centre for Health Systems and Policy Research The Chinese University of Hong KongHong Kong Special Administrative RegionChina Clinical Trials and Biostatistics Laboratory Shenzhen Research InstituteThe Chinese University of Hong KongShenzhenChina Division of Landscape Architecture Department of ArchitectureFaculty of ArchitectureThe University of Hong KongHong Kong Special Administrative RegionChina School of Public Health Shanghai Jiao Tong University School of MedicineShanghaiChina School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina

The potential for dengue fever epidemic due to climate change remains uncertain in tropical *** study aims to assess the impact of climate change on dengue fever transmission in four South and Southeast Asian *** collected weekly data of dengue fever incidence,daily mean temperature and rainfall from 2012 to 2020 in Singapore,Colombo,Selangor,and Chiang *** for temperature and rainfall were drawn for three Shared Socioeconomic Pathways(SSP126,SSP245,and SSP585)*** a disease transmission model,we projected the dengue fever epidemics until 2090s and determined the changes in annual peak incidence,peak time,epidemic size,and outbreak duration.A total of 684,639 dengue fever cases were reported in the four locations between 2012 and *** projected change in dengue fever transmission would be most significant under the SSP585 *** comparison to the 2030s,the peak incidence would rise by 1.29 times in Singapore,2.25 times in Colombo,1.36 times in Selangor,and>10 times in Chiang Mai in the 2090s under ***,the peak time was projected to be earlier in Singapore,Colombo,and Selangor,but be later in Chiang Mai under the SSP585 *** in a milder emission scenario of SSP126,the epidemic size was projected to increase by 5.94%,10.81%,12.95%,and 69.60%from the 2030se2090s in Singapore,Colombo,Selangor,and Chiang Mai,*** outbreak durations in the four settings were projected to be prolonged over this century under SSP126 and SSP245,while a slight decrease is expected in 2090s under *** results indicate that climate change is expected to increase the risk of dengue fever transmission in tropical areas of South and Southeast *** greenhouse gas emissions could be crucial in reducing the transmission of dengue fever in the future.

关键词： Temperature Rainfall Extreme weather event Dengue fever

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Evaluating the necessity of autumn irrigation on salinized soil by considering changes in soil physicochemical properties

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Pedosphere 2024年第4期34卷 837-842页

作者： Hang ZHAO Jingwei WU Changsen LI yawen LIU Rui ZHANG Qiang ZHAO State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan 430072China

Dear Editor,Soil salinization is one of the main forms of global soil degradation,which seriously threatens food security production (Liu et al.,2022).Proper irrigation is the main management measure to control soil salinization (Aragüés et al.,2015;Machado and Serralheiro,2017).For example,in Hetao Irrigation District in Inner Mongolia of northwestern China,the effects of irrigation,seasonal freezing-thawing,and evaporation have led to serious soil salinization *** the 1980s,autumn irrigation (AI) has typically been implemented widely in Hetao Irrigation District before soil freezing (Li et al.,2010;Lu et al.,2019),to leach the salts accumulated on the surface and maintain sufficient soil moisture to create a suitable environment for the next spring sowing.

关键词： soil freezing irrigation

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Boosting kinetic separation of ethylene and ethane on microporous materials via crystal size control

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Chinese Journal of Chemical Engineering 2024年第1期65卷 85-91页

作者： Yixuan Ma Cong Yu Lifeng Yang Rimin You yawen Bo Qihan Gong Huabin Xing Xili Cui Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310012China Fundamental Science&Advanced Technology Lab PetroChina Petrochemical Research InstituteChina National Petroleum CorporationBeijing 102200China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311200China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Hangzhou 310027China

The adsorptive separation of C_(2)H_(4)and C_(2)H_(6),as an alternative to distillation units consuming high energy,is a promising yet challenging *** great similarity in the molecular size of C_(2)H_(4)and C_(2)H_(6)brings challenges to the regulation of adsorbents to realize efficient dynamic ***,we reported the enhancement of the kinetic separation of C_(2)H_(4)/C_(2)H_(6)by controlling the crystal size of ZnAtzPO_(4)(Atz=3-amino-1,2,4-triazole)to amplify the diffusion difference of C_(2)H_(4)and C_(2)H_(6).Through adjusting the synthesis temperature,reactant concentration,and ligands/metal ions molar ratio,ZnAtzPO4 crystals with different sizes were *** single-component kinetic adsorption tests and binary-component dynamic breakthrough experiments confirmed the enhancement of the dynamic separation of C_(2)H_(4)/C_(2)H_(6)with the increase in the crystal size of ZnAtzPO_(4).The separation selectivity of C_(2)H_(4)/C_(2)H_(6)increased from 1.3 to 98.5 with the increase in the crystal size of ZnAtzPO_(4).This work demonstrated the role of morphology and size control of adsorbent crystals in the improvement of the C_(2)H_(4)/C_(2)H_(6)kinetic separation performance.

关键词： Adsorption Adsorbent Ethylene Binary mixture Crystal size control Kinetic separation

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Simultaneous integration of Fe clusters and NiFe dual single atoms in nitrogen-doped carbon for oxygen reduction reaction

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Nano Research 2024年第4期17卷 2291-2297页

作者： Jirong Bai Yuebin Lian Yaoyao Deng Mei Xiang Peng Xu Quanfa Zhou yawen Tang Yaqiong Su Research Center of Secondary Resources and Environment School of Chemical Engineering and MaterialsChangzhou Institute of TechnologyChangzhou 213022China Jiangsu Key Laboratory of New Power Batteries School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China School of Chemistry Engineering Research Center of Energy Storage Materials and Devices of Ministry of EducationNational Innovation Platform(Center)for Industry-Education Integration of Energy Storage TechnologyXi’an Jiaotong UniversityXi’an 710049China

Atomically-dispersed iron-based electrocatalysts are promising substitutes for noble metal electrocatalysts because of excellent performance in oxygen reduction reaction(ORR).Rationally modulating the local coordination environment of the Fe site and optimizing the binding energy of oxygen reduction intermediates are effective strategies to optimize ORR ***,we report a new method in which Ni is introduced to construct NiFe dual single atoms and iron nanoclusters loaded on the nitrogen-doped carbon with a highly porous *** design plays a synergistic role of dual single atoms and clusters,optimizes the 3d orbital and Fermi level of Fe,breaks the symmetrical structure of Fe-N_(4),and effectively improves the adsorption/desorption behavior of the oxygen-containing *** tests show FeNCs/NiFeSAs-NC has an excellent intrinsic *** calculations show the oxygen-containing species on the Ni active site will move to the middle of NiFe(bridge site connection)after optimization and that the key step is OH desorption,with a reaction energy of 0.27 *** electron exchange between NiFe-N6 and Fe-cluster is very strong,further indicating the introduction of Ni species and Fe clusters has a regulatory effect on the electronic structure of Fe-N_(4).

关键词： NiFe dual single atoms Fe clusters OH*adsorption energy oxygen reduction reaction

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PIM1-HDAC2 axis modulates intestinal homeostasis through epigenetic modification

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3049-3067页

作者： Jianming Yang yawen Xiao Ningning Zhao Geng Pei Yan Sun Xinyu Sun Kaiyuan Yu Chunhui Miao Ran Liu Junqiang Lv Hongyu Chu Lu Zhou Bangmao wang Zhi Yao Quan wang Key Laboratory of Immune Microenvironment and Disease(Ministry of Education) Tianjin Institute of ImmunologyState Key Laboratory of Experimental Hematologythe Province and Ministry Co-sponsored Collaborative Innovation Center for Medical EpigeneticsDepartment of ImmunologySchool of Basic Medical SciencesTianjin Institute of Urologythe Second Hospital of Tianjin Medical UniversityTianjin Key Laboratory of Cellular and Molecular ImmunologyTianjin Medical UniversityTianjin 300070China Department of Pathology Tianjin Medical University Cancer Institute and Hospital/National Clinical Research Center of Cancer/Key Laboratory of Cancer Prevention and TherapyTianjin/Tianjin’s Clinical Research Center of CancerTianjin 30060China Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300070China

The mucosal barrier is crucial for intestinal homeostasis,and goblet cells are essential for maintaining the mucosal barrier *** proviral integration site for Moloney murine leukemia virus-1(PIM1)kinase regulates multiple cellular functions,but its role in intestinal homeostasis during colitis is ***,we demonstrate that PIM1 is prominently elevated in the colonic epithelia of both ulcerative colitis patients and murine models,in the presence of intestinal *** PIM1 leads to decreased goblet cells,thus impairing resistance to colitis and colitis-associated colorectal cancer(CAC)in ***,PIM1 modulates goblet cell differentiation through the Wnt and Notch signaling ***,PIM1 interacts with histone deacetylase 2(HDAC2)and downregulates its level via phosphorylation,thereby altering the epigenetic profiles of Wnt signaling pathway ***,these findings investigate the unknown function of the PIM1-HDAC2 axis in goblet cell differentiation and ulcerative colitis/CAC pathogenesis,which points to the potential for PIM1-targeted therapies of ulcerative colitis and CAC.

关键词： PIM1 HDAC2 Goblet cell Gut microbiota Intestinal homeostasis Epigenetic modification Ulcerative colitis CAC

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Trade-off analyses between food provision and soil conservation service of Grain for Green Program in Mountainous Area

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International Soil and Water Conservation Research 2024年第1期12卷 43-53页

作者： yawen Li Yuxiang Li Xingwu Duan Zhongyin Cai Ya Li Baiyun He Long Yin Institute of International River and Eco-security Yunnan UniversityKunming650091PR China Yunnan Key Laboratory of International Rivers and Trans-boundary Eco-security Kunming650091PR China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085PR China University of Chinese Academy of Sciences Beijing100049PR China

The Grain for Green Program and soil and water conservation engineering initiatives are crucial for controlling erosion in steep-slope ***,it is still unclear how these two management methods should be carried out in respect to the situation in mountainous ***,taking a typical mountainous area in southwest China as an example,we simulated six scenarios in order to compare the food provisioning service(FPS)and soil conservation service of the Grain for Green Program(converting to grassland)and Construction Measures(converting to sloping terrace)under different *** showed that when farmland with a>25°slope was converted into grassland,the amount of soil erosion(M)decreased by 21.0%,while FPS decreased by only 0.7%.However,when farmland with a>25°slope was converted into sloping terrace,M decreased by 31.3%while FPS increased by 18.7%.With the increases of farmland slope ranges in the Construction Measures scenario,M gradually decreased and FPS gradually *** when farmland>15°was converted into sloping terrace,M decreased by 63.9%and FPS increased by 52.7%.Furthermore,the trade-offs of Construction Measures are lower than that of Grain for Green on different slope ***,we conclude that Construction Measures are a more suitable method in mountainous areas than the Grain for Green,and we suggest that further research be conducted to consider the ecological risks of construction engineering measures.

关键词： Soil erosion Grain for green Construction measures Mountainous areas

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基于故障检测上下文的等价变异体识别算法

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计算机研究与发展 2021年第1期58卷 83-97页

作者：于畅王雅文林欢宫云战网络与交换技术国家重点实验室(北京邮电大学) 北京100876

等价变异体识别一直是阻碍变异测试在工业界得以广泛应用的一个关键难题.为此提出了一种基于故障检测上下文的等价变异体识别算法.该算法通过静态分析技术抽取程序中与故障检测条件相关的代码上下文信息,以构造故障检测上下文;接着,故... 详细信息

等价变异体识别一直是阻碍变异测试在工业界得以广泛应用的一个关键难题.为此提出了一种基于故障检测上下文的等价变异体识别算法.该算法通过静态分析技术抽取程序中与故障检测条件相关的代码上下文信息,以构造故障检测上下文;接着,故障检测上下文被转换为文档模型,经过一个文档表示学习网络进行编码;最后通过机器学习模型将变异体分类为等价或非等价变异.在包含了22个C程序和118000个变异体样本的训练集上,该算法取得91%的分类精准度和82%的召回率;同时在跨项目交叉验证中,机器学习模型取得了77%的精准度和78%的召回率.该结果表明基于故障检测上下文的识别技术能够有效地提高等价变异体分类的精准性和泛用性,为提高变异测试技术的有效性提供了技术支持.

关键词：变异测试等价变异体故障检测上下文机器学习静态分析

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