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Inverse correlation between reactive oxygen species in unwashed semen and sperm motion parameters as measured by a computer-assisted semen analyzer

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Asian Journal of Andrology 2017年第3期19卷 350-354页

作者： Teppei Takeshima yasushi Yumura Kengo Yasuda Hiroyuki Sanjo Shinnosuke Kuroda Hiroyuki Yamanaka Akira Iwasaki Department of Urology Reproductive Center Yokohama City University Medical Center Yokohama Kanagawa Japan YMRAC Urology Office Yokohama Kanagawa Japan.

This study investigated the correlation between sperm motion parameters obtained by a computer-assisted semen analyzer and levels of reactive oxygen species in unwashed semen. In total, 847 patients, except for azoospermic patients were investigated. At the time of each patient＇s first consultation, semen parameters were measured using SMASTM or CellSoft 3000TM, and production of reactive oxygen species was measured using a computer-driven LKB Wallac Luminometer 1251 Analyzer. The patients were divided into two groups： reactive oxygen species - positive and negative. The semen parameters within each group were measured using one of the two computer-assisted semen analyzer systems and then compared. Correlations between reactive oxygen species levels and sperm motion parameters in semen from the reactive oxygen species - positive group were also investigated. Reactive oxygen species were detected in semen samples of 282 cases （33.3%）. Sperm concentration （P 〈 0.01; P 〈 0.01）, motility （P 〈 0.01; P 〈 0.05）, and progressive motility （P 〈 0.01; P 〈 0.01） were markedly lower in the reactive oxygen species - positive group than in the reactive oxygen species - negative group. Among the sperm motion parameters in the reactive oxygen species - positive group, sperm concentration （P 〈 0.01; P 〈 0.01）, motility （P 〈 0.05; P 〈 0.01）, mALH （P 〈 0.05; P 〈 0.01）, and progressive motility （P 〈 0.05; P 〈 0.01） also showed inverse correlations with the logarithmic transformed reactive oxygen species levels. Therefore, this study demonstrated that excessive reactive oxygen species in semen damage sperm concentration, motility, and other sperm motion parameters.

关键词： oxidative stress reactive oxygen species semen analysis sperm motility

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An autopsy case of a primary aortoenteric fistula: A pitfall of the endoscopic diagnosis

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World Journal of Gastroenterology 2008年第29期14卷 4701-4704页

作者： Yoko Ihama Tetsuji Miyazaki Chiaki Fuke yasushi Ihama Ryoji Matayoshi Hiroshi Kohatsu Fukunori Kinjo Department of Legal Medicine School of Medicine University of the RyukyusOkinawa 903-0215 Japan Department of Endoscopy University Hospital University of the Ryukyus Okinawa 903-0215 Japan Department of Internal Medicine Okinawa Red Cross HospitalOkinawa 900-8611 Japan

A primary aortoenteric fistula (PAEF), defined as a communication between the native aorta and the gastrointestinal tract, is a rare cause of gastrointes-tinal bleeding. The preoperative diagnosis of PAEF is extremely difficult. Consequently, PAEF may cause sudden and unexpected death. We present an autopsy case of a 68-year-old man who died of massive gastro-intestinal bleeding due to a PAEF. Autopsy revealed a pinhole rupture located on the third part of the duode-nal mucosa and fistulized into the adjacent abdominal aortic aneurysm (AAA). Our case indicates that the aortoenteric fistula can result in fatal gastrointestinal bleeding. Consequently, a PAEF should be included in the differential diagnosis of gastrointestinal bleeding.

关键词： Primary aortoenteric fistula Gastrointestinal bleeding Herald bleeding Misleading Medico-legalautopsy

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Effect of technique parameters on characteristics of hydrogen-free DLC films deposited by surface wave-sustained plasma

Effect of technique parameters on characteristics of hydroge...

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20th Congress of the International Commission for Optics

作者： Hiroyuki Kousaka Noritsugu umehara Nagoya University Furo-cho Chikusa-ku Nagoya 464-8603 Japan Nagoya University Furo-cho Chikusa-ku Nagoya 464-8603 Japan

Hydrogen-free diamond-like carbon (DLC) films were deposited by a new-type surface wave-sustained plasma physical vapor deposition (SWP-PVD) system under various technique conditions. Electron density

关键词： DLC films Surface wave-sustained plasma (SWP) Microwave power Plasma density

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碳化镍钼催化剂的制备及其甲烷干气重整活性(英文)

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催化学报 2011年第5期32卷 771-776页

作者： Taro HIROSE yasushi OZAWA Masatoshi NAGAI Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and Technology Energy Engineering Research Laboratory Central Research Institute of Electric Power Industry

Nickel molybdenum carbide catalysts were prepared and their activities in the CO2 reforming of methane at a low CO2/CH4 reactant ratio were investigated using a microreactor at atmospheric pressure and at 973 *** effect of the catalyst preparation method and the Ni/Mo ratio on the increase in catalyst life and the promotion of catalytic activity were investigated using N2 adsorption,X-ray diffraction, temperature-programmed carburization,temperature-programmed reaction,and a reforming *** 25Ni75Mo catalyst that was carburized at 813 K exhibited the highest hydrogen formation ability and gave the least carbon *** incomplete carburization of the Mo oxide species in the catalyst that was carburized at a lower temperature gradually gave a more active carburized *** NiMoOxCy in the catalyst was more active in hydrogen formation during the dry reforming of methane whileβ-Mo2C andη-Mo3C2 were less active.

关键词： catalyst activation catalyst selectivity fuel dry reforming methane

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Application of Sparse-Coding Super-Resolution to 16-Bit DICOM Images for Improving the Image Resolution in MRI

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Open Journal of Medical Imaging 2017年第4期7卷 144-155页

作者： Junko Ota Kensuke umehara Naoki Ishimaru Takayuki Ishida Department of Medical Physics and Engineering Graduate School of Medicine Osaka University Suita Japan

Purpose: To improve the image resolution of magnetic resonance imaging (MRI), conventional interpolation methods are commonly used to magnify images via various image processing approaches;however, these methods tend to produce artifacts. While super-resolution (SR) schemes have been introduced as an alternative approach to apply medical imaging, previous studies applied SR only to medical images in 8-bit image format. This study aimed to evaluate the effectiveness of sparse-coding super-resolution (ScSR) for improving the image quality of reconstructed high-resolution MR images in 16-bit digital imaging and communications in medicine (DICOM) image format. Materials and Methods: Fifty-nine T1-weighted images (T1), 84 T2-weighted images (T2), 85 fluid attenuated inversion recovery (FLAIR) images, and 30 diffusion-weighted images (DWI) were sampled from The Repository of Molecular Brain Neoplasia Data as testing datasets, and 1307 non-medical images were sampled from the McGill Calibrated Color Image Database as a training dataset. We first trained the ScSR to prepare dictionaries, in which the relationship between low- and high-resolution images was learned. Using these dictionaries, a high-resolution image was reconstructed from a 16-bit DICOM low-resolution image downscaled from the original test image. We compared the image quality of ScSR and 4 interpolation methods (nearest neighbor, bilinear, bicubic, and Lanczos interpolations). For quantitative evaluation, we measured the peak signal-to-noise ratio (PSNR) and structural similarity (SSIM). Results: The PSNRs and SSIMs for the ScSR were significantly higher than those of the interpolation methods for all 4 MRI sequences (PSNR: p p Conclusion: ScSR provides significantly higher image quality in terms of enhancing the resolution of MR images (T1, T2, FLAIR, and DWI) in 16-bit DICOM format compared to the interpolation methods.

关键词： Super-Resolution Sparse-coding Super-Resolution (ScSR) MRI DICOM 16-Bit

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mPGES-1 expression in non-cancerous liver tissue impacts on postoperative recurrence of HCC

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World Journal of Gastroenterology 2010年第38期16卷 4846-4853页

作者： Koichi Nonaka Hikaru Fujioka yasushi Takii Seigo Abiru Kiyoshi Migita Masahiro Ito Takashi Kanematsu Hiromi Ishibashi Clinical Research Center and Department of Surgery National Hospital Organization Nagasaki Medical Center2-1001-1 Kubara Omura 856-8652Japan Department of Hepatology Nagasaki University Graduate School of Biomedical Sciences Department of Transplant and Digestive Surgery Nagasaki University Graduate School of Biomedical Sciences Clinical Research Center and Department of Surgery National Hospital Organization Nagasaki Medical Center2-1001-1 Kubara Omura 856-8652Japan

AIM:To investigate whether microsomal prostaglandin E synthase-1 (mPGES-1) expression in hepatocellular carcinoma (HCC) and in non-cancerous liver affects HCC prognosis after hepatectomy. METHODS: The relationship between patient clinical prof iles, tumor factors, surgical determinants, and mPGES-1 expression and the recurrence-free survival rate were examined in 64 patients who underwent curative hepatectomy between March 2003 and December 2006. RESULTS: The scores for mPGES-1 expression were higher in well differentiated and moderately differentiated HCC tissues than in poorly differentiated HCC tissues (well differentiated, 5.1 ± 2.7; moderately differentiated, 5.1 ± 1.7; poorly differentiated, 3.0 ± 1.8). In noncancerous liver tissues, the mPGES-1 levels were higher in injured liver tissues than in normal tissues. Cirrhotic livers had higher mPGES-1 levels than livers with chronic hepatitis (normal livers, 3.3 ± 0.7; chronic hepatitic livers, 5.4 ± 1.9; cirrhotic livers, 6.4 ± 1.6). A univariate analysis revealed that the recurrence-free survival rate was signif icantly lower in patients with vascular invasion,a higher mPGES-1 level in non-cancerous liver tissue,a larger tumor diameter (≥5 cm), and a lower serum albumin level (≤3.7 g/dL). The mPGES-1 expression in HCC tissues did not correlate well with postoperative recurrence. A multivariate analysis demonstrated that the presence of vascular invasion and higher mPGES-1 levels were statistically significant independent predictors for early postoperative recurrence of ***: Increased mPGES-1 expression in noncancerous liver tissues is closely associated with the early recurrence of HCC after curative resection.

关键词： Curative resection Hepatocellular carcinoma Microsomal prostaglandin E synthase-1 Noncancerous liver tissue Recurrence-free survival

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Sporadic fundic gland polyps with dysplasia or carcinoma:Clinical and endoscopic characteristics

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World Journal of Gastrointestinal Oncology 2021年第7期13卷 662-672页

作者： Wataru Sano Fumihiro Inoue Daizen Hirata Mineo Iwatate Santa Hattori Mikio Fujita yasushi Sano Gastrointestinal Center Sano HospitalKobe 655-0031HyogoJapan

Fundic gland polyps(FGPs)are the most common gastric polyps and have been regarded as benign lesions with little malignant potential,except in the setting of familial adenomatous ***,in recent years,the prevalence of FGPs has been increasing along with the widespread and frequent use of proton pump inhibitors(PPIs).To date,several cases of FGPs with dysplasia or carcinoma(FGPD/CAs)have been *** this review,we evaluated the clinical and endoscopic characteristics of sporadic FGPD/*** of the patients with sporadic FGPD/CAs were middle-aged women receiving PPI therapy and without Helicobacter pylori(***)*** of the sporadic FGPD/CAs occurred in the body of the stomach and were sessile and small with a mean size of 5.4 *** sporadic FGPs with carcinoma showed redness,irregular surface structure,depression,or erosion during white light observation and irregular microvessels on the lesion surface during magnifying narrow-band *** addition,sporadic FGPs,even with dysplasia,are likely to progress to cancer ***,frequent endoscopy is not required for patients with sporadic ***,histopathological evaluation is necessary if endoscopic findings different from ordinary FGPs are observed,regardless of their *** the future,the prevalence of FGPs is expected to further increase along with the widespread and frequent use of PPIs and decreasing infection rate of ***,it is unclear whether FGPD/CAs will also increase in the same way as ***,the trends of these lesions warrant further attention in the future.

关键词： Sporadic Fundic gland polyp Dysplasia Carcinoma Proton pump inhibitor Helicobacter pylori

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Multi-component background learning automates signal detection for spectroscopic data

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npj Computational Materials 2019年第1期5卷 484-490页

作者： Sebastian E.Ament Helge S.Stein Dan Guevarra Lan Zhou Joel A.Haber David A.Boyd Mitsutaro umehara John M.Gregoire Carla P.Gomes Department of Computer Science Cornell UniversityIthacaNY 14850USA Joint Center for Artificial Photosynthesis California Institute of TechnologyPasadenaCA 91125USA Future Mobility Research Department Toyota Research Institute of North AmericaAnn ArborMI 48105USA

Automated experimentation has yielded data acquisition rates that supersede human processing *** Intelligence offers new possibilities for automating data interpretation to generate large,high-quality *** subtraction is a long-standing challenge,particularly in settings where multiple sources of the background signal coexist,and automatic extraction of signals of interest from measured signals accelerates data ***,we present an unsupervised probabilistic learning approach that analyzes large data collections to identify multiple background sources and establish the probability that any given data point contains a signal of *** approach is demonstrated on X-ray diffraction and Raman spectroscopy data and is suitable to any type of data where the signal of interest is a positive addition to the background *** the model can incorporate prior knowledge,it does not require knowledge of the signals since the shapes of the background signals,the noise levels,and the signal of interest are simultaneously learned via a probabilistic matrix factorization *** identification of interpretable signals by unsupervised probabilistic learning avoids the injection of human bias and expedites signal extraction in large datasets,a transformative capability with many applications in the physical sciences and beyond.

关键词： signal component spectroscopic

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Endoscopic and histopathological study on the duodenum of Strongyloides stercoralis hyperinfection

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World Journal of Gastroenterology 2008年第11期14卷 1768-1773页

作者： Kazuto Kishimoto Akira Hokama Tetsuo Hirata yasushi Ihama Manabu Nakamoto Nagisa Kinjo Fukunori Kinjo Jiro Fujita Department of Endoscopy Ryukyu University HospitalOkinawa 903-0215Japan Department of Medicine and Therapeutics(First Department of Internal Medicine) Control and Prevention of Infectious DiseaseFaculty of Medicine University of the RyukyusOkinawa 903-0215Japan

AIM:To investigate endoscopic and histopathological findings in the duodenum of patients with Strongyloides stercoralis(***)hyperinfection. METHODS:Over a period of 23 years(1984-2006),we investigated 25 patients *** hyperinfection who had had an esophagogastroduodenoscopy before undergoing treatment for *** clinical and endoscopic findings were analyzed retrospectively. RESULTS:Twenty-four(96%)of the patients investigated were under immunocompromised condition which was mainly due to a human T lymphotropic virus type 1(HTLV-1)*** abnormal endoscopic findings,mainly edematous mucosa,white villi and erythematous mucosa,were observed in 23(92%) *** degree of duodenitis including villous atrophy/destruction and inflammatory cell infiltration corresponded to the severity of the endoscopic findings. The histopathologic yield for identifying larvae was 71.4% by duodenal *** endoscopic findings of duodenitis were more severe in patients whose biopsies were positive for larvae than those whose biopsies were negative(Endoscopic severity score:4.86±2.47vs 2.71 ±1.38,P<0.05). CONCLUSION:Our study clearly demonstrates that,in addition to stool analysis,endoscopic observation and biopsies are very *** also emphasize that *** and HTLV-1 infections should be ruled out before immunosuppressive therapy is administered in endemic regions.

关键词： Strongyloides stercoralis Strongyloidiasis Hyperinfection Endoscopy Histopathology Duodenum

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Comparison of minimally invasive glaucoma surgery with trabecular micro-bypass stent and microhook ab interno trabeculotomy performed in conjunction with cataract surgery

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1082-1088页

作者： Naoto Tokuda yasushi Kitaoka Ayaka Tsukamoto Yasuhiro Toyoda Yusuke Yamada Kana Sase Hitoshi Takagi Department of Ophthalmology St Marianna University School of Medicine2-16-1 Sugao Miyamae-ku Kawasaki-shiKanagawa 216-8851Japan

AIM: To evaluate the effectuality and safety of cataract surgery combined with either ab interno trabeculotomy by the microhook(μLOT) or a single i Stent? trabecular bypass implantation(i Stent) in eyes with cataract and mild-tomoderate glaucoma. METHODS: This study enrolled subjects with mild-tomoderate open angle glaucoma with visually significant cataract who used two or more ophthalmic antiglaucoma agents between 60 and 90 y of age. Patients underwent cataract surgery cooperated with either implantation of an i Stent(i Stent-phaco) or excisional goniotomy with the μLOT(μLOT-phaco). Patients underwent μLOT-phaco in the eye with lower the mean deviation, according to the Humphrey field analyzer, while i Stent-phaco was carried out on the other eye. Intraocular pressure(IOP) pre-and post-surgery, alterations in anterior chamber flare(ACF), and corneal endothelial cell density(ECD) were ***: Twenty subjects were enrolled(mean age: 73.6±7.3 y). The mean medicated preoperative IOP was 16.7 mm Hg in the μLOT and 16.2 mm Hg in the i Stent eyes. The mean final IOP at 12 mo was 13.6 mm Hg in the μLOT eyes and 13.6 mm Hg in the i Stent eyes, representing a 17.8% and 17.2% reduction, respectively. The preoperative ACF in the μLOT eyes was 9.5 pc/ms and it returned to normal in 30 d postoperatively, with a value of 11.4 pc/ms. In the i Stent eyes, ACF was 9.6 pc/ms preoperatively and it returned to normal by 7 d postoperatively(11.2 pc/ms atday 7), demonstrating that postoperative inflammation was less in the i Stent eyes. The corneal ECD in both groups was not significantly ***: In this study, i Stent and μLOT are both effective through 12 mo of follow-up. Safety is more favorable in the i Stent eyes, based on early anterior chamber inflammation.

关键词： minimally invasive glaucoma surgery iStent ab interno trabeculotomy

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