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Severe acute cholestatic hepatitis of unknown etiology successfully treated with the Chinese herbal medicine Inchinko-to (TJ-135)

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World Journal of Gastroenterology 2009年第23期15卷 2927-2929页

作者： Susumu Ohwada Isao Kobayashi Nobuo Harasawa Kyoichiro Tsuda Yosikatsu inui Kanetsu Chuo Hospital Kitaharacho 71 Takasaki Gunma 370-3513 Japan inui Clinic of Internal Medicine Shimokobanamachi Takasaki Gunma 370-0076 Japan

Severe acute hepatitis of unknown etiology is difficult to treat and often progresses to subacute fulminant hepatitis or late-onset hepatic failure. A 45-year-old wellnourished, healthy man had progressive fatigue and his liver function tests showed severe liver dysfunction. The etiology of sever acute cholestatic hepatitis was unknown. The liver function tests normalized gradually, which excluded high persistent total bilirubin after starting on predonine. A liver biopsy showed chronic active hepatitis with mild f ibrosis (A2, F1). Oral Inchinko-to, a Chinese herbal medicine, at 7.5 g daily was prescribed. The treatment was effective with no adverse effects. We present a successfully treated case and discuss hepatoprotective and choleretic effects of Inchinko-to.

关键词：亚急性肝炎治疗中药病因肝功能损害疲劳试验高速公路

Weight loss induced by whole grain-rich diet is through a gut microbiota-independent mechanism

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World Journal of Diabetes 2020年第2期11卷 26-32页

作者： Wen-Chi Wu Akio inui Chih-Yen Chen Department of Medicine Taipei Veterans General HospitalTaipei 11217Taiwan Pharmacological Department of Herbal Medicine Kagoshima University Graduate School of Medical and Dental SciencesKagoshima 890-8544Japan Division of Gastroenterology and Hepatology Department of MedicineTaipei Veterans General HospitalTaipei 11217Taiwan Faculty of Medicine and Institute of Emergency and Critical Medicine National Yang-Ming University School of MedicineTaipei 11221Taiwan Association for the Study of Small Intestinal Diseases Taoyuan 33305Taiwan Chinese Taipei Society for the Study of Obesity Taipei 110Taiwan

The prevalence of overweight and obesity has increased *** is a well-known risk factor of type 2 diabetes mellitus and cardiovascular disease and raises public health *** dietary guidelines encourage the replacement of refined grains with whole grains(WGs)to enhance body weight *** evidence regarding interrelationships among WGs,body weight,and gut microbiota is limited and *** this editorial,we comment on the article by Roager et al published in the recent issue of the Gut 2019;68(1):*** the study,obese patients(25

关键词： Whole grain Obesity Microbiota Short-chain fatty acids Brown adipose tissue Adiponectin

Pancreatolithiasis with an anatomic variant of Wirsung duct:a case report

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Gastroenterology Report 2023年第1期11卷 585-587页

作者： Satoshi Yamamoto Kazuo inui Yoshiaki Katano Senju Hashimoto Hironao Miyoshi Takashi Kobayashi Yoshihiko Tachi Department of Gastroenterology Fujita Health University Bantane HospitalOtoubashiNakagawa-kuNagoyaAichiJapan Department of Gastroenterology Yamashita HospitalNakamachiIchinomiyaAichiJapan Board Chairman Geriatric Health Services Facility YukiMizuhomachiHandaAichiJapan Department of Gastroenterology Fujita Health University Okazaki Medical CenterHarisakichoOkazakiAichiJapan

Introduction In contrast to familiar developmental anomalies,such as pancreatobiliary maljunction and pancreas divisum,a double orifice of the ampulla of Vater is a much more rare congenital *** encountered a patient with pancreatolithiasis associated with anatomic variation of Wirsung duct showing a single major duodenal papilla with a double orifice and no minor papilla.

关键词： Vater orifice congenital

Analysis of ABC (D) stratification for screening patients with gastric cancer

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World Journal of Gastroenterology 2011年第43期17卷 4793-4798页

作者： Tomohiro Kudo Satoru Kakizaki Naondo Sohara Yasuhiro Onozato Shinichi Okamura Yoshikatsu inui Masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashi Department of Endoscopy and Endoscopic Surgery Shirakawa Clinic inui Clinic of Internal Medicine

AIM:To evaluate the value of ABC(D) stratification [combination of serum pepsinogen and Helicobacter pylori(***) antibody]of patients with gastric ***:Ninety-five consecutive patients with gastric cancer were enrolled into the *** serum pepsinogenⅠ(PGⅠ) /pepsinogenⅡ(PGⅡ) and *** antibody levels were *** were classified into five groups of ABC(D) stratification according to their serological *** findings of atrophic gastritis and histological differentiation were also analyzed in relation to the ABC(D) ***:The mean patient age was(67.9±8.9) *** patients(3.2%) were classified into group A,7 patients(7.4%) into group A',27 patients(28.4%) into group B,54 patients(56.8%) into group C,and 4patients(4.2%) into group D,*** were only three cases in group A when the patients taking acid proton pump inhibitors and those who had undergone eradication therapy for ***(group A') were *** three cases had mucosal atrophy in the grey zone according to the diagnostic manual of ABC(D) ***,the mean age of the patients with well differentiated adenocarcinoma was significantly higher than that of the patients with poorly differentiated adenocarcinoma(P<0.05) .There were no differences in the pattern of atrophy in the endoscopies between the well differentiated and poorly differentiated ***:ABC(D) stratification is a good method for screening patients with gastric *** is needed for grey zone cases to check the extent of mucosal atrophy.

关键词：分层分析 ABC 患者胃癌筛选幽门螺旋杆菌胃蛋白酶原组织分化

Microstructure and Mechanical Properties of Two-phaseTiAl Alloys in Lamellar Form

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Journal of Materials Science & Technology 1994年第3期10卷 193-204页

作者： Masaharu Yamaguchi and Haruyuki inui(Department of Metal Science and Technology, Kyoto University, Sakyo-ku, Kyoto 606, Japan) Kyoto Univ Kyoto Japan

In two-phase TiAl alloys, the lamellar structures are of special interest and importance since they are so common and persistent. not only under as-cast conditions but also after thermal treatment. However. the lamellar structures are still poor in ductility,although they are beneficial for toughness and high temperature strength. This article will review the recent progress made in understanding the basic mechanical properties of the γ and α2 phases which comprise the two-phase alloys in Iamellar form, and discuss how an improved balance of strength and ductillty in the lamellar form may be achieved

关键词： Microstructure and Mechanical Properties of Two-phaseTiAl Alloys in Lamellar Form Ti Figure NATO TMS

Liver cirrhosis in a child associated with Castleman's disease: A case report

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World Journal of Clinical Cases 2020年第9期8卷 1656-1665页

作者： Soya Kobayashi Ayano inui Tomoyuki Tsunoda Syuichiro Umetsu Tsuyoshi Sogo Masaaki Mori Masato Shinkai Tomoo Fujisawa Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohama City Tobu HospitalYokohama 230-8765Japan Department of Lifetime Clinical Immunology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyo 113-8519Japan Department of Surgery Kanagawa Children’s Medical CenterYokohama 232-8555Japan

BACKGROUND Castleman's disease(CD)is a lymphoproliferative *** syndrome is classified as a variant of CD based on its key clinical manifestations of thrombocytopenia,anasarca(generalized edema and pleural effusion),fever(pyrexia),reticulin fibrosis in the bone marrow and the proliferation of megakaryocytes,and organomegaly(such as hepatosplenomegaly and multiple lymphadenopathies);TAFRO syndrome is mainly reported in Japanese *** our knowledge,this is the first pediatric case report detailing a CD-associated disorder progressing to *** SUMMARY A 10-year old male patient presented with fever and *** months before hospitalization,he had remarkable abdominal ***,he visited a clinic for a fever that lasted 5 *** physical findings were marked hepatosplenomegaly and cervical lymphadenopathy.A blood test revealed leukocytosis,microcytic anemia,aspartate aminotransferase-dominant transaminase elevation,high levels of C-reactive protein,polyclonal hypergammaglobulinemia,and high levels of interleukin-6 and vascular endothelial growth *** contrast computed tomography and magnetic resonance imaging suggested cirrhosis,which was confirmed by liver *** findings in the enlarged hepatic lymph nodes revealed both hyperplasia and atrophy of lymphoid follicles with some vascular hyperplasia and moderate plasmacytosis between the lymphoid follicles,which is compatible with lymph node histology in TAFRO *** was not effective in reducing the patient’s symptoms;therefore,the patient was prescribed *** date,the patient remains free of fever and continues to receive *** We described the clinicopathological features of TAFRO syndrome to highlight the clinical presentation of this rare disease in a pediatric case.

关键词： Castleman disease Case report Multi-centric Castleman’s disease Liver cirrhosis Tocilizumab Child

Childhood-onset inflammatory bowel diseases associated with mutation of Wiskott-Aldrich syndrome protein gene

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World Journal of Gastroenterology 2017年第48期23卷 8544-8552页

作者： Takashi Ohya Masakatsu Yanagimachi Kentaro Iwasawa Shuichiro Umetsu Tsuyoshi Sogo Ayano inui Tomoo Fujisawa Shuichi Ito Department of Pediatrics Yokohama City University Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohama-shi Tobu Hostopital Department of Pediatrics Tokyo Medical and Dental University

AIM To screen primary immunodeficiency,Wiskott-Aldrich syndrome(WAS),and chronic granulomatous disease(CGD) among children with inflammatory bowel disease(IBD).METHODS This was a single-center retrospective study. Eighteen children with IBD were investigated. We analyzed their expression of Wiskott-Aldrich syndrome protein(WASP) in lymphocytes and superoxide generation in phagocytes using flow cytometry. When the expression of WASP or superoxide generation was low or absent,we performed genetic analysis to determine the cause of this. RESULTS Eighteen patients were classified as having ulcerative colitis(n = 10),Crohn's disease(n = 5),or IBDunclassified(n = 3). In total,three patients revealed low expression of WASP associated with a WAS gene c.1378 C>T ***460 Ser mutation,which has previously been reported as a pathogenic mutation in WAS and X-linked thrombocytopenia. However,with respect to the major symptoms of WAS,none of these three patients showed either thrombocytopenia or increased susceptibility to infection,but one patient showed generalized eczema. No CGD patients were discovered in this *** Despite the lack of typical clinical manifestations of WAS,low expression of WASP could be associated with the pathogenesis of a subtype of IBD patients.

关键词： Inflammatory bowel disease WiskottAldrich syndrome Primary immunodeficiency Children Screening

What's new about ghrelin in 2008?

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World Journal of Gastroenterology 2008年第41期14卷 6298-6298页

作者： Akio inui Department of Psychosomatic Internal Medicine Kagoshima University Graduate School of Medical and Dental Sciences 7-5-1 Saku-ragaoka

9th NPY Meeting was held for the f irst time in Japan in March 2008, which was organized by Akio inui, Profes-sor and Chairman, Department of Psychosomatic In-ternal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. We have invited him to write TOPIC HIGHLIGHT for WJG focused on ghrelin along the gut-brain *** TOPIC HIGHLIGHT is the 'ghrelin version' of the proceedings of 9th NPY Meeting and presents ex-amples of the critical interplay in ghrelin-NPY pathway in response to environmental,

关键词：医学研讨会临床医学医疗条件医疗技术

Alanine Aminotransferase as the First Test Parameter for Wilson's Disease

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Journal of Clinical and Translational Hepatology 2019年第4期7卷 293-296页

作者： Hisao Hayashi Kazumasa Watanabe Ayano inui Ayako Kato Yasuaki Tatsumi Akihiko Okumura Tomoo Fujisawa Koichi Kato Department of Medicine Aichi Gakuin University School of PharmacyChikusa-kuNagoyaJapan Department of Gastroenterology Kainan HospitalYatomiJapan Department of Pediatric Gastroenterology and Hepatology Saiseikai Yokohama Toub HospitalYokohamaKanagawaJapan

Background and Aims: The liver is the first organ affected by toxic copper in the classical and severe hepatic forms of Wilson's disease(WD).Because their associated chronic liver damage is mostly asymptomatic,an intervention using a special test including serum alanine aminotransferase(ALT)activity is needed for detecting ***: Using the modified international criteria for the diagnosis of WD,45 patients were selected from the collective databases of our institutions,and 7 infants were reviewed from the *** patients had the severe hepatic form,with nor-moceruloplasminemia and no mutations in *** rapid ALT change during hemolytic anemia was adjusted for a *** diagnostic potential of the ALT test was assessed from the age-dependent natural course of the liver damage of ***: The natural course had three *** were still low in some infants younger than 4 *** were high in all children between the ages of 4 and 8 years-old;then,they reduced to low levels in some patients over 9 years of *** high ALT stage represents chronic active hepatitis,and the sub-sequent low ALT stage is due to silent *** hepatic cop-per content is a reliable but invasive test,while urinary copper secretion is an alternative,non-invasive test for copper toxicosis of *** serum ceruloplasmin and ATP7B analyses are sub-type tests of *** response to anti-copper regimens is the final test ***: ALTcould be the first parameter to test to detect WD in children between the ages of 4 and 8 years.

关键词： Alanine aminotransferase ATP7B Ceruloplasmin Chronic active hepatitis Wilson's disease