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Clinicopathological Characteristics of Basal Type Breast Cancer in Triple-Negative Breast Cancer

Journal of Cancer Therapy 2012年第5期3卷 836-840页

作者： Goro Kutomi Tousei Ohmura yasuyo suzuki Hidekazu Kameshima Hiroaki Shima Tomoko Takamaru Fukino Satomi Seiko Otokozawa Mitsuru Mori Koichi Hirata Department of Public Health Sapporo Medical University School of Medicine Sapporo Japan First Department of Surgery Sapporo Medical University School of Medicine Sapporo Japan

Background: Triple-negative breast cancer (TNBC) is defined by the absence of estrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor 2 (HER2) expression. Patients with TNBC derive no benefit from molecularly targeted treatments, such as endocrine therapy or trastuzumab, as they lack the appropriate targets for these drugs. TNBC is characterized by its biological aggressiveness and poor prognosis, and consists of two subtypes, basal and nonbasal. The purpose of our study is to differentiate the clinicopathological characteristics of the two subtypes. Methods: 367 patients with primary breast cancer were recruited from April 2004 to December 2010 at 1st Department of Surgery, Sapporo Medical University. ER, PgR, and HER2 status were evaluated in all cases. Moreover, we classified TNBC into basal, nonbasal subtypes on the basis of immunohistochemical staining of epidermal growth factor receptor (EGFR), cytokeratin (CK) 5/6. Basal type was defined as CK5/6-positive and/or EGFR-positive, and nonbasal type was defined as no expression of these two markers. Results: Breast cancer subtypes by molecular classification were Hormone receptor (HR)-positive/HER2-negative (61%), HR-positive/HER2-positive (10%), HR-negative/HER2-positive (14%), and HR-negative/HER2-negative (15%). There was no difference between the basal type and the nonbasal type in clinicopathological factors. But, the basal type was significantly associated with Ki67 labeling index (p=0.0002), p53 expression (p=0.047), and BRCA1 expression (p=0.03). Further, patients with the basal type TNBC showed a shorter overall survival (p=0.032) than did patients with the nonbasal type. Conclusion: Classification of TNBC subtypes by EGFR, CK5/6 is a very useful prognostic factor, and highlights the need for the development of an adequate new strategy for the basal type TNBC.

关键词： Triple-Negative Breast Cancer Basal Type EGFR CK5/6

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Clutch Cutter knife efficacy in endoscopic submucosal dissection for early gastric neoplasms

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World Journal of Gastrointestinal Oncology 2018年第12期10卷 487-495页

作者： yasuyo Hayashi Mitsuru Esaki Sho suzuki Eikichi Ihara Azusa Yokoyama Seiichiro Sakisaka Taizo Hosokawa Yoshimasa Tanaka Takahiro Mizutani Shinichi Tsuruta Aya Iwao Shun Yamakawa Akira Irie Yosuke Minoda Yoshitaka Hata Haruei Ogino Hirotada Akiho Yoshihiro Ogawa Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu University Department of Gastroenterology Kitakyushu Municipal Medical Center Division of Gastroenterology and Hepatology Department of MedicineNihon University School of Medicine Department of Anatomic Pathology Graduate School of Medical Sciences Kyushu University

AIM To compare the outcomes of endoscopic submucosal dissection(ESD) for gastric neoplasms using Clutch Cutter(ESD-C) or other knives(ESD-O).METHODS This was a single-center retrospective study. Gastric neoplasms treated by ESD between April 2016 and October 2017 at Kitakyushu Municipal Medical Center were reviewed. Multivariate analyses and propensity score matching were used to reduce biases. Covariates included factors that might affect outcomes of ESD, including age, sex, underlying disease, anti-thrombotic drugs use, tumor location, tumor position, tumor size, tumor depth, tumor morphology, tumor histology, ulcer(scar), and operator skill. The treatment outcomes were compared among two groups. The primary outcome was ESD procedure time. Secondary outcomes were en bloc, complete, and curative resection rates, and adverse events rates including perforation and delayed *** A total of 155 patients were included in this study; 44 pairs were created by propensity score matching. Background characteristics were quite similar among two groups after matching. Procedure time was significantly shorter for ESD-C(median; 49 min) than for ESD-O(median; 88.5 min)(P < 0.01). However, there was no significant difference in treatment outcomes between ESD-C and ESD-O including en bloc resection rate(100% in both groups), complete resection rate(100% in both groups), curative resection rate(86.4% vs 88.6%, P = 0.730), delayed bleeding(2.3% vs 6.8%, P = 0.62) and perforation(0% in both groups).CONCLUSION ESD-C achieved shorter procedure time without an increase in complication risk. Therefore, ESD-C could become an effective ESD option for gastric neoplasms.

关键词： Endoscopic submucosal dissection Clutch Cutter Gastric neoplasm Knife Propensity score

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