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CAD Exchange Format in the Field of Public Works Japan

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Journal of Civil Engineering and Architecture 2012年第11期6卷 1523-1529页

作者： yasushi Kawanai Standard Department Japan Construction Information Center Tokyo 107-8416 Japan

There is a CAD （computer-aided design） data exchange format named SXF （scadec exchange format） in the field of Japanese public works which was developed by a consortium in 1999 to be based on the ISO 10303-202, so that the MLIT （Ministry of Land, Infi＇astructure, Transportation and Tourism） could start e-delivery （e-submit） of CAD drawings. It is one of targets for CALS/EC （continuous acquisition and lifecycle support/electric commerce） program which MLIT are promoting since 1999. Most of local governments have followed the MLIT to start e-delivery, so that SXF has become to be a standard in the public works in Japan with many problems. SXF is an exchange format and so many design companies or contractors would submit the CAD drawings with transferred format before the delivery of e-submit even if they use usually another CAD in their offices. This paper will introduce the standard of CAD exchange format SXF through the activities of Japanese public works.

关键词： CAD CALS/EC public works exchange format MLIT SXF.

Effects of Pitavastatin on the Intima-Media Thickness of the Carotid Artery in Patients with Ischemic Stroke: The Pitavastatin Efficacy Study on Surrogate Markers and Imaging for Stroke (PESSMIST)

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World Journal of Neuroscience 2014年第4期4卷 306-312页

作者： yasushi Shibata Department of Neurosurgery University of Tsukuba Mito Medical Center Mito Kyodo General Hospital Mito Japan

Pitavastatin is a strong statin that was developed in Japan. The clinical impact of pitavastatin treatment in patients with ischemic stroke has not been reported. We conducted a prospective, open label, clinical case-control study to determine the secondary preventive effects of pitavastatin for patients with cerebral infarction and hyperlipidemia. The pitavastatin group included 20 Japanese patients diagnosed with cerebral infarction and hyperlipidemia without previous statin intake. The control group included 22 patients diagnosed with cerebral infarction without hyperlipidemia. The pitavastatin group of patients received 2 mg of pitavastatin once a day after dinner. The mean age of the patients was 69.3 and 75.5 years for the pitavastatin and control groups, respectively, and the age of the pitavastatin group was significantly younger than that of the control group (P < 0.05). The serum TCho and LDL-C levels significantly decreased two months after the initiation of pitavastatin treatment. The mean and maximum intima-media thickness (IMT) also decreased after the initiation of pitavastatin. The mean and maximum IMT did not show any significant changes in the control group. The change of IMT %/year was less than zero for the pitavastatin group, and was almost zero or higher for the control group. Pitavastatin showed beneficial effects by improving the surrogate makers of stroke. These surrogate makers were effective to evaluate the efficacy of pitavastatin to prevent secondary stroke. Although a prospective randomized study is required to elucidate the long-term effects of pitavastatin, the current study suggests that pitavastatin may be effective to prevent secondary stroke in patients with stroke and hyperlipidemia.

关键词： Pitavastatin Stroke ECHO IMT Hyperlipidemia

Endoscopic papillectomy of minor papillar adenoma associated with pancreas divisum

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World Journal of Gastroenterology 2009年第9期15卷 1138-1140页

作者： Akira Kanamori Takashi Kumada Seiki Kiriyama Yasuhiro Sone Makoto Tanikawa Yasuhiro Hisanaga Hidenori toyoda Hiroki Kawashima Akihiro Itoh Yoshiki Hirooka Hidemi Goto Department of Gastroenterology Ogaki Municipal HospitalOgaki 503-8502Japan Department of Gastroenterology Nagoya University Graduate School ofMedicineNagoya 466-8560Japan Department of Gastroenterology Nagoya University Graduate School of MedicineNagoya 466-8560Japan Department of Endoscopy Nagoya University HospitalNagoya 466-8560Japan

Tumors of the minor papilla of the duodenum are quite *** successfully and safely treated an 18-mm adenoma of the minor papilla associated with pancreas divisum using endoscopic papillectomy.A 64-year-old man was admitted to our hospital for treatment of an asymptomatic mass in the minor papilla detected by upper gastrointestinal *** analysis showed an 18-mm,whitish,sessile mass,located in the duodenum proximal to a normal-appearing major *** retrograde pancreatography did not reveal the pancreatic *** resonance cholangiopancreatography showed a lack of the ventral pancreatic *** suspected this case was associated with pancreatic divisum;therefore,we performed endoscopic papillectomy of the minor papilla ***,endoscopic pancreatic stent placement in the minor papilla was done to prevent drainage *** patient has been asymptomatic without recurrence of tumor or stenosis of the Santorini orifice upon endoscopic examination for the past 2 years.

关键词： Endscopic papitlectomy Minor papill aradenoma Pancreas divisum Endoscopic pancreatic stent Endoscopic retrograde pancreatography

Eye-Movement While Generating a Trajectory Using the Upper Limb

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Journal of Energy and Power Engineering 2012年第11期6卷 1733-1744页

作者： Nozomi toyoda Ryohei Yamamoto Tetsuro Yabuta Faculty of Engineering Yokohama National University Yokohama 2408501 Japan

This paper describes the experimental analysis of eye-movement during the generation of a trajectory by the human upper limb, carried out to elucidate the human mechanism for visual-information recognition. The results showed that the subjects adopted an eye-movement pattern called the subgoal travel method （fixating in the vicinity of the fingertip while drawing/tracing） for the complete circle. Subsequently, when the target trajectory was one of incomplete shapes, some subjects continued following the subgoal travel method by drawing the missing part of the target trajectory, while others followed two other eye-movement patterns. The first is called the center-point fixation method, in which subjects consider the center point as the most important point for generating the target-image trajectory, and therefore, fix their gaze at the center point throughout the experiment. The second is called the point-to-point travel method, in which the subjects＇ gazes shift between the center point of a displayed image and their fingertip. Further, the results confirmed that the eye-movement pattern, movement accuracy, and drawing speed are correlated. Additional experiments clarified the conditions for which different eye-movement patterns are suitable： the subgoal travel method is suitable for high-accuracy drawing; the center-point fixation method is suitable for higher-sneed drawing

关键词： Eye-movement pattern drawing strategy visual information upper-limb motion.

Conversion of Methane to Hydrogen via Pulsed Corona Discharge

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Journal of Natural Gas Chemistry 2004年第2期13卷 82-86页

作者： Lekha Nath Mishra Kanetoshi Shibata Hiroaki Ito Noboru Yugami yasushi Nishida Energy and Environmental Science Graduate School of Engineering Utsunomiya University 7-1-2 Yoto Utsunomiya Tochigi 321-8585 Japan

Experiments are performed to develop a pulsed corona discharge system for the conversion of methane to hydrogen at atmospheric pressure (≈760 Torr) without using a catalyst. The corona discharge was energized by 10-12 μs wide voltage pulses (≤7 kV) at a repetition rate of about 1.0-1.5 kHz. The residual gases were characterized by mass spectrometry. The conversion of methane is as high as 50.8% producing the 70% yield of hydrogen. The influences of argon on the discharge of methane were studied. This result could be useful for the mass production of hydrogen in both academic and industrial point of view.

关键词： pulsed corona discharge mass spectrometer methane hydrogen

Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease

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World Journal of Stem Cells 2018年第11期10卷 146-159页

作者： Saifun Nahar Yoshiki Nakashima Chika Miyagi-Shiohira Takao Kinjo Zensei toyoda Naoya Kobayashi Issei Saitoh Masami Watanabe Hirofumi Noguchi Jiro Fujita Department of Infectious Respiratory and Digestive Medicine Graduate School of Medicine University of the Ryukyus Okinawa 903-0215 Japan Department of Regenerative Medicine Graduate School of Medicine University of the Ryukyus Okinawa 903-0215 Japan Department of Basic Laboratory Sciences School of Health Sciences in the Faculty of Medicine University of the Ryukyus Okinawa 903-0215 Japan Okayama Saidaiji Hospital Okayama 704-8192 Japan Division of Pediatric Dentistry Graduate School of Medical and Dental Science Niigata University Niigata 951-8514 Japan Department of Urology Okayama Univer sity Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan

Adipose-derived mesenchymal stem cells （ADSCs） are a treatment cell source for patients with chronic liver injury. ADSCs are characterized by being harvested from the patient’s own subcutaneous adipose tissue, a high cell yield （ i.e. , reduced immune rejection res-ponse）, accumulation at a disease nidus, suppression of excessive immune response, production of various growth factors and cytokines, angiogenic effects, anti-apoptotic effects, and control of immune cells via cell-cell interaction. We previously showed that conditioned medium of ADSCs promoted hepatocyte proliferation and improved the liver function in a mouse model of acute liver failure. Furthermore, as found by many other groups, the administration of ADSCs improved liver tissue fbrosis in a mouse model of liver cirrhosis. A comprehensive protein expression analysis by liquid chromatography with tandem mass spectrometry show-ed that the various cytokines and chemokines produced by ADSCs promote the healing of liver disease. In this review, we examine the ability of expressed protein com-ponents of ADSCs to promote healing in cell therapy for liver disease. Previous studies demonstrated that ADSCs are a treatment cell source for patients with chronic liver injury. This review describes the various cytokines and chemokines produced by ADSCs that promote the healing of liver disease.

关键词： Cell transplantation therapy Cytokine Hepatocytes Liquid chromatography with tandem mass spectrometry Liver cirrhosis Adipose-derived mesenchymal stem cells

Severe hypercholesterolemia associated with primary biliary cirrhosis in a 44-year-old Japanese woman

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World Journal of Gastroenterology 2004年第17期10卷 2607-2608页

作者： Tatsuo Kanda Osamu Yokosuka Hiroshige Kojima Fumio Imazeki Keiich Nagao Ichiro Tatsuno yasushi Saito Hiromitsu Saisho First Department of Medicine Chiba University School of MedicineChiba 260-8670Japan Health Sciences CenterChiba UniversityChiba 260-8670Japan Health Sciences Center Chiba UniversityChiba 260-8670Japan Second Department of Medicine Chiba University School of MedicineChiba 260-8670Japan

A 44-year-old woman developed jaundice and was diagnosed as stage Ⅱ of primary biliary cirrhosis(PBC).She showed a severely high total cholesterol *** article focuses on atypical presentations of PBC and the need to ... 详细信息

关键词： Adult Cholesterol Female Humans Hypercholesterolemia Japan Liver Cirrhosis, Biliary Severity of Illness Index

Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients

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Asian Journal of Andrology 2012年第4期14卷 580-583页

作者： Toshinobu Miyamoto Aldra Tsujimura yasushi Miyagawa Eitetsu Koh Mikio Namiki Michiharu Horikawa Yasuaki Saijo Kazuo Sengoku Department of Obstetrics and Gynecology Asahikawa Medical University Asahikawa Hokkaido 078-8510 Japan Department of Urology Osaka University Graduate School of Medicine Suita 565-0871 Japan Department of Integrated Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa 920-1192 Japan Division of Community Medicine and Epidemiology Department of Health Science Asahikawa Medical University Asahikawa 078-8510 Japan

Genetic mechanisms are implicated as a cause of some male infertility, yet are poorly understood. Meiosis is unique to germ cells and essential for reproduction. The synaptonemal complex is a critical component for chromosome pairing, segregation and recombination. Hormadl is essential for mammalian gametogenesis as knockout male mice are infertile. Hormadl-deficient testes exhibit meiotic arrest in the early pachytene stage and synaptonema! complexes cannot be visualized. To analyze the hypothesis that the human HORMAD1 gene defects are associated with human azoospermia caused by meiotic arrest, mutational analysis was performed in all coding regions by direct sequence analysis of 30 Japanese men diagnosed with azoospermia resulting from meiotic arrest. By the sequence analysis, three polymorphism sites, Single Nucleotide Polymorphism 1 （c. 163A〉G）, SNP2 （c. 501T〉G） and SNP3 （c. 918C〉T）, were found in exons 3, 8 and 10. The 30 patients with azoospermia and 80 normal pregnancy-proven, fertile men were analyzed for HORMAD1 polymorphisms. Both SNP1 and SNP2 were associated with human azoospermia caused by complete early meiotic arrest （P〈0.0S）. We suggest that the HORMAD1 has an essential meiotic function in human spermatogenesis.

关键词： azoospermia HORMAD1 male infertility male meiosis SNP

Application of the Childhood Autism Rating Scale to Grasp Autistic Characteristics of the Trainees with Intellectual Disabilities in Agricultural Vocational Training

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Journal of Behavioral and Brain Science 2019年第8期9卷 301-312页

作者： Masahiro toyoda Yuko Yokota Midori Kaneko Graduate School of Landscape Design and Management University of Hyogo Kobe Japan

The purpose of this study was to propose indicators for grasping autistic characteristics of people with intellectual disabilities who were going to engage in agricultural vocational training. We analyzed the data of the Childhood Autism Rating Scale (CARS) of 44 students at the high school course of a special needs education school who participated in agricultural vocational training. The data were divided into two groups according to the scores of “General Impressions”, one of 15 question items of the CARS: one was the group whose score was 1 (usual), and the other was the group whose scores were 1.5 to 4 (unusual). The results of the Mann-Whitney U test showed significant differences between two groups in eight items including “Relating to People” (p Relating to People” with six other items. As a result, “Relating to People” was considered to be the most effective item to know the participant’s autistic characteristics at a very early stage of training. Eventually, adding two items, “Body Use” and “Imitation” which are necessary to master agricultural tasks, to “Relating to People”, we proposed three indicators.

关键词： Agricultural Vocational Training CARS (Childhood Autism Rating Scale) Behavioral Observation Cooperation between Agriculture and Welfare