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Spatial Modeling and Mapping of Tuberculosis Using Bayesian Hierarchical Approaches

Open Journal of Statistics 2016年第3期6卷 482-513页

作者： Abdul-Karim Iddrisu yaw ampem amoako Department of Statistical Sciences University of Cape Town Cape Town South Africa Department of Medicine Komfo Anokye Teaching Hospital Kumasi Ghana

Global spread of infectious disease threatens the well-being of human, domestic, and wildlife health. A proper understanding of global distribution of these diseases is an important part of disease management and policy making. However, data are subject to complexities by heterogeneity across host classes. The use of frequentist methods in biostatistics and epidemiology is common and is therefore extensively utilized in answering varied research questions. In this paper, we applied the hierarchical Bayesian approach to study the spatial distribution of tuberculosis in Kenya. The focus was to identify best fitting model for modeling TB relative risk in Kenya. The Markov Chain Monte Carlo (MCMC) method via WinBUGS and R packages was used for simulations. The Deviance Information Criterion (DIC) proposed by [1] was used for models comparison and selection. Among the models considered, unstructured heterogeneity model perfumes better in terms of modeling and mapping TB RR in Kenya. Variation in TB risk is observed among Kenya counties and clustering among counties with high TB Relative Risk (RR). HIV prevalence is identified as the dominant determinant of TB. We find clustering and heterogeneity of risk among high rate counties. Although the approaches are less than ideal, we hope that our formulations provide a useful stepping stone in the development of spatial methodology for the statistical analysis of risk from TB in Kenya.

关键词： Bayesian Hierarchical Heterogeneity Deviance Information Criterion (DIC) Markov Chain Monte Carlo (MCMC) Host Classes Relative Risk

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Mental health and quality of life burden in Buruli ulcer disease patients in Ghana

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Infectious Diseases of Poverty 2021年第4期10卷 93-94页

作者： yaw ampem amoako Nancy Ackam John-Paul Omuojine Michael Ntiamoah Oppong Abena Gyawu Owusu-Ansah Harriet Boateng Mohammed Kabiru Abass George Amofa Elizabeth Ofori Portia Boakye Okyere Michael Frimpong Freddie Bailey David Hurst Molyneux Richard Odame Phillips Kumasi Centre for Collaborative Research in Tropical Medicine Kwame Nkrumah University of Science and TechnologyKumasiGhana 不详

Background Buruli ulcer disease(BUD)is a necrotic skin neglected tropical disease(NTD)that has both a mental and physical health impact on affected *** there is increasing evidence suggesting a strong association between neglected tropical diseases(NTDs)and mental illness,there is a relative lack of information on BUD’s impact on the mental health and quality of life(QoL)of affected individuals in *** study is to assess the impact of BUD on mental health and quality of life of patients with active and past BUD infection,and their *** We conducted a case control study in 3 BUD endemic districts in Ghana between August and November ***-to-face structured questionnaire-based interviews were conducted on BUD patients with active and past infection,as well as caregivers of BUD patients using WHO Quality of Life scale,WHO Disability Assessment Schedule,Self-Reporting Questionnaire,Buruli Ulcer Functional Limitation Score and Hospital Anxiety and Depression Scale data *** statistics were used to summarize the characteristics of the study *** groups were compared using student t test and chi-square(χ2)or Fisher’s exact *** quality of life scores are reported with their respective 95%confidence *** was analysed using STATA statistical *** Our results show that BUD patients with active and past infection,along with their caregivers,face significant levels of distress and mental health sequelae compared to ***(P=0.003)was more common in participants with active(27%)and past BU infection(17%),compared to controls(0%).Anxiety was found in 42%(11/26)and 20%(6/29)of participants with active and past BUD infection compared to 14%(5/36)of *** of life was also significantly diminished in active BUD infection,compared to *** the physical health domain,mean QoL scores were 54±11.1 and 56±11.0(95%CI:49.5‒58.5 and 52.2‒59.7)respectively for p

关键词： Mental health Depression Anxiety Quality of life Buruli ulcer disease Neglected tropical disease

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