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Calcium carbonate supplementation causes memory impairment in mice

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Asian Pacific Journal of Tropical Medicine 2018年第10期11卷 576-582页

作者： yasushi hasegawa Tatsurou Inoue Tatsuya Fuji College of Environmental Technology Muroran Institute of TechnologyJapan

Objective: To investigate the influence of calcium carbonate supplementation on cognitive function in mice. Methods: Mice were fed diets containing 1.0% calcium carbonate for 8 weeks, following which they were evaluated for memory function using object recognition, Y-maze, and Barnes maze tests. Next, the expression levels of cAMP response element binding protein(CREB) and phosphorylated CREB, which is involved in the memory process were investigated in both the hippocampus and cerebral cortex using western blotting methods. Results: Mice fed on a diet containing calcium carbonate showed memory impairments in object recognition, Y-maze, and Barnes maze tests with respect to the mice that were on a control diet. Further, mice that were fed a diet containing calcium carbonate and a nimodipine(an L-type calcium channel antagonist), reversed calcium carbonate-induced memory impairments, thus suggesting that excessive entry of calcium in cells may cause memory impairments. A study using western blot revealed that expression of CREB and phosphorylated CREB in hippocampus and cerebral cortex was significantly lower in the calcium carbonatefed mice than in the control-diet-fed mice. Conclusions: These results suggest that a calcium carbonate diet may cause memory impairment by decreasing CREB expression. This is the first report of calcium carbonate supplementation causing memory impairment. This simple animal model may be useful as a novel cognitive impairment model for drug development.

关键词： Calcium carbonate Memory impairment CREB

Effects of scallop shell extract on scopolamine-induced memory impairment and MK801-induced locomotor activity

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Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 643-647页

作者： yasushi hasegawa Tatsuro Inoue Satoshi Kawaminami Miho Fujita College of Environmental Technology Muroran Institute of Technology

Objective:To evaluate the neuroprotective effects of the organic components of scallop shells(scallop shell extract) on memory impairment and locomotor activity induced by scopolamine or 5-methyl-10,11-dihydro-5H-dibenzo(a,d) cyclohepten-5,10-imine(MK801).Methods:Effect of the scallop shell extract on memory impairment and locomotor activity was investigated using the Y-maze test,the Morris water maze test,and the open field ***:Scallop shell extract significantly reduced scopolamine-induced short-term memory impairment and partially reduced scopolamine-induced spatial memory impairment in the Morris water maze *** shell extract suppressed scopolamine-induced elevation of acetylcholine esterase activity in the cerebral *** with scallop shell extract reversed the increase in locomotor activity induced by *** shell extract also suppressed the increase in locomotor activity induced by ***:Our results provide initial evidence that scallop shell extract reduces scopolamine-induced memory impairment and suppresses MK-801-induced hyperlocomotion.

关键词： Locomotor activity Memory impairment Scallop shell Schizophrenia

Time to take another Iook at perceived disadvantages of robotic hepatectomy

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 208-210页

作者： yasushi hasegawa Hiroyuki Nitta Takeshi Takahara Akira Sasaki Department of Surgery Iwate Medical University School of MedicineMorioka CityIwateJapan

Robotic hepatectomy remains controversial to date,despite continuous advances in the technology and more surgeons gaining experience with the *** et al.(1)recently published an interesting article in Hepatobiliary Surgery and Nutrition,titled"Selecting incision-dominant cases for robotic liver resection:towards outpatient hepatectomy with rapid recovery."The authors evaluated 97 cases of robotically-assisted liver resection(RLR)arguing that it is difficult to reach the superior-posterior liver segments with the straight instruments used in conventional laparoscopic liver resection(LLR).The articulated instruments of the surgical robot are better suited for hepatectomies in these difficult-to-reach areas of the *** concluded that cases where the incision of an open approach would be large and affect recovery results in the highest likelihood of patients benefitting from a robotic *** think that the authors present an interesting perspective by focusing on the strong points of RLR compared to LLR.

关键词： hepatectomy Surgery straight

Does laparoscopic resection for colorectal cancer liver metastasis have a long-term oncologic advantage?

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 246-248页

作者： yasushi hasegawa Minoru Kitago Yuta Abe Yuko Kitagawa Department of Surgery Keio University School of MedicineTokyoJapan

The long-term advantages of laparoscopic liver resection(LLR)over open liver resection(OLR)for colorectal cancer liver metastasis(CLM)have not been *** et al.(1)recently published an interesting article in the Annals of Surgery,titled“Survival Advantage of Laparoscopic Versus Open Resection for Colorectal Liver Metastases:A Meta-analysis of Individual Patient Data from Randomized Trials and Propensity-score Matched Studies.”The authors performed a meta-analysis of individual participant data from two randomized trials and thirteen propensity score-matched studies that compared long-term outcomes between patients undergoing LLR and OLR for CLM.A total of 1,275 patients who underwent LLR and 1,873 patients who underwent OLR were *** found that LLR was associated with a lower risk of death and concluded that LLR had a long-term survival benefit compared to OLR.

关键词： metastasis Surgery liver

Peritoneal dissemination of pancreatic cancer caused by endoscopic ultrasound-guided fine needle aspiration:A case report and literature review

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World Journal of Gastroenterology 2021年第3期27卷 294-304页

作者： Hideaki Kojima Minoru Kitago Eisuke Iwasaki Yohei Masugi Yohji Matsusaka Hiroshi Yagi Yuta Abe yasushi hasegawa Shutaro Hori Masayuki Tanaka Yutaka Nakano Yusuke Takemura Seiichiro Fukuhara Yoshiyuki Ohara Michiie Sakamoto Shigeo Okuda Yuko Kitagawa Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Division of Gastroenterology and Hepatology Department of Internal MedicineKeio University School of MedicineTokyo 160-8582Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan Department of Radiology Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)is a biopsy technique widely used to diagnose pancreatic tumors because of its high sensitivity and *** needle-tract seeding caused by EUS-FNA has been recently reported,dissemination of pancreatic cancer cells is generally considered to be a rare complication that does not affect patient ***,the frequency of dissemination and needle-tract seeding appears to have been *** present a case of peritoneal dissemination of pancreatic cancer due to preoperative *** SUMMARY An 81-year-old man was referred to the Department of Surgery of our hospital in Japan owing to the detection of a pancreatic mass on computed tomography during medical ***-gastric EUS-FNA revealed that the mass was an adenocarcinoma;hence laparoscopic distal pancreatectomy with lymphadenectomy was *** intraoperative peritoneal dissemination and liver metastasis were visually detected,and pelvic lavage cytology was negative for carcinoma *** postoperative surgical specimen was negative for carcinoma cells at the dissected margin and the cut end margin;however,pathological findings revealed adenocarcinoma cells on the peritoneal surface proximal to the needle puncture site,and the cells were suspected to be disseminated via ***,the patient received adjuvant therapy with S-1(tegafur,gimeracil,and oteracil potassium);however,computed tomography performed 5 mo after surgery revealed liver metastasis and cancerous *** patient received palliative therapy and died 8 mo after the *** The indications of EUS-FNA should be carefully considered to avoid iatrogenic dissemination,especially for cancers in the pancreatic body or tail.

关键词： Case report Pancreatic carcinoma Endoscopic ultrasound-guided fine needle aspiration Peritoneal dissemination Cancerous peritonitis Biopsy

Change in myosin Ⅰ content in A10 vascular smooth muscle cell by growth factor stimulations.

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Change in myosin Ⅰ content in A10 vascular smooth muscle ce...

Maintenance treatment with infliximab for ulcerative ileitis after intestinal transplantation: A case report

Third Congress of the Asian-Pacific Organization for Cell Biology

作者： yasushi hasegawa Shiho Tsuwaki Naruhito Yamada Takahiro Araki Yon Okamoto Department of Applied Chemistry Muroran Institute of Technology. MizumotoMuroranHokkaido 050Japan

We isolated and identified a 110-kDa myosin I from porcine aorta media smooth muscle (Y. hasegawa et al. (1996) J. Biochemistry, 120, 971-976). Partial peptide sequences of the 110-kDa myosin I fragments

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World Journal of Clinical Cases 2021年第19期9卷 5270-5279页

作者： Takumi Fujimura Yohei Yamada Tomoshige Umeyama Yumi Kudo Hiroki Kanamori Teizaburo Mori Takahiro Shimizu Mototoshi Kato Miho Kawaida Naoki Hosoe yasushi hasegawa Kentaro Matsubara Naoki Shimojima Masahiro Shinoda Hideaki Obara Makoto Naganuma Yuko Kitagawa Ken Hoshino Tatsuo Kuroda Department of Pediatric Surgery National Saitama HospitalWako ShiSaitama 351-0102Japan Department of Pediatric Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan Center for Diagnostic and Therapeutic Endoscopy Keio University School ofMedicineTokyo 160-8582Japan Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Digestive Diseases Center International University of Health and WelfareMita HospitalTokyo 108-8329Japan Department of Gastroenterology and Hepatology Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Evidence has been published on the successful applications of the anti-tumor necrosis factor alpha antibody infliximab,such as induction therapy,salvage treatment for acute cellular rejection,and treatment for chronic ulcerative inflammation,in intestinal transplant ***,the optimal protocol for the effective use of infliximab remains largely undetermined due to scarcity of available clinical *** report a continuative application of infliximab as maintenance therapy for recurrent chronic ulcerative ileitis in a recipient of isolated intestinal transplantation(ITx).CASE SUMMARY The patient was a 11-year-old boy with intestinal motility disorder classified as a hypogenic type of intestinal *** patient underwent living-donor related intestinal *** immunosuppression regimen consisted of daclizumab,tacrolimus,and *** he did not show rejection while on tacrolimus monotherapy,routine screening endoscopy showed several ulcerative lesions in the distal end of the graft 2 years after the intestinal *** work up to evaluate the progression of anemia revealed stenosis with ulcerative inflammatory changes and multiple longitudinal ulcers in the *** the endoscopic findings suggested ulcerative lesions in Crohn’s disease,infliximab treatment was *** with infliximab and a small dose of oral prednisolone afforded successful withdrawal of total parenteral nutrition and maintenance of a well-functioning graft without infectious complications for 5 years since the administration of the first dose of *** Infliximab is effective as maintenance therapy for recurrent chronic ulcerative ileitis in an isolated ITx patient.

关键词： Intestinal transplantation Chronic ulcer Infliximab Crohn’s disease Tumor necrosis factor alpha Case report

Novel procedure for hepatic venous outflow block after liver resection:A case report

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World Journal of Clinical Cases 2024年第29期12卷 6320-6326页

作者： Hisanobu Higashi Yuta Abe Kodai Abe Yutaka Nakano Masayuki Tanaka Shutaro Hori yasushi hasegawa Hiroshi Yagi Minoru Kitago Yuko Kitagawa Department of Surgery National Hospital Organization Saitama HospitalWako 351-0102Japan Department of Surgery Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Postoperative complications like remnant hepatic vein(HV)outflow block and liver torsion can occur after right *** falciform ligament fixation is typically used to prevent liver *** report a novel procedure to manage outflow *** SUMMARY An 80-year-old man developed HV outflow block after remnant right hepatectomy,despite liver fixation and intraoperative HV flow *** had a history of cholangiocellular carcinoma and had undergone posterior segmentectomy and *** falciform ligament fixation was inadequate to maintain liver *** surgery was performed,using an omental flap and mobilized right side colon with ileocecal region to prevent liver dislocation due to intraabdominal *** postoperative course was *** This is the first report providing a novel surgical procedure when the falciform ligament is insufficient for remnant liver fixation.

关键词： Hepatectomy Postoperative complications Budd-Chiari syndrome Hepatic vein outflow block Emergency surgery Case report

Effects of reductive annealing on insulating polycrystalline thin films of Nb-doped anatase TiO2:recovery of high conductivity

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Journal of Semiconductors 2016年第2期37卷 10-13页

作者： Shoichiro Nakao yasushi Hirose Tetsuya hasegawa Kanagawa Academy of Science and Technology(KAST) Kawasaki 213-0012Japan Japan Science and Technology Agency CRESTBunkyoTokyo 113-0033Japan Department of Chemistry The University of TokyoBunkyoTokyo 113-0033Japan

We studied the effects of reductive annealing on insulating polycrystalline thin films of anatase Nb- doped TiO2 （TNO）. The insulating TNO films were intentionally fabricated by annealing conductive TNO films in oxygen ambient at 400 ℃. Reduced free carrier absorption in the insulating TNO films indicated carrier com- pensation due to excess oxygen. With H2-annealing, both carrier density and Hall mobility recovered to the level of conducting TNO, demonstrating that the excess oxygen can be efficiently removed by the annealing process without introducing additional scattering centers.

关键词： transparent conductive oxide Nb-doped TiOa pulsed laser deposition