检索结果-南通市图书馆

Hepatocellular carcinoma recurrence in HCV patients treated with direct-acting antivirals after curative treatment

Hepatoma Research 2019年第5期5卷 26-36页

作者： Shinichiro Nakamura Kazuhiro Nouso Hiroyuki Okada Hideki Onishi Shin-ichi Fujioka yasuyukiaraki Shouta Iwadou Takashi Kumada Hidenori Toyoda Kenta Motomura Kazuya Kariyama Haruhiko Kobashi Toshihiko Kaneyoshi Masaharu Ando Akio Moriya Hideaki Taniguchi YouichiMorimoto Hiroaki Hagihara Masatoshi Tanaka Okayama University Graduate School of Medicine Dentistry and Pharmaceutical SciencesOkayama 700-8558Japan Okayama Saiseikai General Hospital Okayama 700-8558Japan Hiroshima City Hiroshima Citizens Hospital Hiroshima 731-0293Japan Ogaki Municipal Hospital Gifu 503-8502Japan Iizuka Hospital Fukuoka 820-8505Japan Okayama City Hospital Okayama 700-8557Japan Okayama Red Cross General Hospital Okayama 700-8607Japan Fukuyama Medical Center Hiroshima 720-8520Japan Mitoyo General Hospital Kagawa 769-1695Japan Tottori Municipal Hospital Tottori 680-8501Japan Kurashiki Central Hospital Okayama 710-8602Japan Sumitomo Besshi Hospital Ehime 792-8543Japan Yokokura Hospital Fukuoka 839-0215Japan Japanese Red Cross Society Himeji Hospital Hyogo 670-8540Japan

Aim:The increased risk of hepatocellular carcinoma(HCC)recurrence in hepatitis C virus(HCV)-infected patients treated with direct-acting antivirals(DAAs)after curative treatment for HCC is *** purpose of this study was to examine the risk of HCC recurrence after DAA ***:We conducted a retrospective cohort study of 312 consecutive patients with HCV-related HCC who received DAA therapy in participating institutions between September 2014 and July *** patients received curative ;hepatectomy or radio-frequency *** calculated the annual incidence of HCC recurrence after DAA therapy and identified the risk factors for HCC recurrence using Cox regression ***:The median age was 74 years old,and a sustained virological response was achieved by 288 *** 3-year-overall survival rate was 95.4%in a median follow-up period of 855 *** recurred in 135 *** 1-,2-and 3-year recurrence rates were 18.3%,38.8%and 55.4%,respectively.A multivariate analysis revealed that the following factors were associated with HCC recurrence:multiple tumors at the first HCC treatment[hazard ratio(HR)=2.21;95%CI:1.41-3.49],a history of multiple treatments for HCC(HR=1.97;95%CI:1.28-3.02),andα-fetoprotein(AFP-L3)≥10%at the initiation of DAA therapy(HR=4.74;95%CI:2.10-10.7).Conclusion:Among patients treated with DAAs after the curative treatment of HCC,multiple tumors at the first HCC treatment,multiple prior HCC treatments and a high AFP-L3 level before DAA therapy were associated with recurrence,and the rate of recurrence was comparable to that before the DAA era.

关键词： Hepatocellular carcinoma hepatitis C virus direct-acting antiviral recurrence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：