检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

《黄帝内经》“肉”的理论框架探析

中华中医药学刊 2024年第3期42卷 103-107页

作者：宋雅文尹萌朱鹏举郑煜凡鞠宝兆孙秀业辽宁中医药大学辽宁沈阳110847 辽宁中医药大学附属第二医院辽宁沈阳110034

“肉”是人体结构的重要组成部分。现代医学研究发现,肉的相关生理病理机制已涉及如糖尿病、风湿性疾病以及肥胖症等领域。此类患者皆面临疾病起病隐蔽,病机复杂,病程漫长,常伴终生,西医无特效药物治疗等困境。因此,临床治疗与发展亟须... 详细信息

“肉”是人体结构的重要组成部分。现代医学研究发现,肉的相关生理病理机制已涉及如糖尿病、风湿性疾病以及肥胖症等领域。此类患者皆面临疾病起病隐蔽,病机复杂,病程漫长,常伴终生,西医无特效药物治疗等困境。因此,临床治疗与发展亟须系统全面的中医理论基础作为指导与支撑。而《黄帝内经》对肉的论述分散于各篇章中,未设立专篇,后世更缺乏对其相关理论内容的系统总结。通过检索《黄帝内经》中关于肉的相关论述,并结合历代医家的注解及临床应用,介绍肉的理论起源,整理肉及其相关概念的定义与内涵,发掘肉与脾、肺、肾等脏腑及经络的联系,全面总结肉的生理功能、病因病机、诊断方法、治疗方法等内容,构建较为系统的肉的理论框架,以期进一步推动中医人体结构的基础理论研究,为中医外科、针灸等以中医外治疗法为主的诊疗实践提供理论指导。

关键词：黄帝内经肉中医基础理论临床治疗

维普期刊数据库博看期刊

基于BaCo_(0.4)Fe_(0.4)Zr_(0.1)Y_(0.1)O_(3-δ)空气电极的可逆质子陶瓷膜电池性能研究

在线全文

学校读者我要写书评

暂无评论

材料研究与应用 2024年第1期18卷 24-30页

作者：宋雅雯张小珍周成志袁列鹏王禧斌景德镇陶瓷大学材料科学与工程学院江西景德镇333403

采用柠檬酸络合-硝酸盐燃烧法合成的BaCo_(0.4)Fe_(0.4)Zr_(0.1)Y_(0.1)O_(3-δ)(BCFZY)作为空气电极材料,组装了燃料电极支撑的可逆质子陶瓷膜电池(R-HCMC),并且探讨了单电池在不同工作模式下的电化学性能。结果表明:在900℃下合成的BC... 详细信息

采用柠檬酸络合-硝酸盐燃烧法合成的BaCo_(0.4)Fe_(0.4)Zr_(0.1)Y_(0.1)O_(3-δ)(BCFZY)作为空气电极材料,组装了燃料电极支撑的可逆质子陶瓷膜电池(R-HCMC),并且探讨了单电池在不同工作模式下的电化学性能。结果表明:在900℃下合成的BCFZY表现为单一立方钙钛矿结构,在700℃燃料电池模式下,单电池最大输出功率为424.7 mW·cm^(-2)、最低的极化阻抗为0.23Ω·cm^(2);在电解模式下,电解电压为1.4 V时,最大电流密度为1084 mW·cm^(-2)、氢气产率为3.1 mL·min^(-1)·cm^(-2)。说明,BCFZY空气电极在中低温条件下表现出良好的电催化活性和结构与性能稳定性。

关键词：可逆陶瓷膜电池质子导体极化电阻输出功率产氢率电化学性能燃烧法电极材料

Solution processed low power organic field-effect transistor bio-chemical sensor of high transconductance efficiency

在线全文

学校读者我要写书评

暂无评论

npj Flexible Electronics 2022年第1期6卷 160-167页

作者： Wei Tang Ying Fu Yukun Huang Yuanzhe Li yawen song Xin Xi Yude Yu Yuezeng Su Feng Yan Xiaojun Guo School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongChina State Key Laboratory of Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China

Developing organic field-effect transistor(OFET)biosensors for customizable detection of biomarkers for many diseases would provide a low-cost and convenient tool for both biological studies and clinical *** this work,design principles of the OFET transducer for biosensors were derived to relate the signal-to-noise ratio(SNR)to the device-performance *** subthreshold swing(SS),proper threshold voltage(Vth),good-enough bias-stress stability,and mechanical durability are shown to be the key prerequisites for realizing OFET bio-sensors of high transconductance efficiency(gm/ID)for large *** a low trap-density channel and a high-k/low-k gate dielectric layer,low-temperature(<100℃)solution-processed flexible OFETs can meet the performance requirements to maximize the gm/*** extended gate-structure OFET biosensor was further implemented for label-free detection of miR-21,achieving a detection limit below 10 pM with high selectivity at a low operation voltage(<1 V).

关键词： transistor effect durability

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

针刺治疗动眼神经麻痹研究进展

中国中医药图书情报杂志 2024年第4期48卷 268-272页

作者：王东霞赵小鹏曹水清赵峰贾成文宋亚文文新甘肃中医药大学甘肃兰州730000 甘肃中医药大学附属医院甘肃兰州730099

针刺治疗动眼神经麻痹包括单纯针刺疗法、特色针刺疗法、针刺联合疗法,其中特色针刺疗法可分为醒脑开窍针法、温通针法、维筋相交针刺法、调跷脉合维脉法、“补荥通俞”针刺法,针刺联合疗法可分为联合电针、联合灸法、联合推拿手法、联... 详细信息

针刺治疗动眼神经麻痹包括单纯针刺疗法、特色针刺疗法、针刺联合疗法,其中特色针刺疗法可分为醒脑开窍针法、温通针法、维筋相交针刺法、调跷脉合维脉法、“补荥通俞”针刺法,针刺联合疗法可分为联合电针、联合灸法、联合推拿手法、联合营养神经药物及中药方剂,机制研究主要围绕调节局部血流微循环、促进轴突再生展开。现对针刺治疗动眼神经麻痹研究进行综述,以期为临床治疗提供参考。

关键词：针刺动眼神经麻痹综述

Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion and metastasis

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2021年第5期15卷 649-656页

作者： Jingyue Zhang yawen song Qianqian Shi Li Fu Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Breast Cancer Prevention and TherapyTianjin Medical universityMinistry of EducationTianjin 300060China

Tumorigenesis involves metabolic reprogramming and abnormal lipid metabolism,which is manifested by increased endogenous fat mobilization,hypertriglyceridemia,and increased fatty acid *** acid synthase(FASN)is a key enzyme for the de novo synthesis of fatty acids,and monoacylglycerol esterase(MGLL)is an important metabolic enzyme that converts triglycerides into free fatty *** enzymes play an important role in lipid metabolism and are associated with tumor-related signaling pathways,the most common of which is the PI3K–AKT signaling *** can also regulate the immune microenvironment,participate in epithelial–mesenchymal transition,and then regulate tumor invasion and *** literature have shown that these two genes are abnormally expressed in many types of tumors and are highly correlated with tumor migration and *** article introduces the structures and functions of FASN and MGLL,their relationship with abnormal lipid metabolism,and the mechanism of the regulation of tumor invasion and metastasis and reviews the research progress of the relationship of FASN and MGLL with tumor invasion and metastasis.

关键词： FASN MGLL lipid metabolism tumor invasion metastasis

Single-cell transcriptomic atlas of goat ovarian aging

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2024年第1期15卷 146-161页

作者： Dejun Xu Shuaifei song Fuguo Wang yawen Li Ziyuan Li Hui Yao Yongju Zhao Zhongquan Zhao Chongqing Key Laboratory of Herbivore Science College of Animal Science and TechnologySouthwest UniversityChongqing 400715China

Background The ovaries are one of the first organs that undergo degenerative changes earlier in the aging process,and ovarian aging is shown by a decrease in the number and quality of ***,little is known about the molecular mechanisms of female age-related fertility decline in different types of ovarian cells during aging,especially in ***,the aim of this study was to reveal the mechanisms driving ovarian aging in goats at single-cell *** For the first time,we surveyed the single-cell transcriptomic landscape of over 27,000 ovarian cells from newborn,young and aging goats,and identified nine ovarian cell types with distinct gene-expression *** enrichment analysis showed that ovarian cell types were involved in their own unique biological processes,such as Wnt beta-catenin signalling was enriched in germ cells,whereas ovarian steroidogenesis was enriched in granulosa cells(GCs).Further analysis showed that ovarian aging was linked to GCs-specific changes in the antioxidant system,oxidative phosphorylation,and ***,we identified a series of dynamic genes,such as AMH,CRABP2,THBS1 and TIMP1,which determined the fate of ***,FOXO1,SOX4,and HIF1A were identified as significant regulons that instructed the differentiation of GCs in a distinct manner during ovarian *** This study revealed a comprehensive aging-associated transcriptomic atlas characterizing the cell typespecific mechanisms during ovarian aging at the single-cell level and offers new diagnostic biomarkers and potential therapeutic targets for age-related goat ovarian diseases.

关键词： Goat Granulosa cells Ovarian aging Single-cell transcriptomic

Carbon capture in power sector of China towards carbon neutrality and its comparison to renewable power

在线全文

学校读者我要写书评

暂无评论

Fundamental Research 2024年第4期4卷 916-925页

作者： Sheng Li Lin Gao song He Dongtai Yang Chaowei Wang yawen Zheng School of mechanical engineering Beijing Institute of TechnologyBejing 100081China Laboratory of Integrated Energy System and Renewable Eery Institute of Engineering ThemophysicsChinese Academyof SciencesBejing0010China

CO_(2)capture from coal power plants is an important and necessary solution to realizing carbon neutrality in China,but ccs demonstration deployment in power sector is far behind ***,the reduction potential of energy consumption and cost for CcS and its competitiveness to renewable powers are very important to make roadmaps and policies toward carbon *** the popular recognition that capturing CO_(2)from flue gases is technically and commercially mature,this paper notes that it has been proved to be technically feasible but far beyond technology maturity and high energy penalty leads to its immaturity and therefore causes high ***,the potential energy penalty reduction of capture is investigated thermodynamically,and future CO_(2)avoidance cost is predicted and compared to renewable power(solar PV and onshore wind power).Results show that energy penalty for CO_(2)capture can be reduced by 48%-57%.When installation capacity reaches a similar scale to that of solar PV in China(250 GW),CO_(2)capture cost in coal power plants can be reduced from the current 28-40 USs/ton to 10-20 USs/ton,and efficiency upgrade contributes to 67%-75%in cost reduction for high coal price *** China,CO_(2)capture in coal power plants can be cost competitive with solar PV and onshore wind *** it is worth noting that the importance and share of CCS role in CO_(2)emission reduction is decreasing since renewable power is already well deployed and there is still a lack of large-scale CO_(2)capture demonstrations in *** capture technologies with low energy penalties need to be developed to promote *** in this work can provide informative references for making roadmaps and policies regarding CO_(2)emission reductions that contribute towards carbon neutrality.

关键词： Carbon capture and storage Carbon neutrality Energy consumption Fluegas Renewable energy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

民主革命时期知识界关于五四运动的解读

中国国家博物馆馆刊 2023年第3期 140-149页

作者：宋亚文中国国家博物馆北京100006

五四运动作为民主革命时期的大事件,其深远的影响集中体现于知识界在诸多报章杂志的相关报道或相关论文、著作经久不衰的言说中。或者说,国人对五四的纪念从未中断过、对五四的解读也从未停止过,五四运动的成因、性质、意义、精神在这... 详细信息

五四运动作为民主革命时期的大事件,其深远的影响集中体现于知识界在诸多报章杂志的相关报道或相关论文、著作经久不衰的言说中。或者说,国人对五四的纪念从未中断过、对五四的解读也从未停止过,五四运动的成因、性质、意义、精神在这种不断的探讨中逐步趋于共识并得到升华,五四的荣光与精神也由此得到了传承和光大。百余年来,“爱国、进步、民主、科学”的五四精神始终散发着不朽的光芒,它不但激励着中国人民取得了新民主主义革命的胜利,也将在实现中华民族伟大复兴的新征程上继续发扬光大。

关键词：民主革命时期知识界五四运动五四精神纪念

Glucose-6-phosphate dehydrogenase neutralizes stresses by supporting reductive glutamine metabolism and AMPK activation

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第3期6卷 580-583页

作者： Benfu Zhong Dewei Jiang Yang Hong Lifang Li Li Qiu Ronghui Yang Xiaohan Jin yawen song Ceshi Chen Binghui Li Department of Cancer Cell Biology and National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and HospitalTianjin 300060P.R.China Department of Biochemistry and Molecular Biology Capital Medical UniversityBeijing 100069P.R.China Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China

Dear Editor,Glucose-6-phosphate dehydrogenase(G6PD)is the rate-limiting enzyme in the oxidative pentose phosphate pathway(oxPPP)that can generate cytosolic NADPH(Fig.1a)for biosynthesis and oxidative ***,we reveal a previously unidentified function of ***,even the natural G6PD deficiency-associated mutant without the activity to maintain the normal oxPPP,can antagonize the stresses by supporting the reductive glutamine metabolism and AMPK activation,independently of the NADPH generation by the oxPPP.

关键词： supporting reductive oxidative