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Perception gaps for recognition behavior between staff nurses and their managers

Open Journal of Nursing 2013年第7期3卷 485-492页

作者： Chiharu Miyata Hidenori arai Sawako Suga Department of Human Health Sciences Kyoto University Graduate School of Medicine Kyoto Japan Department of Nursing Kansai University of Nursing and Health Sciences Hyogo Japan

Nurse managers play a critical role in improving the work environment. Important leadership characteristics for nurse managers include visibility, accessibility, communication, recognition, and support. The nurse manager’s recognition behaviors strongly influence the job satisfaction of staff nurses. In our previous study, we investigated how staff nurses perceived the nurse manager’s recognition behaviors and revealed that there was a divergence in practical approaches to these behaviors between the nurse manager and the staff. We assume that one factor causing this divergence could be perception gaps between the nurse manager and the staff. The aim of this study, therefore, was to uncover what types of perception gaps exist between the nurse manager and staff nurses and whether the background of staff nurses, such as years of experience or academic background, could affect the staff nurses’ perceptions. This quantitative, cross-sectional study involved 10 hospitals in Japan. A total of 1425 nurses completed the questionnaire. The results showed that staff nurses considered “Respect job schedule preferences” to be the most important of the recognition behaviors. In contrast, nurse managers gave “Nurse manager meets with the staff nurses to discuss patient care and unit management” the highest score for importance. Four factors (marriage status, age, years of clinical experience, and training background) affected the professional awareness of recognition behaviors. Our results suggest that nurse managers need to consider these factors when they conduct recognition behaviors.

关键词： Recognition Behavior Nurse Manager Staff Nurses

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Chemogenetic activation of G12 signaling enhances adipose tissue browning

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3923-3926页

作者： Yuki Ono Ryo Ito Kaito arai Gurdeep Singh Tsuyoshi Saitoh Robert BRussell Francesco Raimondi Junken Aoki Juro Sakai Asuka Inoue Molecular and Cellular Biochemistry Graduate School of Pharmaceutical SciencesTohoku UniversitySendaiMiyagi 980-8578Japan Division of Molecular Physiology and Metabolism Graduate School of MedicineTohoku UniversitySendaiMiyagi 980-8574Japan Bioquant Heidelberg UniversityIm Neuenheimer Feld 26769120 HeidelbergGermany Biochemie Zentrum Heidelberg(BZH) Heidelberg UniversityIm Neuenheimer Feld 32869120 HeidelbergGermany International Institute for Integrative Sleep Medicine(WPI-IIIS) University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8575Japan Graduate School of Comprehensive Human Sciences University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8575Japan Laboratorio di Biologia Bio@SNS Scuola Normale SuperiorePiazza dei Cavalieri 7Pisa 56126Italy Department of Health Chemistry Graduate School of Pharmaceutical SciencesThe University of TokyoBunkyo-kuTokyo 113-0033Japan Division of Metabolic Medicine Research Center for Advanced Science and TechnologyThe University of TokyoMeguro-kuTokyo 153-8904Japan

Dear Editor,Beige adipocytes,which increase energy expenditure by dissipating energy as heat,have gained attention as a therapeutic target for combating obesity.1 Adipocytes express many types of G-protein-coupled receptors(GPCRs),each of which has a unique preference for the Gs,Gi,Gq,and G12 *** the function of Gs-coupledβ-adrenergic receptors in beige adipocyte induction is well established,2 little is known about the function of G12-coupled GPCRs beyond its suppressive roles in white adipocyte maturation.3 In this study,we generated transgenic mice conditionally expressing a G12-coupled designer GPCR using a Cre-loxP system and investigated the potential effects of G12 signaling on adipocyte biology.

关键词： activation gained expressing

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Balloon-occluded transcatheter arterial chemoembolization for hepatocellular carcinoma

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World Journal of Hepatology 2018年第7期10卷 485-495页

作者： Takeshi Hatanaka Hirotaka arai Satoru Kakizaki Department of Gastroenterology Saiseikai Maebashi Hospital Department of Gastroenterology Maebashi Red Cross Hospital Department of Gastroenterology and Hepatology Gunma University Graduate School of Medicine

Transcatheter arterial chemoembolization(TACE) is widely accepted as a treatment for patients with hepatocellular carcinoma(HCC) in the intermediate stage according to the Barcelona Clinic Liver Cancer(BCLC) guidelines. Recently, balloon-occluded TACE(B-TACE) was developed in Japan. Despite the lack of a clear definition, B-TACE is generally defined as the infusion of emulsion of chemotherapeutic agents with lipiodol followed by gelatin particles under the occlusion of feeding arteries by a microballoon catheter, which leads to the dense lipiodol emulsion(LE) accumulation in HCC nodules. This phenomenon cannot be explained only by the prevention of proximal migration and leakage of embolization materials; it further involves causing local changes in the hemodynamics of the surrounding occlusion artery and targeted HCC nodules. Balloon-occluded arterial stump pressure plays an important role in the dense LE accumulation in targeted HCC nodules. Although randomized controlled trials comparing the therapeutic effect and the prognosis of B-TACE to those of the other TACE procedures, such as conventional-TACE and drug-eluting beads TACE, are still lacking, B-TACE is thought to be a promising treatment. The purpose of this review is to summarize the mechanism, therapeutic effect, indication, prognosis and complications of BTACE.

关键词： Hepatocellular carcinoma Treatment effect Transcatheter arterial chemoembolization Prognosis Balloon-occluded arterial stump pressure Dense lipiodol emulsion accumulation Balloon-occluded transcatheter arterial chemoembolization Microballoon catheter

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Wound Closure on the Neonatal Rat Skin I. The Modulation of the Thickness of Epidermis at the Closing Incisional Wounds

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CellBio 2013年第4期2卷 248-256页

作者： Mary arai Takashi Matsuzaki Setsunosuke Ihara Department of Biological Science Faculty of Life and Environmental Science Shimane University Matsue Japan

Full-thickness incisional wounds were made on the dorsal skin of 1-day-old rats to elucidate the mechanism of the fluctuation of the epidermal thickness after the wound closure. The thickness of the epidermis covering the wound reached a peak around 96 h post-wounding (PW), and became thinner thereafter. The analyses of the cell proliferation and apoptosis at the epidermal wound regions revealed that the rate of TUNEL-positive cells that displays the cells undergoing apoptosis increased as the epidermis became thinner around 120 h PW. Next, immunohistochemical analyses using antibodies against keratinocyte differentiation marker proteins indicated that the delay or interruption of the spinous to granular transition from 96 to 120 h PW might result in the epidermal thickening in the wound region. Third, the region undyed with anti-caspase-14 antibody extended downward in the thickened epidermis by 96 h PW, and in turn, it became intensely and widely stained with this antibody in the thinning epidermis by 120 h PW. Taken together, it is likely that the delay and acceleration of the terminal differentiation, including cornification of the epidermal keratinocytes may coordinately cause the fluctuation of the thickness of the epidermis at the wound site in rat neonates.

关键词： Wound Healing Reepithelialization Rat Neonate Epidermis Terminal Differentiation Cornification

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Development of a career-orientation scale for public health nurses

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Open Journal of Nursing 2013年第1期3卷 16-24页

作者： Mika Okura Chizuko Noro Hidenori arai Department of Human Health Sciences Kyoto University Graduate School of Medicine Kyoto Japan Department of Human Nursing Sonoda Women’s University Amagasaki Japan

Objective: The purpose of this study was to develop a career-orientation scale for public health nurses (PHNs) and to validate the scale. Methods: Self-administered questionnaires were sent to 7170 PHNs in 10 prefectures. A retest survey was sent to 252 participants. Results: The valid responses from 2003 PHNs in the first survey were analyzed for major factors by varimax rotation. The analysis resulted in five orientation factors and 19 items being selected. The cumulative contribution ratio was 46.9%, and Cronbach’s coefficient alpha was 0.863. The exact match ratio of test-retest was 59.7% (from 47.7% to 72.1% for each item and from 12.0% to 92.0% for each participant). Conclusions: The reliability and validity of this survey were confirmed;however, further research is required to confirm the reproducibility. This scale can be used as a self-assessment tool when managers need to advise their staff on career development.

关键词： Career Orientation Development of Scale Professionalism Public Health Nurse Significance of Working

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Aspect of QOL Assessment and Proposed New Scale for Evaluation

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Open Journal of Immunology 2015年第3期5卷 147-182页

作者： Nobuo Yamaguchi Matsuo arai Tsugiya Murayama Department of Fundamental Research for CAM Kanazawa Medical University Ishikawa Japan Ishikawa Natural Medicinal Products Research Center Ishikawa Japan Faculty of Pharmaceutical Sciences Department of Microbiology and Immunology Hokuriku University Ishikawa Japan

According to the reports from Ministry of Health in each country, the average life span is elongated over the past decade. This trend is expected to be keeping constant further in the future and at the same time continued efforts should be made. Next, it is necessary for us to consent about improving the quality of life. In an effort of improving the quality of life, other than the western medicine, we have attempted to introduce many traditional medical practices, including the oriental medicine, from various parts of the world into the medical field as a complementary & alternative medicine (CAM). Judging both positive and negative aspects by the evaluation standard of the Western medicine, we try to obtain numerical aspects in termed of QOL. Some methods of alternative medicine involved in this review are acupuncture, moxibustion, TCM and other traditional medicine. Above all, WHO suggests selecting the suzerain nation of acupuncture moxibustion, which has been developed in the oriental countries as a specialized cure, by identifying merits & demerits and ascertaining which nation can be a the best model for special field. At the moment for evaluating CAM, for example, what kind of methods is/are suitable for evaluating each CAM. We have been trying to propose the peripheral leukocyte, that is one of the best marker for evaluating CAM. Our trial is a hot spring hydrotherapy, acupuncture and moxibution, light exercise and Ondle/floor heating etc. In these trials, we find the common results from leukocyte effects which exhibit a strong correlation for the regulation in number and function, as a new scale for evaluating QOL. The contents are the result from the data showing the much in number of volunteer tend to down regulate, on the other hand, lower number of volunteer is up-regulated at next day by each menu of CAM as a constitution dependent manner. However, even in western medical methodology, double blind and cross over system are the better way to evaluation

关键词： QOL Leukocyte Subset Granulocyte Lymphocyte Constitution Dependent Assay System Double Blind-Cross Over System Immunological Factors Emotional Hormone Adrenalin Dopamine Anti-Oxidative Assay by Macrophage

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Synthesis of powdered silver nanoparticles using hydrogen in aqueous medium

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Particuology 2012年第1期10卷 140-143页

作者： Kushal D. Bhatte Krishna M.Deshmukh Yogesh P.Patil Dinesh N.Sawant Shin-Ichiro Fujita Masahiko arai Bhalchandra M.Bhanage Department of Chemistry Institute of Chemical Technology Chemical Process Engineering Divison Graduate School of EngineeringHokkaido University

Environmentally benign one-pot protocol is used in the synthesis of silver nanoparticles （AgNPs） in powder form, involving the reduction of silver nitrate in the presence of fully hydrolyzed polyvinyl alcohol （PVA） as stabilizer by hydrogen （H2） as reducing agent in aqueous medium. Fully hydrolyzed biodegradable PVA has extremely low cytotoxicity, making it a favorable stabilizer from green perspective. In the present methodology, essentially naked silver nanoparticles are obtained in good yield. The prepared sil- ver nanoparticles were characterized by TEM, XRD, EDAX, UV-Vis spectroscopy and DLS histogram, and studied for its activity as a recyclable catalyst for synthesis of different enaminones.

关键词： Silver nanoparticlesAqueous mediaHydrogenCatalysisEnaminones synthesis

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The new 2005 CPR guidelines

The new 2005 CPR guidelines

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2006年中华医学会全国麻醉学术年会

作者： arai,T． Department of Anesthesiology and Resuscitology Ehime University School of Medicine M．D

Basic Measures of CPR BLS:ABC & AED ALS :CPR measures with instruments (ACLS) Defibrillation, Drugs (Epinephrine) Post-resuscitation Treatment Development of CPR methods Epinephrine : Latzko, 1904 A:Airway control (intra-cardiac) Elam, JAMA, 1954 B:MMB Beck 1947 AC on 14 yB Safar, JAMA. 1961 1955 AC on a M.D. C:CCCC Zoll 1956 AC on 4 pt, Ext. Kouwenhouven, JAMA, 1960 (AC on 3 pt) Lown 1962 AC or DC?

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Vascular remodeling and mobilization of bone marrow-derived cells in cuff-induced vascular injury in LDL receptor knockout mice

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Chinese Medical Journal 2008年第3期121卷 220-226页

作者： XU Yang arai Hidenori MURAYAMA Toshinori KITA Toru YOKODE Masayuki Institute of Medicinal Plant Development Chinese Academy ofMedical Sciences and Peking Union Medical College Beijing100094 China Department of Clinical Innovative Medicine Kyoto University Graduate School of Medicine 54 Kawahara-cho Shogoin Sakyo-ku Kyoto 606-8507 Japan Department of Geriatric Medicine Kyoto University Graduate School of Medicine 54 Kawahara-cho Shogoin Sakyo-ku Kyoto 606-8507 Japan Department of Cardiovascular Medicine Kyoto University Graduate School of Medicine 54 Kawahara-cho Shogoin Sakyo-ku Kyoto 606-8507 Japan Translational Research Center Kyoto University Graduate School of Medicine 54 Kawahara-cho Shogoin Sakyo-ku Kyoto 606-8507 Japan

Background Vascular remodeling is an important pathologic process in vascular injury for various vascular disorders such as atherosclerosis, postangioplasty restenosis and transplant arteriopathy. Recently, pathologic change and the role of bone marrow derived cells were wildly studied in atherosclerosis and restenosis. But the manner of lesion formation in neointima and cell recruitment in vascular remodeling lesion in the present of hypercholesterolemia is not yet fully understood. Methods Double-transgenic mice knockout of LDL receptor gene （LDL-/-） and expressing ubiquitously green fluorescent protein （GFP） were obtained by cross-breeding LDL -/- mice with the GFP-expressing transgenic mice. LDL-/- mice （22-24 weeks of age） fed high fat diet containing 1.25% （w/w） cholesterol were subjected to 9Gy irradiation and received bone marrow （BM） cells from the double-transgenic mice. Four weeks later, a nonconstrictive cuff was placed around the right femoral artery. After another 2 weeks, both right and left femoral arteries were harvested and subjected to histochemical analysis. Apoptosis was analyzed in situ using TUNEL assay. Results Two weeks after cuff placement, atherosclerotic lesions developed in the intima consisting of a massive accumulation of foam cells. The tissue stained with anti-α smooth muscle actin （SMA） antibody, showed a number of SMA-positive cells in the intimal lesion area. They were also positive for GFP, indicating that BM-derived cells can differentiate to SMCs in the intima in cuff-induced vascular remodeling lesions. Numerous small vessels in the adventitia as well as the endothelial lining of the intima were positive both for CD31 and GFP. The intima and media showed a large number of TUNEL-positive signals after 2 weeks cuff injury, indicating the presence of apoptosis in vascular remodeling. Conclusions Atherosclerotic lesions in mice can be developed in the intima after 2 weeks of cuff-induced vascular injury under the hypercholes

关键词： vascular remodeling macrophage smooth muscle cell endothelial cell bone marrow

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Nurse Managers Stress and Coping

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Open Journal of Nursing 2015年第11期5卷 957-964页

作者： AChiharu Miyata Hidenori arai Sawako Suga Department of Human Health Sciences Kyoto University Graduate School of Medicine Kyoto Japan National Center for Geriatrics and Gerontology Obu Aichi Japan Department of Health Sciences Kyoto Tachibana University Kyoto Japan

Objective: The purpose of this study was to gain insight into nurse managers’ stress experiences and coping strategies in order to better support them. Design: A qualitative exploratory descriptive research design was used in this study. Subject: Fifteen nurse managers participated in this study. Results: Three descriptive themes related to nurse managers’ occupational stress were identified: role overload, loneliness, and role conflict. We also identified three descriptive themes that contributed to their stress management: sufficient support and advice, taking mental breaks while off duty, and individual coping strategies. Conclusions: Our study proposes two recommendations to reduce nurse managers’ stress. First, for nurse managers who experience work overload, hospitals should support them in learning how to work efficiently and how to manage their response to work demands. Second, nurse managers’ primary stressors were loneliness and role conflict. Nurse managers are known to juggle multiple demands from the hospital nursing director and staff nurses. Although it is difficult to eliminate the role conflict, nurse managers should be guided on how to manage conflicting demands, the hospital nursing director and staff nurses.

关键词： Nurse Managers Role Stressors Role Conflict Coping Strategy

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