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中华医学杂志(英文版) 2025年第2期138卷 219-221页

作者： Yan Kexiang Zhu Jie Zhang Mengmeng Zhang Fuxin Wang Bing Han Ling Huang Qiong Tang Yulong Li Yuan yawalkar nikhil Zhang Zhenghua Niu Zhenmin Department of Dermatology Huashan Hospital Fudan University Shanghai China State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and Development School of Life Sciences Human Phenome Institute Fudan University Shanghai China Department of Dermatology Inselspital Bern University Hospital University of Bern Bern CH-Bern Switzerland Department of Genetics Shanghai-MOST Key Laboratory of Health and Disease Genomics Chinese National Human Genome Center at Shanghai (CHGC) and Shanghai Academy of Science &amp Technology (SAST) Shanghai China

经表皮试验及淋巴细胞转化试验证实由A组皮质类固醇激素诱发的口服泼尼松龙后出现急性泛发性发疹性脓疱病

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世界核心医学期刊文摘（皮肤病学分册） 2006年第9期2卷 49-50页

作者： Buettiker U. Keller M. PichlerW.J. N. yawalkar 吴佳纹 Department of Dermatology Inselspital CH- 3010 Berne Switzerland Dr.

Background: Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous eruption which is often provoked by drugs. Case Report: We report 2 cases of AGEP which showed rapidly spreading pustular eruptions accompanied by malaise, fever and neutrophilia after the administration of systemic prednisolone (corticosteroid of group A, hydrocortisone type). The histological examination showing neutrophilic subcorneal spongiform pustules was consistent with the diagnosis of AGEP. In both cases the rash cleared within a week upon treatment with topical steroids (corticosteroid of group D1, beta-methasonediprop-ionate type and corticosteroid of group D2, hydrocortisone-17-butyrate type). Three months after recovery, the sensitization to corticosteroids of group A was confirmed by epicutaneous testing and positive lymphocyte transformation tests. Conclusion: These cases show that systemic corticosteroids can induce AGEP and demonstrate that epicutaneous testing and lymphocyte transformation tests may be helpful in identifying the causative drug. Our data support previous reports indicating an important role for drug-specific T cells in inducing neutrophil inflammation in this disease.

关键词：急性泛发性发疹性脓疱病淋巴细胞转化试验皮质类固醇激素泼尼松龙激素诱发皮试验丁酸氢化可的松嗜中性粒细胞

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依法珠单抗治疗部分普秃

世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 13-14页

作者： Kaelin U. Hassan A.S. Braathen L.R. yawalkar N. 任建文

Alopecia areata (AA) is considered an autoimmune disease targeted at hair follicles with T-lymphocytes playing an important role in the pathogenesis. Treatment of AA, particularly the totalis and universalis subtypes, is often difficult and remains a therapeutic challenge. Novel biologic therapies that have been developed for the treatment of other immune-mediated inflammatory skin diseases may represent a new therapeutic modality for this disease. Efalizumab is a humanized monoclonal anti-CD11a antibody that inhibits T-cell activation and migration. We report a case of a 19-year-old man suffering from AA partim universalis, treated with efalizumab monotherapy. The treatment was well tolerated with no reported side effects. The striking improvement warrants further studies with this biologic therapy in AA.

关键词：普秃单抗治疗全秃生物疗法炎症性皮肤病自身免疫性疾病免疫介导单克隆抗体中起

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0.05%CGP14 458软膏治疗银屑病的疗效及其对肾上腺功能的影响

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中华皮肤科杂志 1988年第5期21卷 322-323页

作者：胡兹嘉靳培英岳晓玉邵长庚叶干运 yawalkar S. J. 中国医学科学院皮肤病研究所瑞士Ciba-Geigy有限公司医学部

0.05%CGP14 458是一种新的外用强效皮质类固醇制剂。本研究用CGP治疗13例银屑病住院患者, 所有病人在3周内达到治愈和显著进步。血浆皮质醇测定显示在封包期间显著降低(P<0.01)。研究表明如果皮损面积限制在20%体表面积以下, 每周剂量小... 详细信息

0.05%CGP14 458是一种新的外用强效皮质类固醇制剂。本研究用CGP治疗13例银屑病住院患者, 所有病人在3周内达到治愈和显著进步。血浆皮质醇测定显示在封包期间显著降低(P<0.01)。研究表明如果皮损面积限制在20%体表面积以下, 每周剂量小于60 g, 每日2次涂患处是安全有效的, 封包不宜作常规使用。

关键词：肾上腺皮质激素类/血液消炎药/治疗应用银屑病/药物疗法

Miracorten软膏治疗皮肤淀粉样变病疗效观察

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中华皮肤科杂志 1993年第5期26卷 321-321页

作者：刘季和戴玉琳章青叶干运 S. J. yawalkar 中国医学科学院、中国协和医科大学皮肤病研究所卫生部上海检疫所 Medica department Ciba-Geigy Ltd Basel Switzerland

近年来,我们用瑞士Ciba-Geigy有限公司提供的一种新合成的强效类固醇激素制剂Miracorten软膏,治疗本病40例,取得了较好的结果,现简报如下。一、病例和方法 40例患者均来自我所门诊,经临床及病理检查确诊。男女各20例,年龄20～75岁,病期1... 详细信息

近年来,我们用瑞士Ciba-Geigy有限公司提供的一种新合成的强效类固醇激素制剂Miracorten软膏,治疗本病40例,取得了较好的结果,现简报如下。一、病例和方法 40例患者均来自我所门诊,经临床及病理检查确诊。男女各20例,年龄20～75岁,病期1～40年(中位数为9年),其中23例为苔藓型,6例斑疹型,1例皮肤异色型,10例混合型。21例累及四肢伸侧、肩、背等处,7例累及四肢伸侧,而12例仅限于下肢胫前区域。方法:在一侧肢体或背部外用

关键词：淀粉样变皮肤治疗

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每月服1次利福平对结节性麻疯的治疗作用

国外医药(抗生素分册) 1984年第2期 173-173页

作者： yawalkar S.J. ,孙爱英

麻疯,在其严重极性和亚极性(severepolar and subpolar)的结节型时,需要长期持续化疗,对有些病人尚需终生持续治疗。氨苯砜是一种应用非常广泛的抗麻疯药,虽对麻疯杆菌仅有缓慢的杀菌作用,但它的优点是价格低廉和耐受性良好。然而,在近1... 详细信息

麻疯,在其严重极性和亚极性(severepolar and subpolar)的结节型时,需要长期持续化疗,对有些病人尚需终生持续治疗。氨苯砜是一种应用非常广泛的抗麻疯药,虽对麻疯杆菌仅有缓慢的杀菌作用,但它的优点是价格低廉和耐受性良好。然而,在近18年来它对麻疯杆菌的耐药性有所发展而且这

关键词：利福平利福霉素治疗作用结节性

用咪喹莫特局部成功治疗的恶性雀斑样痣中细胞浸润的特点

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世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 60-60页

作者： Michalopoulos P. yawalkar N. Brnnimann M. 党倩丽 Department of Dermatology University of Bern Inselspital 3010 Bern Switzerland

Lentigo maligna (LM) is an in situ melanoma which usually occurs in s un-dam aged skin on the head and neck of elderly patients. Depending on the anatomical site and its size treatment of LM can be problematic and usually includes surgic al excision or radiotherapy. Recent reports indicate that topical imiquimodmay b e an effective treatment. However, no data on the underlying immune response in the skin during treatment of LM with topical imiquimod are available so far. We report a 62- year-old caucasian woman with a histologically verified LM which was successfully treated with topical imiquimod 5% cream. Skin biopsy specime ns were obtained before, during (at week 10) and 4 weeks after cessation of topi cal treatment with imiquimod 5% cream. Histological and immunohistochemical ex amination was performed in order to detect residual atypical melanocytes and to characterize the inflammatory infiltrate. A complete clinical and histological c learance of the skin lesion was achieved, with no recurrence up to 9 months afte r the end of treatment. During topical application of imiquimod 5% cream a dep letion of epidermal and dermal CD1a+ dendritic cells was observed. The inflamm atory infiltrate consisted of CD68+ macrophages and mainly of CD3+ T cells w ith a slight predominance of CD8+ T cells. An enhanced expression of granzyme B and TIA- 1 was also noted particularly in the epidermis and near the dermoepi dermal junction. In conclusion, our data indicate that imiquimod 5% cream indu ces a cytotoxic T-cell-mediated immune response in situ which may account fo r the complete destruction of the malignant melanocytes in LM. Further clinical trials and longer follow-up periods on the use of imiquimod for LM are warrant ed.

关键词：恶性雀斑样痣咪喹莫特黑色素瘤外科切除免疫组化检查白细胞浸润活检组织组织活检免疫反应

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